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Benner's Model And Duchscher's Theory: Providing The Framework For Understanding New Graduate Nurses' Transition To Practice, Melanie Murray, Deborah Sundin, Vicki Cope Dec 2019

Benner's Model And Duchscher's Theory: Providing The Framework For Understanding New Graduate Nurses' Transition To Practice, Melanie Murray, Deborah Sundin, Vicki Cope

ECU Publications Post 2013

The transition to quality and safety in the new graduate registered nurses' practice remains problematic directly impacting patient outcomes. Effective mentoring during transition serves to enhance experiential learning, allowing the development and establishment of safe, quality nursing practice. Comprehensive understanding of the transition process, including the barriers and effective enablers to transition is the key to effective mentoring. A theoretical framework guided by Duchscher's Stages of Transition Theory and Transition Shock Model and Benner's From novice to expert model can facilitate such understanding. Nurse Theorists play an important part in shaping nurse education and practice and have provided ...


Impacts Of Cannabinoid Epigenetics On Human Development: Reflections On Murphy Et. Al. 'Cannabinoid Exposure And Altered Dna Methylation In Rat And Human Sperm' Epigenetics 2018; 13: 1208-1221, Albert Stuart Reece, Gary Kenneth Hulse Nov 2019

Impacts Of Cannabinoid Epigenetics On Human Development: Reflections On Murphy Et. Al. 'Cannabinoid Exposure And Altered Dna Methylation In Rat And Human Sperm' Epigenetics 2018; 13: 1208-1221, Albert Stuart Reece, Gary Kenneth Hulse

ECU Publications Post 2013

Recent data from the Kollins lab ('Cannabinoid exposure and altered DNA methylation in rat and human sperm' Epigenetics 2018; 13: 1208-1221) indicated epigenetic effects of cannabis use on sperm in man parallel those in rats and showed substantial shifts in both hypo- and hyper-DNA methylation with the latter predominating. This provides one likely mechanism for the transgenerational transmission of epigenomic instability with sperm as the vector. It therefore contributes important pathophysiological insights into the probable mechanisms underlying the epidemiology of prenatal cannabis exposure potentially explaining diverse features of cannabis-related teratology including effects on the neuraxis, cardiovasculature, immune stimulation, secondary genomic ...


Development And Validation Of The Needs Of Children Questionnaire: An Instrument To Measure Children's Self-Reported Needs In Hospital, Mandie Foster, Lisa Whitehead, Diana Arabiat Oct 2019

Development And Validation Of The Needs Of Children Questionnaire: An Instrument To Measure Children's Self-Reported Needs In Hospital, Mandie Foster, Lisa Whitehead, Diana Arabiat

ECU Publications Post 2013

AIM: To develop and psychometrically test the needs of children questionnaire (NCQ), a new instrument to measure school-aged children's self-reported psychosocial physical and emotional needs in paediatric wards.

DESIGN: This is an instrument development study based on recommendations for developing a reliable and valid questionnaire.

METHOD: The NCQ was developed over three phases between February 2013-April 2017 and included item generation; content adequacy assessment; questionnaire administration; factor analysis; internal consistency assessment and construct validity. Psychometric properties were assessed after 193 school-aged children completed the needs of children's questionnaire in four paediatric areas in Australia and New Zealand.

RESULTS ...


Examining The Effects Of Creatine Supplementation In Augmenting Adaptations To Resistance Training In Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy: A Randomised, Double-Blind, Placebo-Controlled Trial, Ciaran M. Fairman, Kristina L. Kendall, Robert U. Newton, Nicolas H. Hart, Dennis R. Taaffe, Raphael Chee, Colin I. Tang, Daniel A. Galvao Sep 2019

Examining The Effects Of Creatine Supplementation In Augmenting Adaptations To Resistance Training In Patients With Prostate Cancer Undergoing Androgen Deprivation Therapy: A Randomised, Double-Blind, Placebo-Controlled Trial, Ciaran M. Fairman, Kristina L. Kendall, Robert U. Newton, Nicolas H. Hart, Dennis R. Taaffe, Raphael Chee, Colin I. Tang, Daniel A. Galvao

ECU Publications Post 2013

INTRODUCTION: Creatine supplementation has consistently been demonstrated to augment adaptations in body composition, muscle strength and physical function in a variety of apparently healthy older adults and clinical populations. The effects of creatine supplementation and resistance training in individuals with cancer have yet to be investigated. This study aims to examine the effects of creatine supplementation in conjunction with resistance training on body composition, muscle strength and physical function in prostate cancer patients undergoing androgen deprivation therapy.

METHODS AND ANALYSIS: This is a randomised, double-blind, placebo-controlled trial designed to examine the effects of creatine supplementation in addition to resistance training ...


Autophagy Modulation As A Treatment Of Amyloid Diseases, Zoe Mputhia, Eugene Hone, Timir Tripathi, Tim Sargeant, Ralph Martins, Prashant Bharadwaj Sep 2019

Autophagy Modulation As A Treatment Of Amyloid Diseases, Zoe Mputhia, Eugene Hone, Timir Tripathi, Tim Sargeant, Ralph Martins, Prashant Bharadwaj

ECU Publications Post 2013

Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several chronic disorders. More than 30 diseases show deposition of fibrous amyloid proteins associated with cell loss and degeneration in the affected tissues. Evidence demonstrates that amyloid diseases result from protein aggregation or impaired amyloid clearance, but the connection between amyloid accumulation and tissue degeneration is not clear. Common examples of amyloid diseases are Alzheimer's disease (AD), Parkinson's disease (PD) and tauopathies, which are the most common forms of neurodegenerative diseases, as well as polyglutamine disorders and certain peripheral metabolic diseases. In these diseases, increased accumulation ...


A "Human Knockout" Model To Investigate The Influence Of The Α-Actinin-3 Protein On Exercise-Induced Mitochondrial Adaptations, I. D. Papadimitriou, N. Eynon, X. Yan, F. Munson, M. Jacques, J. Kuang, S. Voisin, K. N. North, David Bishop Sep 2019

A "Human Knockout" Model To Investigate The Influence Of The Α-Actinin-3 Protein On Exercise-Induced Mitochondrial Adaptations, I. D. Papadimitriou, N. Eynon, X. Yan, F. Munson, M. Jacques, J. Kuang, S. Voisin, K. N. North, David Bishop

ECU Publications Post 2013

Research in α-actinin-3 knockout mice suggests a novel role for α-actinin-3 as a mediator of cell signalling. We took advantage of naturally-occurring human "knockouts" (lacking α-actinin-3 protein) to investigate the consequences of α-actinin-3 deficiency on exercise-induced changes in mitochondrial-related genes and proteins, as well as endurance training adaptations. At baseline, we observed a compensatory increase of α-actinin-2 protein in ACTN3 XX (α-actinin-3 deficient; n = 18) vs ACTN3 RR (expressing α-actinin-3; n = 19) participants but no differences between genotypes for markers of aerobic fitness or mitochondrial content and function. There was a main effect of genotype, without an interaction, for RCAN1-4 ...


Exercising Choice And Control: A Qualitative Meta-Synthesis Of Perspectives Of People With A Spinal Cord Injury, Carolyn M. Murray, Gisela Van Kessel, Michelle Guerin, Susan Hillier, Mandy Stanley Sep 2019

Exercising Choice And Control: A Qualitative Meta-Synthesis Of Perspectives Of People With A Spinal Cord Injury, Carolyn M. Murray, Gisela Van Kessel, Michelle Guerin, Susan Hillier, Mandy Stanley

ECU Publications Post 2013

OBJECTIVE: To systematically search the literature and construct a meta-synthesis of how choice and control are perceived by people with spinal cord injury (SCI).

DATA SOURCES: Medline, Academic Search Premier, CINAHL, Cochrane, EMBASE, HealthSource, ProQuest, PsychInfo, SAGE, and SCOPUS were searched from 1980 until September 2018 including all languages. Reference lists of selected studies were also reviewed.

STUDY SELECTION: Eligible qualitative studies included perspectives about choice of control as reported by people with an SCI. Studies were excluded if they included perspectives from other stakeholder groups. A total of 6706 studies were screened for title and abstract and full text ...


Testosterone Replacement For Male Military Personnel - A Potential Countermeasure To Reduce Injury And Improve Performance Under Extreme Conditions, Nicolas H. Hart, Robert U. Newton Sep 2019

Testosterone Replacement For Male Military Personnel - A Potential Countermeasure To Reduce Injury And Improve Performance Under Extreme Conditions, Nicolas H. Hart, Robert U. Newton

ECU Publications Post 2013

Tactical operators, inclusive of soldiers in the military, are reliant upon their physiological and psychological state in often volatile and extreme life or death situations that require correct decisions and precise actions to ensure operational success with minimal collateral damage. Accordingly, the development of physical and mental resilience are hallmarks of prophylactic and remedial programs designed to ensure military personnel are combat ready, thus optimising their capacity to perform at expert levels, while reducing their risk of injury or the severity of injury sustained...


Weight Management Merits Attention In Women With Infertility: A Cross-Sectional Study On The Association Of Anthropometric Indices With Hormonal Imbalance In A Ghanaian Population, William K. B. A. Owiredu, Peter Ntim Ofori, Cornelius Archer Turpin, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Eddie-Williams Owiredu, Evans Asamoah Adu Aug 2019

Weight Management Merits Attention In Women With Infertility: A Cross-Sectional Study On The Association Of Anthropometric Indices With Hormonal Imbalance In A Ghanaian Population, William K. B. A. Owiredu, Peter Ntim Ofori, Cornelius Archer Turpin, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Eddie-Williams Owiredu, Evans Asamoah Adu

ECU Publications Post 2013

OBJECTIVE: This study determined the association of anthropometric indices with hormonal imbalance among infertile women in a Ghanaian population.

RESULTS: Follicle stimulating hormone (FSH) levels (18.47 vs. 8.67, p-value = 0.002), and luteinizing hormone (LH) (12.43 vs. 8.01, p-value = 0.044) were higher in women with primary infertility compared with women presenting with secondary infertility. Waist circumference (WC) and waist-to-height ratio (WHtR) showed significant negative partial correlation with prolactin in both primary and secondary infertile women. Also a significant negative partial correlation was observed between BMI and prolactin in secondary infertile women only. Waist-to-hip ratio (WHR ...


Whole-Body Cryotherapy Does Not Augment Adaptations To High-Intensity Interval Training, James R. Broatch, Mathilde Poignard, Christophe Hausswirth, David J. Bishop, François Bieuzen Aug 2019

Whole-Body Cryotherapy Does Not Augment Adaptations To High-Intensity Interval Training, James R. Broatch, Mathilde Poignard, Christophe Hausswirth, David J. Bishop, François Bieuzen

ECU Publications Post 2013

The aim of this study was to investigate the effects of regular post-exercise whole-body cryotherapy (WBC) on physiological and performance adaptations to high-intensity interval training (HIT). In a two-group parallel design, twenty-two well-trained males performed four weeks of cycling HIT, with each session immediately followed by 3 min of WBC (−110 °C) or a passive control (CON). To assess the effects of WBC on the adaptive response to HIT, participants performed the following cycling tests before and after the training period; a graded exercise test (GXT), a time-to-exhaustion test (Tmax), a 20-km time trial (20TT), and a 120-min ...


Flavonoid Intake Is Associated With Lower Mortality In The Danish Diet Cancer And Health Cohort, Nicola P. Bondonno, Frederik Dalgaard, Cecilie Kyrø, Kevin Murray, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Gunnar Gislason, Augustin Scalbert, Aedin Cassidy, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson Aug 2019

Flavonoid Intake Is Associated With Lower Mortality In The Danish Diet Cancer And Health Cohort, Nicola P. Bondonno, Frederik Dalgaard, Cecilie Kyrø, Kevin Murray, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Gunnar Gislason, Augustin Scalbert, Aedin Cassidy, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson

ECU Publications Post 2013

Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; studies on cancer mortality are scarce and moderating effects of lifestyle risk factors for early mortality are unknown. In this prospective cohort study including 56,048 participants of the Danish Diet, Cancer, and Health cohort crosslinked with Danish nationwide registries and followed for 23 years, there are 14,083 deaths. A moderate habitual intake of flavonoids is inversely associated with all-cause, cardiovascular- and cancer-related mortality. This strong association plateaus at intakes of approximately 500 mg/day. Furthermore, the inverse associations between total flavonoid ...


Safety Attitudes In Hospital Emergency Departments: A Systematic Review, Naif Alzahrani, Russell Jones, Amir Rizwan, Mohamed E. Abdel-Latif Aug 2019

Safety Attitudes In Hospital Emergency Departments: A Systematic Review, Naif Alzahrani, Russell Jones, Amir Rizwan, Mohamed E. Abdel-Latif

ECU Publications Post 2013

PURPOSE: The purpose of this paper is to perform and report a systematic review of published research on patient safety attitudes of health staff employed in hospital emergency departments (EDs).

DESIGN/METHODOLOGY/APPROACH: An electronic search was conducted of PsychINFO, ProQuest, MEDLINE, EMBASE, PubMed and CINAHL databases. The review included all studies that focussed on the safety attitudes of professional hospital staff employed in EDs.

FINDINGS: Overall, the review revealed that the safety attitudes of ED health staff are generally low, especially on teamwork and management support and among nurses when compared to doctors. Conversely, two intervention studies showed the ...


Newly Defined Atp-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing Of Chronic Iron-Overload Wounds Via Secretion Of Interleukin-1 Receptor Antagonist, Seppe Vander Beken, Juliane C. De Vries, Barbara Meier-Schiesser, Patrick Meyer, Dongsheng Jiang, Anca Sindrilaru, Filipa F. Ferreira, Adelheid Hainzl, Susanne Schatz, Jana Muschhammer, Natalie J. Scheurmann, Panagiotis Kampilafkos, Andreas M. Seitz, Lutz Dürselen, Anita Ignatius, Mark A. Kluth, Christoph Ganss, Meinhard Wlaschek, Karmveer Singh, Pallab Maity, Natasha Y. Frank, Markus H. Frank, Karin Scharffetter-Kochanek Aug 2019

Newly Defined Atp-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing Of Chronic Iron-Overload Wounds Via Secretion Of Interleukin-1 Receptor Antagonist, Seppe Vander Beken, Juliane C. De Vries, Barbara Meier-Schiesser, Patrick Meyer, Dongsheng Jiang, Anca Sindrilaru, Filipa F. Ferreira, Adelheid Hainzl, Susanne Schatz, Jana Muschhammer, Natalie J. Scheurmann, Panagiotis Kampilafkos, Andreas M. Seitz, Lutz Dürselen, Anita Ignatius, Mark A. Kluth, Christoph Ganss, Meinhard Wlaschek, Karmveer Singh, Pallab Maity, Natasha Y. Frank, Markus H. Frank, Karin Scharffetter-Kochanek

ECU Publications Post 2013

In this study, we report the beneficial effects of a newly identified dermal cell subpopulation expressing the ATP‐binding cassette subfamily B member 5 (ABCB5) for the therapy of nonhealing wounds. Local administration of dermal ABCB5+‐derived mesenchymal stem cells (MSCs) attenuated macrophage‐dominated inflammation and thereby accelerated healing of full‐thickness excisional wounds in the iron‐overload mouse model mimicking the nonhealing state of human venous leg ulcers. The observed beneficial effects were due to interleukin‐1 receptor antagonist (IL‐1RA) secreted by ABCB5+‐derived MSCs, which dampened inflammation and shifted the prevalence of unrestrained proinflammatory M1 macrophages toward ...


A Mediterranean Diet With Fresh, Lean Pork Improves Processing Speed And Mood: Cognitive Findings From The Medpork Randomised Controlled Trial, Alexandra T. Wade, Courtney R. Davis, Kathryn A. Dyer, Jonathan M. Hodgson, Richard J. Woodman, Hannah A. D. Keage, Karen J. Murphy Jul 2019

A Mediterranean Diet With Fresh, Lean Pork Improves Processing Speed And Mood: Cognitive Findings From The Medpork Randomised Controlled Trial, Alexandra T. Wade, Courtney R. Davis, Kathryn A. Dyer, Jonathan M. Hodgson, Richard J. Woodman, Hannah A. D. Keage, Karen J. Murphy

ECU Publications Post 2013

Background: The Mediterranean diet may be capable of improving cognitive function. However, the red meat restrictions of the diet could impact long-term adherence in Western populations. The current study therefore examined the cognitive effects of a Mediterranean diet with additional red meat. Methods: A 24-week parallel crossover design compared a Mediterranean diet with 2–3 weekly servings of fresh, lean pork (MedPork) and a low-fat (LF) control diet. Thirty-five participants aged between 45 and 80 years and at risk of cardiovascular disease followed each intervention for 8 weeks, separated by an 8-week washout period. Cognitive function was assessed using the ...


Peer Support For The Maintenance Of Physical Activity And Health In Cancer Survivors: The Peer Trial - A Study Protocol Of A Randomised Controlled Trial, Kirsten N. Adlard, David G. Jenkins, Chloe E. Salisbury, Kate A. Bolam, Sjaan R. Gomersall, Joanne F. Aitken, Suzanne K. Chambers, Jeff C. Dunn, Kerry S. Courneya, Tina L. Skinner Jul 2019

Peer Support For The Maintenance Of Physical Activity And Health In Cancer Survivors: The Peer Trial - A Study Protocol Of A Randomised Controlled Trial, Kirsten N. Adlard, David G. Jenkins, Chloe E. Salisbury, Kate A. Bolam, Sjaan R. Gomersall, Joanne F. Aitken, Suzanne K. Chambers, Jeff C. Dunn, Kerry S. Courneya, Tina L. Skinner

ECU Publications Post 2013

BACKGROUND: Despite an overwhelming body of evidence showing the benefits of physical activity (PA) and exercise for cancer survivors, few survivors meet the exercise oncology guidelines. Moreover, initiating, let alone maintaining exercise programs with cancer survivors continues to have limited success. The aim of this trial is to evaluate the influence of peer support on moderate-to-vigorous PA (MVPA) and various markers of health 12 months following a brief supervised exercise intervention in cancer survivors.

METHODS: Men and women previously diagnosed with histologically-confirmed breast, colorectal or prostate cancer (n = 226), who are >1-month post-treatment, will be invited to participate in this ...


A Qualitative Analysis Of Problematic And Non-Problematic Alcohol Use After Bariatric Surgery, Danielle L. Reaves, Joanne M. Dickson, Jason C. G. Halford, Paul Christiansen, Charlotte A. Hardman Jul 2019

A Qualitative Analysis Of Problematic And Non-Problematic Alcohol Use After Bariatric Surgery, Danielle L. Reaves, Joanne M. Dickson, Jason C. G. Halford, Paul Christiansen, Charlotte A. Hardman

ECU Publications Post 2013

OBJECTIVES: Bariatric surgery is an effective weight loss tool, but an under-communicated side effect may include the increased risk for alcohol problems. Few studies have examined contributors towards alcohol problems following surgery using a qualitative approach. Therefore, the current study aimed to generate insight informed by participants with problematic alcohol use following bariatric surgery, in comparison with participants without.

METHODS: Participants (14; females, n = 9; males, n = 5) completed semi-structured interviews using questions relating to alcohol use, relationship to food, support and surgical experiences. Thematic analysis was conducted to provide insight into the factors which influenced drinking behaviours that participants ...


Nivolumab Plus Ipilimumab Versus Chemotherapy As First-Line Treatment In Advanced Non-Small-Cell Lung Cancer With High Tumour Mutational Burden: Patient-Reported Outcomes Results From The Randomised, Open-Label, Phase Iii Checkmate 227 Trial, Martin Reck, Michael Schenker, Ki Hyeong Lee, Mariano Provencio, Makoto Nishio, Krzysztof Lesniewski-Kmak, Randeep Sangha, Samreen Ahmed, Judith Raimbourg, Kynan Feeney, Romain Corre, Fabio Andre Franke, Eduardo Richardet, John R. Penrod, Yong Yuan, Faith E. Nathan, Prabhu Bhagavatheeswaran, Michael Derosa, Fiona Taylor, Rachael Lawrance, Julie Brahmer Jul 2019

Nivolumab Plus Ipilimumab Versus Chemotherapy As First-Line Treatment In Advanced Non-Small-Cell Lung Cancer With High Tumour Mutational Burden: Patient-Reported Outcomes Results From The Randomised, Open-Label, Phase Iii Checkmate 227 Trial, Martin Reck, Michael Schenker, Ki Hyeong Lee, Mariano Provencio, Makoto Nishio, Krzysztof Lesniewski-Kmak, Randeep Sangha, Samreen Ahmed, Judith Raimbourg, Kynan Feeney, Romain Corre, Fabio Andre Franke, Eduardo Richardet, John R. Penrod, Yong Yuan, Faith E. Nathan, Prabhu Bhagavatheeswaran, Michael Derosa, Fiona Taylor, Rachael Lawrance, Julie Brahmer

ECU Publications Post 2013

BACKGROUND: In the phase III CheckMate 227 study, first-line nivolumab + ipilimumab significantly prolonged progression-free survival (co-primary end-point) versus chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC) and high tumour mutational burden (TMB; ≥10 mutations/megabase).

AIM: To evaluate patient-reported outcomes (PROs) in this population.

METHODS: Disease-related symptoms and general health status were assessed using the validated PRO questionnaires Lung Cancer Symptom Scale (LCSS) and EQ-5D, respectively. LCSS average symptom burden index (ASBI) and three-item global index (3-IGI) and EQ-5D visual analogue scale (VAS) and utility index (UI) scores and changes from baseline were analysed descriptively. Longitudinal changes were assessed ...


Measuring Masculinity In Men With Chronic Disease, Stefano Occhipinti, Kirstyn Laurie, Melissa K. Hyde, Sean Martin, John Oliffe, Gary Wittert, Suzanne K. Chambers Jul 2019

Measuring Masculinity In Men With Chronic Disease, Stefano Occhipinti, Kirstyn Laurie, Melissa K. Hyde, Sean Martin, John Oliffe, Gary Wittert, Suzanne K. Chambers

ECU Publications Post 2013

The Masculinity in Chronic Disease Inventory (MCD-I) is a new measure of internalized masculine beliefs previously validated in the context of prostate cancer. The present study assessed the validity of the MCD-I in men with other chronic diseases to explore its potential for wider application. A cross-sectional survey of 633 men aged 47–93 years old (M = 68 years), of whom 68% reported 2 chronic conditions, was conducted. Measures included the MCD-I and Erectile Function. Exploratory and confirmatory factor analyses were performed followed by tests for discriminant validity. A five-factor structure was confirmed that explained 60% of the variance, with ...


Reducing Aerodynamic Drag By Adopting A Novel Road-Cycling Sprint Position, Paul F. J. Merkes, Paolo Menaspa, Chris R. Abbiss Jul 2019

Reducing Aerodynamic Drag By Adopting A Novel Road-Cycling Sprint Position, Paul F. J. Merkes, Paolo Menaspa, Chris R. Abbiss

ECU Publications Post 2013

PURPOSE: To assess the influence of seated, standing, and forward-standing cycling sprint positions on aerodynamic drag (CdA) and the reproducibility of a field test of CdA calculated in these different positions.

METHODS: A total of 11 recreational male road cyclists rode 250 m in 2 directions at around 25, 32, and 40 km·h

RESULTS: A main effect of position showed that the average CdA of the 2 d was lower for the forward-standing position (0.295 [0.059]) compared with both the seated (0.363 [0.071], P = .018) and standing positions (0.372 [0.077], P = .037). Seated ...


Resistant Starch Is Actively Fermented By Infant Faecal Microbiota And Increases Microbial Diversity, Geetha Gopalsamy, Elissa Mortimer, Paul Greenfield, Anthony R. Bird, Graeme P. Young, Claus T. Christophersen Jun 2019

Resistant Starch Is Actively Fermented By Infant Faecal Microbiota And Increases Microbial Diversity, Geetha Gopalsamy, Elissa Mortimer, Paul Greenfield, Anthony R. Bird, Graeme P. Young, Claus T. Christophersen

ECU Publications Post 2013

In adults, fermentation of high amylose maize starch (HAMS), a resistant starch (RS), has a prebiotic effect. Were such a capacity to exist in infants, intake of RS might programme the gut microbiota during a critical developmental period. This study aimed to determine if infant faecal inocula possess the capacity to ferment HAMS or acetylated-HAMS (HAMSA) and characterise associated changes to microbial composition. Faecal samples were collected from 17 healthy infants at two timepoints: Preweaning and within 10 weeks of first solids. Fermentation was assessed using in vitro batch fermentation. Following 24 h incubation, pH, short-chain fatty acid (SCFA) production ...


Overexpression Of Mirna-25-3p Inhibits Notch1 Signaling And Tgf-Β-Induced Collagen Expression In Hepatic Stellate Cells, Berit Genz, Miranda A. Coleman, Katharine M. Irvine, Jamie R. Kutasovic, Mariska Miranda, Francis D. Gratte, Janina E. E. Tirnitz-Parker, John K. Olynyk, Diego A. Calvopina, Anna Weis, Nicole Cloonan, Harley Robinson, Michelle M. Hill, Fares Al-Ejeh, Grant A. Ramm Jun 2019

Overexpression Of Mirna-25-3p Inhibits Notch1 Signaling And Tgf-Β-Induced Collagen Expression In Hepatic Stellate Cells, Berit Genz, Miranda A. Coleman, Katharine M. Irvine, Jamie R. Kutasovic, Mariska Miranda, Francis D. Gratte, Janina E. E. Tirnitz-Parker, John K. Olynyk, Diego A. Calvopina, Anna Weis, Nicole Cloonan, Harley Robinson, Michelle M. Hill, Fares Al-Ejeh, Grant A. Ramm

ECU Publications Post 2013

During chronic liver injury hepatic stellate cells (HSCs), the principal source of extracellular matrix in the fibrotic liver, transdifferentiate into pro-fibrotic myofibroblast-like cells - a process potentially regulated by microRNAs (miRNAs). Recently, we found serum miRNA-25-3p (miR-25) levels were upregulated in children with Cystic Fibrosis (CF) without liver disease, compared to children with CF-associated liver disease and healthy individuals. Here we examine the role of miR-25 in HSC biology. MiR-25 was detected in the human HSC cell line LX-2 and in primary murine HSCs, and increased with culture-induced activation. Transient overexpression of miR-25 inhibited TGF-β and its type 1 receptor (TGFBR1 ...


Local Challenges And Successes Associated With Transitioning To Sustainable Food System Practices For A West Australian Context: Multi-Sector Stakeholder Perceptions, Ros Sambell, Lesley Andrew, Stephanie Godrich, Justin Wolfgang, Dieter Vandenbroeck, Katie Stubley, Nick Rose, Lenore Newman, Pierre Horwitz, Amanda Devine Jun 2019

Local Challenges And Successes Associated With Transitioning To Sustainable Food System Practices For A West Australian Context: Multi-Sector Stakeholder Perceptions, Ros Sambell, Lesley Andrew, Stephanie Godrich, Justin Wolfgang, Dieter Vandenbroeck, Katie Stubley, Nick Rose, Lenore Newman, Pierre Horwitz, Amanda Devine

ECU Publications Post 2013

Large-scale food system practices have diminished soil and water quality and negatively impacted climate change. Yet, numerous opportunities exist to harness food system practices that will ensure better outcomes for human health and ecosystems. The objective of this study was to consider food Production, Processing, Access and Consumption domains, and for each determine the challenges and successes associated with progressing towards a sustainable food system. A workshop engaging 122 participants including producers, consultants, consumers, educators, funders, scientists, media, government and industry representatives, was conducted in Perth, Western Australia. A thematic analysis of statements (Successes (n = 170) or Challenges (n = 360 ...


The Effects Of Alcohol On Plasma Lipid Mediators Of Inflammation Resolution In Patients With Type 2 Diabetes Mellitus, Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M. Hodgson, Ian Puddey, Trevor A. Mori Jun 2019

The Effects Of Alcohol On Plasma Lipid Mediators Of Inflammation Resolution In Patients With Type 2 Diabetes Mellitus, Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M. Hodgson, Ian Puddey, Trevor A. Mori

ECU Publications Post 2013

Background

Type 2 diabetes mellitus is characterized by peripheral insulin resistance and low-grade systemic inflammation. Inflammation resolution is recognised as an important process driven by specialised pro-resolving mediators of inflammation (SPMs) and has the potential to moderate chronic inflammation. Alcohol has the potential to affect synthesis of SPMs by altering key enzymes involved in SPM synthesis and may influence ongoing inflammation associated with Type 2 diabetes mellitus.

Aims

(i) To examine the effects of alcohol consumed as red wine on plasma SPM in men and women with Type 2 diabetes in a randomised controlled trial and (ii) compare baseline plasma ...


Reply To Om Shannon Et Al, Lauren C. Blekkenhorst, Joshua R. Lewis, Richard L. Prince, Amanda Devine, Nicola P. Bondonno, Catherine P. Bondonno, Lisa G. Wood, Ian B. Puddey, Natalie C. Ward, Kevin D. Croft, Richard J. Woodman, Lawrence J. Beilin, Jonathan M. Hodgson Jun 2019

Reply To Om Shannon Et Al, Lauren C. Blekkenhorst, Joshua R. Lewis, Richard L. Prince, Amanda Devine, Nicola P. Bondonno, Catherine P. Bondonno, Lisa G. Wood, Ian B. Puddey, Natalie C. Ward, Kevin D. Croft, Richard J. Woodman, Lawrence J. Beilin, Jonathan M. Hodgson

ECU Publications Post 2013

No abstract provided.


Comt Val158met Is Not Associated With Aβ-Amyloid And Apoe Ε4 Related Cognitive Decline In Cognitively Normal Older Adults, Tenielle Porter, Samantha C. Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Hamid R. Sohrabi, Madeline Peretti, Yen Ying Lim, Michael Weinborn, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L. Villemagne, Simon M. Laws Jun 2019

Comt Val158met Is Not Associated With Aβ-Amyloid And Apoe Ε4 Related Cognitive Decline In Cognitively Normal Older Adults, Tenielle Porter, Samantha C. Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Hamid R. Sohrabi, Madeline Peretti, Yen Ying Lim, Michael Weinborn, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L. Villemagne, Simon M. Laws

ECU Publications Post 2013

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aβ-amyloid (Aβ) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer’s disease (AD). In 598 cognitively normal older adults with known neocortical Aβ levels, linear mixed modelling revealed no significant independent or interactional associations ...


Dietary Nitrate Intake Is Associated With Muscle Function In Older Women, Marc Sim, Joshua R. Lewis, Lauren C. Blekkenhorst, Catherine P. Bondonno, Amanda Devine, Kun Zhu, Peter Peeling, Richard L. Prince, Jonathan M. Hodgson Jun 2019

Dietary Nitrate Intake Is Associated With Muscle Function In Older Women, Marc Sim, Joshua R. Lewis, Lauren C. Blekkenhorst, Catherine P. Bondonno, Amanda Devine, Kun Zhu, Peter Peeling, Richard L. Prince, Jonathan M. Hodgson

ECU Publications Post 2013

Background

In younger individuals, dietary nitrate supplementation has been shown to improve short‐term vascular and muscle function. The role of higher habitual nitrate intake as part of a typical diet on muscle function in ageing has not been investigated. A cross‐sectional study of relationships between dietary nitrate and measures of muscle function in older community‐dwelling Australian women (n = 1420, ≥70 years) was undertaken.

Methods

Participants completed a semi‐quantitative food frequency questionnaire assessing dietary intake over the previous year. Total nitrate from vegetables and non‐vegetable sources was calculated from a validated instrument that quantified the nitrate ...


Variables Associated With Successful Vascular Access Cannulation In Hemodialysis Patients: A Prospective Cohort Study, Linda L. Coventry, Jon M. Hosking, Doris T. Chan, Evelyn Coral, Wai H. Lim, Amanda Towell-Barnard, Diane E. Twigg, Claire M. Rickard May 2019

Variables Associated With Successful Vascular Access Cannulation In Hemodialysis Patients: A Prospective Cohort Study, Linda L. Coventry, Jon M. Hosking, Doris T. Chan, Evelyn Coral, Wai H. Lim, Amanda Towell-Barnard, Diane E. Twigg, Claire M. Rickard

ECU Publications Post 2013

BACKGROUND: Successful vascular access (VA) cannulation is integral to the delivery of adequate dialysis, highlighting the importance of ensuring the viability of arteriovenous access in hemodialysis (HD) patients. Missed VA cannulation can lead to infection, infiltration, hematoma or aneurysm formation resulting in the need for access revision, central venous catheter (CVC) placement, or permanent loss of VA. Cannulation-related complications can also negatively impact on a patient's dialysis experience and quality of life. This study aimed to identify patient, VA and nurse factors associated with unsuccessful VA cannulations.

METHODS: A prospective cohort study was conducted in HD patients with a ...


The Current State Of Weight-Cutting In Combat Sports, Oliver R. Barley, Dale W. Chapman, Chris R. Abbiss May 2019

The Current State Of Weight-Cutting In Combat Sports, Oliver R. Barley, Dale W. Chapman, Chris R. Abbiss

ECU Publications Post 2013

In combat sports, athletes are divided into categories based on gender and body mass. Athletes attempt to compete against a lighter opponent by losing body mass prior to being weighed (i.e., 'weight-cutting'). The purpose of this narrative review was to explore the current body of literature on weight-cutting and outline gaps for further research. Methods of weight-loss include energy intake restriction, total body fluid reduction and pseudo extreme/abusive medical practice (e.g., diuretics). The influence of weight-cutting on performance is unclear, with studies suggesting a negative or no effect. However, larger weight-cuts (~5% of body mass inh) do ...


Predominant Complications Of Type 2 Diabetes In Kumasi: A 4-Year Retrospective Cross-Sectional Study At A Teaching Hospital In Ghana, Max Efui Annani-Akollor, Otchere Addai-Mensah, Linda Ahenkorah Fondjo, Lorraine Sallah, Eddie-Williams Owiredu, Emmanuel Acheampong, Solomon Akamugri May 2019

Predominant Complications Of Type 2 Diabetes In Kumasi: A 4-Year Retrospective Cross-Sectional Study At A Teaching Hospital In Ghana, Max Efui Annani-Akollor, Otchere Addai-Mensah, Linda Ahenkorah Fondjo, Lorraine Sallah, Eddie-Williams Owiredu, Emmanuel Acheampong, Solomon Akamugri

ECU Publications Post 2013

Background and objectives: Diabetes mellitus type 2 (T2DM) has been associated with several microvascular and macrovascular complications. However, studies regarding the predominant complications of T2DM in Ghana have not been conducted. This study evaluated the prevalence and predominant complications of T2DM and assessed the sociodemographic factors associated with the development of diabetes-related complications in Kumasi, Ghana. Materials and Methods: This was a retrospective cross-sectional study conducted at Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. A total of 1600 Ghanaian T2DM adults were included in this study. Patients’ clinical data from 2012 to 2016 were retrieved from the hospital’s archive ...


Spatial Distribution Of Tuberculosis And Its Association With Meteorological Factors In Mainland China, Yingjie Zhang, Mengyang Liu, Samuel S. Wu, Hui Jiang, Junjie Zhang, Songwang Wang, Wei Ma, Qihuan Li, Yuan Ma, Yue Liu, Wei Feng, Endawoke Amsalu, Xia Li, Wei Wang, Weimin Li, Xiuhua Guo May 2019

Spatial Distribution Of Tuberculosis And Its Association With Meteorological Factors In Mainland China, Yingjie Zhang, Mengyang Liu, Samuel S. Wu, Hui Jiang, Junjie Zhang, Songwang Wang, Wei Ma, Qihuan Li, Yuan Ma, Yue Liu, Wei Feng, Endawoke Amsalu, Xia Li, Wei Wang, Weimin Li, Xiuhua Guo

ECU Publications Post 2013

BACKGROUND: The incidence of tuberculosis (TB) remains high worldwide. Current strategies will not eradicate TB by 2035; instead, by 2182 is more likely. Therefore, it is urgent that new risk factors be identified.

METHODS: An ecological study was conducted in 340 prefectures in China from 2005 to 2015. The spatial distribution of TB incidence was shown by clustering and hotspot analysis. The relationship between the distribution patterns and six meteorological factors was evaluated by the geographically weighted regression (GWR) model.

RESULTS: During the 11 years of the study period, TB incidence was persistently low in the east and high in ...