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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
The Relationship Of Anxiety, Coping, Thinking Style, Life Satisfaction, Social Support, And Selected Demographics Among Young Adult College Students, Jihan Saber Raja Mahmoud
The Relationship Of Anxiety, Coping, Thinking Style, Life Satisfaction, Social Support, And Selected Demographics Among Young Adult College Students, Jihan Saber Raja Mahmoud
University of Kentucky Doctoral Dissertations
Anxiety is prevalent among 13 % of young adult college students and is associated with emotional and behavioral consequences that adversely affect their mental and physical well-being. The major challenge for implementing evidence-based interventions is the lack of a multidimensional approach for evaluating anxiety in this population.
The purpose of this dissertation was to develop an evidence-based theoretical framework for studying the phenomenon of anxiety in young adult college students. Three studies were conducted to achieve this purpose. First, the psychometric properties of the 21-item shortened version of the Depression Anxiety and Stress Scale (DASS-21) were evaluated in a sample …
The Role Of The Nr4a Orphan Nuclear Receptor Nor1 In Vascular Cells And Atherosclerosis, Yue Zhao
The Role Of The Nr4a Orphan Nuclear Receptor Nor1 In Vascular Cells And Atherosclerosis, Yue Zhao
University of Kentucky Doctoral Dissertations
The neuron-derived orphan receptor 1 (NOR1) belongs to the NR4A nuclear receptor subfamily. As an immediate early response gene, NOR1 is rapidly induced by a broad spectrum of physiological and pathological signals. Functional studies demonstrate NOR1 as a constitutively active ligand-independent nuclear receptor whose transcriptional activity is dependent on both expression level and posttranslational modifications. To date, an increasing number of studies have demonstrated a pivotal role of NOR1 in the transcriptional control of metabolism and the development of cardiovascular diseases.
In this dissertation, we demonstrate NOR1 expression in endothelial cells and sub-endothelial cells of human atherosclerotic lesions. In response …
Post Discharge Nausea And Vomiting In Ambulatory Surgical Patients: Incidence And Management Strategies, Jan Odom Forren
Post Discharge Nausea And Vomiting In Ambulatory Surgical Patients: Incidence And Management Strategies, Jan Odom Forren
University of Kentucky Doctoral Dissertations
Approximately 65% of all surgeries are conducted in the outpatient surgery setting involving more than 35 million patients. Thirty-five to fifty percent of these outpatients will experience post discharge nausea and vomiting (PDNV), nausea and vomiting that occurs after discharge from the health care facility after surgery. A dearth of literature details the problems associated with nausea and vomiting experienced by patients after discharge home from outpatient surgery.
The purposes of this dissertation were to (1) review the current knowledge in the area of post discharge nausea and vomiting; (2) present results of an integrative review of the research literature …
Age May Be Hazardous To Outcome Following Traumatic Brain Injury: The Mitochondrial Connection, Lesley Knight Gilmer
Age May Be Hazardous To Outcome Following Traumatic Brain Injury: The Mitochondrial Connection, Lesley Knight Gilmer
University of Kentucky Doctoral Dissertations
Older individuals sustaining traumatic brain injury (TBI) experience a much higher incidence of morbidity and mortality. This age-related exacerbated response to neurological insult has been demonstrated experimentally in aged animals, which can serve as a model to combat this devastating clinical problem. The reasons for this worse initial response are unknown but may be related to age-related changes in mitochondrial respiration.
Evidence is shown that mitochondrial dysfunction occurs early following traumatic brain injury (TBI), persists long after the initial insult, and is severitydependent. Synaptic and extrasynaptic mitochondrial fractions display distinct respiration capacities, stressing the importance to analyze these fractions separately. …