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GSBS Dissertations and Theses

Apoptosis

Genetic Phenomena

2001

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Stress Activated Protein Kinase Regulation Of Gene Expression In Apoptotic Neurons: A Dissertation, Gerard S. De Zutter Jul 2001

Stress Activated Protein Kinase Regulation Of Gene Expression In Apoptotic Neurons: A Dissertation, Gerard S. De Zutter

GSBS Dissertations and Theses

Summary

Basic biological processes require gene expression. Tightly regulated molecules known as transcription factors mediate the expression of genes in development and disease. Signal transduction pathways, which respond to environmental cues or stressors are major regulators of the transcription factors. Use of macromolecular synthesis inhibitors in models of normal neurodevelopment and neurodegenerative cell death has led to the discovery that gene expression is required for these processes to occur (Martin et. al.,(1988), J Cell Biol 106p829). To date, however, the identities of very few of the genes required in these events have been revealed. Hence, the activation or ...