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Reproductive Toxicology, Robert L. Brent
Reproductive Toxicology, Robert L. Brent
Department of Pediatrics Faculty Papers
Summary
1. WEC has many useful scientific purposes.
2. You cannot utilize WEC to label a drug or chemical as a teratogen if the exposures utilized will result in embryonic or fetal death in vivo.
3. WEC can indicate that a drug or chemical is embryotoxic.
4. If the exposure level for clinical use of a drug or environmental exposure of a chemical is known, it should be used in WEC studies along with higher exposures as well.
5. You cannot predict that a drug is a cardiac teratogen from WEC when no cardiac malformations are observed, as in this …