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Medicine and Health Sciences Commons

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Full-Text Articles in Medicine and Health Sciences

Neutralizing Antibodies Against West Nile Virus Identified Directly From Human B Cells By Single-Cell Analysis And Next Generation Sequencing, K. Tsioris, N. T. Gupta, A. O. Ogunniyi, R. M. Zimnisky, F. Qian, Y. Yao, X. Wang, J. N. Stern, R. Chari, J. C. Love, +8 Additional Authors Jan 2015

Neutralizing Antibodies Against West Nile Virus Identified Directly From Human B Cells By Single-Cell Analysis And Next Generation Sequencing, K. Tsioris, N. T. Gupta, A. O. Ogunniyi, R. M. Zimnisky, F. Qian, Y. Yao, X. Wang, J. N. Stern, R. Chari, J. C. Love, +8 Additional Authors

Journal Articles

West Nile virus (WNV) infection is an emerging mosquito-borne disease that can lead to severe neurological illness and currently has no available treatment or vaccine. Using microengraving, an integrated single-cell analysis method, we analyzed a cohort of subjects infected with WNV - recently infected and post-convalescent subjects - and efficiently identified four novel WNV neutralizing antibodies. We also assessed the humoral response to WNV on a single-cell and repertoire level by integrating next generation sequencing (NGS) into our analysis. The results from single-cell analysis indicate persistence of WNV-specific memory B cells and antibody-secreting cells in post-convalescent subjects. These cells exhibited …


Implications Of Epigenetic Variability Within A Cell Population For "Cell Type" Classification, I. Tabansky, J. N.H. Stern, D. W. Pfaff Jan 2015

Implications Of Epigenetic Variability Within A Cell Population For "Cell Type" Classification, I. Tabansky, J. N.H. Stern, D. W. Pfaff

Journal Articles

Here, we propose a new approach to defining nerve "cell types" in reaction to recent advances in single cell analysis. Among cells previously thought to be equivalent, considerable differences in global gene expression and biased tendencies among differing developmental fates have been demonstrated within multiple lineages. The model of classifying cells into distinct types thus has to be revised to account for this intrinsic variability. A "cell type" could be a group of cells that possess similar, but not necessarily identical properties, variable within a spectrum of epigenetic adjustments that permit its developmental path toward a specific function to be …


Use Of Team-Based Learning Pedagogy For Internal Medicine Ambulatory Resident Teaching, S. Balwan, A. Fornari, P. Dimarzio, J. Verbsky, R. Pekmezaris, J. Stein, S. Chaudhry Jan 2015

Use Of Team-Based Learning Pedagogy For Internal Medicine Ambulatory Resident Teaching, S. Balwan, A. Fornari, P. Dimarzio, J. Verbsky, R. Pekmezaris, J. Stein, S. Chaudhry

Journal Articles

BACKGROUND: Team-based learning (TBL) is used in undergraduate medical education to facilitate higher-order content learning, promote learner engagement and collaboration, and foster positive learner attitudes. There is a paucity of data on the use of TBL in graduate medical education. Our aim was to assess resident engagement, learning, and faculty/resident satisfaction with TBL in internal medicine residency ambulatory education. METHODS: Survey and nominal group technique methodologies were used to assess learner engagement and faculty/resident satisfaction. We assessed medical learning using individual (IRAT) and group (GRAT) readiness assurance tests. RESULTS: Residents (N = 111) involved in TBL sessions reported contributing to …


Not For Industry Only: Medical Students And Office-Based Academic Detailing The Pivot (Pregnant Women Influenza Vaccine Optimization Team) Initiative, D. A. Blitz, J. R. Mallen, T. G. Kwiatkowski, J. M. Rabin, Y. D. Dlugacz, R. A. Silverman Jan 2015

Not For Industry Only: Medical Students And Office-Based Academic Detailing The Pivot (Pregnant Women Influenza Vaccine Optimization Team) Initiative, D. A. Blitz, J. R. Mallen, T. G. Kwiatkowski, J. M. Rabin, Y. D. Dlugacz, R. A. Silverman

Journal Articles

Academic detailing is a method of educational outreach that utilizes individualized encounters with physicians to broach specific medical issues in an evidence-based and quality-driven manner. Medical students utilized the matter of influenza vaccination during pregnancy as a lens through which to explore the methods of academic detailing in a community setting. Structured and customized dialogues between North Shore-LIJ affiliated obstetricians and Hofstra North Shore-LIJ medical students were conducted regarding the disparity between the proportion of providers that recommend the vaccine and the percentage of pregnant women being vaccinated annually. Ultimately the project aimed to increase vaccine-carrying rates throughout office based …


Promoting Faculty Scholarship - An Evaluation Of A Program For Busy Clinician-Educators, S. Reader, A. Fornari, S. Simon, J. Townsend Jan 2015

Promoting Faculty Scholarship - An Evaluation Of A Program For Busy Clinician-Educators, S. Reader, A. Fornari, S. Simon, J. Townsend

Journal Articles

BACKGROUND: Clinician educators face barriers to scholarship including lack of time, insufficient skills, and access to mentoring. An urban department of family medicine implemented a federally funded Scholars Program to increase the participants' perceived confidence, knowledge and skills to conduct educational research. METHOD: A part-time faculty development model provided modest protected time for one year to busy clinician educators. Scholars focused on designing, implementing, and writing about a scholarly project. Scholars participated in skill seminars, cohort and individual meetings, an educational poster fair and an annual writing retreat with consultation from a visiting professor. We assessed the increases in the …