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Articles 1 - 30 of 1655

Full-Text Articles in Medicine and Health Sciences

Introducing E-Consents In A Clinical Setting, Jesse Weiss, Donna A. Santillan, Kellie Thomas, Heather Davis, Mark K. Santillan, Debra Sue Brandt Dec 2018

Introducing E-Consents In A Clinical Setting, Jesse Weiss, Donna A. Santillan, Kellie Thomas, Heather Davis, Mark K. Santillan, Debra Sue Brandt

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is a multiorgan hypertensive-disorder in pregnancy that causes significant maternal-fetal mortality and morbidity. The diagnostics and therapeutics for PE are limited due to its unclear etiology. Using the UI Maternal Fetal Tissue Bank, our lab has demonstrated that copeptin is robustly predictive of PE. To investigate copeptin further, we developed the Rule Out Pre-Eclampsia Study (ROPE). The ROPE study recruits women admitted to Labor and Delivery for evaluation of PE. Women are admitted for PE evaluation at all hours. Research team members are not available at all times to obtain consent which limits recruitment. Our project aimed to ...


Identifying Risk Factors For Preeclampsia In Subsequent Pregnancies In Women With A History Of Preeclampsia, Michaela Wiltgen, Donna A. Santillan, Kellie Thomas, Adam Fitzsimmons, Lindsay Krotz, Heather Davis, Laura Jacobus, Mark K. Santillan, Debra S. Brandt Dec 2018

Identifying Risk Factors For Preeclampsia In Subsequent Pregnancies In Women With A History Of Preeclampsia, Michaela Wiltgen, Donna A. Santillan, Kellie Thomas, Adam Fitzsimmons, Lindsay Krotz, Heather Davis, Laura Jacobus, Mark K. Santillan, Debra S. Brandt

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is a prevalent hypertensive disorder of pregnancy that causes significant maternal-fetal mortality. It has been reported that 60% of maternal mortality can be prevented. Studies have demonstrated that nursing has the ability to influence the mortality rates by providing proactive and competent care. Part of proactive, competent care is to identify those women at the highest risk for PE. Multiple studies have identified a history of PE as a significant risk factor for PE in future gestations. We conducted a nested case control study with our Rule Out Pre-Eclampsia (ROPE) cohort to identify comorbidities most likely to lead ...


First Trimester Elevation In Circulating Endothelin-1 And Arterial Stiffness Are Predictive Of Late Pregnancy Preeclampsia, Alexandria M. Betz, Gary L. Pierce, Donna A. Santillan, Eric J. Devor, Sabrina M. Scroggins, Debra S. Brandt, Amy K. Stroud, Kellie M. Thomas, Seth W. Holwerda, Allison O’Deen, Lyndsey E. Dubose, Justin L. Grobe, Curt D. Sigmund, Mark K. Santillan Dec 2018

First Trimester Elevation In Circulating Endothelin-1 And Arterial Stiffness Are Predictive Of Late Pregnancy Preeclampsia, Alexandria M. Betz, Gary L. Pierce, Donna A. Santillan, Eric J. Devor, Sabrina M. Scroggins, Debra S. Brandt, Amy K. Stroud, Kellie M. Thomas, Seth W. Holwerda, Allison O’Deen, Lyndsey E. Dubose, Justin L. Grobe, Curt D. Sigmund, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

Preeclampsia (PE) is characterized by late pregnancy hypertension and proteinuria. PE causes significant morbidity for the maternal-fetal unit. Circulating endothelin-1 (ET-1), a potent vasoconstrictor, is elevated at the time of diagnosis of human PE. In addition, women with PE demonstrate arterial stiffness as early as the end of the first trimester. However, it is unknown if arterial stiffness is associated with a first trimester elevation in ET-1 and post-delivery placental ET-1. We hypothesized that 1) first trimester plasma ET-1 is elevated and is associated with arterial stiffness in women who develop PE; 2) first trimester ET-1 is predictive of PE ...


Betamethasone: A Novel Therapeutic Intervention For Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan Dec 2018

Betamethasone: A Novel Therapeutic Intervention For Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

The early pathogenesis of preeclampsia (PE) involves a systemic inflammatory immune response. Recent data demonstrate that increased circulating arginine vasopressin (AVP) in humans is predictive of PE and that infusion of AVP in mouse dams phenocopies the pregnancy-specific cardiovascular and immune alterations observed in human PE. Specifically, AVP suppresses anti-inflammatory cytokines and cells. Betamethasone (BMTZ), commonly given to women at risk for preterm birth, is both an AVP and immune response modulator. We hypothesize that early treatment with BMTZ will prevent the development of AVP-induced PE.


Regulatory Dendritic Cell Treatment Prevents The Development Of Vasopressin-Induced Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan Dec 2018

Regulatory Dendritic Cell Treatment Prevents The Development Of Vasopressin-Induced Preeclampsia, Sabrina M. Scroggins, Donna A. Santillan, Jeremy A. Sandgren, Gary L. Pierce, Curt D. Sigmund, Justin L. Grobe, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

The concept that persistent feto-placental intolerance is important in the pathogenesis of preeclampsia (PE) has been demonstrated by our lab and others. Arginine vasopressin (AVP) infusion during pregnancy induces cardiovascular, renal, and immune alterations in mice consistent with human PE. These findings identify AVP as a potential contributor to poor fetal tolerance and the development of PE. In addition to their conventional immuno-stimulatory role, dendritic cells (DCs) also play a vital role in immune tolerance. In contrast to conventional DCs, regulatory DCs (DCregs) express low levels of co-stimulatory markers, produce anti-inflammatory cytokines, induce T regulatory cells, and promote tolerance. In ...


Static Urine Osmolality With Elevated First Trimester Urine Copeptin In Human Preeclampsia, Donna A. Santillan, Sabrina M. Scroggins, Alyssa T. Ray, Shao Y. Zhang, Curt D. Sigmund, Gary L. Pierce, Justin L. Grobe, Mark K. Santillan Dec 2018

Static Urine Osmolality With Elevated First Trimester Urine Copeptin In Human Preeclampsia, Donna A. Santillan, Sabrina M. Scroggins, Alyssa T. Ray, Shao Y. Zhang, Curt D. Sigmund, Gary L. Pierce, Justin L. Grobe, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

We have previously shown that maternal plasma copeptin (CPP), as a marker of vasopressin, is highly predictive of preeclampsia (PE) in the first trimester and remains elevated throughout pregnancy. Furthermore, in maternal urine samples we demonstrated that CPP was also significantly elevated in the first trimester in women who later developed PE. Because a urine dipstick test could be easily used in the clinic, we sought to validate this finding in a new and expanded cohort of samples and to determine whether these changes persist throughout pregnancy. In addition, to begin to address the mechanism for this difference, we also ...


Good News About Women & Hpv By Alexander Mortakis Md, Phd, Colleen Stockdale Dec 2018

Good News About Women & Hpv By Alexander Mortakis Md, Phd, Colleen Stockdale

Proceedings in Obstetrics and Gynecology

Dr. Mortakis is recognized internationally as an expert in HPV infections and lower genital tract diseases. ‘Good News About Women & HPV’ was written to provide an accurate and informational resource for his many patients who are concerned about HPV infections and their health. This book is a practical, hands-on approach for women as well as their partners. In addition to well organized chapters (starting with definitions and an introduction to the HPV virus), he poses and answers over 300 questions. The format is straight forward and presents information using both medical terms and lay definitions to assist the reader in ...


Successful Management Of A Supralevator Intraperitoneal Puerperal Hematoma With Angiographic Embolization, Fatimah Z. Fahimuddin, Andrea Seid, Anubhav Agrawal Nov 2018

Successful Management Of A Supralevator Intraperitoneal Puerperal Hematoma With Angiographic Embolization, Fatimah Z. Fahimuddin, Andrea Seid, Anubhav Agrawal

POG In Press

Puerperal hematomas are rare, yet often life threatening, complications following vaginal deliveries. The etiology remains broad; however, early recognition is vital in preventing postpartum hemorrhage and maternal death. Our case illustrates treatment of a supralevator hematoma with angiographic embolization following a spontaneous vaginal delivery in a young woman. Her labor course was complicated by persistent occiput posterior presentation that failed spontaneous and manual rotation.


Atypical Hemolytic Uremic Syndrome In The Postpartum Period: A Case Series, Jordan N. Mattson, Jessica S. Sheng, Kimberly K. Leslie Nov 2018

Atypical Hemolytic Uremic Syndrome In The Postpartum Period: A Case Series, Jordan N. Mattson, Jessica S. Sheng, Kimberly K. Leslie

POG In Press

Background: Atypical hemolytic uremic syndrome (aHUS) may present in either the antepartum or postpartum period and is often indistinguishable from other pregnancy-associated diseases. Timely recognition and appropriate treatment can greatly reduce maternal morbidity and mortality.

Cases: This case series describes two cases of aHUS in the post-partum period, the difficulty in distinguishing the diagnosis, and the implementation of appropriate treatment with eculizumab, a terminal complement inhibitor.

Conclusion: As a terminal complement inhibitor, eculizumab, has been shown to significantly improve clinical and long term renal outcomes, early diagnosis of aHUS is increasingly important. These two cases of aHUS demonstrate the path ...


Pregnancy Predictors In The Fresh Cycle Using Dual Trigger Protocol, Rebecca Chung, Abigail Mancuso, Amy E.T. Sparks, E. Hakan Duran, Rachel A. Mejia Nov 2018

Pregnancy Predictors In The Fresh Cycle Using Dual Trigger Protocol, Rebecca Chung, Abigail Mancuso, Amy E.T. Sparks, E. Hakan Duran, Rachel A. Mejia

Proceedings in Obstetrics and Gynecology

Dual trigger protocol using a combination of GnRH agonist and hCG for final oocyte maturation has been shown to minimize ovarian hyperstimulation syndrome (OHSS) risk without compromising fresh embryo transfer outcomes. Therefore, we sought to determine if any cycle characteristics were associated with predictive of pregnancy outcomes in fresh cycles that utilized this protocol for in-vitro fertilization.


Vasopressin, Depression, Pain & Preeclampsia, Julie A. Vignato, Sabrina Scroggins, Wendy Hamilton, Debra Brandt, Kellie Thomas, Donna A. Santillan, Mark K. Santillan Nov 2018

Vasopressin, Depression, Pain & Preeclampsia, Julie A. Vignato, Sabrina Scroggins, Wendy Hamilton, Debra Brandt, Kellie Thomas, Donna A. Santillan, Mark K. Santillan

Proceedings in Obstetrics and Gynecology

Preeclampsia (PreE) is a prevalent hypertensive disorder of pregnancy leading to a death every minute worldwide. Predictive and preventative challenges in PreE stems from its unclear early-pregnancy etiology. Arginine vasopressin (AVP) secretion, as measured by copeptin, activates the stress response system and is a novel, early pregnancy predictor of PreE. In addition, elevated AVP is associated with stress, depression and pain. Our Precision Healthcare goal is to understand how AVP-associated changes in depression and pain affect the phenotype of PreE to develop preventative and therapeutic modalities against it. We hypothesize that in humans, antecedent depression and pain affects early pregnancy ...


Recovery From Cesarean Delivery At Uihc: A Comparison To Enhanced Recovery Protocols, Grace Chabal, Noelle C. Bowdler, Donna A. Santillan Nov 2018

Recovery From Cesarean Delivery At Uihc: A Comparison To Enhanced Recovery Protocols, Grace Chabal, Noelle C. Bowdler, Donna A. Santillan

Proceedings in Obstetrics and Gynecology

Enhanced Recovery After Surgery programs (ERAS) have been used by some specialties for years, and are now becoming popular for gynecologic and obstetrics surgeries. ERAS programs consist of evidence-based interventions during a patient’s hospital stay that are intended to promote early return to activities such as eating, ambulation, and voiding and to manage pain. These programs reduce the risk of complications post-operatively and shorten a patient’s hospital stay. The University of Iowa Hospitals and Clinics (UIHC) is developing an ERAS protocol for cesarean deliveries. Our goal was to determine how current practices and outcomes for cesarean deliveries at ...


Project To Decrease Medical Student Refusal In The Obstetric And Gynecology Clinic At The University Of Iowa, Kristin C. Bremer, Sarah A. Shaffer, Sally J. Fisher Nov 2018

Project To Decrease Medical Student Refusal In The Obstetric And Gynecology Clinic At The University Of Iowa, Kristin C. Bremer, Sarah A. Shaffer, Sally J. Fisher

Proceedings in Obstetrics and Gynecology

Purpose: To describe the frequency at which students are refused from patient care, and to evaluate the impact of interventions designed to reduce medical student refusal.

Background: Medical student refusal from patient care is perceived to be a common problem during the Ob-Gyn clerkship at the University of Iowa. Review of the literature shows that medical student refusal is common in a variety of clerkships1-4. Few studies have evaluated interventions to reduce the rate of refusal.

Methods: Beginning in 2016, surveys measuring medical students’ perception of refusal were administered upon completion of the Ob-Gyn clerkship. Interventions to reduce refusal of ...


Prevalence, Attitudes And Knowledge Of Misoprostol For Self-Induction Of Abortion In Women Presenting For Abortion At Midwestern Reproductive Health, Courtney Kerestes, Kelsey Sheets, Colleen Stockdale, Abbey J. Hardy-Fairbanks Nov 2018

Prevalence, Attitudes And Knowledge Of Misoprostol For Self-Induction Of Abortion In Women Presenting For Abortion At Midwestern Reproductive Health, Courtney Kerestes, Kelsey Sheets, Colleen Stockdale, Abbey J. Hardy-Fairbanks

Proceedings in Obstetrics and Gynecology

Expansive restrictions to legal abortion have led to reports of self-induced termination of undesired pregnancies with misoprostol obtained without a prescription or provider. This study seeks to describe the prevalence of women seeking or employing misoprostol for self-induced abortion and how they access information.

Women are accessing information regarding misoprostol for self-induction of abortion on the internet and as barriers to legal abortion increase, women may be more likely to self-induce abortion.


Effects Of Biological Factors On The Expression Of Arginine Vasopressin Receptors, Lauren A. Davis, Eric J. Devor, Lydia E. Sharp, Mark K. Santillan, Sabrina M. Scroggins, Donna A. Santillan Nov 2018

Effects Of Biological Factors On The Expression Of Arginine Vasopressin Receptors, Lauren A. Davis, Eric J. Devor, Lydia E. Sharp, Mark K. Santillan, Sabrina M. Scroggins, Donna A. Santillan

Proceedings in Obstetrics and Gynecology

Arginine vasopressin (AVP) is a hormone that functions to regulate blood pressure and bodily fluid homeostasis. Vasopressin has three main receptors AVPR1a, AVPR1b, and AVPR2 which were investigated in this project along with OXTR, LNPEP, and CUL5. AVPR1a functions in the smooth muscle and causes vasoconstriction, AVPR1b functions in the pituitary helping to regulate adrenocorticotropic hormone release, and AVPR2 is expressed highly in the kidneys and works to concentrate urine. This project investigates how these various receptors are expressed with different factors related to pregnancy such as, sex of the baby, chronically hypertensive mothers, and gestational age at delivery


The Impact Of Great Leadership, Emily Boevers Oct 2018

The Impact Of Great Leadership, Emily Boevers

Proceedings in Obstetrics and Gynecology

The mentorship I’ve enjoyed from some UIHC Ob-Gyn faculty has influenced not only my decision to enter this field, but also shaped the way I will practice in the future and given me reason to teach and mentor others. Finding faculty who really pushed me to be not just a better student but a more engaged health care provider, teacher, citizen and leader has cemented my career trajectory. I hope it will lead to richer experiences for the others that I work with along the way. Beyond what I have experienced in other departments, Ob-Gyn faculty at UIHC are ...


Simulation Training In Forceps Assisted Vaginal Birth: Trainee Competence, Clinical Behavior And Procedural Competence, Marygrace Elson, Michael L. Haugsdal, Donna A. Santillan Oct 2018

Simulation Training In Forceps Assisted Vaginal Birth: Trainee Competence, Clinical Behavior And Procedural Competence, Marygrace Elson, Michael L. Haugsdal, Donna A. Santillan

Proceedings in Obstetrics and Gynecology

To determine whether simulation training in forceps assisted vaginal delivery affected:

· The confidence of the trainee in offering and performing forceps assisted vaginal delivery before and after the intervention
· The frequency with which forceps assisted vaginal delivery is offered to the parturient compared to vacuum assisted vaginal delivery.


The Foundation For A Successful Career In Academic Medicine, Alireza A. Shamshirsaz Oct 2018

The Foundation For A Successful Career In Academic Medicine, Alireza A. Shamshirsaz

Proceedings in Obstetrics and Gynecology

After being exposed to all facets of medicine, I have found Obstetrics and Gynecology to be the most challenging, artistic and amazing field in medicine. The University of Iowa Obstetrics and Gynecology Residency Program shaped my personality to become a successful academic obstetrician and gynecologist. With the confidence built at the University of Iowa, Department of Obstetrics and Gynecology I saw Fetal Surgery/ Maternal Fetal Medicine as an opportunity to combine these two passions and I did it, thanks to my residency program at Iowa.


Obstetrics In Uganda: A Reflection, Eleanor Germano Oct 2018

Obstetrics In Uganda: A Reflection, Eleanor Germano

Proceedings in Obstetrics and Gynecology

After having been immersed in rural maternal care in Uganda and completing my Ob/Gyn clerkship at the University of Iowa, I appreciate even more how limited the resources, technology, and preventive measures truly are and how incredibly fortunate we are to practice medicine in the United States. We have hospitals with sterile equipment, post-partum hemorrhage and mass transfusion protocols, access to emergency transport services, and so much more to maximize good outcomes. This experience gave me so much insight and encouraged me to pursue my interests in global women’s health but also to appreciate the training I’m ...


The University Of Iowa Residency Training Program In Obstetrics And Gynecology And Impact Of Recent State Abortion Legislation, Marygrace Elson Oct 2018

The University Of Iowa Residency Training Program In Obstetrics And Gynecology And Impact Of Recent State Abortion Legislation, Marygrace Elson

Proceedings in Obstetrics and Gynecology

Impact of state legislation on the University of Iowa residency progam in Obstetrics and Gynecology.


Let’S Talk About Sex History: Impact Of A Communication Curriculum On Medical Student Performance And Perceived Competency, Colleen K. Stockdale, John Kippes, Marcy Rosenbaum, Marygrace Elson Oct 2018

Let’S Talk About Sex History: Impact Of A Communication Curriculum On Medical Student Performance And Perceived Competency, Colleen K. Stockdale, John Kippes, Marcy Rosenbaum, Marygrace Elson

Proceedings in Obstetrics and Gynecology

Introduction: Communication in general, but especially regarding difficult topics such as sexual health is inadequately addressed in undergraduate medical education. Students often feel they are poorly trained in this area due to a lack of opportunities to practice taking sexual history. Thus, a communication curriculum was implemented to address this gap, including formal small group practice sessions on taking a sexual history during the Obstetrics and Gynecology (OB/GYN) clerkship.

Aim: Determine whether medical students who completed a sexual history communication curriculum performed better during a formal standardized patient based assessment (PBA) at the conclusion of the OB/GYN clerkship ...


Marygrace Elson, Md, Mme Oct 2018

Marygrace Elson, Md, Mme

Proceedings in Obstetrics and Gynecology

Dr. Marygrace Elson is a Clinical Professor of General Obstetrics and Gynecology at the University of Iowa Hospital and Clinics. She received a BA from the University of Illinois, an MD from the University of Illinois College of Medicine and completed a residency in Obstetrics and Gynecology at the University of Wisconsin Hospitals and Clinics. She received an MME from the University of Iowa Carver College of Medicine. Dr. Elson worked as a private practitioner in California and Illinois, before joining the University of Iowa Hospitals and Clinics to serve as a clinical physician and on the medical faculty. She ...


University Of Iowa Hospitals And Clinics Obstetrics And Gynecology Residency: Vital For Iowa Women, Abigail Mancuso Oct 2018

University Of Iowa Hospitals And Clinics Obstetrics And Gynecology Residency: Vital For Iowa Women, Abigail Mancuso

Proceedings in Obstetrics and Gynecology

I knew right away when I came to the University of Iowa Hospitals and Clinics for my residency interview that it was where I wanted to complete my training; and now that I am done with residency and continuing on in fellowship, I’ve never had one regret about choosing to come to Iowa. Iowa is a unique place – it is a nationally recognized program with faculty that are leaders in their fields, yet it is also a close-knit program where the trainees are treated with respect. The ObGyn residents receive well-rounded training and fortunately, many find that after 4 ...


Healthy Moms. Healthy Babies., Jennifer C. Steines Oct 2018

Healthy Moms. Healthy Babies., Jennifer C. Steines

Proceedings in Obstetrics and Gynecology

Healthy moms. Healthy babies. That's my goal as a board certified OB/GYN.

The University of Iowa, most specifically the Women's Health Department, will always remain a special place to me. I will forever be grateful for the knowledge I learned, the support I continue to receive, and for the camaraderie that we have in support of Women's health for all of Iowa.


Reflections On The University Of Iowa Department Of Obstetrics And Gynecology, Thaddeus L. Anderson Oct 2018

Reflections On The University Of Iowa Department Of Obstetrics And Gynecology, Thaddeus L. Anderson

Proceedings in Obstetrics and Gynecology

My association with the University of Iowa Department of Obstetrics and Gynecology began over 30 years ago as a fourth year medical student when I did a rotation on the High Risk Antepartum service. I am fortunate to have been trained by, and my care supported by, the University of Iowa Department of Obstetrics and Gynecology.


Colleen K. Stockdale, Md, Ms Sep 2018

Colleen K. Stockdale, Md, Ms

Proceedings in Obstetrics and Gynecology

Dr. Colleen K. Stockdale is a Clinical Professor of General Obstetrics and Gynecology at the University of Iowa Hospitals and Clinics. She received a BS in Nursing from Eastern Washington University, Post Baccalaureate Pre-Med at the University of Pennsylvania, MD from the Medical College of Pennsylvania, MS in Epidemiology from the University of Iowa, and completed a residency in Obstetrics and Gynecology at the University of Iowa Hospitals and Clinics. She has served as the Program Director for the Medical Student Clerkship and is now the Associate Residency Program Director. She is the Director of the Colposcopy Clinic and the ...


A Case Of Uterine Gangrene After Termination Of Second Trimester Pregnancy Complicated By Chorioamnionitis, Mohammed N. Salem, Ibrahim M. A. Hassanin, Ahmed M. Abbas Sep 2018

A Case Of Uterine Gangrene After Termination Of Second Trimester Pregnancy Complicated By Chorioamnionitis, Mohammed N. Salem, Ibrahim M. A. Hassanin, Ahmed M. Abbas

Proceedings in Obstetrics and Gynecology

Uterine gangrene is a rare event during pregnancy. Here, we report the case of a 22-year-old patient pregnant in her second trimester presenting with premature rupture of membranes and a low-lying placenta. Hysterotomy was done to evacuate the pregnancy. The procedure was complicated by hemorrhage so bilateral uterine arteries and the left internal iliac artery were ligated to control the bleeding. She continued to run a fever in spite of antibiotics and on the 11th postoperative day, the patient developed signs of septicemia. Abdominal re-exploration was done revealing a gangrenous uterus with signs of peritonitis. Subtotal hysterectomy was done ...


Relapsed Ovarian High-Grade Serous Carcinoma With Long-Term Survival Associated With Synchronous Primary Squamous Cell Carcinoma Of The Colon, Karla Sladoljev, Ena Perin, Ani Mihaljević Ferrari, Marko Klarić, Alemka Brnčić-Fischer, Senija Eminović, Danijela Vrdoljak-Mozetič, Emina Babarovic Sep 2018

Relapsed Ovarian High-Grade Serous Carcinoma With Long-Term Survival Associated With Synchronous Primary Squamous Cell Carcinoma Of The Colon, Karla Sladoljev, Ena Perin, Ani Mihaljević Ferrari, Marko Klarić, Alemka Brnčić-Fischer, Senija Eminović, Danijela Vrdoljak-Mozetič, Emina Babarovic

Proceedings in Obstetrics and Gynecology

High-grade serous ovarian cancer (HGSOC) is the most common and also the most aggressive subtype of ovarian cancer while squamous cell carcinoma (SCC) of the colon is an extremely rare histologic subtype of all colonic malignancies with poor prognosis.

Here we report a unique case of synchronous primary SCC of the colon and second recurrence of HGSOC in a patient with 15-years survival. Our patient developed two recurrent HGSOCs with disease-free survival time of five and nine years, respectively. The second recurrence of HGSOC was associated with the synchronous primary SCC of the ascending colon and was further complicated with ...


Prediction Of Preterm Birth With And Without Preeclampsia Using Mid-Pregnancy Immune And Growth-Related Molecular Factors And Maternal Characteristics, Laura L. Jelliffe-Pawlowski, Larry Rand, Bruce Bedell, Rebecca J. Baer, Scott P. Oltman, Mary E. Norton, Gary M. Shaw, David K. Stevenson, Jeffrey C. Murray, Kelli K. Ryckman Aug 2018

Prediction Of Preterm Birth With And Without Preeclampsia Using Mid-Pregnancy Immune And Growth-Related Molecular Factors And Maternal Characteristics, Laura L. Jelliffe-Pawlowski, Larry Rand, Bruce Bedell, Rebecca J. Baer, Scott P. Oltman, Mary E. Norton, Gary M. Shaw, David K. Stevenson, Jeffrey C. Murray, Kelli K. Ryckman

Stead Family Department of Pediatrics Publications

OBJECTIVE: To evaluate if mid-pregnancy immune and growth-related molecular factors predict preterm birth (PTB) with and without (±) preeclampsia.

STUDY DESIGN: Included were 400 women with singleton deliveries in California in 2009-2010 (200 PTB and 200 term) divided into training and testing samples at a 2:1 ratio. Sixty-three markers were tested in 15-20 serum samples using multiplex technology. Linear discriminate analysis was used to create a discriminate function. Model performance was assessed using area under the receiver operating characteristic curve (AUC).

RESULTS: Twenty-five serum biomarkers along with maternal age80% of women with PTB ± preeclampsia with best performance in women with ...


Patient Satisfaction And Oral Health-Related Quality Of Life Outcomes In Edentulous Patients Being Treated With Complete Dentures By Dental Students At The University Of Iowa College Of Dentistry And Dental Clinics, José Miguel García Loera Aug 2018

Patient Satisfaction And Oral Health-Related Quality Of Life Outcomes In Edentulous Patients Being Treated With Complete Dentures By Dental Students At The University Of Iowa College Of Dentistry And Dental Clinics, José Miguel García Loera

Theses and Dissertations

Objectives:

The aim of this study is to investigate the impact of multiple factors in the Oral Health Related Quality of Life of patients being treated with Conventional Complete Dentures, including: a) Level of expertise of the dental provider (third year dental student vs. fourth year dental student); b) Length of time edentulous; c) Number of previous prostheses; d) Race; e) Sex; f) Age; g) Systemic conditions; h) Condition of the bone ridge; i) Economic factor and insurance coverage, in patients at the University of Iowa College of Dentistry (D3 and D4 Clinics).

Materials and methods:

Eighty-one subjects who had ...