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University of North Texas Health Science Center

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Full-Text Articles in Medicine and Health Sciences

Standard Operating Procedures And Their Effect On Confidence Levels, Luke Bailey Dec 2018

Standard Operating Procedures And Their Effect On Confidence Levels, Luke Bailey

Theses and Dissertations

No abstract provided.


The Role Of Disease Duration And Pain Catastrophizing In Patients With Chronic Nonspecific Low Back Pain, Theodora Costin Dec 2018

The Role Of Disease Duration And Pain Catastrophizing In Patients With Chronic Nonspecific Low Back Pain, Theodora Costin

Theses and Dissertations

Introduction: Psychological factors such as pain catastrophizing and depression may negatively impact pain perception and could put low back pain sufferers at risk for prolonged pain. PRECISION TEXAS, a low back pain research registry at the University of North Texas Health Science Center administered a survey to gain better understanding of psychosocial and other influences on chronic pain. One objective was to assess, based on the survey, the association between pain intensity, duration, and extent of depression with pain catastrophizing. Methods: A survey containing the Pain Catastrophizing Scale (PCS), PROMIS-29 Quality of Life (QoL) questionnaire, and Numerical Rating Scale (NRS ...


Quality Assurance Training: Will A New Training Lntervention Lmprove Data Collectlon Of The Texas Emergency Medicine Research Associate Program (Temrap)?, Miguel Antonio Saldana Dec 2018

Quality Assurance Training: Will A New Training Lntervention Lmprove Data Collectlon Of The Texas Emergency Medicine Research Associate Program (Temrap)?, Miguel Antonio Saldana

Theses and Dissertations

Introduction: Data collection is vital for the success of a clinical research project. The purpose of this practicum was to address the inadequate data collection by the Texas Emergency Medicine Research Associate Program (TEMRAP) research associates (RAs). The primary goal was to incorporate a more efficient training method to reduce the RAs’ error rate in the documentation. The secondary aim of this experiment was to determine if RAs’ knowledge of clinical research studies and/or their self-confidence when enrolling a patient had an effect on quality of data collection and if these variables could be improved by a new training ...


Atrophied Thymus, A Tumor Reservoir For Harboring Melanoma Cells, Olga Sizova Dec 2018

Atrophied Thymus, A Tumor Reservoir For Harboring Melanoma Cells, Olga Sizova

Theses and Dissertations

Tumor metastatic relapse is the major cause of cancer-associated mortality. Metastatic relapse is believed to arise from quantities of tumor cells that are below detectable thresholds, which are able to resist radio/chemotherapy by obtaining a dormant state and hiding in certain organs, i.e., tumor reservoirs. The thymus, the central T-cell immune organ, has been suggested to be a pre-metastatic tumor reservoir for B-lymphoma cells. However, it remains unknown whether the thymus is able to harbor nonlymphoid solid tumor cells, and whether chemotherapy can thoroughly eliminate cancer cells in the thymus. If chemotherapy is not able to eliminate these ...


Nortex Fall 2018 Newsletter, North Texas Primary Care Practice-Based Research Network Oct 2018

Nortex Fall 2018 Newsletter, North Texas Primary Care Practice-Based Research Network

North Texas Primary Care Practice-Based Research Network (NorTex) Newsletter

No abstract provided.


Interleukin-17a (Il-17a) Worsens Severe Murine Respiratory Mycoplasma Disease, Maximillion Mize Aug 2018

Interleukin-17a (Il-17a) Worsens Severe Murine Respiratory Mycoplasma Disease, Maximillion Mize

Theses and Dissertations

The purpose of these studies was to determine the role of Interleukin-17A (IL-17A) in the immune response to respiratory mycoplasma infection. Serum levels of IL-17A increase in disease-susceptible BALB/c mice, but not disease-resistant C57BL/6 mice, infected with Mycoplasma pulmonis. Increased serum IL-17A was associated with mycoplasma pathology during infection in BALB/c mice, including: the presence of pulmonary neutrophils, progressive weight loss, and the development of inflammatory lung lesions. Neutralizing the function of IL-17A using monoclonal anti-IL-17A antibodies during mycoplasma infection reduced disease severity in disease-susceptible BALB/c mice, but not disease-resistant C57BL/6 mice. Providing daily intra-peritoneal ...


The Phenotype Of Cells Expressing Estrogen Receptor Alpha In The Nucleus Of The Solitary Tract, Christopher L. Horn May 2018

The Phenotype Of Cells Expressing Estrogen Receptor Alpha In The Nucleus Of The Solitary Tract, Christopher L. Horn

Theses and Dissertations

Estrogen protects females from hypertension. The nucleus tractus solitarius (NTS) is a hindbrain site involved in the regulation of blood pressure, however little is known about estrogen receptors within the NTS. The purpose of these studies was to determine the phenotype of the cells expressing estrogen alpha receptors in the nucleus tractus solitarius. Four female Sprague-Dawley rats were transcardially perfused with 4% paraformaldehyde and hindbrains harvested. In coronal sections containing the NTS (40μm thick), immunohistochemistry was performed to determine which type of cells were expressed with estrogen receptor alpha (ERα) expressing cells. We used the anti-ERα antibody with an antibody ...


Spectral Properties Of Doxorubicin Doped Rhdl Nanoparticles, Sunil Shah May 2018

Spectral Properties Of Doxorubicin Doped Rhdl Nanoparticles, Sunil Shah

Theses and Dissertations

Doxorubicin, also known as Adriamycin, is an anthracycline antibiotic which first gained clinical prominence in the early 1970’s as an effective antitumor agent. It is still used today to treat a spectrum of cancers like lymphoma, bladder, stomach, lung, breast, ovarian, and several others. Due to its production of free radicals to attack tumor cells, Doxorubicin interferes with mitochondrial phosphorylation and also induces cardiotoxicity. Thus, efficient and biocompatible delivery methods are needed for targeted drug delivery to overcome systemic toxicity. To maintain a high level of growth, tumor cells overexpress Scavenger receptors type B-1 (SR-B1). This cellular characteristic can ...


The Effect Of Diet On Craniofacial Growth In Osteogenesis Imperfecta Mouse Model, Summer H. Ladd May 2018

The Effect Of Diet On Craniofacial Growth In Osteogenesis Imperfecta Mouse Model, Summer H. Ladd

Theses and Dissertations

Osteogenesis imperfecta (OI, or “brittle bone disease”) is a rare disorder that is caused by genetic point mutations (COL1A1/COL1A2) that affect type 1 collagen. In OI type III (severe) patients, limb bones are more susceptible to skeletal fractures and the bones of the craniofacial region are underdeveloped. Some OI type III patients also suffer from dental malocclusions or fractures (dentinogenesis imperfecta, DI). The goals of this project are 1) to describe the facial phenotype in an OI mouse model, to see if this model can be used to test potential behavioral and pharmaceutical interventions; and 2) to determine if ...


Analysis Of Patient Recruitment Methods For Clinical Trials Of Different Heart And Lung Diseases, Oghenevovwero Vovwe Sido May 2018

Analysis Of Patient Recruitment Methods For Clinical Trials Of Different Heart And Lung Diseases, Oghenevovwero Vovwe Sido

Theses and Dissertations

Patient recruitment is key to the success of any clinical trial, as clinical trials cannot be conducted without the willful participation of subjects. However, clinical trial recruitment has always been a great challenge in clinical studies. This practicum project conducted over an eight-month period, compares three different methods of subject recruitment into 2 clinical research studies conducted at the Heart & Lung Transplant and Pulmonary Research Department of Baylor Scott & White Research Institute, Dallas. The three recruitment methods are: Physician Referral, EHR Screening and Online Portals. We hypothesize that Physician referral is a more successful method for enrolling patients into clinical ...


Nortex Spring 2018 Newsletter, North Texas Primary Care Practice-Based Research Network Apr 2018

Nortex Spring 2018 Newsletter, North Texas Primary Care Practice-Based Research Network

North Texas Primary Care Practice-Based Research Network (NorTex) Newsletter

No abstract provided.


Administration Accountability, Fiscal Year 2018, University Of North Texas Health Science Center At Fort Worth Jan 2018

Administration Accountability, Fiscal Year 2018, University Of North Texas Health Science Center At Fort Worth

Office of Finance

No abstract provided.


University Of North Texas Health Science Center Texas Government Code, 2018 Section 659.026 Report, University Of North Texas Health Science Center At Fort Worth Jan 2018

University Of North Texas Health Science Center Texas Government Code, 2018 Section 659.026 Report, University Of North Texas Health Science Center At Fort Worth

Office of Finance

No abstract provided.


Factors Affecting Study Subject Recruitment And Retention In A Major Depressive Disorder Study, Barbara Karnkowska Dec 2017

Factors Affecting Study Subject Recruitment And Retention In A Major Depressive Disorder Study, Barbara Karnkowska

Theses and Dissertations

The purpose of a clinical trial is to demonstrate safety, tolerability and efficacy of investigational medications before receiving FDA approval for medical use. The success of clinical trials heavily relies on quick patient recruitment as well as long-term patient retention throughout the duration of the study. Recruitment and retention have been identified as the most expensive components of research, in some instances consisting of up to 33% of the designated budget spanning from phase I to III trials [3]. In light of the rising costs of pharmaceutical research, it is important to investigate factors implicated in patient recruitment and retention ...


Pain Management After Appendectomy And Cholecystectomy: An Innovative Protocol Using Exparel, Pete Newman Dec 2017

Pain Management After Appendectomy And Cholecystectomy: An Innovative Protocol Using Exparel, Pete Newman

Theses and Dissertations

To reduce post-operative pain correlates such as opioid consumption and length of stay, a novel pain management protocol has been utilized for laparoscopic appendectomy and laparoscopic cholecystectomy. Research was performed on a retrospective patient population who were given local anesthetic for pain management, specifically liposomal bupivacaine, also known as Exparel. The objective was to determine if using the most recent protocol utilizing Exparel had any effect on pain correlates such as opioid consumption or post-operative or total length of stay. Results showed that the use of the most recent Exparel protocol results in a statistically significant decrease in opioid consumption ...


A Pilot Study Into The Impact Of Remote Monitoring On The Trial Site, Brendan Paulman Dec 2017

A Pilot Study Into The Impact Of Remote Monitoring On The Trial Site, Brendan Paulman

Theses and Dissertations

Remote monitoring as the primary method of clinical trial oversight is increasingly common due to advancements in technology which allow SDV to be performed without site visits. However, remote monitoring often changes the workflow of the clinical trial site staff. This study aims to determine how remote monitoring affects the time allocation of site staff toward duties related to monitoring visits, and to identify which tasks are most affected when the sponsor uses a remote monitoring strategy. A survey was sent out to clinical research staff within BSWRI. Research staff tended to spend less time toward remote monitoring duties than ...


Role Of Scavenger Receptor Class B Type 1 In High-Risk Neuroblastoma, Marlyn Panchoo Dec 2017

Role Of Scavenger Receptor Class B Type 1 In High-Risk Neuroblastoma, Marlyn Panchoo

Theses and Dissertations

Neuroblastoma (NB), the most common extra-cranial childhood cancer in the United States is responsible for 15% of all pediatric cancer deaths. Due to advancements in treatment approaches, survival in low- and intermediate-risk NB patients now exceeds 90%. However, patient outcome for high-risk NB still remains poor with an overall survival of less than 50%. Nearly all high-risk NB patients present with metastatic disease at diagnosis and are unresponsive to intense chemotherapy, radiotherapy or aggressive surgery. Recently, the high-density lipoprotein (HDL) receptor, scavenger receptor class B type 1 (SR-B1), has emerged as an important indicator of cancer progression and patient outcome ...


Role Of Extracellular Matrix Crosslinking Enzyme Tissue Transglutaminase In Trabecular Meshwork Homeostasis And Regulating Intraocular Pressure, Urmimala Raychaudhuri Dec 2017

Role Of Extracellular Matrix Crosslinking Enzyme Tissue Transglutaminase In Trabecular Meshwork Homeostasis And Regulating Intraocular Pressure, Urmimala Raychaudhuri

Theses and Dissertations

Increased intraocular pressure (IOP) is one of the major known risk factors for primary open angle glaucoma (POAG). The main cause of IOP elevation is obstruction to aqueous humor (AH) outflow at the trabecular meshwork (TM) in the eye. Cellularity and ECM turnover rates affect the normal physiology of the TM tissue. Various factors including transforming growth factor (TGFβ2) have been found responsible for a large number of glaucomatous changes. Increased expression and activity of tissue transglutaminase (TGM2), an enzyme induced by TGFβ2, has been seen in the glaucomatous TM. TGM2 can covalently crosslink ECM proteins including collagens, fibronectin and ...


Mechanisms Of Glucocorticoid-Induced Ocular Hypertension And Glaucoma, Gaurang C. Patel Dec 2017

Mechanisms Of Glucocorticoid-Induced Ocular Hypertension And Glaucoma, Gaurang C. Patel

Theses and Dissertations

Glucocorticoid (GC)-induced ocular hypertension (OHT) is a serious side-effect of prolonged GC therapy that can lead to iatrogenic glaucoma and permanent vision loss. Patients with GCOHT have open iridocorneal angles and increased outflow resistance in the trabecular meshwork (TM) outflow pathway, similar to that seen in POAG. However, the molecular mechanisms responsible for GC-induced OHT are not entirely clear. GCs acts through glucocorticoid receptor (GR), and GR can regulate transcription both through transactivation and transrepression mechanisms. However, there is no evidence showing which of the two mechanisms play role in GC-induced OHT. In addition, the alternatively spliced isoform of ...


Crosstalk Between Transforming Growth Factor Beta-2 And Toll-Like Receptor 4 In The Trabecular Meshwork, Humberto Hernandez Dec 2017

Crosstalk Between Transforming Growth Factor Beta-2 And Toll-Like Receptor 4 In The Trabecular Meshwork, Humberto Hernandez

Theses and Dissertations

The trabecular meshwork (TM) is the main site of outflow resistance in primary-open angle glaucoma (POAG) patients. In these patients, aqueous humor outflow resistance increases, subsequently leading to a rise in intraocular pressure (IOP). The rise in IOP ultimately damages the optic nerve and leads to blindness. Accumulation of extracellular matrix (ECM) at the TM has been shown by our laboratory and many others to be responsible for the increase in outflow resistance. The molecular mechanisms underlying the pathology are beginning to be elucidated. The pro-fibrotic cytokine, transforming growth factor beta-2 (TGFβ2), has been shown to be elevated in the ...


Genetic Profiling Of Skin Microbiomes For Forensic Human Identification, Sarah E. Schmedes Dec 2017

Genetic Profiling Of Skin Microbiomes For Forensic Human Identification, Sarah E. Schmedes

Theses and Dissertations

The field of microbial forensics has expanded from a focus in biodefense and biocrime attribution to include various metagenomics and microbiome applications made possible by advancements in sequencing and bioinformatics technologies. Recent developments in metagenomics and microbiome research with application to the forensic sciences, include post-mortem interval, body fluid identification, recent geolocation, and human identification. The primary goal of the dissertation described herein was to assess the feasibility of human identification from skin microbiomes using both shotgun metagenomic sequencing and targeted enrichment strategies. The main studies of this dissertation were conducted under the hypothesis that genes from stable, universal microbial ...


Taargeting Astrogliosis And Mitochondrial Dysfunction During Meth Exposure And Hiv-Relevant Neuroinflammation, Kathleen Borgmann Dec 2017

Taargeting Astrogliosis And Mitochondrial Dysfunction During Meth Exposure And Hiv-Relevant Neuroinflammation, Kathleen Borgmann

Theses and Dissertations

As a popular psychostimulant, methamphetamine (METH) use leads to long-lasting, strong euphoric effects. METH exacerbates the severity and onset of HIV-associated neurocognitive disorders (HAND), which affect 30-70% of the 37.6 million people globally infected with HIV. Most neurodegenerative diseases share neuroinflammation as a common pathogenic mechanism. Neuroinflammation, HIV and METH dysregulate a wide range of brain functions including neuronal signaling, glial activation, viral infection, oxidative stress and excitotoxicity. Since neuroglia determine the outcome of neurological disease, we investigate the mechanisms regulating astrocyte-mediated neurotoxicity in the context of METH and HIV comorbidity. To these ends, we examined the expression, localization ...


A Retrospective Study On Delayed Graft Function After Deceased-Donor Kidney Transplantation, Kamaryn Keeton Dec 2017

A Retrospective Study On Delayed Graft Function After Deceased-Donor Kidney Transplantation, Kamaryn Keeton

Theses and Dissertations

Delayed graft function (DGF) following renal transplantation may be more severe in kidneys from deceased vs. living donors due to ischemia-reperfusion. Data was analyzed from 40 living and 49 deceased donor-recipient pairs from January 2012-13 at two centers. DGF incidence was greater in kidneys from deceased (52.1%) vs. living donors (12.1%). Comparison of DGF incidence in deceased vs. living donor kidneys yielded χ2 = 14.225 and p = 0.0002. Regression analyses of post- vs. pre-graft changes in serum creatinine vs. cold ischemic time, donor body mass index, donor age and terminal serum creatinine were not significant. These results ...


Feasibility And Effectiveness Of The Glb-Aim (Group Lifestyle Balance Adapted For Individuals With Impaired Mobility) Intervention For People Living With Spinal Cord Injury, Zachary Mazurek Dec 2017

Feasibility And Effectiveness Of The Glb-Aim (Group Lifestyle Balance Adapted For Individuals With Impaired Mobility) Intervention For People Living With Spinal Cord Injury, Zachary Mazurek

Theses and Dissertations

Purpose: The prevalence of obesity in the population living with spinal cord injury (SCI) is greater than the general population. Obesity linked coronary heart disease is a leading cause of morbidity and mortality in the population living with SCI. Behavioral interventions to promote weight loss are limited for the SCI population. GLB-AIM looks to address the lack of behavioral interventions by providing a feasible and effective program to promote weight loss for people living with SCI. Methods: The GLB-AIM was delivered to participants over the course of 12 months. The sample was assessed for feasibility as measured by attendance over ...


A Survey Of Anticoagulation Non-Adherence In Emergency Department Patients Presenting With Atrial Fibrillation, Sean Harla Dec 2017

A Survey Of Anticoagulation Non-Adherence In Emergency Department Patients Presenting With Atrial Fibrillation, Sean Harla

Theses and Dissertations

Introduction: Patients with atrial fibrillation are at an increased risk of stroke. As part of stroke prevention, these patients are prescribed anticoagulants. The Emergency Medicine Department at the University of Texas Southwestern undertook a survey study to ascertain why some Emergency Department (ED) patients with atrial fibrillation are compliant with taking their anticoagulant therapy, whereas others are not. The objective was to assess whether or not patient health literacy/ numeracy played a significant impact on patient anticoagulant non-adherence. Methods: The Newest Vital Sign (NVS) survey and Modified Morisky Scale (MMS) survey were administered to the subjects to measure their health ...


The Association Of Health Literacy With The Management Of Type 2 Diabetes, Samita Kumar Dec 2017

The Association Of Health Literacy With The Management Of Type 2 Diabetes, Samita Kumar

Theses and Dissertations

Introduction: Type 2 Diabetes (T2D) is a chronic metabolic disease characterized by high blood glucose levels in the blood. It is associated with microvascular and macrovascular complications which can lead to potential threats such as to amputations and even death. The irony of the disease is that these complications are preventable with appropriate treatment and self-management. The Emergency Medicine Department (ED) at University of Southwestern Medical center conducted this study to assess health literacy Parkland Memorial Hospital patients with T2D. The objective for the research study was to assess the for association of health literacy with management of T2D. Methods ...


Effects Of Tgfβ2 And Bmp4 Downstream Targets Id1 And Id3 In Trabecular Meshwork: Implications In Lowering Iop, Avani A. Mody Dec 2017

Effects Of Tgfβ2 And Bmp4 Downstream Targets Id1 And Id3 In Trabecular Meshwork: Implications In Lowering Iop, Avani A. Mody

Theses and Dissertations

Purpose: Primary open angle glaucoma (POAG) is one of the most prevalent forms of glaucoma, which is a major cause of irreversible vision loss. The major risk factor associated with POAG is increased intra ocular pressure (IOP). Elevated transforming growth factor β2 (TGFβ2) expression in the trabecular meshwork (TM) increases the deposition of extracellular matrix (ECM) and prevents ECM turnover by increasing expression of plasminogen activator inhibitor I (PAI-1) and ECM cross-linking enzymes. These disruptions in ECM physiology in the TM elevate IOP and decrease aqueous humor outflow facility. Bone morphogenetic proteins (BMPs) regulate TGFβ2 induced profibrotic ECM production. The ...


Student Assessment Methods Used In Undergraduate Medical Education, Christine Savi Oct 2017

Student Assessment Methods Used In Undergraduate Medical Education, Christine Savi

Fort Worth M.D. School

This document outlines student assessment methods used in undergraduate medical education. It highlights the strengths and limitations of each method, lists relevant competency domains and indicates whether the method is formative or summative. Assessment methods highlighted include authentic assessment, case presentation, chart review, direct observation, discussion, interactive computer assessment, journal, Mini-CEX (Clinical Evaluation Exercise), verbal examination, OSCE (Objective Structured Clinical Examination), peer assessment, portfolio, Script Concordance Test (SCT), self-assessment, reflection, simulation, small group interaction, survey, questionnaire, written examination (multiple choice or short answer), written log or prescription, checklist, rating scale, rubric and narrative response.


Nortex Fall 2017 Newsletter, North Texas Primary Care Practice-Based Research Network Oct 2017

Nortex Fall 2017 Newsletter, North Texas Primary Care Practice-Based Research Network

North Texas Primary Care Practice-Based Research Network (NorTex) Newsletter

No abstract provided.


The Vascular Aging Of The Cerebellum, Christopher L. Mcelroy Aug 2017

The Vascular Aging Of The Cerebellum, Christopher L. Mcelroy

Theses and Dissertations

The cerebellum has been discovered to have an increased role in our daily lives than was previously recognized. It not controls fine motor skills, posture, and gait, but newer research has shown that it has a role in cognitive thought, memory and emotion, as well as other non-motor specific functions. It is important to know how this part of the brain ages and why. It is well established that during the aging process the cerebellum in some regions decreases in size due to atrophy, but the reasoning for this is not well understood. One possible mechanism that could explain the ...