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- Diabetes; Renal Allografts; Humoral Antibodies; Antibodies; Gamma Globulin; Homografts; Serum Electrophoresis (1)
- Diabetes; Somatostatin; Growth Hormone; Blood Glucose; Hypothalamic (1)
- Education; Screening; Counseling; Richmond; Sickle Cell Anemia; Hemoglobinopathies (1)
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- Human Genetics; Case Report; Motor Neuron Disease; ALS; Heterogeneity (1)
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- Human Genetics; Case Report; Saethre-Chotzen; Craniooculodental Syndrome; Facial Asymmetry (1)
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Articles 1 - 30 of 63
Full-Text Articles in Medicine and Health Sciences
Contents
MCV/Q, Medical College of Virginia Quarterly
Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1977, Volume Thirteen, Number One.
Introduction, H. St. George Tucker
Introduction, H. St. George Tucker
MCV/Q, Medical College of Virginia Quarterly
A Symposium on Diabetes was presented at the Medical College of Virginia on September 23, 1976, sponsored jointly by the Division of Endocrinology and Metabolism of the Department of Medicine, and by the Department of Continuing Education. The symposium was also sponsored in part by a grant-in-aid for continuing medical education from the Upjohn Company.
Insulin Receptors, William G. Blackard
Insulin Receptors, William G. Blackard
MCV/Q, Medical College of Virginia Quarterly
Much of the emphasis in the pathogenesis of diabetes mellitus has justifiably been placed on the endocrine gland, the pancreas. Extensive studies on the biosynthesis and release of insulin from the beta cell, bihormonal control of metabolism by insulin and glucagon, and more recently the role of somatostatin have attracted the attention of students of the subject; but considerable evidence exists to suggest at least some role of tissue resistance to insulin in the pathogenesis of this disorder. There have been many advocates for extra pancreatic factors causing diabetes. One of the first was Mirsky, who proposed that diabetes might …
Insulin Treatment Of Diabetes Mellitus, H. St. George Tucker
Insulin Treatment Of Diabetes Mellitus, H. St. George Tucker
MCV/Q, Medical College of Virginia Quarterly
In summary, I believe in aiming for the best possible control for each patient through an empirical approach which seeks to arrive at the best schedule for the individual patient. We want especially tight control for the pregnant diabetic, and for this patient it is likely that multiple insulin injections are needed. If further experience confirms the benefits of multiple injections for juvenile patients, this type of treatment may also be indicated for these patients.
Oral Hypoglycemic Agents, Harold Rifkin
Oral Hypoglycemic Agents, Harold Rifkin
MCV/Q, Medical College of Virginia Quarterly
In conclusion, comment is made on the findings of the University Group Diabetes Program (UGDP). The purpose of the UGDP was to determine whether or not control of blood glucose levels would help to prevent or delay vascular disease in non-insulin-requiring diabetics. After 8 1/2 years of follow-up at 12 university-affiliated treatment centers, "The findings of the study indicate that the combination of diet and tolbutamide therapy is no more effective than diet alone in prolonging life. Moreover, the findings suggest that tolbutamide and diet may be less effective than diet alone or diet and insulin, at least insofar as …
Book Review, Frederick J. Spencer
Book Review, Frederick J. Spencer
MCV/Q, Medical College of Virginia Quarterly
Book reviews for Epidemics, Geoffrey Marks and William K. Beatty, Scribner's, 1976 and Plagues and Peoples, William H. McNeill, Doubleday, 1976.
Contents
MCV/Q, Medical College of Virginia Quarterly
Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1977, Volume Thirteen, Number Two.
The Emerging Clinical Usefulness Of Complement Measurements, Shaun Ruddy
The Emerging Clinical Usefulness Of Complement Measurements, Shaun Ruddy
MCV/Q, Medical College of Virginia Quarterly
Not many years ago the main purpose of “complement” seemed to be to drill holes in sheep erythrocytes. In the classic experiment which was part of every medical student’s microbiology laboratory experience, a magic stuff called complement, somewhat mysteriously obtained from guinea pigs, was either “fixed” or not “fixed” and the sheep cells either not lysed or lysed accordingly. That was about all there was to know about complement, and all one needed to know. Today the term "complement" embodies a group of plasma proteins which react in a complex sequence to mediate a variety of inflammatory effects, including changes …
Immunology And Disease Of Connective Tissue, Robert Irby
Immunology And Disease Of Connective Tissue, Robert Irby
MCV/Q, Medical College of Virginia Quarterly
Since immune responses play a major role in the development of connective tissue diseases, it is not surprising that a number of laboratory studies reflect these responses. Prior to the 1940s when rheumatoid and LE factors became widely known, one relied mainly on erythrocyte sedimentation rate and serum electrophoresis to identify protein abnormality. Elevated sedimentation rate depends on rouleaux formation, and rouleaux formation is dependent upon large asymmetric molecules of fibrinogen and gamma globulin in plasma. The demonstration of gamma globulin has become the cornerstone of the immunologist’s edifice. It is amazing to see how the subspecialty of immunology has …
Contents
MCV/Q, Medical College of Virginia Quarterly
Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1977, Volume Thirteen, Number Three.
Introduction, John R. Taylor
Introduction, John R. Taylor
MCV/Q, Medical College of Virginia Quarterly
This issue of the MCV Quarterly is devoted to a review of some of the problems in clinical neurology that present soon after onset and often require urgent evaluation and care. Problems such as seizures and headache are regular features of many types of practice. Others such as acute ophthalmoplegias are infrequently seen outside the field of neurology. Still others, for instance, head injury, are commonly seen but often require the attention of physicians with specialized training, such as Dr. Miller of the MCV Division of Neurosurgery. While every acute neurologic problem cannot be reviewed in a single issue, the …
Acute Bilateral Ophthalmoplegias, John B. Selhorst
Acute Bilateral Ophthalmoplegias, John B. Selhorst
MCV/Q, Medical College of Virginia Quarterly
Bilateral ophthalmoplegia is that condition of weakness or paralysis involving one or more ocular muscles in each eye. Its sudden appearance due to an acute ocular myopathy is indeed unusual. Swash reported a single patient with acute necrotizing orbital myositis and carcinomatosis neuromyopathy. The more common bilateral ocular muscle diseases, such as dysthyroid exophthalmopathy, orbital myositis, and progressive external ophthalmoplegia, develop insidiously and are restricted to the orbit.
Acute Seizure Problems, Cary Suter
Acute Seizure Problems, Cary Suter
MCV/Q, Medical College of Virginia Quarterly
Seizures are a symptom and not a disease. A seizure is the result of an abnormal electrical discharge of a collection or group of living but damaged or abnormal neurons. When the group of neurons is in the cerebral cortex, a focal or partial seizure occurs, producing abnormal activity related to that part of the brain. The victim may experience a focal jerking or focal numbness, or flashing lights if the lesion is in the occipital lobe; or he or she may be subject to peculiar automatic behavior if the lesion is in the temporal lobe. When the activity spreads …
Indications For Antenatal Genetic Diagnosis, Fay Redwine, Robert E. Petres
Indications For Antenatal Genetic Diagnosis, Fay Redwine, Robert E. Petres
MCV/Q, Medical College of Virginia Quarterly
The future of antenatal genetic diagnosis is an exciting one. Recent advances include the application of chromosal banding techniques to identify subtle abnormalities and rearrangements; ultrasonography, using high resolution gray scale equipment to permit delineation of fetal soft tissue and skeletal anomalies; and fetoscopy, using a small fiberoptic instrument to view the fetus directly and observe its development. With these advances in technology, it should be possible to enable even more women at high risk for genetically diseased offspring to bear healthy children.
Recent Advances In Cytogenetic Technology For Antenatal Genetic Testing, Judith A. Brown, Anna Carr, Elizabeth S. Cooper, Deborah W. Heritage
Recent Advances In Cytogenetic Technology For Antenatal Genetic Testing, Judith A. Brown, Anna Carr, Elizabeth S. Cooper, Deborah W. Heritage
MCV/Q, Medical College of Virginia Quarterly
The examination of human chromosomes has been a part of the physician’s laboratory armamentarium since the correct diploid number of human chromosomes was established and a method was developed for the in vitro growth of peripheral blood leukocytes to yield metaphase chromosomes. The discovery that on ultraviolet microscopy (UV), metaphase chromosomes stained with fluorochrome dyes displayed a characteristic pattern of bright and dull bands unique for a given pair of homologous chromosomes, was a major technological breakthrough in human cytogenetics; for the first time, every chromosome in the karyotype could be unequivocally identified. Although the short storage life of fluorochrome-stained …
The Genetic Counseling Program At Mcv, Phyllis Winter, Peter Mamunes, Walter E. Nance
The Genetic Counseling Program At Mcv, Phyllis Winter, Peter Mamunes, Walter E. Nance
MCV/Q, Medical College of Virginia Quarterly
The Genetic Counseling Clinic at the Medical College of Virginia, established by Drs. Peter Mamunes and R.B. Young in 1973, has been supported since its inception by a clinical service grant from the National Foundation – March of Dimes; it is one of 83 genetic counseling programs in the United States and one of three in Virginia that receive support from the Foundation. The Clinic provides counseling and diagnostic services for a variety of genetic disease and is the focus of clinical teaching and research activities of the Department of Human Genetics. The Clinic is staffed by member of the …
The Virginia Sickle Cell Anemia Awareness Program: Education, Screening, And Counseling, Florence N. Cooper, Robert B. Scott
The Virginia Sickle Cell Anemia Awareness Program: Education, Screening, And Counseling, Florence N. Cooper, Robert B. Scott
MCV/Q, Medical College of Virginia Quarterly
In 1968, a program of screening for sickle trait carriers was begun as part of the work of the Hematology Division, Department of Medicine, at the Medical College of Virginia. It was felt that sickle cell anemia was more of a public health problem than was generally recognized, and in addition to instituting screening and education programs, data were collected to document the relative neglect of the problem.
The Genetic And Somatic Effects Of Radiation: A Balance Between Benefits And Risks, Timothy Merz
The Genetic And Somatic Effects Of Radiation: A Balance Between Benefits And Risks, Timothy Merz
MCV/Q, Medical College of Virginia Quarterly
The present clinical interest in mutagenic agents in general and radiation in particular can be seen in the current proliferation of popular articles and reports on the effect of mutagens and radiation on biological systems. In spite of the continuing controversy over the effects of radiation from environmental sources, the most significant problem today is the increasing x-ray exposure of individuals due to the increasing radiological diagnostic capability and the expanding importance of radiographic procedures in medical diagnosis.
Syndrome Identification [Case Reports], Peter Mamunes
Syndrome Identification [Case Reports], Peter Mamunes
MCV/Q, Medical College of Virginia Quarterly
What’s in a name? This question is often asked of a genetic counselor when a syndrome is newly delineated. The brief case reports that follow demonstrate the importance of establishing precise diagnoses. They also emphasize that many of these syndromes are recognizable only after careful physical examination of the proband and family members, consultation with other subspecialties (for example, neurology, radiology, orthopedics, dentistry, pathology), and a review of the medical literature.
A Report Of Familiar Ring (9) Chromosome [Case Study], Robin J. Caldwell, Judith A. Brown, Reuben B. Young
A Report Of Familiar Ring (9) Chromosome [Case Study], Robin J. Caldwell, Judith A. Brown, Reuben B. Young
MCV/Q, Medical College of Virginia Quarterly
Ring chromosomes originate in the simultaneous occurrence of two breaks at opposite ends of the chromosome and the subsequent reuniting of the free ends to form a ring. They may be compatible with normal life, as only a fractional loss of genetic material has occurred, or they may lead to spontaneous abortion or to an offspring with severe physical and mental handicap attributable to significant genetic alterations.
A Case Of Saethre-Chotzen Syndrome, Catherine Mckeon-Kern, Peter Mamunes
A Case Of Saethre-Chotzen Syndrome, Catherine Mckeon-Kern, Peter Mamunes
MCV/Q, Medical College of Virginia Quarterly
Saethre-Chotzen syndrome was described independently by the Norwegian psychiatrist, Saethre, and the German psychiatrist, Chotzen, in the 1930s; since that time many cases have been reported, some using the terms acrocephalosyndactyly, type III, and craniooculodental syndrome. Clinically, the syndrome is characterized by premature closure of the cranial sutures, low-set hairline, nasal septum deviation, brachydactyly, and ptosis. It is inherited as an autosomal dominant with complete penetrance and great variability in expression. Because of this variable in expressivity, the syndrome is difficult to diagnose in the less severe form without a positive family history.
Contents
MCV/Q, Medical College of Virginia Quarterly
Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1977, Volume Thirteen, Number Four.
Virginia Dental Journal (Vol. 54, No. 2, 1977)
Virginia Dental Journal (Vol. 54, No. 2, 1977)
Virginia Dental Journal
No abstract provided.
The Polymorphonuclear Neutrophilic Phagocyte, Gerald L. Mandell
The Polymorphonuclear Neutrophilic Phagocyte, Gerald L. Mandell
MCV/Q, Medical College of Virginia Quarterly
Patients who have too few functioning mature polymorphonuclear neutrophils frequently develop fatal bacterial or fungal infections despite our best efforts to prevent and treat those infections. Recently new facets of white cell function which enable us to better understand both normal and abnormal states have been found. Several review articles about polymorphonucler neutrophils (also called neutrophils and granulocytes – the latter term includes eosinophils and basophils) have been published recently and the reader is referred to these for more comprehensive coverage of the field.
The Relevance Of Genetics To Medicine [Introduction], Walter E. Nance
The Relevance Of Genetics To Medicine [Introduction], Walter E. Nance
MCV/Q, Medical College of Virginia Quarterly
This issue of the MCV Quarterly focuses on the explosion of knowledge in the field of human genetics. The activities of the new Department of Human Genetics at the Medical College of Virginia encompass the traditional medical school triad of teaching, patient care, and research, and an active graduate program has been developed with curricula leading to masters and doctorate degrees. The program is supported by a recently awarded National Institutes of Health predoctoral training grant as well as State and local funds from the A.D. Williams Foundation.
Population Screening For Genetic Disease, Peter Mamunes
Population Screening For Genetic Disease, Peter Mamunes
MCV/Q, Medical College of Virginia Quarterly
Recent advances in genetics and laboratory techniques have raised difficult issues for both the medical and lay communities. The desirability of initiating population screening programs is an example of one such issue that has engendered considerable confusion concerning is intent – so much so that the National Academy of Sciences recently reviewed this subject and in 1975 published a book entitled, Genetic Screening – Programs, Principles and Research. This presentation will describe the four major forms of population screening for genetic disease and, from the Virginia experience with some of them, demonstrate their strengths and shortcomings.
Influence Of Duration Of Homograft On Humoral Responses In Man, Marion Waller, James C. Pierce, Gerardo Mendez-Picon, Hyung M. Lee
Influence Of Duration Of Homograft On Humoral Responses In Man, Marion Waller, James C. Pierce, Gerardo Mendez-Picon, Hyung M. Lee
MCV/Q, Medical College of Virginia Quarterly
Elevated titers of natural antibodies have been demonstrated in the sera of patients following transplantation. These humoral responses were thought to be associated with rejection. This concept was challenged by investigators whose studies associated these responses with infection or with injection of heterologous serum. Nevertheless, the possible prognostic significance of these relatively simple tests has continued to evoke interest. This study was undertaken to compare the humoral responses in three different groups of patients with organ transplants in order to evaluate the influence of duration of the homograft and the attendant immunosuppression.
Brain Death, Cary Suter
Brain Death, Cary Suter
MCV/Q, Medical College of Virginia Quarterly
Until recently determination of death was simple. The heart stopped. There was no pulse, no recordable blood pressure, and no heart sounds. There was no breathing. Now, methods of cardiopulmonary resuscitation are common knowledge, both to the layman and to the physician. Hospitals have special “Code Blue” teams; emergency rooms and intensive care units are superbly equipped for life support; hearts that stop are started again. Machines do an excellent job of respiration. Nevertheless, the patient’s brain may be dead and damaged beyond recovery, either in whole or in part. When the whole brain is seriously damaged, including the cerebral …
Immunology And Disease Of The Kidney, William F. Falls Jr.
Immunology And Disease Of The Kidney, William F. Falls Jr.
MCV/Q, Medical College of Virginia Quarterly
The emphasis of this paper is the review of several aspects of renal disease which have immunologic overtones and clinical relevance. The pathogenesis of several subtypes of glomerulonephritis will be discussed, the immunologic implications of amyloidosis will be noted, and the relation between immune mechanisms and tubulointerstitial disease will be mentioned. The discussion will then be completed by an analysis of the prognosis of the aforementioned renal disease, and by an attempt to place contemporary therapeutic modalities in a proper perspective.
Genetics And Cancer, John M. Mueller, Robert B. Diasio
Genetics And Cancer, John M. Mueller, Robert B. Diasio
MCV/Q, Medical College of Virginia Quarterly
The existence of a relationship between cancer and heredity has been recognized for years, but only recently has emerging knowledge in this area enabled physicians to detect and treat cancer earlier in affected individuals and to prevent its occurrence in others.