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Articles 1 - 30 of 1688

Full-Text Articles in Medicine and Health Sciences

Introducing E-Consents In A Clinical Setting, Jesse Weiss, Donna A. Santillan, Kellie Thomas, Heather Davis, Mark K. Santillan, Debra Sue Brandt Dec 2018

Introducing E-Consents In A Clinical Setting, Jesse Weiss, Donna A. Santillan, Kellie Thomas, Heather Davis, Mark K. Santillan, Debra Sue Brandt

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is a multiorgan hypertensive-disorder in pregnancy that causes significant maternal-fetal mortality and morbidity. The diagnostics and therapeutics for PE are limited due to its unclear etiology. Using the UI Maternal Fetal Tissue Bank, our lab has demonstrated that copeptin is robustly predictive of PE. To investigate copeptin further, we developed the Rule Out Pre-Eclampsia Study (ROPE). The ROPE study recruits women admitted to Labor and Delivery for evaluation of PE. Women are admitted for PE evaluation at all hours. Research team members are not available at all times to obtain consent which limits recruitment. Our project aimed to ...


Betamethasone: A Novel Therapeutic Intervention For Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan Dec 2018

Betamethasone: A Novel Therapeutic Intervention For Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

The early pathogenesis of preeclampsia (PE) involves a systemic inflammatory immune response. Recent data demonstrate that increased circulating arginine vasopressin (AVP) in humans is predictive of PE and that infusion of AVP in mouse dams phenocopies the pregnancy-specific cardiovascular and immune alterations observed in human PE. Specifically, AVP suppresses anti-inflammatory cytokines and cells. Betamethasone (BMTZ), commonly given to women at risk for preterm birth, is both an AVP and immune response modulator. We hypothesize that early treatment with BMTZ will prevent the development of AVP-induced PE.


Static Urine Osmolality With Elevated First Trimester Urine Copeptin In Human Preeclampsia, Donna A. Santillan, Sabrina M. Scroggins, Alyssa T. Ray, Shao Y. Zhang, Curt D. Sigmund, Gary L. Pierce, Justin L. Grobe, Mark K. Santillan Dec 2018

Static Urine Osmolality With Elevated First Trimester Urine Copeptin In Human Preeclampsia, Donna A. Santillan, Sabrina M. Scroggins, Alyssa T. Ray, Shao Y. Zhang, Curt D. Sigmund, Gary L. Pierce, Justin L. Grobe, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

We have previously shown that maternal plasma copeptin (CPP), as a marker of vasopressin, is highly predictive of preeclampsia (PE) in the first trimester and remains elevated throughout pregnancy. Furthermore, in maternal urine samples we demonstrated that CPP was also significantly elevated in the first trimester in women who later developed PE. Because a urine dipstick test could be easily used in the clinic, we sought to validate this finding in a new and expanded cohort of samples and to determine whether these changes persist throughout pregnancy. In addition, to begin to address the mechanism for this difference, we also ...


Good News About Women & Hpv By Alexander Mortakis Md, Phd, Colleen Stockdale Dec 2018

Good News About Women & Hpv By Alexander Mortakis Md, Phd, Colleen Stockdale

Proceedings in Obstetrics and Gynecology

Dr. Mortakis is recognized internationally as an expert in HPV infections and lower genital tract diseases. ‘Good News About Women & HPV’ was written to provide an accurate and informational resource for his many patients who are concerned about HPV infections and their health. This book is a practical, hands-on approach for women as well as their partners. In addition to well organized chapters (starting with definitions and an introduction to the HPV virus), he poses and answers over 300 questions. The format is straight forward and presents information using both medical terms and lay definitions to assist the reader in ...


Developing A Program For Residents To Support Training In Research, Donna Santillan, Michaela Wiltgen, Marygrace Elson, Mark K. Santillan Dec 2018

Developing A Program For Residents To Support Training In Research, Donna Santillan, Michaela Wiltgen, Marygrace Elson, Mark K. Santillan

POG In Press

Physicians are expected to be life-long learners and to assimilate and evaluate new knowledge gained from research. Many residencies also require completion of a scholarly project during their residency. However, the majority of residency training is dedicated to enhancing clinical knowledge base and skills. Often, residents are not provided with a structured learning experience and support system for research.


Vestibular Schwannoma Growth During Pregnancy: Case Report Of Neurofibromatosis Type 2 In Pregnancy, Sraavya S. Akella, Jordan N. Mattson, Nina N. Moreira Md Dec 2018

Vestibular Schwannoma Growth During Pregnancy: Case Report Of Neurofibromatosis Type 2 In Pregnancy, Sraavya S. Akella, Jordan N. Mattson, Nina N. Moreira Md

POG In Press

Background: Acoustic neuromas are a common sequela of neurofibromatosis type 2 and have been shown to grow at an increased rate during pregnancy.

Case: 21-year-old female, gravida 1 para 0, with history of neurofibromatosis type 2 presented for prenatal care following new onset seizures and progressive deafness. She was found to have bilateral slow-growing acoustic neuromas. Over the course of her pregnancy, her acoustic neuroma began growing and she became completely deaf. She underwent surgical decompression during her pregnancy and had a late preterm vaginal delivery due to preeclampsia with severe features. She subsequently had further operative and medical treatment ...


Identifying Risk Factors For Preeclampsia In Subsequent Pregnancies In Women With A History Of Preeclampsia, Michaela Wiltgen, Donna A. Santillan, Kellie Thomas, Adam Fitzsimmons, Lindsay Krotz, Heather Davis, Laura Jacobus, Mark K. Santillan, Debra S. Brandt Dec 2018

Identifying Risk Factors For Preeclampsia In Subsequent Pregnancies In Women With A History Of Preeclampsia, Michaela Wiltgen, Donna A. Santillan, Kellie Thomas, Adam Fitzsimmons, Lindsay Krotz, Heather Davis, Laura Jacobus, Mark K. Santillan, Debra S. Brandt

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is a prevalent hypertensive disorder of pregnancy that causes significant maternal-fetal mortality. It has been reported that 60% of maternal mortality can be prevented. Studies have demonstrated that nursing has the ability to influence the mortality rates by providing proactive and competent care. Part of proactive, competent care is to identify those women at the highest risk for PE. Multiple studies have identified a history of PE as a significant risk factor for PE in future gestations. We conducted a nested case control study with our Rule Out Pre-Eclampsia (ROPE) cohort to identify comorbidities most likely to lead ...


Regulatory Dendritic Cell Treatment Prevents The Development Of Vasopressin-Induced Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan Dec 2018

Regulatory Dendritic Cell Treatment Prevents The Development Of Vasopressin-Induced Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

The concept that persistent feto-placental intolerance is important in the pathogenesis of preeclampsia (PE) has been demonstrated by our lab and others. Arginine vasopressin (AVP) infusion during pregnancy induces cardiovascular, renal, and immune alterations in mice consistent with human PE. These findings identify AVP as a potential contributor to poor fetal tolerance and the development of PE. In addition to their conventional immuno-stimulatory role, dendritic cells (DCs) also play a vital role in immune tolerance. In contrast to conventional DCs, regulatory DCs (DCregs) express low levels of co-stimulatory markers, produce anti-inflammatory cytokines, induce T regulatory cells, and promote tolerance. In ...


Multimodal Perioperative Pain Protocol For Gynecologic Oncology Laparotomy Reduces Length Of Hospital Stay, Jordan N. Mattson, Mackenzie Thayer, Sarah L. Mott, Yasmin A. Lyons, Henry D. Reyes, Megan E. Mcdonald, Abbey J. Hardy-Fairbanks, Emily K. Hill Dec 2018

Multimodal Perioperative Pain Protocol For Gynecologic Oncology Laparotomy Reduces Length Of Hospital Stay, Jordan N. Mattson, Mackenzie Thayer, Sarah L. Mott, Yasmin A. Lyons, Henry D. Reyes, Megan E. Mcdonald, Abbey J. Hardy-Fairbanks, Emily K. Hill

Proceedings in Obstetrics and Gynecology

Our primary objective was to evaluate the impact of a multimodal perioperative pain regimen on length of hospital stay for patients undergoing laparotomy with a gynecologic oncologist.


Impact Of An Entrustable Professional Activities-Based Assessment System, Megan Lord, Amanda B. Murchison, Alaina Lawrence, Isaiah Johnson Dec 2018

Impact Of An Entrustable Professional Activities-Based Assessment System, Megan Lord, Amanda B. Murchison, Alaina Lawrence, Isaiah Johnson

Proceedings in Obstetrics and Gynecology

Background: Beginning in 2014, all Accreditation Counsel of Graduate Medical Education (ACGME) accredited residency programs were required to move to a Milestones-based system for biannual resident assessment. The resident assessment system for the Virginia Tech-Carilion Obstetrics and Gynecology (OB/GYN) residency program was re-designed to meet this requirement in July, 2014. The ACGME Milestones based assessment tool was identified on multiple faculty surveys as an area for improvement. To address this issue, an entrustable professional activities (EPA) based assessment system was designed and implemented for assessment of all OB/GYN rotations.

Objective: To evaluate the impact of an EPA based ...


Small Cell Carcinoma Of The Cervix: A Retrospective Analysis Of Characteristics Important In Outcomes, Jordan N. Mattson, Sarah L. Mott, Yasmin A. Lyons, Jean-Marie Stephan, Michael J. Goodheart Dec 2018

Small Cell Carcinoma Of The Cervix: A Retrospective Analysis Of Characteristics Important In Outcomes, Jordan N. Mattson, Sarah L. Mott, Yasmin A. Lyons, Jean-Marie Stephan, Michael J. Goodheart

Proceedings in Obstetrics and Gynecology

To assess clinical characteristics and treatment modalities in patients with small cell carcinoma of the cervix and the effect this has on overall (OS) and recurrence free survival (RFS).


Superficial Versus Deep Lymph Node Dissection In Early Stage Vulvar Carcinoma, Jordan N. Mattson, Jenna Emerson, Amita Kulkarni, Amelia Underwood, Grace Sun, Sarah L. Mott, Katina Robison, Emily K. Hill Dec 2018

Superficial Versus Deep Lymph Node Dissection In Early Stage Vulvar Carcinoma, Jordan N. Mattson, Jenna Emerson, Amita Kulkarni, Amelia Underwood, Grace Sun, Sarah L. Mott, Katina Robison, Emily K. Hill

Proceedings in Obstetrics and Gynecology

Our primary objective was to evaluate the difference in overall survival, recurrence rate, and post-operative morbidity related to superficial versus deep inguinal lymphadenectomy in squamous cell carcinoma of the vulva.


Bilateral Serous Tubal Intraepithelial Carcinoma Associated With High-Grade Serous Carcinoma Of The Peritoneum: Evidence For Transcoelomic Tumor Spread By Extended Lymph Node Evaluation, Hermann Brustmann Dec 2018

Bilateral Serous Tubal Intraepithelial Carcinoma Associated With High-Grade Serous Carcinoma Of The Peritoneum: Evidence For Transcoelomic Tumor Spread By Extended Lymph Node Evaluation, Hermann Brustmann

POG In Press

Serous tubal intraepithelial carcinoma (STIC) is now considered a putative precursor lesion of most extrauterine high-grade serous carcinomas (HGSC). It is frequently reported in high-risk women and women with advanced-stage serous carcinoma. This case study reports a serous high-grade carcinoma (HGSC) consisting of a bilateral STIC with a focus of stromal invasion in the left tube, and a peritoneal HGSC. The grossly normal-appearing tubes including the fimbriated ends were sectioned following the SEE-FIM protocol. In both tubes, tumor aggregates were exfoliated extensively to the tubal lumens. The neoplastic epithelia in any location were diffusely positive for p53 in strong nuclear ...


First Trimester Elevation In Circulating Endothelin-1 And Arterial Stiffness Are Predictive Of Late Pregnancy Preeclampsia, Alexandria M. Betz, Gary L. Pierce, Donna A. Santillan, Eric J. Devor, Sabrina M. Scroggins, Debra S. Brandt, Amy K. Stroud, Kellie M. Thomas, Seth W. Holwerda, Allison O’Deen, Lyndsey E. Dubose, Justin L. Grobe, Curt D. Sigmund, Mark K. Santillan Dec 2018

First Trimester Elevation In Circulating Endothelin-1 And Arterial Stiffness Are Predictive Of Late Pregnancy Preeclampsia, Alexandria M. Betz, Gary L. Pierce, Donna A. Santillan, Eric J. Devor, Sabrina M. Scroggins, Debra S. Brandt, Amy K. Stroud, Kellie M. Thomas, Seth W. Holwerda, Allison O’Deen, Lyndsey E. Dubose, Justin L. Grobe, Curt D. Sigmund, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is characterized by late pregnancy hypertension and proteinuria. PE causes significant morbidity for the maternal-fetal unit. Circulating endothelin-1 (ET-1), a potent vasoconstrictor, is elevated at the time of diagnosis of human PE. In addition, women with PE demonstrate arterial stiffness as early as the end of the first trimester. However, it is unknown if arterial stiffness is associated with a first trimester elevation in ET-1 and post-delivery placental ET-1. We hypothesized that 1) first trimester plasma ET-1 is elevated and is associated with arterial stiffness in women who develop PE; 2) first trimester ET-1 is predictive of PE ...


Postpartum Larc Use In Low-Risk Women In Centeringpregnancy® Versus Traditional Certified Nurse Midwife Prenatal Care, Tara Hoff, Petra Hahn, Deepti Sharma, Abbey J. Hardy-Fairbanks, Colleen K. Stockdale Dec 2018

Postpartum Larc Use In Low-Risk Women In Centeringpregnancy® Versus Traditional Certified Nurse Midwife Prenatal Care, Tara Hoff, Petra Hahn, Deepti Sharma, Abbey J. Hardy-Fairbanks, Colleen K. Stockdale

Proceedings in Obstetrics and Gynecology

Contraception satisfaction and utilization is linked to pre-use clinical counseling. Group prenatal care may offer increased opportunity for education on postpartum contraception options. This study evaluated postpartum long acting reversible contraception (LARC) rates in women who attend CenteringPregnancy® group prenatal (CP) care versus individual prenatal care with Certified Nurse Midwives (CNM).


Effect Of Endometrial Thickness On Live Birth Rates In Fresh And Frozen Embryo Transfers In Women Under 38 Years Of Age, Trenton L. Place, Rachel A. Mejia, Amy E.T. Sparks, Karen M. Summers, E. Hakan Duran, Patrick Ten Eyck, Bradley J. Van Voorhis Dec 2018

Effect Of Endometrial Thickness On Live Birth Rates In Fresh And Frozen Embryo Transfers In Women Under 38 Years Of Age, Trenton L. Place, Rachel A. Mejia, Amy E.T. Sparks, Karen M. Summers, E. Hakan Duran, Patrick Ten Eyck, Bradley J. Van Voorhis

Proceedings in Obstetrics and Gynecology

Many IVF clinics use endometrial thickness as a predictive factor for IVF outcomes, as research has shown a positive association between endometrial thickness and favorable IVF outcomes. A thickness of 6-8 mm is often used as a cut-off in for the decision of whether or not to transfer an embryo in both fresh and frozen cycles. However, prior studies investigating the relationship between a thin endometrium and IVF outcomes have overwhelmingly been performed in fresh cleavage stage embryo transfers. Given the recent trend toward the transfer of frozen blastocyst transfers, we aimed to determine whether endometrial thickness predicts live birth ...


Higher Body Weight Is Associated With Lower Concentrations Of Progesterone And Estrogen In Early Pregnancy Following In Vitro Fertilization, Edward B. Nguyen, Rachel B. Mejia, Karen M. Summers, Patrick Ten Eyck Institute For Clinical And Translational Science, University Of Iowa, Iowa City, Iowa, Amy E.T. Sparks, Bradley J. Van Voorhis Dec 2018

Higher Body Weight Is Associated With Lower Concentrations Of Progesterone And Estrogen In Early Pregnancy Following In Vitro Fertilization, Edward B. Nguyen, Rachel B. Mejia, Karen M. Summers, Patrick Ten Eyck Institute For Clinical And Translational Science, University Of Iowa, Iowa City, Iowa, Amy E.T. Sparks, Bradley J. Van Voorhis

Proceedings in Obstetrics and Gynecology

To evaluate if body weight impacts progesterone and estradiol concentration levels in early pregnancy in women conceiving following single embryo transfer.


Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward, Ashley L. Cooney, Paul B. Mccray, Patrick L. Sinn Nov 2018

Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward, Ashley L. Cooney, Paul B. Mccray, Patrick L. Sinn

Stead Family Department of Pediatrics Publications

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes a cAMP-regulated anion channel. Although CF is a multi-organ system disease, most people with CF die of progressive lung disease that begins early in childhood and is characterized by chronic bacterial infection and inflammation. Nearly 90% of people with CF have at least one copy of the ΔF508 mutation, but there are hundreds of CFTR mutations that result in a range of disease severities. A CFTR gene replacement approach would be efficacious regardless of the disease-causing mutation. After ...


Successful Management Of A Supralevator Intraperitoneal Puerperal Hematoma With Angiographic Embolization, Fatimah Z. Fahimuddin, Andrea Seid, Anubhav Agrawal Nov 2018

Successful Management Of A Supralevator Intraperitoneal Puerperal Hematoma With Angiographic Embolization, Fatimah Z. Fahimuddin, Andrea Seid, Anubhav Agrawal

POG In Press

Puerperal hematomas are rare, yet often life threatening, complications following vaginal deliveries. The etiology remains broad; however, early recognition is vital in preventing postpartum hemorrhage and maternal death. Our case illustrates treatment of a supralevator hematoma with angiographic embolization following a spontaneous vaginal delivery in a young woman. Her labor course was complicated by persistent occiput posterior presentation that failed spontaneous and manual rotation.


Atypical Hemolytic Uremic Syndrome In The Postpartum Period: A Case Series, Jordan N. Mattson, Jessica S. Sheng, Kimberly K. Leslie Nov 2018

Atypical Hemolytic Uremic Syndrome In The Postpartum Period: A Case Series, Jordan N. Mattson, Jessica S. Sheng, Kimberly K. Leslie

POG In Press

Background: Atypical hemolytic uremic syndrome (aHUS) may present in either the antepartum or postpartum period and is often indistinguishable from other pregnancy-associated diseases. Timely recognition and appropriate treatment can greatly reduce maternal morbidity and mortality.

Cases: This case series describes two cases of aHUS in the post-partum period, the difficulty in distinguishing the diagnosis, and the implementation of appropriate treatment with eculizumab, a terminal complement inhibitor.

Conclusion: As a terminal complement inhibitor, eculizumab, has been shown to significantly improve clinical and long term renal outcomes, early diagnosis of aHUS is increasingly important. These two cases of aHUS demonstrate the path ...


Pregnancy Predictors In The Fresh Cycle Using Dual Trigger Protocol, Rebecca Chung, Abigail Mancuso, Amy E.T. Sparks, E. Hakan Duran, Rachel A. Mejia Nov 2018

Pregnancy Predictors In The Fresh Cycle Using Dual Trigger Protocol, Rebecca Chung, Abigail Mancuso, Amy E.T. Sparks, E. Hakan Duran, Rachel A. Mejia

Proceedings in Obstetrics and Gynecology

Dual trigger protocol using a combination of GnRH agonist and hCG for final oocyte maturation has been shown to minimize ovarian hyperstimulation syndrome (OHSS) risk without compromising fresh embryo transfer outcomes. Therefore, we sought to determine if any cycle characteristics were associated with predictive of pregnancy outcomes in fresh cycles that utilized this protocol for in-vitro fertilization.


Recovery From Cesarean Delivery At Uihc: A Comparison To Enhanced Recovery Protocols, Grace Chabal, Noelle C. Bowdler, Donna A. Santillan Nov 2018

Recovery From Cesarean Delivery At Uihc: A Comparison To Enhanced Recovery Protocols, Grace Chabal, Noelle C. Bowdler, Donna A. Santillan

Proceedings in Obstetrics and Gynecology

Enhanced Recovery After Surgery programs (ERAS) have been used by some specialties for years, and are now becoming popular for gynecologic and obstetrics surgeries. ERAS programs consist of evidence-based interventions during a patient’s hospital stay that are intended to promote early return to activities such as eating, ambulation, and voiding and to manage pain. These programs reduce the risk of complications post-operatively and shorten a patient’s hospital stay. The University of Iowa Hospitals and Clinics (UIHC) is developing an ERAS protocol for cesarean deliveries. Our goal was to determine how current practices and outcomes for cesarean deliveries at ...


Project To Decrease Medical Student Refusal In The Obstetric And Gynecology Clinic At The University Of Iowa, Kristin C. Bremer, Sarah A. Shaffer, Sally J. Fisher Nov 2018

Project To Decrease Medical Student Refusal In The Obstetric And Gynecology Clinic At The University Of Iowa, Kristin C. Bremer, Sarah A. Shaffer, Sally J. Fisher

Proceedings in Obstetrics and Gynecology

Purpose: To describe the frequency at which students are refused from patient care, and to evaluate the impact of interventions designed to reduce medical student refusal.

Background: Medical student refusal from patient care is perceived to be a common problem during the Ob-Gyn clerkship at the University of Iowa. Review of the literature shows that medical student refusal is common in a variety of clerkships1-4. Few studies have evaluated interventions to reduce the rate of refusal.

Methods: Beginning in 2016, surveys measuring medical students’ perception of refusal were administered upon completion of the Ob-Gyn clerkship. Interventions to reduce refusal of ...


Prevalence, Attitudes And Knowledge Of Misoprostol For Self-Induction Of Abortion In Women Presenting For Abortion At Midwestern Reproductive Health, Courtney Kerestes, Kelsey Sheets, Colleen Stockdale, Abbey J. Hardy-Fairbanks Nov 2018

Prevalence, Attitudes And Knowledge Of Misoprostol For Self-Induction Of Abortion In Women Presenting For Abortion At Midwestern Reproductive Health, Courtney Kerestes, Kelsey Sheets, Colleen Stockdale, Abbey J. Hardy-Fairbanks

Proceedings in Obstetrics and Gynecology

Expansive restrictions to legal abortion have led to reports of self-induced termination of undesired pregnancies with misoprostol obtained without a prescription or provider. This study seeks to describe the prevalence of women seeking or employing misoprostol for self-induced abortion and how they access information.

Women are accessing information regarding misoprostol for self-induction of abortion on the internet and as barriers to legal abortion increase, women may be more likely to self-induce abortion.


Effects Of Biological Factors On The Expression Of Arginine Vasopressin Receptors, Lauren A. Davis, Eric J. Devor, Lydia E. Sharp, Mark K. Santillan, Sabrina M. Scroggins, Donna A. Santillan Nov 2018

Effects Of Biological Factors On The Expression Of Arginine Vasopressin Receptors, Lauren A. Davis, Eric J. Devor, Lydia E. Sharp, Mark K. Santillan, Sabrina M. Scroggins, Donna A. Santillan

Proceedings in Obstetrics and Gynecology

Arginine vasopressin (AVP) is a hormone that functions to regulate blood pressure and bodily fluid homeostasis. Vasopressin has three main receptors AVPR1a, AVPR1b, and AVPR2 which were investigated in this project along with OXTR, LNPEP, and CUL5. AVPR1a functions in the smooth muscle and causes vasoconstriction, AVPR1b functions in the pituitary helping to regulate adrenocorticotropic hormone release, and AVPR2 is expressed highly in the kidneys and works to concentrate urine. This project investigates how these various receptors are expressed with different factors related to pregnancy such as, sex of the baby, chronically hypertensive mothers, and gestational age at delivery


Vasopressin, Depression, Pain & Preeclampsia, Julie A. Vignato, Sabrina Scroggins, Wendy Hamilton, Debra Brandt, Kellie Thomas, Donna A. Santillan, Mark K. Santillan Nov 2018

Vasopressin, Depression, Pain & Preeclampsia, Julie A. Vignato, Sabrina Scroggins, Wendy Hamilton, Debra Brandt, Kellie Thomas, Donna A. Santillan, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

Preeclampsia (PreE) is a prevalent hypertensive disorder of pregnancy leading to a death every minute worldwide. Predictive and preventative challenges in PreE stems from its unclear early-pregnancy etiology. Arginine vasopressin (AVP) secretion, as measured by copeptin, activates the stress response system and is a novel, early pregnancy predictor of PreE. In addition, elevated AVP is associated with stress, depression and pain. Our Precision Healthcare goal is to understand how AVP-associated changes in depression and pain affect the phenotype of PreE to develop preventative and therapeutic modalities against it. We hypothesize that in humans, antecedent depression and pain affects early pregnancy ...


Clinical Use Of Flt3 Inhibitors In Acute Myeloid Leukemia, Grerk Sutamtewagu, Carlos E. Vigil Oct 2018

Clinical Use Of Flt3 Inhibitors In Acute Myeloid Leukemia, Grerk Sutamtewagu, Carlos E. Vigil

Department of Internal Medicine Publications

Acute myeloid leukemia (AML) is a highly heterogeneous disease. Mutation with internal tandem duplication of fms-like tyrosine kinase-3 (FLT3-ITD) is one of the two most common driver mutations and the presence of FLT3-ITD delivers poor prognosis. A number of ongoing clinical efforts are focused on FLT3 inhibitor use to improve the outcomes of this otherwise difficult leukemia. Midostaurin has been shown to improve outcomes in FLT3-mutated AML in the frontline setting. Several FLT3 inhibitors, especially second-generation agents, have shown clinically meaningful activity in relapsed or refractory AML and in patients not amenable to intensive therapy. In this ...


The University Of Iowa Residency Training Program In Obstetrics And Gynecology And Impact Of Recent State Abortion Legislation, Marygrace Elson Oct 2018

The University Of Iowa Residency Training Program In Obstetrics And Gynecology And Impact Of Recent State Abortion Legislation, Marygrace Elson

Proceedings in Obstetrics and Gynecology

Impact of state legislation on the University of Iowa residency progam in Obstetrics and Gynecology.


Let’S Talk About Sex History: Impact Of A Communication Curriculum On Medical Student Performance And Perceived Competency, Colleen K. Stockdale, John Kippes, Marcy Rosenbaum, Marygrace Elson Oct 2018

Let’S Talk About Sex History: Impact Of A Communication Curriculum On Medical Student Performance And Perceived Competency, Colleen K. Stockdale, John Kippes, Marcy Rosenbaum, Marygrace Elson

Proceedings in Obstetrics and Gynecology

Introduction: Communication in general, but especially regarding difficult topics such as sexual health is inadequately addressed in undergraduate medical education. Students often feel they are poorly trained in this area due to a lack of opportunities to practice taking sexual history. Thus, a communication curriculum was implemented to address this gap, including formal small group practice sessions on taking a sexual history during the Obstetrics and Gynecology (OB/GYN) clerkship.

Aim: Determine whether medical students who completed a sexual history communication curriculum performed better during a formal standardized patient based assessment (PBA) at the conclusion of the OB/GYN clerkship ...


Marygrace Elson, Md, Mme Oct 2018

Marygrace Elson, Md, Mme

Proceedings in Obstetrics and Gynecology

Dr. Marygrace Elson is a Clinical Professor of General Obstetrics and Gynecology at the University of Iowa Hospital and Clinics. She received a BA from the University of Illinois, an MD from the University of Illinois College of Medicine and completed a residency in Obstetrics and Gynecology at the University of Wisconsin Hospitals and Clinics. She received an MME from the University of Iowa Carver College of Medicine. Dr. Elson worked as a private practitioner in California and Illinois, before joining the University of Iowa Hospitals and Clinics to serve as a clinical physician and on the medical faculty. She ...