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Full-Text Articles in Medicine and Health Sciences

Nortex Fall 2018 Newsletter, North Texas Primary Care Practice-Based Research Network Oct 2018

Nortex Fall 2018 Newsletter, North Texas Primary Care Practice-Based Research Network

North Texas Primary Care Practice-Based Research Network (NorTex) Newsletter

No abstract provided.


Interleukin-17a (Il-17a) Worsens Severe Murine Respiratory Mycoplasma Disease, Maximillion Mize Aug 2018

Interleukin-17a (Il-17a) Worsens Severe Murine Respiratory Mycoplasma Disease, Maximillion Mize

Theses and Dissertations

The purpose of these studies was to determine the role of Interleukin-17A (IL-17A) in the immune response to respiratory mycoplasma infection. Serum levels of IL-17A increase in disease-susceptible BALB/c mice, but not disease-resistant C57BL/6 mice, infected with Mycoplasma pulmonis. Increased serum IL-17A was associated with mycoplasma pathology during infection in BALB/c mice, including: the presence of pulmonary neutrophils, progressive weight loss, and the development of inflammatory lung lesions. Neutralizing the function of IL-17A using monoclonal anti-IL-17A antibodies during mycoplasma infection reduced disease severity in disease-susceptible BALB/c mice, but not disease-resistant C57BL/6 mice. Providing daily intra-peritoneal ...


The Phenotype Of Cells Expressing Estrogen Receptor Alpha In The Nucleus Of The Solitary Tract, Christopher L. Horn May 2018

The Phenotype Of Cells Expressing Estrogen Receptor Alpha In The Nucleus Of The Solitary Tract, Christopher L. Horn

Theses and Dissertations

Estrogen protects females from hypertension. The nucleus tractus solitarius (NTS) is a hindbrain site involved in the regulation of blood pressure, however little is known about estrogen receptors within the NTS. The purpose of these studies was to determine the phenotype of the cells expressing estrogen alpha receptors in the nucleus tractus solitarius. Four female Sprague-Dawley rats were transcardially perfused with 4% paraformaldehyde and hindbrains harvested. In coronal sections containing the NTS (40μm thick), immunohistochemistry was performed to determine which type of cells were expressed with estrogen receptor alpha (ERα) expressing cells. We used the anti-ERα antibody with an antibody ...


Spectral Properties Of Doxorubicin Doped Rhdl Nanoparticles, Sunil Shah May 2018

Spectral Properties Of Doxorubicin Doped Rhdl Nanoparticles, Sunil Shah

Theses and Dissertations

Doxorubicin, also known as Adriamycin, is an anthracycline antibiotic which first gained clinical prominence in the early 1970’s as an effective antitumor agent. It is still used today to treat a spectrum of cancers like lymphoma, bladder, stomach, lung, breast, ovarian, and several others. Due to its production of free radicals to attack tumor cells, Doxorubicin interferes with mitochondrial phosphorylation and also induces cardiotoxicity. Thus, efficient and biocompatible delivery methods are needed for targeted drug delivery to overcome systemic toxicity. To maintain a high level of growth, tumor cells overexpress Scavenger receptors type B-1 (SR-B1). This cellular characteristic can ...


The Effect Of Diet On Craniofacial Growth In Osteogenesis Imperfecta Mouse Model, Summer H. Ladd May 2018

The Effect Of Diet On Craniofacial Growth In Osteogenesis Imperfecta Mouse Model, Summer H. Ladd

Theses and Dissertations

Osteogenesis imperfecta (OI, or “brittle bone disease”) is a rare disorder that is caused by genetic point mutations (COL1A1/COL1A2) that affect type 1 collagen. In OI type III (severe) patients, limb bones are more susceptible to skeletal fractures and the bones of the craniofacial region are underdeveloped. Some OI type III patients also suffer from dental malocclusions or fractures (dentinogenesis imperfecta, DI). The goals of this project are 1) to describe the facial phenotype in an OI mouse model, to see if this model can be used to test potential behavioral and pharmaceutical interventions; and 2) to determine if ...


Analysis Of Patient Recruitment Methods For Clinical Trials Of Different Heart And Lung Diseases, Oghenevovwero Vovwe Sido May 2018

Analysis Of Patient Recruitment Methods For Clinical Trials Of Different Heart And Lung Diseases, Oghenevovwero Vovwe Sido

Theses and Dissertations

Patient recruitment is key to the success of any clinical trial, as clinical trials cannot be conducted without the willful participation of subjects. However, clinical trial recruitment has always been a great challenge in clinical studies. This practicum project conducted over an eight-month period, compares three different methods of subject recruitment into 2 clinical research studies conducted at the Heart & Lung Transplant and Pulmonary Research Department of Baylor Scott & White Research Institute, Dallas. The three recruitment methods are: Physician Referral, EHR Screening and Online Portals. We hypothesize that Physician referral is a more successful method for enrolling patients into clinical ...


Nortex Spring 2018 Newsletter, North Texas Primary Care Practice-Based Research Network Apr 2018

Nortex Spring 2018 Newsletter, North Texas Primary Care Practice-Based Research Network

North Texas Primary Care Practice-Based Research Network (NorTex) Newsletter

No abstract provided.


Administration Accountability, Fiscal Year 2018, University Of North Texas Health Science Center At Fort Worth Jan 2018

Administration Accountability, Fiscal Year 2018, University Of North Texas Health Science Center At Fort Worth

Office of Finance

No abstract provided.


University Of North Texas Health Science Center Texas Government Code, 2018 Section 659.026 Report, University Of North Texas Health Science Center At Fort Worth Jan 2018

University Of North Texas Health Science Center Texas Government Code, 2018 Section 659.026 Report, University Of North Texas Health Science Center At Fort Worth

Office of Finance

No abstract provided.


Factors Affecting Study Subject Recruitment And Retention In A Major Depressive Disorder Study, Barbara Karnkowska Dec 2017

Factors Affecting Study Subject Recruitment And Retention In A Major Depressive Disorder Study, Barbara Karnkowska

Theses and Dissertations

The purpose of a clinical trial is to demonstrate safety, tolerability and efficacy of investigational medications before receiving FDA approval for medical use. The success of clinical trials heavily relies on quick patient recruitment as well as long-term patient retention throughout the duration of the study. Recruitment and retention have been identified as the most expensive components of research, in some instances consisting of up to 33% of the designated budget spanning from phase I to III trials [3]. In light of the rising costs of pharmaceutical research, it is important to investigate factors implicated in patient recruitment and retention ...


Student Assessment Methods Used In Undergraduate Medical Education, Christine Savi Oct 2017

Student Assessment Methods Used In Undergraduate Medical Education, Christine Savi

Fort Worth M.D. School

This document outlines student assessment methods used in undergraduate medical education. It highlights the strengths and limitations of each method, lists relevant competency domains and indicates whether the method is formative or summative. Assessment methods highlighted include authentic assessment, case presentation, chart review, direct observation, discussion, interactive computer assessment, journal, Mini-CEX (Clinical Evaluation Exercise), verbal examination, OSCE (Objective Structured Clinical Examination), peer assessment, portfolio, Script Concordance Test (SCT), self-assessment, reflection, simulation, small group interaction, survey, questionnaire, written examination (multiple choice or short answer), written log or prescription, checklist, rating scale, rubric and narrative response.


Nortex Fall 2017 Newsletter, North Texas Primary Care Practice-Based Research Network Oct 2017

Nortex Fall 2017 Newsletter, North Texas Primary Care Practice-Based Research Network

North Texas Primary Care Practice-Based Research Network (NorTex) Newsletter

No abstract provided.


The Vascular Aging Of The Cerebellum, Christopher L. Mcelroy Aug 2017

The Vascular Aging Of The Cerebellum, Christopher L. Mcelroy

Theses and Dissertations

The cerebellum has been discovered to have an increased role in our daily lives than was previously recognized. It not controls fine motor skills, posture, and gait, but newer research has shown that it has a role in cognitive thought, memory and emotion, as well as other non-motor specific functions. It is important to know how this part of the brain ages and why. It is well established that during the aging process the cerebellum in some regions decreases in size due to atrophy, but the reasoning for this is not well understood. One possible mechanism that could explain the ...


Uncovering The Multifaceted Hand Of Reactive Astrocytes In Hiv-Associated Neurocognitive Disorders, Shruthi Nooka Aug 2017

Uncovering The Multifaceted Hand Of Reactive Astrocytes In Hiv-Associated Neurocognitive Disorders, Shruthi Nooka

Theses and Dissertations

Despite the advent of antiretroviral therapy (ART), central nervous system (CNS) complications associated with HIV-1 infection, collectively referred to as HIV-associated neurocognitive disorders (HAND), continue to increase. HIV infection promotes cognitive dysfunction and neurodegeneration through persistent inflammation, oxidative stress from infected and/or activated macrophages, astrocytes and neurons. Additionally, recent studies demonstrated that neurotoxic side effects of antiretroviral (ARV) drugs are among several contributing factors to this continued prevalence of HAND. In recent years, a new appreciation of the role of astrocytes in regulating HIV-1 CNS infection has emerged. Thus, investigating the elusive cellular and molecular mechanisms regulated by astrocytes ...


Tolfenamic Acid Enhances The Anti-Proliferative Activity Of Vincristine In Medulloblastoma Cell Lines, Shruti Vikas Patil Aug 2017

Tolfenamic Acid Enhances The Anti-Proliferative Activity Of Vincristine In Medulloblastoma Cell Lines, Shruti Vikas Patil

Theses and Dissertations

Medulloblastoma (MB) is the most common pediatric malignant brain tumor and usually originates in the cerebellum. These tumors have the propensity to disseminate throughout the central nervous system and are often difficult to treat. Chemotherapy is widely accepted as part of the multimodality treatment approach for MB. However, it is associated with debilitating toxicity and potential long-term disabilities. Vincristine (VCR), a commonly used chemotherapeutic agent for MB treatment, is known to induce some toxic effects including peripheral neuropathy. Reducing the dose of the drug to minimize the toxic effect also reduces the cytotoxic efficacy of the drug. The aim of ...


Novel Androgen Receptor Splice Variant In The Substantia Nigra, Jo Garza Contreras Aug 2017

Novel Androgen Receptor Splice Variant In The Substantia Nigra, Jo Garza Contreras

Theses and Dissertations

Testosterone can increase calcium influx and cell death in dopamine neurons via a putative membrane androgen receptor (mAR). The mAR induced calcium increase may be due to activation of G-proteins involved in calcium mobilization. Previous studies using an N-terminal targeted androgen receptor (AR) antibody yielded low AR expression in dopamine neurons. Studies in our lab show high AR expression using a C-terminal targeted AR antibody. This difference in expression may be due to an AR variant.

We hypothesize an AR variant is present in the membrane of dopaminergic neurons and associated with G proteins.

To identify the presence of AR ...


Analysis Of Patient Compliance And Progression Of Diabetic Foot Ulcer Healing, Waasae M. Hussain Aug 2017

Analysis Of Patient Compliance And Progression Of Diabetic Foot Ulcer Healing, Waasae M. Hussain

Theses and Dissertations

Self-reporting serves as a mask for non-compliance in subjects in research studies. If a subject stays compliant with research guidelines it is assumed their diabetic foot ulcer would heal. This study evaluates the correlation between alleged patient compliance and the rate of healing of diabetic foot ulcers using a retrospective chart analysis. There was no correlation seen and the results showed normal distribution. This could be caused by unreported non-adherence.


Endothelin Receptor-Mediated Neurodegeneration In Glaucoma, Nolan Mcgrady Aug 2017

Endothelin Receptor-Mediated Neurodegeneration In Glaucoma, Nolan Mcgrady

Theses and Dissertations

Primary open-angle glaucoma (POAG) is a complex set of optic neuropathies which are characterized by the degeneration of the optic nerve, cupping of the optic disk and loss of retinal ganglion cells (RGCs). There are approximately 3 million Americans who currently suffer from this disease although this is most likely an underestimation since many individuals with glaucoma are unaware that they have the disease. POAG is an age-related disease progressing slowly over the course of several decades and is most commonly associated with an elevation in intraocular pressure (IOP). Currently available treatments for glaucoma, both surgical and pharmacological, are solely ...


“Ecstasy” To Addiction: Mechanistic And Reinforcing Effects Of Synthetic Cathinone Analogs Of Mdma, Sean B. Dolan May 2017

“Ecstasy” To Addiction: Mechanistic And Reinforcing Effects Of Synthetic Cathinone Analogs Of Mdma, Sean B. Dolan

Theses and Dissertations

Following widespread scheduling, many synthetic cathinone compounds have been diverted from “bath salts” to “Ecstasy” tablets or “Molly” powder formulations in addition to or in lieu of 3,4-methylenedioxymethamphetamine (MDMA). The current study aimed to assess the mechanism and reinforcing effects of three under-researched synthetic cathinone analogs of MDMA frequently used as adulterants in “Ecstasy” formulations: methylone, butylone, and pentylone. To assess the mechanism of these compounds in vitro, we utilized whole-cell patch clamp electrophysiology on HEK293 cells expressing the serotonin transporter (SERT). The abuse-related, in vivo mechanisms were determined using a drug discrimination assay with rats trained to discriminate ...


Creating Novel Purification And Biochemical Characterization Protocols For C. Collagenase From Clostridium Histolyticum, Developing A New Emergency Medicine Product, And Formulating Several Novel Therapies For Chronic And Acute Wound Treatment, Jason P. Mars May 2017

Creating Novel Purification And Biochemical Characterization Protocols For C. Collagenase From Clostridium Histolyticum, Developing A New Emergency Medicine Product, And Formulating Several Novel Therapies For Chronic And Acute Wound Treatment, Jason P. Mars

Theses and Dissertations

The pharmaceutical industry not only includes infinite areas of specialization, but also consists of distinct areas that do not typically overlap. Biotechnology is the branch of medicinal research that bridges the gap between the fields within the pharmaceutical industry by being able to take on the challenges that require knowledge of a vast range of information. This practicum was organized to put the scientific knowledge and the interdisciplinary practices of biotechnology to use in a modern day, pharmaceutical company specializing in wound therapy and skincare: Smith & Nephew Biotherapeutics. Wound therapy has the widest range of application due to being one ...


Measurement Of Traumatic Brain Injury (Tbi) Inpatient Activity Levels Through Accelerometry, Jeffrey T. Ramsey May 2017

Measurement Of Traumatic Brain Injury (Tbi) Inpatient Activity Levels Through Accelerometry, Jeffrey T. Ramsey

Theses and Dissertations

Purpose: The purpose of this study was to use retrospective analysis of actigraphy data to describe activity levels for patients undergoing inpatient rehabilitation. This study also examined the differences between activity levels of the different areas of therapy. The final aim of this study was to examine the affect of demographic factors, and injury characteristics on activity levels.

Method: Fifty individuals with Traumatic Brain Injury (TBI) undergoing inpatient rehabilitation wore accelerometers. Activity Counts (ACs) were summarized in one-minute intervals. ACs, demographic and outcome variables were analyzed using descriptive statistics and general linear regression analysis.

Results: During active therapy patients averaged ...


Approaches To Mitochondrial Genome Sequencing Using The Oxford Nanopore Minion Device, Kelcie C. Thorson May 2017

Approaches To Mitochondrial Genome Sequencing Using The Oxford Nanopore Minion Device, Kelcie C. Thorson

Theses and Dissertations

Current DNA sequencing methods rely on polymerase chain reaction (PCR) to create sufficient copies of targeted DNA fragments to serve as a library. PCR and subsequent clean-up steps add considerable time and cost to the process and provide opportunity for introduction of amplification errors or contamination. The aim of this study was to develop a reliable method for mitochondrial genome sequencing sans PCR using the Oxford Nanopore MinION. Our hypothesis was that results generated from native DNA sequencing would be concordant to sequencing results generated from PCR-enriched libraries. Error-rates of 1.47% (enriched) and 1.26% (native) were observed when ...


Assisting The Implementation Of A Centralized Irb In Multiple Categories Of Research At Medical City Of Fort Worth, Pawanpreet Randhawa May 2017

Assisting The Implementation Of A Centralized Irb In Multiple Categories Of Research At Medical City Of Fort Worth, Pawanpreet Randhawa

Theses and Dissertations

Introduction: As a collection of ethical principles and guidelines regarding biomedical research on humans, the Common Rule has remained largely unchanged since its inception while the clinical research landscape has grown dramatically in size and complexity. Now with the Common Rule being modernized, one of the proposed changes being executed is the requirement of a centralized Institutional Review Board (IRB) for multi-site research studies. This transition of a research site operating under a local IRB to a centralized IRB is expected to greatly improve collaborative studies.

Objective: The main goal of this practicum project is to assist in the implementation ...


Obstacles Associated With Physician Referral Of Patients Into Clinical Trials, Nick Torrez May 2017

Obstacles Associated With Physician Referral Of Patients Into Clinical Trials, Nick Torrez

Theses and Dissertations

Understanding the safety and efficacy of potential new medications relies on evidence gained through the participation of subjects in clinical drug trials. Many clinical trial sites struggle with recruitment of suitable participants which can delay the progress of drug development. Physicians can play a significant role in influencing patients to enter into a clinical trial, however many physicians due not utilize their unique position to facilitate the recruitment of patients into clinical trials, which may help to advance medical science and improve future treatment options. The lack of participation by physicians in the referral of patients into clinical trials (Crosson ...


An Anatomical Approach To Lower Extremity Reconstructive Surgery, Addison R. Wood May 2017

An Anatomical Approach To Lower Extremity Reconstructive Surgery, Addison R. Wood

Theses and Dissertations

Orthopaedic surgery of the lower extremity can be approached in several ways, but many times it is divided into soft tissue and boney reconstructive modalities. Orthopaedic sports surgery subspecialists tend to focus on soft tissue reconstruction; often with the goal of restoring as much natural motion as possible. Adult reconstructive orthopaedic surgery subspecialists often focus on boney alignment and use implants to replace degenerated cartilage and bone. There is significant overlap in these subspecialties as both make use of implants to mimic the structure and function of native anatomy to drive stability and motion. This dissertation focuses on the intersection ...


The Role Of Wnt/Β-Catenin Signaling In The Trabecular Meshwork Relating To Ocular Hypertensive Primary Open Angle Glaucoma, Hannah C. Webber May 2017

The Role Of Wnt/Β-Catenin Signaling In The Trabecular Meshwork Relating To Ocular Hypertensive Primary Open Angle Glaucoma, Hannah C. Webber

Theses and Dissertations

Ocular hypertension is the greatest causative risk factor of primary open angle glaucoma (POAG), the most prevalent subset of age-related glaucoma. Wnt signaling antagonist sFRP1 is increased in the trabecular meshwork (TM) of patients with POAG and induces ocular hypertension in human ex vivo eyes and in mice, which is resolved upon downstream Wnt/β-catenin signaling activation. The molecular mechanisms behind this remain unknown. β-catenin plays a role as an accessory protein to classical cadherin cytosolic domains, connecting these cell-cell adhesion proteins to the actin cytoskeleton. In other cell types, Wnt/β-catenin signaling crosstalks with the TGFβ/SMAD pathway, which ...


A Validation Of Strmix™ For Forensic Casework, Allison Conway May 2017

A Validation Of Strmix™ For Forensic Casework, Allison Conway

Theses and Dissertations

The interpretation of complex DNA profiles has been a controversial issue in forensic biology. The current methods of interpretation are limited in scope and do not make full use of the data. Efforts have been made to develop software which can incorporate more data and process more calculations than were previously possible. One such program, STRmix™ (Institute of Environmental Science and Research, Porirua, New Zealand), uses a Markov Chain Monte Carlo (MCMC) principle to simulate many different possible profiles and determine the probability of observing a profile in the evidence. A validation of this software is necessary to indicate which ...


Combination Therapy To Enhance Anti-Cancer Activity Against Neuroblastoma And Ewing Sarcoma Cells, Sagar Shelake May 2017

Combination Therapy To Enhance Anti-Cancer Activity Against Neuroblastoma And Ewing Sarcoma Cells, Sagar Shelake

Theses and Dissertations

Anti-neoplastic drugs used for the treatment of various cancers often cause severe toxicity. Chemotherapy induced side effects are highly detrimental in pediatric and adolescent and young adult (AYA) cancers. This project is aimed at evaluating the strategies to induce the therapeutic efficacy of anti-neoplastic agents in a pediatric and an AYA cancer models, neuroblastoma (NB) and Ewing Sarcoma (ES) respectively. NB is a most common type of pediatric cancer that arises from autonomic nervous system while ES is a very aggressive bone and soft tissue sarcoma diagnosed in AYA patients. Small molecules such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are under ...


Adaptation Of The Genetic Risk Prediction Model Brcapro For Primary Care Settings, Philamer M. Atienza May 2017

Adaptation Of The Genetic Risk Prediction Model Brcapro For Primary Care Settings, Philamer M. Atienza

Theses and Dissertations

Identifying women at high risks of carrying the breast cancer susceptibility genes is crucial for providing timely surveillance and necessary health management interventions. BRCAPRO is one of the most widely used statistical models for breast cancer risk prediction in genetic counseling. It provides carrier probabilities of BRCA1/2 mutations and calculates the risks of developing breast and ovarian cancers. This calculation requires extensive personal and family history information, which makes it difficult to use in primary care where a wider population could be reached. Thus, we developed a two-stage approach for the genetic risk prediction of BRCA1/2 mutation. In ...


Anatomical Investigation Of The Tensor Vastus Intermedius In The Quadriceps Muscle Group, Christopher T. Collins May 2017

Anatomical Investigation Of The Tensor Vastus Intermedius In The Quadriceps Muscle Group, Christopher T. Collins

Theses and Dissertations

Past anatomical research has shown examples of fusion of the quadriceps muscle group. Researchers have seen examples of this muscle group exhibiting extra muscle bellies or multiple small flaps. A recent study has confirmed a consistent variation to this muscle group, that could qualify as a new muscle, the tensor vastus intermedius (TVI). This study investigates the presence and type of TVI muscle found in 70 cadavers, with additional focus on the arterial supply to the lateral aspect of the quadriceps muscle group and the variations associated with these vessels. To further understand the function and clinical implications of this ...