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Full-Text Articles in Medicine and Health Sciences
Female Rats Display Higher Methamphetamine-Primed Reinstatement And C-Fos Immunoreactivity Than Male Rats, Steven T. Pittenger, Shinnyi Chou, Nathan J. Murawski, Scott T. Barrett, Olivia Loh, Juan F. Duque, Ming Li, Rick A. Bevins
Female Rats Display Higher Methamphetamine-Primed Reinstatement And C-Fos Immunoreactivity Than Male Rats, Steven T. Pittenger, Shinnyi Chou, Nathan J. Murawski, Scott T. Barrett, Olivia Loh, Juan F. Duque, Ming Li, Rick A. Bevins
Department of Psychology: Faculty Publications
Methamphetamine (meth) dependence is often characterized by persistent and chronic relapse (i.e., return to drug use). Previous work suggests females may be at greater risk to relapse. In this study, we extended this limited evidence and identified sex-dependent neural substrates related to meth-triggered reinstatement. Male and female Sprague-Dawley rats were implanted with indwelling jugular catheters. Half of the rats were then trained to self-administer meth (0.05 mg/kg/inf); the other half self-administered saline during 21 daily sessions (2 h). Rats were then given 12 extinction sessions. Twenty-four hours after the last extinction session, rats received reinstatement testing. Half of the rats …
Differential Effects Of Acute Amphetamine And Phencyclidine Treatment And Withdrawal From Repeated Amphetamine Or Phencyclidine Treatment On Social Interaction And Social Memory In Rats, Ming Li, Wei He, Rebecca Munro
Differential Effects Of Acute Amphetamine And Phencyclidine Treatment And Withdrawal From Repeated Amphetamine Or Phencyclidine Treatment On Social Interaction And Social Memory In Rats, Ming Li, Wei He, Rebecca Munro
Department of Psychology: Faculty Publications
Although animal models based on amphetamine (AMPH) or phencyclidine (PCP) treatment have been used extensively to study the neurobiological and behavioral characteristics of schizophrenia, there are conflicting reports regarding their validity in modeling the negative symptoms and cognitive deficits of schizophrenia. The present study examined how acute AMPH or PCP treatment (Experiment 1) and withdrawal from repeated AMPH treatment (Experiment 2) or PCP treatment (Experiment 3) affects social behavior and social recognition memory in male Sprague-Dawley rats. Each subject was tested on two consecutive days. On the first day, the rats were tested four times (5 min/each) at 10-min intervals …
Iptakalim: A Potential Antipsychotic Drug With Novel Mechanisms?, Tao Sun, Changjiu Zhao, Gang Hu, Ming Li
Iptakalim: A Potential Antipsychotic Drug With Novel Mechanisms?, Tao Sun, Changjiu Zhao, Gang Hu, Ming Li
Department of Psychology: Faculty Publications
Iptakalim is a novel putative adenosine triphosphate (ATP)-sensitive potassium (KATP) channel opener. In the brain, iptakalim is thought to act on the neuronal and astrocytic plasma membrane and/or mitochondrial KATP channels. Because iptakalim demonstrates an action on the regulation of dopamine and glutamate release in the forebrain regions, we examined its potential antipsychotic efficacy in several preclinical tests. First, we show that iptakalim is effective in reducing amphetamine- and phencyclidine-induced hyperlocomotion as well as selectively disrupting conditioned avoidance responding. Next, we show that combined iptakalim and amphetamine treatment produces a reduction on prepulse inhibition of acoustic startle …
Amphetamine Selectively Enhances Avoidance Responding To A Less Salient Stimulus In Rats, Ming Li, Wei He, Rebecca Munro
Amphetamine Selectively Enhances Avoidance Responding To A Less Salient Stimulus In Rats, Ming Li, Wei He, Rebecca Munro
Department of Psychology: Faculty Publications
This preclinical study examined the psychological processes affected by amphetamine that contribute to human psychosis. Using a novel avoidance conditioning paradigm involving two conditioned stimuli (CS) with varied salience, we found that acute amphetamine (1.5 mg/ kg, i.p.) selectively enhanced avoidance responding to a less salient stimulus, but not to a salient one. These findings suggest that elevated dopaminergic activity selectively enhances the attributions of motivational salience to a less salient stimulus, a process that may bear relevance to the development of human delusional thoughts.
Characterization Of Nicotine’S Ability To Serve As A Negative Feature In A Pavlovian Appetitive Conditioning Task In Rats, Rick A. Bevins, Jamie L. Wilkinson, Matthew I. Palmatier, Hannah L. Siebert, Steven M. Wiltgen
Characterization Of Nicotine’S Ability To Serve As A Negative Feature In A Pavlovian Appetitive Conditioning Task In Rats, Rick A. Bevins, Jamie L. Wilkinson, Matthew I. Palmatier, Hannah L. Siebert, Steven M. Wiltgen
Department of Psychology: Faculty Publications
Rationale Pavlovian feature negative discriminations have been widely used to understand inhibitory conditioning processes using exteroceptive stimuli. Comparatively little is known about inhibitory conditioning processes using a drug state as a negative feature. A negative feature signals that presentation of a conditional stimulus (CS) will not be paired with an unconditioned stimulus. Objectives: The present research examined whether nicotine served as a negative feature and started characterizing its properties. Methods and results: In acquisition, rats received intermixed saline and nicotine (0.4 mg/kg, base) sessions. On saline sessions, a 15-s light CS was paired with 4-s access to sucrose; the CS …
Nicotine As A Signal For The Presence Or Absence Of Sucrose Reward: Pavlovian Drug Appetitive Conditioning Preparation In Rats, Joyce Besheer, Matthew I. Palmatier, Dawn M. Metschke, Rick A. Bevins
Nicotine As A Signal For The Presence Or Absence Of Sucrose Reward: Pavlovian Drug Appetitive Conditioning Preparation In Rats, Joyce Besheer, Matthew I. Palmatier, Dawn M. Metschke, Rick A. Bevins
Department of Psychology: Faculty Publications
Rationale: In Pavlovian conditioning research, nicotine is typically conceptualized as the unconditioned stimulus (US) that becomes associated with an exteroceptive conditioned stimulus (CS). This research has not explored the possibility that nicotine can also function as a CS. Objectives: The present research examined whether nicotine served as a CS for the presence (CS+) or absence (CS–) of sucrose and started defining its specificity. Methods and results: Rats trained in the CS+ condition had nicotine (0.4 mg/kg, base) paired intermittently with brief access to sucrose. Intermixed were saline sessions without sucrose. Nicotine acquired the ability to evoke goal tracking. This conditioned …
Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo
Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo
Department of Psychology: Faculty Publications
Previous work has shown that individual differences in locomotor activity in an inescapable novel environment can predict acquisition of amphetamine self-administration. The current study examined whether individual differences in approach to novelty in a free choice test could also predict amphetamine self-administration. Further, the current study examined whether individual differences in either free choice or inescapable novelty tests could predict responding for a nondrug reinforcer (sucrose) in the presence and absence of amphetamine. Male and female rats were first tested for their response to free choice novelty (playground maze and novelty-induced place preference tests) and inescapable novelty. They were then …
Locomotion And Conditioned Place Preference Produced By Acute Intravenous Amphetamine: Role Of Dopamine Receptors And Individual Differences In Amphetamine Self-Administration, M. T. Bardo, J. M. Valone, Rick A. Bevins
Locomotion And Conditioned Place Preference Produced By Acute Intravenous Amphetamine: Role Of Dopamine Receptors And Individual Differences In Amphetamine Self-Administration, M. T. Bardo, J. M. Valone, Rick A. Bevins
Department of Psychology: Faculty Publications
Although previous studies have shown that dopamine (DA) antagonists block amphetamine reward, these studies have utilized animal models that involve repeated exposures to amphetamine. The present investigation examined the effect of DA antagonists on single-trial conditioned place preference (CPP) produced by acute intravenous (IV) amphetamine in rats. In the first experiment, rats were prepared with a jugular catheter and then received an acute IV injection of amphetamine (0.1–3 mg/kg) paired with one compartment of a CPP apparatus. Relative to sham controls (no IV catheter), amphetamine produced a dose-dependent increase in locomotor activity and CPP. Two further experiments demonstrated that both …
Individual Differences In Response To Novelty, Amphetamine-Induced Activity And Drug Discrimination In Rats, Rick A. Bevins, J. E. Klebaur, M. T. Bardo
Individual Differences In Response To Novelty, Amphetamine-Induced Activity And Drug Discrimination In Rats, Rick A. Bevins, J. E. Klebaur, M. T. Bardo
Department of Psychology: Faculty Publications
Rats mere pre-tested in several individual difference screens - novelty-induced activity, novelty-induced place preference, novel-object interaction, and amphetamine-induced activity. Rats that were more sensitive to the locomotor effects of amphetamine were more active in an inescapable novel environment and displayed a greater preference for a novel environment. All animals were then trained to discriminate amphetamine (1 mg/kg) from saline in a two-bar discrimination procedure using food-maintained responding. After acquisition of the discrimination (mean =37 trials), two amphetamine generalization tests (0.0625,0.125,0.25,0.5, 1.0 and 2.0 mg/kg) were conducted. In the second generalization test, rats that were more sensitive to the activating effect …