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Umccts Newsletter, May 2021, Umass Center For Clinical And Translational Science May 2021

Umccts Newsletter, May 2021, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the May 2021 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.


Exposure To Weight Management Counseling Among Students At 8 U.S. Medical Schools, Karen M. Ashe, Alan C. Geller, Jyothi A. Pendharkar, Lori Pbert, Sybil L. Crawford, Melissa A. Clark, Christine F. Frisard, Cassie A. Eno, Jamie Faro, Judith K. Ockene May 2021

Exposure To Weight Management Counseling Among Students At 8 U.S. Medical Schools, Karen M. Ashe, Alan C. Geller, Jyothi A. Pendharkar, Lori Pbert, Sybil L. Crawford, Melissa A. Clark, Christine F. Frisard, Cassie A. Eno, Jamie Faro, Judith K. Ockene

University of Massachusetts Medical School Faculty Publications

INTRODUCTION: Clinical guidelines support physician intervention consistent with the Ask, Advise, Assess, Assist, Arrange framework for adults who have obesity. However, weight management counseling curricula vary across medical schools. It is unknown how frequently students receive experiences in weight management counseling, such as instruction, observation, and direct experience.

METHODS: A cross-sectional survey, conducted in 2017, of 730 third-year medical students in 8 U.S. medical schools assessed the frequency of direct patient, observational, and instructional weight management counseling experiences that were reported as summed scores with a range of 018. Analysis was completed in 2017.

RESULTS: Students reported the least ...


The Clinical Review Committee: Impact Of The Development Of In Vitro Diagnostic Tests For Sars-Cov-2 Within Radx Tech, Matthew L. Robinson, Laura L. Gibson, David D. Mcmanus Apr 2021

The Clinical Review Committee: Impact Of The Development Of In Vitro Diagnostic Tests For Sars-Cov-2 Within Radx Tech, Matthew L. Robinson, Laura L. Gibson, David D. Mcmanus

Open Access Publications by UMMS Authors

The NIH Rapid Acceleration of Diagnostics (RADx SM ) Tech Program was created to speed the development, validation, and commercialization of innovative point-of-care (POC) and home-based tests, and to improve clinical laboratory tests, that can directly detect SARS-CoV-2. Leveraging the experience of the Point-of-Care Technologies Research Network, a Clinical Review Committee (CRC) composed of clinicians, bioengineers, regulatory experts, and laboratorians was created to provide structured feedback to SARS-CoV-2 diagnostic innovators. The CRC convened 53 meetings with 49 companies offering SARS-CoV-2 tests in POC and reference laboratory formats as well as collection materials. The CRC identified common barriers to device design finalization ...


The Radx Tech Clinical Studies Core: A Model For Academic Based Clinical Studies, Laura L. Gibson, Nisha M. Fahey, Nathaniel Hafer, John P. Broach, Bruce A. Barton, Stephenie C. Lemon, Allison Blodgett, David D. Mcmanus Apr 2021

The Radx Tech Clinical Studies Core: A Model For Academic Based Clinical Studies, Laura L. Gibson, Nisha M. Fahey, Nathaniel Hafer, John P. Broach, Bruce A. Barton, Stephenie C. Lemon, Allison Blodgett, David D. Mcmanus

Open Access Publications by UMMS Authors

The National Institutes of Health (NIH) launched the Rapid Acceleration of Diagnostics (RADx SM ) Tech initiative to support the development and commercialization of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) point-of-care test devices. The primary objective of the Clinical Studies Core (CSC) was to perform SARS-CoV-2 device studies involving diverse populations and settings. Within a few months, the infrastructure for clinical studies was developed, including a master protocol, digital study platform, data management system, single IRB, and multi-site partnerships. Data from some studies are being used to support Emergency Use Authorization of novel SARS-CoV-2 test devices. The CSC reduced ...


The Radx Tech Test Verification Core And The Acme Poct In The Evaluation Of Covid-19 Testing Devices: A Model For Progress And Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, David D. Mcmanus Apr 2021

The Radx Tech Test Verification Core And The Acme Poct In The Evaluation Of Covid-19 Testing Devices: A Model For Progress And Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, David D. Mcmanus

Open Access Publications by UMMS Authors

Faced with the COVID-19 pandemic, the US system for developing and testing technologies was challenged in unparalleled ways. This article describes the multi-institutional, transdisciplinary team of the “RADx SM Tech Test Verification Core” and its role in expediting evaluations of COVID-19 testing devices. Expertise related to aspects of diagnostic testing was coordinated to evaluate testing devices with the goal of significantly expanding the ability to mass screen Americans to preserve lives and facilitate the safe return to work and school. Focal points included: laboratory and clinical device evaluation of the limit of viral detection, sensitivity, and specificity of devices in ...


Global Health Leadership Pathway: A Novel Approach To Global Radiology Curriculum Integration For Residents, Katrina Mcginty, Robert G. Dixon, Melissa P. Culp Apr 2021

Global Health Leadership Pathway: A Novel Approach To Global Radiology Curriculum Integration For Residents, Katrina Mcginty, Robert G. Dixon, Melissa P. Culp

Journal of Global Radiology

Purpose: Our radiology residency programs are at an academic medical center in the southeastern United States and are accredited by the Accreditation Council for Graduate Medical Education (ACGME). During the initial eight years of our department’s global health program, 22 residents participated in our global health collaborations with a related $31,000 in extradepartmental travel awards. Increasingly, residents applying to our program convey interest in the integration of global health into their careers as radiologists. To that end, our administration, global health faculty, and residency program directors created and approved a Global Health Leadership Pathway (GHLP). The Pathway spans ...


Validation Of A Locally Designed Computed Tomography Dose Phantom: A Comparison Study With A Standard Acrylic Phantom In South-South, Nigeria, Anwuli Christiana Tobi, Chukwuka Emmanuel Mokobia, Joyce Ekeme Ikubor, Akintayo Daniel Omojola Apr 2021

Validation Of A Locally Designed Computed Tomography Dose Phantom: A Comparison Study With A Standard Acrylic Phantom In South-South, Nigeria, Anwuli Christiana Tobi, Chukwuka Emmanuel Mokobia, Joyce Ekeme Ikubor, Akintayo Daniel Omojola

Journal of Global Radiology

Purpose: The aim of this study was to determine the mean volume computed tomography dose index (CTDIvol) for the standard head and body phantoms and locally designed head and body phantoms respectively. Similarly, this study determined and compared the displayed mean CTDIvol and Dose Length Product (DLP) for the above phantoms from the CT monitor. In addition, the percentage deviations of both phantoms were compared with the recommended limits from the International Atomic Energy Agency (IAEA) and the American College of Radiologists (ACR). Materials and

Methods: Dose measurements were made using a standard polymethymethacrylate (PMMA) phantom for head and body ...


Clinician Perspectives On The Need For Training And Caring For Pregnant Women With Intellectual And Developmental Disabilities, Nili S. Amir, Lauren Smith, Anne M. Valentine, Monika Mitra, Susan L. Parish, Tiffany Moore Simas Apr 2021

Clinician Perspectives On The Need For Training And Caring For Pregnant Women With Intellectual And Developmental Disabilities, Nili S. Amir, Lauren Smith, Anne M. Valentine, Monika Mitra, Susan L. Parish, Tiffany Moore Simas

Senior Scholars Program

Background: Women with intellectual and developmental disabilities (IDD) experience disparities in obstetric care access and quality, in addition to communication gaps with healthcare providers. Many obstetric providers are untrained and uneducated about critical aspects of providing care to persons with IDD.

Objectives: The present study was conducted (1) to describe obstetric clinicians’ training experiences related to providing obstetric care to women with IDD, (2) to assess obstetric clinicians’ perceived need for formalized training, and (3) to identify recommendations for training content and dissemination.

Methods: This study involved qualitative individual interviews (n=9) and one focus group (n=8) with obstetric ...


A Multi-Institutional Partnership Catalyzing The Commercialization Of Medical Devices And Biotechnology Products., Nathaniel Hafer, Bryan Buchholz, Denise Dunlap, Brennan Fournier, Scott Latham, Mary Ann Picard, Steven Tello, Laura L. Gibson, Craig M. Lilly, David D. Mcmanus Apr 2021

A Multi-Institutional Partnership Catalyzing The Commercialization Of Medical Devices And Biotechnology Products., Nathaniel Hafer, Bryan Buchholz, Denise Dunlap, Brennan Fournier, Scott Latham, Mary Ann Picard, Steven Tello, Laura L. Gibson, Craig M. Lilly, David D. Mcmanus

COVID-19 Publications by UMMS Authors

The commercialization of medical devices and biotechnology products is characterized by high failure rates and long development lead times particularly among start-up enterprises. To increase the success rate of these high-risk ventures, the University of Massachusetts Lowell (UML) and University of Massachusetts Medical School (UMMS) partnered to create key academic support centers with programs to accelerate entrepreneurship and innovation in this industry. In 2008, UML and UMMS founded the Massachusetts Medical Device Development Center (M2D2), which is a business and technology incubator that provides business planning, product prototyping, laboratory services, access to clinical testing, and ecosystem networking to medical device ...


Opening Medical Humanities To The World: Reflecting On Library Support For The Medical Humanities Lab, Lisa A. Palmer, Tess Grynoch, Regina Fisher Raboin Apr 2021

Opening Medical Humanities To The World: Reflecting On Library Support For The Medical Humanities Lab, Lisa A. Palmer, Tess Grynoch, Regina Fisher Raboin

Library Publications

This poster tells the story of how the Lamar Soutter Library at UMass Medical School has successfully collaborated with faculty leaders and medical students to launch the Medical Humanities Lab, which integrates the arts and humanities into medical education and healthcare through student, faculty, and staff collaborations fostering humanism in medicine. The Library has provided leadership, technology expertise, space for in-person meetings, logistical support for virtual meetings during the pandemic, and promotional assistance. In just over a year, the Lab has sponsored a dozen projects, including a storytelling event, a creative writing and photography journal, a blog, two podcasts, and ...


Umccts Newsletter, April 2021, Umass Center For Clinical And Translational Science Apr 2021

Umccts Newsletter, April 2021, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the April 2021 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.


Predictors Of Irritability Symptoms In Mildly Depressed Perimenopausal Women, Anouk E. De Wit, Erik J. Giltay, Marrit K. De Boer, Margo Nathan, Aleta Wiley, Sybil L. Crawford, Hadine Joffe Apr 2021

Predictors Of Irritability Symptoms In Mildly Depressed Perimenopausal Women, Anouk E. De Wit, Erik J. Giltay, Marrit K. De Boer, Margo Nathan, Aleta Wiley, Sybil L. Crawford, Hadine Joffe

Graduate School of Nursing Publications

OBJECTIVE: Irritability is a highly burdensome complaint, commonly, but not universally, linked with depressive symptoms. While increased variability in estradiol has been associated with depressive symptoms during perimenopause, more insight is needed into reproductive hormone dynamics and other factors that predispose perimenopausal women to irritable mood.

METHODS: Among 50 mildly depressed perimenopausal women (mean (SD) age 48.4 (3.9) years), severity of irritability symptoms (on Symptom Questionnaire Hostility subscale, range 0-23) was assessed weekly for eight weeks, concurrent with potential predictors. Associations between these were examined using generalized estimating equating models.

RESULTS: Most women (82.0%) reported having moderate ...


Global Impact Of The Covid-19 On Stroke Care, Svin Covid-19 Global Registry, Raul Nogueira, Ajit S. Puri, Anna L. Kuhn, Thanh Nguyen Mar 2021

Global Impact Of The Covid-19 On Stroke Care, Svin Covid-19 Global Registry, Raul Nogueira, Ajit S. Puri, Anna L. Kuhn, Thanh Nguyen

COVID-19 Publications by UMMS Authors

BACKGROUND: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide.

AIMS: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy (MT), stroke, and intracranial hemorrhage (ICH) hospitalizations over a 3-month period at the height of the pandemic (March 1 to May 31, 2020) compared with two control 3-month periods (immediately preceding and one year prior).

METHODS: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating ...


Developing Network Adequacy Standards For Va Community Care, Kristin M. Mattocks, A. Rani Elwy, Elizabeth M. Yano, Justin Giovannelli, Michael Adelberg, Michelle A. Mengeling, Kristin J. Cunningham, Kameron L. Matthews Mar 2021

Developing Network Adequacy Standards For Va Community Care, Kristin M. Mattocks, A. Rani Elwy, Elizabeth M. Yano, Justin Giovannelli, Michael Adelberg, Michelle A. Mengeling, Kristin J. Cunningham, Kameron L. Matthews

University of Massachusetts Medical School Faculty Publications

OBJECTIVES: To inform how the VA should develop and implement network adequacy standards, we convened an expert panel to discuss Community Care Network (CCN) adequacy and how VA might implement network adequacy standards for community care.

DATA SOURCES/STUDY SETTING: Data were generated from expert panel ratings and from an audio-recorded expert panel meeting conducted in Arlington, Virginia, in October 2017.

STUDY DESIGN: We used a modified Delphi panel process involving one round of expert panel ratings provided by nine experts in network adequacy standards. Expert panel members received a list of network adequacy standard measures used in commercial and ...


Decline In Subarachnoid Haemorrhage Volumes Associated With The First Wave Of The Covid-19 Pandemic, Thanh N. Nguyen, Ajit S. Puri, Anna L. Kuhn, Raul G. Nogueira Mar 2021

Decline In Subarachnoid Haemorrhage Volumes Associated With The First Wave Of The Covid-19 Pandemic, Thanh N. Nguyen, Ajit S. Puri, Anna L. Kuhn, Raul G. Nogueira

COVID-19 Publications by UMMS Authors

BACKGROUND: During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.

METHODS: We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the ...


Challenges In Defining Long Covid: Striking Differences Across Literature, Electronic Health Records, And Patient-Reported Information, Halie M. Rando, Feifan Liu, Melissa A. Haendel Mar 2021

Challenges In Defining Long Covid: Striking Differences Across Literature, Electronic Health Records, And Patient-Reported Information, Halie M. Rando, Feifan Liu, Melissa A. Haendel

UMass Center for Clinical and Translational Science Supported Publications

Since late 2019, the novel coronavirus SARS-CoV-2 has introduced a wide array of health challenges globally. In addition to a complex acute presentation that can affect multiple organ systems, increasing evidence points to long-term sequelae being common and impactful. The worldwide scientific community is forging ahead to characterize a wide range of outcomes associated with SARS-CoV-2 infection; however the underlying assumptions in these studies have varied so widely that the resulting data are difficult to compare. Formal definitions are needed in order to design robust and consistent studies of Long COVID that consistently capture variation in long-term outcomes. Even the ...


The High Prevalence Of Clostridioides Difficile Among Nursing Home Elders Associates With A Dysbiotic Microbiome, John P. Haran, Doyle V. Ward, Shakti K. Bhattarai, Ethan Loew, Protiva Dutta, Amanda Higgins, Beth A. Mccormick, Vanni Bucci Mar 2021

The High Prevalence Of Clostridioides Difficile Among Nursing Home Elders Associates With A Dysbiotic Microbiome, John P. Haran, Doyle V. Ward, Shakti K. Bhattarai, Ethan Loew, Protiva Dutta, Amanda Higgins, Beth A. Mccormick, Vanni Bucci

University of Massachusetts Medical School Faculty Publications

Clostridioides difficile disproportionally affects the elderly living in nursing homes (NHs). Our objective was to explore the prevalence of C. difficile in NH elders, over time and to determine whether the microbiome or other clinical factors are associated with C. difficile colonization. We collected serial stool samples from NH residents. C. difficile prevalence was determined by quantitative polymerase-chain reaction detection of Toxin genes tcdA and tcdB; microbiome composition was determined by shotgun metagenomic sequencing. We used mixed-effect random forest modeling machine to determine bacterial taxa whose abundance is associated with C. difficile prevalence while controlling for clinical covariates including demographics ...


Measurement In Health: Advancing Assessment Of Delirium, Benjamin K.I. Helfand Mar 2021

Measurement In Health: Advancing Assessment Of Delirium, Benjamin K.I. Helfand

GSBS Dissertations and Theses

Rationale: Delirium is a serious, morbid condition affecting 2.6 million older Americans annually. A major problem plaguing delirium research is difficulty in identification, given a plethora of existing tools. The lack of consensus on key features and approaches has stymied progress in delirium research. The goal of this project was to use advanced measurement methods to improve delirium’s identification.

Aims and Findings:

(1) Determine the 4 most commonly used and well-validated instruments for delirium identification. Through a rigorous systematic review, I identified the Confusion Assessment Method (CAM), Delirium Observation Screening Scale (DOSS), Delirium Rating Scale-Revised-98 (DRS-R-98), and Memorial ...


Determination Of Calibration Factors And Uncertainties Associated With The Irradiation Of Mts-N (Lif: Mg, Ti) Chips With Cesium-137 And X-Ray Sources Under Low Doses For Personal Dosimetry In Diagnostic Radiology, Akintayo Daniel Omojola, Michael Onoriode Akpochafor, Samuel Olaolu Adeneye, Moses Adebayo Aweda Mar 2021

Determination Of Calibration Factors And Uncertainties Associated With The Irradiation Of Mts-N (Lif: Mg, Ti) Chips With Cesium-137 And X-Ray Sources Under Low Doses For Personal Dosimetry In Diagnostic Radiology, Akintayo Daniel Omojola, Michael Onoriode Akpochafor, Samuel Olaolu Adeneye, Moses Adebayo Aweda

Journal of Global Radiology

Purpose: The purpose of this study was to compare calibration factors for deep dose equivalent Hp (10) and shallow dose equivalent Hp (0.07) between Cesium (Cs)-137 and X-ray sources when they are exposed to same dose and to determine uncertainties with MTS-N (LiF: Mg, Ti) chips when they are exposed to low dose ≤ 2mGy.

Material and Methods: Thermoluminescent (TL) chips were annealed at 400oC for one hour and allowed to cool and were subjected to a temperature of 100oC for another two hours using a TLD Furnace Type LAB-01/400. They were then taken ...


Finding Meaningful Opportunities During The Covid-19 Crisis: Developing An International Radiology Elective In Cameroon, Jordan D. Perchik, Matt C. Larrison, Ghislain Feudjio Mar 2021

Finding Meaningful Opportunities During The Covid-19 Crisis: Developing An International Radiology Elective In Cameroon, Jordan D. Perchik, Matt C. Larrison, Ghislain Feudjio

Journal of Global Radiology

Teleradiology and remote video conferences can provide radiology residents the opportunity to participate in global radiology outreach. We reflect on how social distancing measures and remote education resources developed to address COVID-19 were applied to developing an international radiology elective.


Lung Epithelial Cell Transcriptional Regulation As A Factor In Covid-19 Associated Coagulopathies, Ethan S. Fitzgerald, Yongzhi Chen, Katherine A. Fitzgerald, Amanda M. Jamieson Mar 2021

Lung Epithelial Cell Transcriptional Regulation As A Factor In Covid-19 Associated Coagulopathies, Ethan S. Fitzgerald, Yongzhi Chen, Katherine A. Fitzgerald, Amanda M. Jamieson

COVID-19 Publications by UMMS Authors

SARS-CoV-2 has rapidly become a global pandemic. In addition to the acute pulmonary symptoms of COVID-19 (the disease associated with SARS-CoV-2 infection), pulmonary and distal coagulopathies have caused morbidity and mortality in many patients. Currently, the molecular pathogenesis underlying COVID-19 associated coagulopathies are unknown. Identifying the molecular basis of how SARS-CoV-2 drives coagulation is essential to mitigating short and long term thrombotic risks of sick and recovered COVID-19 patients. We aimed to perform coagulation focused transcriptome analysis of in vitro infected primary respiratory epithelial cells, patient derived bronchial alveolar lavage (BALF) cells, and circulating immune cells during SARS-CoV-2 infection. Our ...


Health Education Fair At African Community Education, Worcester, Avina Joshi Mar 2021

Health Education Fair At African Community Education, Worcester, Avina Joshi

Capstone Presentations

Health knowledge and health literacy are important social determinants of health, and can have a major impact on the health and well-being of an individual. Health education, through formal classroom instruction, peer education, or community health fairs, has been effective in increasing health knowledge and literacy. Worcester, MA is home to many refugees and immigrants from around the world, who represent a key population vulnerable to disparities in social determinants of health, especially health knowledge and literacy. This Capstone project created a Health Education Fair at African Community Education (ACE), an afterschool enrichment program in Worcester for refugee and immigrant ...


Joining The Fight Against The Opioid Epidemic Through The Head Start Program In Lowell, Ma, Aniket N. Pandya, Monica Tawadros, Leanne Winchester Mar 2021

Joining The Fight Against The Opioid Epidemic Through The Head Start Program In Lowell, Ma, Aniket N. Pandya, Monica Tawadros, Leanne Winchester

Capstone Presentations

What is Head Start?

Head Start, a federally funded program of the United States Department of Health and Human Services, promotes school readiness and family well-being in children from birth to age five who meet specific criteria.

Lowell Head Start Partnership

The Lowell Head Start program is engaged in efforts to combat the opioid epidemic after an incident involving an overdose by a parent in the center. To support the Lowell Head Start program, our team forged collaborations with facilities close to Head Start in Lowell by creating informational pamphlets that detail services offered to people with substance use disorders ...


Pivotal Trial Of The Neuroform Atlas Stent For Treatment Of Posterior Circulation Aneurysms: One-Year Outcomes, Brian T. Jankowitz, Ajit S. Puri Mar 2021

Pivotal Trial Of The Neuroform Atlas Stent For Treatment Of Posterior Circulation Aneurysms: One-Year Outcomes, Brian T. Jankowitz, Ajit S. Puri

Radiology Publications

BACKGROUND: Stent-assisted coiling of wide-necked intracranial aneurysms (IAs) using the Neuroform Atlas Stent System (Atlas) has shown promising results.

OBJECTIVE: To present the primary efficacy and safety results of the ATLAS Investigational Device Exemption (IDE) trial in a cohort of patients with posterior circulation IAs.

METHODS: The ATLAS trial is a prospective, multicenter, single-arm, open-label study of unruptured, wide-necked, IAs treated with the Atlas stent and adjunctive coiling. This study reports the results of patients with posterior circulation IAs. The primary efficacy endpoint was complete aneurysm occlusion (Raymond-Roy (RR) class I) on 12-month angiography, in the absence of re-treatment or ...


Gwas-Associated Variants, Non-Genetic Factors, And Transient Transcriptome In Multiple Sclerosis Etiopathogenesis: A Colocalization Analysis [Preprint], Renato Umeton, Gianmarco Bellucci, Rachele Bigi, Silvia Romano, Maria Chiara Buscarinu, Roberta Reniè, Virginia Rinaldi, Raffaella Pizzolato Umeton, Emanuele Morena, Carmela Romano, Rosella Mechelli, Marco Salvetti, Giovanni Ristori Mar 2021

Gwas-Associated Variants, Non-Genetic Factors, And Transient Transcriptome In Multiple Sclerosis Etiopathogenesis: A Colocalization Analysis [Preprint], Renato Umeton, Gianmarco Bellucci, Rachele Bigi, Silvia Romano, Maria Chiara Buscarinu, Roberta Reniè, Virginia Rinaldi, Raffaella Pizzolato Umeton, Emanuele Morena, Carmela Romano, Rosella Mechelli, Marco Salvetti, Giovanni Ristori

University of Massachusetts Medical School Faculty Publications

A clinically actionable understanding of multiple sclerosis (MS) etiology goes through GWAS interpretation, prompting research on new gene regulatory models. Our previous works on these topics suggested a stochastic etiologic model where small-scale random perturbations could eventually reach a threshold for MS onset and progression. A new sequencing technology has mapped the transient transcriptome (TT), including intergenic RNAs, and antisense intronic RNAs. Through a rigorous colocalization analysis, here we show that genomic regions coding for the TT were significantly enriched for both MS-associated GWAS variants, and DNA binding sites for molecular transducers mediating putative, non-genetic, etiopathogenetic factors for MS (e ...


Modelling The Impact Of Clot Fragmentation On The Microcirculation After Thrombectomy, Wahbi K. El-Bouri, Andrew Macgowan, Tamas I. Jozsa, Matthew J. Gounis, Stephen J. Payne Mar 2021

Modelling The Impact Of Clot Fragmentation On The Microcirculation After Thrombectomy, Wahbi K. El-Bouri, Andrew Macgowan, Tamas I. Jozsa, Matthew J. Gounis, Stephen J. Payne

Radiology Publications

Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy) do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this 'no-reperfusion' phenomenon is micro-emboli fragmenting off the large clot during thrombectomy and occluding smaller blood vessels downstream of the clot location. This is impossible to observe in-vivo and so we here develop an in-silico model based on in-vitro experiments to model the effect of micro-emboli on brain tissue. Through in-vitro experiments we obtain, under a variety of clot consistencies and thrombectomy techniques, micro-emboli distributions post-thrombectomy. Blood flow through the microcirculation is modelled ...


Experience With An Ultrasound Donation Program In A Low-Income Country, Michelle Hershman, Melody Hershman, Yamile Blain, Marie Evelyne Moise, Natasha Monchil, Amy A. Walters, Berndt P. Schmit Mar 2021

Experience With An Ultrasound Donation Program In A Low-Income Country, Michelle Hershman, Melody Hershman, Yamile Blain, Marie Evelyne Moise, Natasha Monchil, Amy A. Walters, Berndt P. Schmit

Journal of Global Radiology

Increasing radiology capacity in low-income countries (LIC) can improve clinicians’ access to diagnostic imaging tools and improve patient care. Ultrasound (US) is important in LIC due to its lower cost compared to that of CT or MRI scans and its excellent diagnostic ability. The relative portability of the equipment makes it ideal for donation by charitable organizations. We describe our experience as a radiology-capacity-focused charity working with the Haitian healthcare system and propose strategies to increase ultrasound capacity in other poor countries.


Adapting A Traumatic Brain Injury Goals-Of-Care Decision Aid For Critically Ill Patients To Intracerebral Hemorrhage And Hemispheric Acute Ischemic Stroke, Kelsey Goostrey, Christopher Lee, Kelsey Jones, Thomas Quinn, Jesse Moskowitz, Jolanta J. Pach, Andrea K. Knies, Lori Shutter, Robert J. Goldberg, Kathleen M. Mazor, David Y. Hwang, Susanne Muehlschlegel Mar 2021

Adapting A Traumatic Brain Injury Goals-Of-Care Decision Aid For Critically Ill Patients To Intracerebral Hemorrhage And Hemispheric Acute Ischemic Stroke, Kelsey Goostrey, Christopher Lee, Kelsey Jones, Thomas Quinn, Jesse Moskowitz, Jolanta J. Pach, Andrea K. Knies, Lori Shutter, Robert J. Goldberg, Kathleen M. Mazor, David Y. Hwang, Susanne Muehlschlegel

UMass Center for Clinical and Translational Science Supported Publications

Objectives: Families in the neurologic ICU urgently request goals-of-care decision support and shared decision-making tools. We recently developed a goals-of-care decision aid for surrogates of critically ill traumatic brain injury patients using a systematic development process adherent to the International Patient Decision Aid Standards. To widen its applicability, we adapted this decision aid to critically ill patients with intracerebral hemorrhage and large hemispheric acute ischemic stroke.

Design: Prospective observational study.

Setting: Two academic neurologic ICUs.

Subjects: Twenty family members of patients in the neurologic ICU were recruited from July 2018 to October 2018.

Interventions: None.

Measurements and Main Results: We ...


Analyzing Wellness In Umms Students, Pooja Gupta, Abhilash Gazula Mar 2021

Analyzing Wellness In Umms Students, Pooja Gupta, Abhilash Gazula

Capstone Presentations

Background: Burnout in medical school students is an ongoing, growing issue that can be exacerbated in the clinical years, however, there have been challenges addressing individual student needs due to the variance of wellness practices and academic constraints.

Objective: To provide longitudinal support to third year medical students (MS3s) at the University of Massachusetts Medical School while identifying sources of stress. Methods: Beginning in May 2020, MS3s were given four opportunities to participate in large group discussions with fourth year medical students (MS4s) to speak openly about current stressors and concerns. In concert, surveys were sent to MS3s to identify ...


Development Of Potency, Breadth And Resilience To Viral Escape Mutations In Sars-Cov-2 Neutralizing Antibodies [Preprint], Frauke Muecksch, Shurong Hou, Celia A. Schiffer, Michel Nussenzweig, Pamela J. Bjorkman, Theodora Hatziioannou, Paul Bieniasz Mar 2021

Development Of Potency, Breadth And Resilience To Viral Escape Mutations In Sars-Cov-2 Neutralizing Antibodies [Preprint], Frauke Muecksch, Shurong Hou, Celia A. Schiffer, Michel Nussenzweig, Pamela J. Bjorkman, Theodora Hatziioannou, Paul Bieniasz

University of Massachusetts Medical School Faculty Publications

Antibodies elicited in response to infection undergo somatic mutation in germinal centers that can result in higher affinity for the cognate antigen. To determine the effects of somatic mutation on the properties of SARS-CoV-2 spike receptor-binding domain (RBD)-specific antibodies, we analyzed six independent antibody lineages. As well as increased neutralization potency, antibody evolution changed pathways for acquisition of resistance and, in some cases, restricted the range of neutralization escape options. For some antibodies, maturation apparently imposed a requirement for multiple spike mutations to enable escape. For certain antibody lineages, maturation enabled neutralization of circulating SARS-CoV-2 variants of concern and ...