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Full-Text Articles in Medicine and Health Sciences

Increased Incidence Of Thyroid Cancer Among World Trade Center First Responders: A Descriptive Epidemiological Assessment, S. Tuminello, M. A. Van Gerwen, E. Genden, M. Crane, W. Lieberman-Cribbin, E. Taioli Jan 2019

Increased Incidence Of Thyroid Cancer Among World Trade Center First Responders: A Descriptive Epidemiological Assessment, S. Tuminello, M. A. Van Gerwen, E. Genden, M. Crane, W. Lieberman-Cribbin, E. Taioli

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size (p = 0.4), and were diagnosed at a similar age (p = 0 ...


Dietary Inflammatory Index (Dii) And Risk Of Prostate Cancer In A Case–Control Study Among Black And White Us Veteran Men, A. C. Vidal, T. Oyekunle, L. E. Howard, N. Shivappa, A. De Hoedt, J. C. Figueiredo, E. Taioli, J. H. Fowke, P. H. Lin, S. J. Freedland, +1 Additional Author Jan 2019

Dietary Inflammatory Index (Dii) And Risk Of Prostate Cancer In A Case–Control Study Among Black And White Us Veteran Men, A. C. Vidal, T. Oyekunle, L. E. Howard, N. Shivappa, A. De Hoedt, J. C. Figueiredo, E. Taioli, J. H. Fowke, P. H. Lin, S. J. Freedland, +1 Additional Author

Journal Articles

© 2019, Springer Nature America, Inc. Background: We hypothesized a pro-inflammatory diet would be associated with higher prostate cancer (PC) risk. Methods: We prospectively recruited incident PC cases (n = 254) and controls (n = 328) at the Durham Veteran Affairs, from 2007 to 2018. From a self-completed 61-item Food Frequency Questionnaire, we calculated dietary inflammatory index (DII ® ) scores with and without supplements. We examined the association between DII scores with and without supplements and overall PC risk using logistic regression and risk of low-grade PC (grade group 1) and high-grade PC (grade group 2–5) with multinomial logistic regression. Results: Cases were ...


Transfer Of Extracellular Vesicle-Associated-Rnas Induces Drug Resistance In Alk-Translocated Lung Adenocarcinoma, H. H. Kwok, Z. Ning, P. W. Chong, T. S. Wan, M. H. Ng, G. Y. Ho, M. S. Ip, D. C. Lam Jan 2019

Transfer Of Extracellular Vesicle-Associated-Rnas Induces Drug Resistance In Alk-Translocated Lung Adenocarcinoma, H. H. Kwok, Z. Ning, P. W. Chong, T. S. Wan, M. H. Ng, G. Y. Ho, M. S. Ip, D. C. Lam

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Anaplastic lymphoma kinase (ALK) translocation is an actionable mutation in lung adenocarcinoma. Nonetheless tumour consists of heterogeneous cell subpopulations with diverse phenotypes and genotypes, and cancer cells can actively release extracellular vesicles (EVs) to modulate the phenotype of other cells in the tumour microenvironment. We hypothesized that EVs derived from a drug-resistant subpopulation of cells could induce drug resistance in recipient cells. We have established ALK-translocated lung adenocarcinoma cell lines and subclones. The subclones have been characterized and the expression of EV-RNAs determined by quantitative polymerase chain reaction. The effects of EV ...


The Evidence Of Human Exposure To Glyphosate: A Review, C. Gillezeau, M. Van Gerwen, R. M. Shaffer, I. Rana, L. Zhang, L. Sheppard, E. Taioli Jan 2019

The Evidence Of Human Exposure To Glyphosate: A Review, C. Gillezeau, M. Van Gerwen, R. M. Shaffer, I. Rana, L. Zhang, L. Sheppard, E. Taioli

Journal Articles

© 2019 The Author(s). Background: Despite the growing and widespread use of glyphosate, a broad-spectrum herbicide and desiccant, very few studies have evaluated the extent and amount of human exposure. Objective: We review documented levels of human exposure among workers in occupational settings and the general population. Methods: We conducted a review of scientific publications on glyphosate levels in humans; 19 studies were identified, of which five investigated occupational exposure to glyphosate, 11 documented the exposure in general populations, and three reported on both. Results: Eight studies reported urinary levels in 423 occupationally and para-occupationally exposed subjects; 14 studies reported ...


Change In Quality Of Life After A Cancer Diagnosis Among A Nationally Representative Cohort Of Older Adults In The Us, R. M. Schwartz, K. A. Ornstein, B. Liu, N. Alpert, K. G. Bevilacqua, E. Taioli Jan 2019

Change In Quality Of Life After A Cancer Diagnosis Among A Nationally Representative Cohort Of Older Adults In The Us, R. M. Schwartz, K. A. Ornstein, B. Liu, N. Alpert, K. G. Bevilacqua, E. Taioli

Journal Articles

No abstract provided.


Outcomes Of Pulmonary Resection In Non-Small Cell Lung Cancer Patients Older Than 70 Years Old, A. Tantraworasin, S. Siwachat, N. Tanatip, N. Lertprasertsuke, S. Kongkarnka, J. Euathrongchit, Y. Wannasopha, T. Suksombooncharoen, E. Taioli, S. Saeteng, +1 Additional Author Jan 2019

Outcomes Of Pulmonary Resection In Non-Small Cell Lung Cancer Patients Older Than 70 Years Old, A. Tantraworasin, S. Siwachat, N. Tanatip, N. Lertprasertsuke, S. Kongkarnka, J. Euathrongchit, Y. Wannasopha, T. Suksombooncharoen, E. Taioli, S. Saeteng, +1 Additional Author

Journal Articles

© 2019 Background: An appropriate treatment of older lung cancer patients has become an important issue. The aim of this study is to evaluate the short and long-term surgical outcomes in lung cancer patients using 70 years as a cut-point, and to identify prognostic factors of cancer-specific mortality in patients older than 70 years. Methods: Medical records of non-small cell lung cancer (NSCLC) patients who underwent pulmonary resection at Chiang Mai University Hospital from January 2002 through December 2016 were retrospectively reviewed. Patients were divided into age less than 70 years (control group) and 70 years or more (study group). Primary ...


Molecular Study Of Thyroid Cancer In World Trade Center Responders, M. A. Van Gerwen, S. Tuminello, G. J. Riggins, T. B. Mendes, M. Donovan, E. K. Benn, E. Genden, J. M. Cerutti, E. Taioli Jan 2019

Molecular Study Of Thyroid Cancer In World Trade Center Responders, M. A. Van Gerwen, S. Tuminello, G. J. Riggins, T. B. Mendes, M. Donovan, E. K. Benn, E. Genden, J. M. Cerutti, E. Taioli

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Thyroid cancer incidence is higher in World Trade Center (WTC) responders compared with the general population. It is unclear whether this excess in thyroid cancer is associated with WTC-related exposures or if instead there is an over-diagnosis of malignant thyroid cancer among WTC first responders due to enhanced surveillance and physician bias. To maximize diagnostic yield and determine the false positive rate for malignancy, the histological diagnoses of thyroid cancer tumors from WTC responders and age, gender, and histology matched non-WTC thyroid cancer cases were evaluated using biomarkers of malignancy. Using a ...


A Quality Improvement Assessment Of The Delivery Of Mental Health Services Among Wtc Responders Treated In The Community, M. Bellehsen, J. Moline, R. Rasul, K. Bevilacqua, S. Schneider, J. Kornrich, R. M. Schwartz Jan 2019

A Quality Improvement Assessment Of The Delivery Of Mental Health Services Among Wtc Responders Treated In The Community, M. Bellehsen, J. Moline, R. Rasul, K. Bevilacqua, S. Schneider, J. Kornrich, R. M. Schwartz

Journal Articles

No abstract provided.


Changes In Quality Of Life After Surgery Or Radiotherapy In Early-Stage Lung Cancer, R. M. Schwartz, N. Alpert, K. Rosenzweig, R. Flores, E. Taioli Jan 2019

Changes In Quality Of Life After Surgery Or Radiotherapy In Early-Stage Lung Cancer, R. M. Schwartz, N. Alpert, K. Rosenzweig, R. Flores, E. Taioli

Journal Articles

No abstract provided.


Controversies On Lung Cancers Manifesting As Part-Solid Nodules., R. Yip, K. Li, L. Liu, D. Xu, K. Tam, D. F. Yankelevitz, E. Taioli, B. Becker, C. I. Henschke Jan 2018

Controversies On Lung Cancers Manifesting As Part-Solid Nodules., R. Yip, K. Li, L. Liu, D. Xu, K. Tam, D. F. Yankelevitz, E. Taioli, B. Becker, C. I. Henschke

Journal Articles

PURPOSE: Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs).

METHODS: PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs

RESULTS: Twenty studies reported on PSNs

CONCLUSION: A clear definition of the upper limit of solid component of a PSN is needed ...


Lack Of Access To Medical Care During Hurricane Sandy And Mental Health Symptoms, J. Ruskin, R. Rasul, S. Schneider, K. Bevilacqua, E. Taioli, R. M. Schwartz Jan 2018

Lack Of Access To Medical Care During Hurricane Sandy And Mental Health Symptoms, J. Ruskin, R. Rasul, S. Schneider, K. Bevilacqua, E. Taioli, R. M. Schwartz

Journal Articles

© 2018 The Authors Destruction caused by natural disasters compromises medical providers’ and hospitals’ abilities to administer care. Hurricane Sandy was particularly devastating, resulting in massive disruptions of medical care in the region. This study aimed to determine whether a lack of access to medical care during Hurricane Sandy was associated with posttraumatic stress disorder (PTSD) symptoms and other mental health/substance abuse outcomes. A secondary aim was to examine whether having a chronic illness moderates those associations. Self-reported medical access and mental health symptomatology were obtained from New York City and Long Island residents (n = 1669) following Hurricane Sandy under ...


The U.S. Science And Technology “Triple Threat”: A Regulatory Treatment Plan For The Nation’S Addiction To Prescription Opioids, Michael J. Malinowski Jan 2018

The U.S. Science And Technology “Triple Threat”: A Regulatory Treatment Plan For The Nation’S Addiction To Prescription Opioids, Michael J. Malinowski

Journal Articles

No abstract provided.


The Development Of A Biobank Of Cancer Tissue Samples From World Trade Center Responders, W. Lieberman-Cribbin, S. Tuminello, C. Gillezeau, M. Van Gerwen, R. Brody, M. Donovan, E. Taioli Jan 2018

The Development Of A Biobank Of Cancer Tissue Samples From World Trade Center Responders, W. Lieberman-Cribbin, S. Tuminello, C. Gillezeau, M. Van Gerwen, R. Brody, M. Donovan, E. Taioli

Journal Articles

© 2018 The Author(s). Background: World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. Studies of cancer incidence in this population have reported elevated risks of cancer compared to the general population. There is a need to supplement current epidemiologic cancer follow-up with a cancer tissue bank in order to better elucidate a possible connection between each cancer and past WTC exposure. This work describes the implementation of a tissue bank system for the WTC newly diagnosed cancers, focused on advancing the understanding of the biology of these tumors. This will ultimately impact the ...


Prevalence, Comorbidity, And Correlates Of Psychiatric And Substance Use Disorders And Associations With Hiv Risk Behaviors In A Multisite Cohort Of Women Living With Hiv, J. A. Cook, J. K. Burke-Miller, P. J. Steigman, R. M. Schwartz, N. A. Hessol, J. Milam, D. J. Merenstein, K. Anastos, E. T. Golub, M. H. Cohen Jan 2018

Prevalence, Comorbidity, And Correlates Of Psychiatric And Substance Use Disorders And Associations With Hiv Risk Behaviors In A Multisite Cohort Of Women Living With Hiv, J. A. Cook, J. K. Burke-Miller, P. J. Steigman, R. M. Schwartz, N. A. Hessol, J. Milam, D. J. Merenstein, K. Anastos, E. T. Golub, M. H. Cohen

Journal Articles

© 2018, The Author(s). We used the World Health Organization’s Composite International Diagnostic Interview to determine the prevalence, comorbidity, and correlates of lifetime and 12-month behavioral health disorders in a multisite cohort of 1027 women living with HIV in the United States. Most (82.6%) had one or more lifetime disorders including 34.2% with mood disorders, 61.6% with anxiety disorders, and 58.3% with substance use disorders. Over half (53.9%) had at least one 12-month disorder, including 22.1% with mood disorders, 45.4% with anxiety disorders, and 11.1% with substance use disorders. Behavioral health ...


Thoracic Surgeon And Patient Focus Groups On Decision-Making In Early-Stage Lung Cancer Surgery, R. M. Schwartz, K. Gorbenko, S. M. Kerath, R. Flores, S. Ross, T. N. Taylor, E. Taioli, C. Henschke Jan 2018

Thoracic Surgeon And Patient Focus Groups On Decision-Making In Early-Stage Lung Cancer Surgery, R. M. Schwartz, K. Gorbenko, S. M. Kerath, R. Flores, S. Ross, T. N. Taylor, E. Taioli, C. Henschke

Journal Articles

No abstract provided.


Liver Cancer Disparities In New York City: A Neighborhood View Of Risk And Harm Reduction Factors, G. R. Kamath, E. Taioli, N. N. Egorova, J. M. Llovet, P. V. Perumalswami, J. J. Weiss, M. Schwartz, S. Ewala, N. A. Bickell Jan 2018

Liver Cancer Disparities In New York City: A Neighborhood View Of Risk And Harm Reduction Factors, G. R. Kamath, E. Taioli, N. N. Egorova, J. M. Llovet, P. V. Perumalswami, J. J. Weiss, M. Schwartz, S. Ewala, N. A. Bickell

Journal Articles

© 2018 Kamath, Taioli, Egorova, Llovet, Perumalswami, Weiss, Schwartz, Ewala and Bickell. Introduction: Liver cancer is the fastest increasing cancer in the United States and is one of the leading causes of cancer-related death in New York City (NYC), with wide disparities among neighborhoods. The purpose of this cross-sectional study was to describe liver cancer incidence by neighborhood and examine its association with risk factors. This information can inform preventive and treatment interventions. Materials and methods: Publicly available data were collected on adult NYC residents (n = 6,407,022). Age-adjusted data on liver and intrahepatic bile duct cancer came from the ...


Preliminary Assessment Of Hurricane Harvey Exposures And Mental Health Impact, R. M. Schwartz, S. Tuminello, S. M. Kerath, J. Rios, W. Lieberman-Cribbin, E. Taioli Jan 2018

Preliminary Assessment Of Hurricane Harvey Exposures And Mental Health Impact, R. M. Schwartz, S. Tuminello, S. M. Kerath, J. Rios, W. Lieberman-Cribbin, E. Taioli

Journal Articles

No abstract provided.


Libby Amphibole Disease: Pulmonary Function And Ct Abnormalities In Vermiculite Miners, A. Miller, J. Szeinuk, C. W. Noonan, C. I. Henschke, J. Pfau, B. Black, D. F. Yankelevitz, M. Liang, Y. Liu, R. Flores, +3 Additional Authors Jan 2018

Libby Amphibole Disease: Pulmonary Function And Ct Abnormalities In Vermiculite Miners, A. Miller, J. Szeinuk, C. W. Noonan, C. I. Henschke, J. Pfau, B. Black, D. F. Yankelevitz, M. Liang, Y. Liu, R. Flores, +3 Additional Authors

Journal Articles

© Copyright 2017 American College of Occupational and Environmental Medicine. Objective: This article describes radiologic and pulmonary function findings among miners exposed to Libby amphibole. Computed tomography (CT) permits the detection of the characteristic thin, lamellar pleural thickening (LPT). Methods: Individuals who worked at the mine for a minimum of 6 months had chest CT and pulmonary function tests. Results: Pleural thickening was noted in 223 (87%) of the 256 miners, parenchymal abnormalities in 49 (19%). LPT, found in 151 (68%), was associated with low values of forced vital capacity and diffusion capacity and significantly lower values in all pulmonary function ...


The Influence Of Insurance Type On Stage At Presentation, Treatment, And Survival Between Asian American And Non-Hispanic White Lung Cancer Patients, A. Tantraworasin, E. Taioli, B. Liu, R. M. Flores, A. J. Kaufman Jan 2018

The Influence Of Insurance Type On Stage At Presentation, Treatment, And Survival Between Asian American And Non-Hispanic White Lung Cancer Patients, A. Tantraworasin, E. Taioli, B. Liu, R. M. Flores, A. J. Kaufman

Journal Articles

© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. The effect of insurance type on lung cancer diagnosis, treatment, and survival in Asian patients living in the United States is still under debate. We have analyzed this issue using the Surveillance, Epidemiology, and End Results database. There were 102,733 lung cancer patients age 18–64 years diagnosed between 2007 and 2013. Multilevel regression analysis was performed to identify the association between insurance types, stage at diagnosis, treatment modalities, and overall mortality in Asian and non-Hispanic White (NHW) patients. Clinical characteristics were significantly different between Asian and NHW patients, except for gender. Asian patients were more likely to present with advanced disease than NHW patients (ORadj= 1.12, 95% CI = 1.06–1.19). Asian patients with non-Medicaid insurance underwent lobectomy more than NHW patients with Medicaid or uninsured; were more likely to undergo mediastinal lymph node evaluation (MLNE) (ORadj= 1.98, 95% CI = 1.72–2.28) and cancer-directed surgery and/or radiation therapy (ORadj= 1.41, 95% CI = 1.20–1.65). Asian patients with non-Medicaid insurance had the best overall survival. Uninsured or Medicaid-covered Asian patients were more likely to be diagnosed with advanced disease, less likely to undergo MLNE and cancer-directed treatments, and had shorter overall survival than their NHW counterpart.


Nfatc3 And Vip In Idiopathic Pulmonary Fibrosis And Chronic Obstructive Pulmonary Disease, A. M. Szema, E. Forsyth, B. Ying, S. A. Hamidi, J. J. Chen, S. Hwang, J. C. Li, D. S. Dwyer, J. M. Ramiro-Diaz, L. V. Gonzalez Bosc, +1 Additional Author Jan 2017

Nfatc3 And Vip In Idiopathic Pulmonary Fibrosis And Chronic Obstructive Pulmonary Disease, A. M. Szema, E. Forsyth, B. Ying, S. A. Hamidi, J. J. Chen, S. Hwang, J. C. Li, D. S. Dwyer, J. M. Ramiro-Diaz, L. V. Gonzalez Bosc, +1 Additional Author

Journal Articles

No abstract provided.


Mesothelioma Patients With Germline Bap1 Mutations Have 7-Fold Improved Long-Term Survival, F. Baumann, E. Flores, A. Napolitano, S. Kanodia, E. Taioli, H. Pass, H. Yang, M. Carbone Jan 2015

Mesothelioma Patients With Germline Bap1 Mutations Have 7-Fold Improved Long-Term Survival, F. Baumann, E. Flores, A. Napolitano, S. Kanodia, E. Taioli, H. Pass, H. Yang, M. Carbone

Journal Articles

BRCA1-associated protein-1 (BAP1) mutations cause a new cancer syndrome, with a high rate of malignant mesothelioma (MM). Here, we tested the hypothesis that MM associated with germline BAP1 mutations has a better prognosis compared with sporadic MM. We compared survival among germline BAP1 mutation MM patients with that of all MM (N = 10 556) recorded in the United States Surveillance, Epidemiology, and End Results (SEER) data from 1973 to 2010. We identified 23 MM patients-11 alive-with germline BAP1 mutations and available data on survival. Ten patients had peritoneal MM, ten pleural MM and three MM in both locations. Thirteen patients ...


Oral Bisphosphonate Use And Risk Of Postmenopausal Endometrial Cancer, P. A. Newcomb, M. N. Passarelli, A. I. Phipps, G. L. Anderson, J. Wactawski-Wende, G. Y. Ho, M. J. O'Sullivan, R. T. Chlebowski Jan 2015

Oral Bisphosphonate Use And Risk Of Postmenopausal Endometrial Cancer, P. A. Newcomb, M. N. Passarelli, A. I. Phipps, G. L. Anderson, J. Wactawski-Wende, G. Y. Ho, M. J. O'Sullivan, R. T. Chlebowski

Journal Articles

PURPOSE: Bisphosphonates are common medications used for the treatment of osteoporosis and are also used to reduce metastases to bone in patients with cancer. Several studies, including the Women's Health Initiative (WHI), have found that use of bisphosphonates is associated with reduced risk of developing breast cancer, but less is known about associations with other common malignancies. This study was aimed at examining the effects of bisphosphonates on the risk of endometrial cancer. METHODS: We evaluated the relationship between use of oral bisphosphonates and endometrial cancer risk in a cohort of 89,918 postmenopausal women participating in the WHI ...


Tlr7 Influences Germinal Center Selection In Murine Sle, A. Boneparth, W. Huang, R. Bethunaickan, M. Woods, R. Sahu, S. Arora, M. Akerman, M. Lesser, A. Davidson Jan 2015

Tlr7 Influences Germinal Center Selection In Murine Sle, A. Boneparth, W. Huang, R. Bethunaickan, M. Woods, R. Sahu, S. Arora, M. Akerman, M. Lesser, A. Davidson

Journal Articles

TLR7 enhances germinal center maturation and migration of B cells to the dark zone where proliferation and somatic hypermutation occur. Our goal was to determine how Tlr7 dose influences selection of the autoreactive B cell repertoire in NZW/BXSB. Yaa mice bearing the site-directed heavy chain transgene 3H9 that encodes for the TLR7 regulated anti-CL response. To create a physiologic setting in which autoreactive B cells compete for survival with non-autoreactive B cells, we generated bone marrow chimeras in which disease onset occurred with similar kinetics and the transferred 3H9+ female non-Yaa, male Yaa or male TLR7(-/Yaa) cells could ...


Circulating Adipokines And Inflammatory Markers And Postmenopausal Breast Cancer Risk, M. J. Gunter, T. Wang, M. Cushman, X. Xue, S. Wassertheil-Smoller, H. D. Strickler, T. E. Rohan, J. E. Manson, A. Mctiernan, G. Y. Ho, +5 Additional Authors Jan 2015

Circulating Adipokines And Inflammatory Markers And Postmenopausal Breast Cancer Risk, M. J. Gunter, T. Wang, M. Cushman, X. Xue, S. Wassertheil-Smoller, H. D. Strickler, T. E. Rohan, J. E. Manson, A. Mctiernan, G. Y. Ho, +5 Additional Authors

Journal Articles

BACKGROUND: Adipokines and inflammation may provide a mechanistic link between obesity and postmenopausal breast cancer, yet epidemiologic data on their associations with breast cancer risk are limited. METHODS: In a case-cohort analysis nested within the Women's Health Initiative Observational Study, a prospective cohort of postmenopausal women, baseline plasma samples from 875 incident breast cancer case patients and 839 subcohort participants were tested for levels of seven adipokines, namely leptin, adiponectin, resistin, interleukin-6, tumor necrosis factor-alpha, hepatocyte growth factor, and plasminogen activator inhibitor-1, and for C-reactive protein (CRP), an inflammatory marker. Data were analyzed by multivariable Cox modeling that included ...


Heart Failure: An Exploration Of Recent Advances In Research And Treatment (A), A. Szema, A. Mclarty, H. Skopicki, M. Bloom, R. Jermyn Jan 2015

Heart Failure: An Exploration Of Recent Advances In Research And Treatment (A), A. Szema, A. Mclarty, H. Skopicki, M. Bloom, R. Jermyn

Journal Articles

No abstract provided.


Seasonal Variations Of Complete Blood Count And Inflammatory Biomarkers In The Us Population - Analysis Of Nhanes Data, B. Liu, E. Taioli Jan 2015

Seasonal Variations Of Complete Blood Count And Inflammatory Biomarkers In The Us Population - Analysis Of Nhanes Data, B. Liu, E. Taioli

Journal Articles

BACKGROUND: Recent studies reported seasonal differences in gene expression in white blood cells, adipose tissue, and inflammatory biomarkers of the immune system. There is no data on the seasonal variations of these biomarkers in the US general population of both children and adults. Then aim of this study is to explore the seasonal trends in complete blood count (CBC), and C-reactive protein (CRP) in a large non-institutionalized US population. METHODS: Seven cross-sectional data collected in the National Health and Nutrition Examination Survey (NHANES) during 1999-2012 were aggregated; participants reporting recent use of prescribed steroids, chemotherapy, immunomodulators and antibiotics were excluded ...


Frequency Of Surgery In Black Patients With Malignant Pleural Mesothelioma, E. Taioli, A. S. Wolf, J. Moline, M. Camacho-Rivera, R. M. Flores Jan 2015

Frequency Of Surgery In Black Patients With Malignant Pleural Mesothelioma, E. Taioli, A. S. Wolf, J. Moline, M. Camacho-Rivera, R. M. Flores

Journal Articles

Introduction. Malignant Pleural Mesothelioma (MPM) is a rare disease, even less frequently described in minority patients. We used a large population-based dataset to study the role of race in MPM presentation, treatment, and survival. Methods. All cases of pathologically proven MPM were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Age, sex, diagnosis year, stage, cancer-directed surgery, radiation, and vital status were analyzed according to self-reported race (black or white). Results. There were 13,046 white and 688 black MPM patients (incidence: 1.1 per 100,000 whites; 0.5 per 100,000 blacks; age-adjusted,P = 0.01 ...


Breast Cancer Risk In Metabolically Healthy But Overweight Postmenopausal Women, M. J. Gunter, X. Xie, X. Xue, G. C. Kabat, T. E. Rohan, S. Wassertheil-Smoller, G. Y. Ho, J. Wylie-Rosett, J. Beasley, H. D. Strickler, +2 Additional Authors Jan 2015

Breast Cancer Risk In Metabolically Healthy But Overweight Postmenopausal Women, M. J. Gunter, X. Xie, X. Xue, G. C. Kabat, T. E. Rohan, S. Wassertheil-Smoller, G. Y. Ho, J. Wylie-Rosett, J. Beasley, H. D. Strickler, +2 Additional Authors

Journal Articles

Adiposity is an established risk factor for postmenopausal breast cancer. Recent data suggest that high insulin levels in overweight women may play a major role in this relationship, due to insulin's mitogenic/antiapoptotic activity. However, whether overweight women who are metabolically healthy (i.e., normal insulin sensitivity) have elevated risk of breast cancer is unknown. We investigated whether overweight women with normal insulin sensitivity [i.e., homeostasis model assessment of insulin resistance (HOMA-IR) index, or fasting insulin level, within the lowest quartile (q1)] have increased breast cancer risk. Subjects were incident breast cancer cases (N = 497) and a subcohort ...


Determinants Of Survival In Malignant Pleural Mesothelioma: A Surveillance, Epidemiology, And End Results (Seer) Study Of 14,228 Patients, E. Taioli, A. S. Wolf, M. Camacho-Rivera, A. Kaufman, D. S. Lee, D. Nicastri, K. Rosenzweig, R. M. Flores Jan 2015

Determinants Of Survival In Malignant Pleural Mesothelioma: A Surveillance, Epidemiology, And End Results (Seer) Study Of 14,228 Patients, E. Taioli, A. S. Wolf, M. Camacho-Rivera, A. Kaufman, D. S. Lee, D. Nicastri, K. Rosenzweig, R. M. Flores

Journal Articles

INTRODUCTION: Left untreated, malignant pleural mesothelioma (MPM) is associated with uniformly poor prognosis. Better survival has been reported with surgery-based multimodality therapy, but to date, no trial has demonstrated survival benefit of surgery over other therapies. We evaluated whether cancer-directed surgery influenced survival independently from other predictors in a large population-based dataset. METHODS: The SEER database was explored from 1973 to 2009 to identify all cases of pathologically-proven MPM. Age, sex, race, year of diagnosis, histology stage, cancer-directed surgery, radiation, and vital status were analyzed. The association between prognostic factors and survival was estimated using Cox regression and propensity matched ...


Remote Video Auditing With Real-Time Feedback In An Academic Surgical Suite Improves Safety And Efficiency Metrics: A Cluster Randomised Study, F. J. Overdyk, O. Dowling, S. Newman, D. Glatt, M. Chester, D. Armellino, B. Cole, G. S. Landis, D. Schoenfeld, J. F. Dicapua Jan 2015

Remote Video Auditing With Real-Time Feedback In An Academic Surgical Suite Improves Safety And Efficiency Metrics: A Cluster Randomised Study, F. J. Overdyk, O. Dowling, S. Newman, D. Glatt, M. Chester, D. Armellino, B. Cole, G. S. Landis, D. Schoenfeld, J. F. Dicapua

Journal Articles

IMPORTANCE: Compliance with the surgical safety checklist during operative procedures has been shown to reduce inhospital mortality and complications but proper execution by the surgical team remains elusive. OBJECTIVE: We evaluated the impact of remote video auditing with real-time provider feedback on checklist compliance during sign-in, time-out and sign-out and case turnover times. DESIGN, SETTING: Prospective, cluster randomised study in a 23-operating room (OR) suite. PARTICIPANTS: Surgeons, anaesthesia providers, nurses and support staff. EXPOSURE: ORs were randomised to receive, or not receive, real-time feedback on safety checklist compliance and efficiency metrics via display boards and text messages, followed by a ...