Medicine and Health Sciences Commons^™

The Hif/Phf8/Ar Axis Promotes Prostate Cancer Progression., D Tong, Q Liu, G Liu, W Yuan, L Wang, Y Guo, W Lan, Dianzheng Zhang, S Dong, Y Wang, H Xiao, J Mu, C Mao, J Wong, J Jiang

PCOM Scholarly Papers

Recent studies provide strong evidence that the androgen receptor (AR) signaling pathway remains active in castration-resistant prostate cancer (CRPC). However, the underlying mechanisms are not well understood. In this study, we demonstrate that plant homeo domain finger protein 8 (PHF8 )interacts with and functions as an essential histone demethylase activity-dependent AR coactivator. Furthermore, we demonstrate that the expression of PHF8 is induced by hypoxia in various prostate cancer cell lines. Knockdown of either hypoxia-inducible factor HIF2α or HIF1α almost completely abolished hypoxia-induced PHF8 expression. Importantly, we observed that PHF8 is highly expressed in clinical androgen deprived prostate cancer samples and …

Pelvic And Breast Examination Skills Curricula In United States Medical Schools: A Survey Of Obstetrics And Gynecology Clerkship Directors, Lorraine Dugoff, Archana Pradhan, Petra Casey, John L Dalrymple, Jodi F Abbott, Samantha D Buery-Joyner, Alice Chuang, Amie J Cullimore, David A Forstein, Brittany S Hampton, Joseph M. Kaczmarczyk, Nadine T Katz, Francis S Nuthalapaty, Sarah M Page-Ramsey, Abigail Wolf, Nancy A Hueppchen

PCOM Scholarly Papers

BACKGROUND: Learning to perform pelvic and breast examinations produces anxiety for many medical students. Clerkship directors have long sought strategies to help students become comfortable with the sensitive nature of these examinations. Incorporating standardized patients, simulation and gynecologic teaching associates (GTAs) are approaches gaining widespread use. However, there is a paucity of literature guiding optimal approach and timing. Our primary objective was to survey obstetrics and gynecology (Ob/Gyn) clerkship directors regarding timing and methods for teaching and assessment of pelvic and breast examination skills in United States medical school curricula, and to assess clerkship director satisfaction with current educational strategies …

Phytochemicals As Novel Agents For The Induction Of Browning In White Adipose Tissue, Yusra Azhar, Ashish Parmar, Colette N Miller, Janaiya S Samuels, Srujana Rayalam

PCOM Scholarly Papers

Obesity and its associated metabolic syndrome continue to be a health epidemic in westernized societies and is catching up in the developing world. Despite such increases, little headway has been made to reverse adverse weight gain in the global population. Few medical options exist for the treatment of obesity which points to the necessity for exploration of anti-obesity therapies including pharmaceutical and nutraceutical compounds. Defects in brown adipose tissue, a major energy dissipating organ, has been identified in the obese and is hypothesized to contribute to the overall metabolic deficit observed in obesity. Not surprisingly, considerable attention has been placed …

Is Parathyroid Hormone (Pth) Replacement Therapy Effective In Treating Patients With Hypoparathyroidism?, Kaidden G. Kelly

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Is Parathyroid Hormone (PTH) replacement therapy an effective treatment for patients with hypoparathyroidism?”

STUDY DESIGN: Review of a randomized control trial published in 2011, a prospective cohort study published in 2013, and a randomized crossover study published in 2012.

DATA SOURCES: All articles used were published in English, and were found in peer-reviewed journals using PubMed.

OUTCOMES MEASURED: The need to remove supplemental calcium from the diet, the amount PTH was used to maintain a normal range, and the method of PTH …

Brief Compression-Only Cardiopulmonary Resuscitation Training Video And Simulation With Homemade Mannequin Improves Cpr Skills., Gregory K Wanner, Arayel Osborne, Charlotte H. Greene Phd

PCOM Scholarly Papers

BACKGROUND: Cardiopulmonary resuscitation (CPR) training has traditionally involved classroom-based courses or, more recently, home-based video self-instruction. These methods typically require preparation and purchase fee; which can dissuade many potential bystanders from receiving training. This study aimed to evaluate the effectiveness of teaching compression-only CPR to previously untrained individuals using our 6-min online CPR training video and skills practice on a homemade mannequin, reproduced by viewers with commonly available items (towel, toilet paper roll, t-shirt).

METHODS: Participants viewed the training video and practiced with the homemade mannequin. This was a parallel-design study with pre and post training evaluations of CPR skills …

Effects Of Anchor Structure And Glycosylation Of Fcî³ Receptor Iii On Ligand Binding Affinity, Ning Jiang, Wei Chen, Prithiviraj Jothikumar, Jaina M. Patel, Rangaiah Shashidharamurthy, Periasamy Selvaraj, Cheng Zhu

PCOM Scholarly Papers

Isoforms of the Fcγ receptor III (FcγRIII or CD16) are cell surface receptors for the Fc portion of IgG and important regulators of humoral immune responses. Different ligand binding kinetics of FcγRIII isoforms are obtained in three dimensions by surface plasmon resonance and in two dimensions by a micropipette adhesion frequency assay. We show that the anchor structure of CD16 isoforms isolated from the cell membrane affects their binding affinities in a ligand-specific manner. Changing the receptor anchor structure from full to partial to none decreases the ligand binding affinity for human IgG1 (hIgG1) but increases it for murine IgG2a …

Pcom Opportunities Academy 2016 Graduation Ceremony, Pcom Office Of Diversity And Community Relations

Diversity and Inclusion

Program for PCOM Opportunities Academy Graduation Ceremony, Inagural Class.

Master of Ceremonies: Meghan Cleghorn, JH, MBA, President of Cleghorn Performance Elevation LLC.

Keynote Speaker: Antonia Novello, MD, 14th Surgeon General of the United States.

Developing A Model System To Study The Mechanisms Of Resveratrol Inhibition Of Ar-V7 Transcriptional Activity, Sarah R. Wilson

PCOM Biomedical Studies Student Scholarship

Prostate cancer is one of the biggest threats to men’s health in the western world and it accounts for the second largest number of male cancer-related deaths in the United States. It is well established that prostate cancer cells depend on the androgen/androgen receptor pathway. Therefore, androgen deprivation therapy (ADT) has become the primary treatment option for prostate cancer. Patients with metastatic prostate cancer who receive (ADT) have shown increased quality of life. However, survival benefit with ADT is reduced dramatically in castration-resistant prostate cancer (CRPC). Androgen receptor (AR) continues to be functional in CRPC through various mechanisms. It is …

Mass Culturing Soil Bacteria From Radium Springs And Analysis Of Antibiotic Activity, Amanda Nguyen

PCOM Biomedical Studies Student Scholarship

Antibiotics have become a regularity in human life. Discovered accidentally, they proved to be vital to public health. Since then, they have become integrated into a variety of widely used products such as detergents, soaps, and clothes. Unfortunately, the overuse of antibiotics as a precautionary tool for the betterment of public health has led to an era in which bacterial strains have evolved resistance and antibiotics are becoming increasingly useless. For example, Enterococcus faecalis, one of six ESKAPE pathogens prevalent in nosocomial infections, is commonly found in the GI tract, but frequently causes infections leading to endocarditis, urinary tract infections, …

The Subjective Experience Of Mild Traumatic Brain Injury In Pediatric Patients, Ruta Clair, Mary Henigan, Sarah Allen, Katy Tresco

Research Day

Mild Traumatic Brain Injury is a neurologic insult that impacts a child’s functioning across domains. Risk factors include previous concussion history, force of impact, and gender. Current research regarding return to school following a brain injury suggests the need for accommodations in a number of areas of learning including changes in schedule, reduced exposure to screens and text, limitations to classroom expectations for tasks such as reading and note-taking, and modified testing. A one-size-fits-all approach to accommodations is problematic as recovery rates vary widely. Studies have also suggested that mood symptoms are comorbid with concussion recovery. Further, pediatric concussion patients …

The Effectiveness Of Coenzyme Q1 And Q10 In Mitigating Myocardial Reperfusion/Ischemia (Mi/R) Injury, Myles Ashitey, Jakob Sutton, Joseph Venditto, Kevin Kucharski, Jason Robbie, Daniel Kuo, Robert Barsotti, Lindon Young, Qian Chen

Research Day

Mitochondria may be a principle source of oxidative stress causing MI/R injury. Coenzyme Q10 (CoQ10) is essential for electron transport in normal mitochondria, has antioxidant properties but its bioavailability is likely reduced due to oxidative stress during MI/R. Coenzyme Q1 (CoQ1) is a derivative of CoQ10, but is a more potent antioxidant than CoQ10 due to a shorter isoprene chain. We hypothesize that CoQ1 will exhibit better cardioprotective effects during MI/R. CoQ1 (MW=250 g/mol; 20 μM, n=5) and CoQ10 (MW=863 g/mol; 20 μM, n=5) were given at reperfusion in isolated rat hearts subjected to I (30 min)/R (45 min). We …

Protein Kinase C (Pkc) Delta Activation Negatively Regulates Phorbol 12-Myristate 13-Acetate (Pma) Induced Superoxide (So) Release In Polymorphonuclear Leukocytes (Pmns), Stephanie Liu, Stephanie Percy, Samuel Johannson, Christine Adekayode, Gregory Stoner, Amelie Bottex, Jovan Adams, Robert Barsotti, Qian Chen

Research Day

It’s known that PMA is a broad-spectrum PKC activator that augments SO release in PMNs viaNADPH oxidase activation. It was shown that PKC delta (δ) negatively regulates PMN elastase release which suggests that PKC δ may also negatively regulate PMN NADPH oxidase SO release. To test the hypothesis, we altered PKC δ activity using selective cell permeable PKC δ activator, inhibitor peptides, and rottlerin, another type of PKC δ inhibitor. We predict that PKC δ activation would attenuate PMA-induced PMN SO release, whereas PKC δ inhibition would augment the response. Isolated PMNs (5x106) from male Sprague-Dawley rats were incubated in …

Financial Toxicity: A Side Effect Of Radiation Therapy For Cancer?, Tejash Patel, Joshua Palmer, Harriet Eldredge-Hindy, John Smyles, Jessie Dinome, Usha Babaria, Richard Stabile, Eric Gressen, Shari Rudoler, Scot Fisher

Research Day

The field of oncology is ever-changing, as new treatment options become available and treatment plans are unceasingly optimized. While the US remains at the forefront of medical innovation and treatment options for serious and complex conditions such as cancer, costs for cancer care are extremely high and continue to increase. Modern healthcare does not come without a price, and medical expenses can have a profound economic impact on American households. Nearly half of bankruptcy filings are in some way a result of medical expenses. While recent healthcare initiatives have increased access to care, many remain underinsured while facing increasing copayments …

Cadaveric And Chart Retrospective On Shoulder Variation: Morphology And Pain, Jeff Capone, Kerin M. Claeson, Lauren Noto-Bell

Research Day

Osteopathic Manipulative Treatment (OMT) is a category of several types of manual techniques used by osteopathic physicians. According to the osteopathic tradition, structure and function are intimately related. This project examined the relationship between shoulder structure and function in an osteopathic framework, with a specific goal to understand how the structure of the acromion affects the development of shoulder injuries. For the first part of this project, cadaveric dissections were performed and muscle diameters were taken of structures within the subacromial space. The second part of this project assessed the efficacy of OMT in shoulder somatic dysfunction for patients treated …

Pharmdigest Volume 2, Issue 3, Philadelphia College Of Osteopathic Medicine, School Of Pharmacy

PharmDigest

This issue of the Pharmacy Student Council newsletter includes the following articles:

• A Year in Review
• Impacting Patient Care
• Getting Your Voice Heard
• 10 Reasons to Counsel
• The Daily Dose: Residency
• AMCP Out West
• Dinner with a Pharmacist
• Introducing... [2016-2017 Pharmacy Student Council]

I Am The Dream 2016, Pcom Office Of Diversity And Community Relations

Diversity and Inclusion

Program for the 2016 event I am the Dream: the Past, Present and Future at Philadelphia College of Osteopathic Medicine. Consists of the Dr. Martin Luther King, Jr. Award Ceremony and William M. King, DO '62 Award Presentation.

Mistress of Ceremonies: Megan Cleghorn, JD, MBA

Awardees: Judith A. Lightfoot, DO ‘92, FACOI; Barbara Williams-Page, DO ‘92; Yuma Iannotti Tomes, PhD, ABA; Olivia Menardy (DO ‘16); Michael Stefanowicz (DO ‘16); Jameel Shareef (DO ‘16); J. Steven Blake, DO ’89, MSc; Israel D. Benjamin (DO ‘19)

Diversity Speakers Series: Leadership In Medicine, Oliver Bullock, Pcom Office Of Diversity And Community Relations

Diversity and Inclusion

Program for "Leadership in Medicine" by Oliver Bullock, DO '78, OJ Snyder Memorial Medal Reipient

2016 Founders' Day, Philadelphia College Of Osteopathic Medicine

Founders Day Programs

The 2016 Founders Day OJ Snyder Memorial Medal recipient was Richard Pascucci DO '75. The Philadelphia Campus Mason W. Pressly Memorial Medal Recipient was Zachary Herrman (DO '16). The Georgia campus Mason W. Pressly Memorial Medal Recipient was Jessica Mormando (DO '16).

Digest Of The Philadelphia College Of Osteopathic Medicine (Winter 2015-2016), Philadelphia College Of Osteopathic Medicine

Digest

The Winter 2015/2016 issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Message from the President
• PCOM Updates
• Inauguration of the eighth President, Jay S. Feldstein, DO '81
• Trained for Trauma Care: PCOM Alumni Were Well Prepared to Treat the Mass Casualties of May's Amtrak Derailment
• Remembering Camille DiLullo, PhD, Professor of Anatomy
• Class Notes
• My Turn

Synapsis: Philadelphia Campus 2016, Philadelphia College Of Osteopathic Medicine

All Yearbooks

No abstract provided.

Adolescent Attitudes Toward And Perceptions Of Suicide, Stigma, And Help-Seeking Behavior, Julia M. Hollinger

PCOM Psychology Dissertations

Suicide is a leading cause of death for adolescents and represents a major national health concern (American Foundation for Suicide Prevention, [AFSP], 2015; (Centers for Disease Control [CDC], 2013). Because adolescents spend the majority of their day at school (Erbacher, Singer, & Poland, 2015), the effectiveness of school-based suicide prevention programs may be improved through better understanding of adolescents’ views on the subject of suicide and the factors that may influence participation in prevention efforts. The present study explored the attitudes and perceptions of seventh grade students from a suburban middle school in Pennsylvania, using archival survey data. Variables that …

The Effects Of A Trauma-Informed Care Training Program On Mental Health Professionals Knowledge, Skills, And Attitudes With The Smi, Angelina Pelletier

PCOM Psychology Dissertations

Trauma has been found to be highly prevalent among individuals diagnosed with SMIs. Mental health professionals have been reported to misdiagnose or avoid addressing trauma in this population. There is a need to provide information about trauma and to foster awareness among mental health professionals who are treating individuals diagnosed with SMIs. With a TIC approach, operating from a recovery-oriented philosophy, there have been interventions created to address trauma and SMIs with the aim of developing awareness about trauma and the impact it may have on someone’s life. With these factors in mind, mental health professionals should be competent in …

Effects Of Nox-1 Inhibition On Real-Time Blood Nitric Oxide And Hydrogen Peroxide In Acute Hyperglycemia, Ashley Mawhinney

PCOM Biomedical Studies Student Scholarship

Hyperglycemia has been associated with vascular endothelial dysfunction in part by a reduction in nitric oxide (NO) production and increased oxidative stress (e.g., increased superoxide (SO) and hydrogen peroxide (H₂O₂). Endothelial-derived NO can be significantly reduced by increased SO/H₂O₂ in part by the activation of NADPH oxidase during hyperglycemia. Of the 7 NADPH oxidase isoforms, NADPH oxidase isoform 1 (NOX1) is mainly expressed in the vasculature and may play a major role in hyperglycemia induced oxidative stress and vascular endothelial dysfunction. This hypothesis was tested by measuring blood NO and H2O2 levels in …

The Relationship Of Chlamydia Antigen, Ad-Like Pathology, And Inflammation In The Brains Of Intranasally Infected Balb/C Mice, Brittany L. Kane

PCOM Biomedical Studies Student Scholarship

Alzheimer's' Disease (AD) is a progressive neurodegenerative disease that affects millions of elderly individuals in the western world. There are two forms of AD, sporadic late-onset AD and Familial AD. The neuropathy seen in both cases of AD is the same; neurofibrillary tangles (NFTs) that are composed of modified tau protein, and neuritic senile plaques (NSPs) composed of deposited beta amyloid peptide. The objective of this study is to continue to investigate the role of infection as a possible risk factor for sporadic AD. Previous mouse models using Chlamydia pneumoniae demonstrated that intranasal inoculation with this organism induced AD-like pathology …

Investigating The Roles Of Zinc-Binding Protein (Zbp-89) And Rela (Nfkb-P65) In The Regulation Of Matrix Metalloproteinase 1 (Mmp1) Gene Expression, Nelly Khaselev

PCOM Biomedical Studies Student Scholarship

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases with the unique ability to breakdown virtually the entire extracellular matrix (ECM). Through ECM remodeling, MMPs play an important role in normal development, tissue repair, angiogenesis, and apoptosis. Studies have shown that unregulated MMP expression plays a role in many cancers and chronic inflammatory diseases. Previous research has used gene sequence analysis ofthe MMP-1 promoter to identify a putative ZBP-89 binding site at -1969 bp. Chromatin immuneprecipitation experiments showed that both ZBP-89 and Re!A (p65) could bind to this binding site. In this thesis research, transfection experiments were used to explore …

Effects Of Hormonal Withdrawal On Prostate Cancer Progression, Jacqueline Chakrya So

PCOM Biomedical Studies Student Scholarship

Prostate cancer, or prostatic carcinoma (PrCa), is the second leading cause of cancer-related deaths in men in the Western world. One in seven men are expected to be diagnosed with the disease in the United States. Suppressing androgen/androgen receptor pathway is a first-line therapeutic treatment known as Androgen Deprivation Therapy (ADT). Most patients respond well to ADT, but an overwhelming majority of PrCa progress to an advanced stage of PrCa independent of hormone, known as Castration Resistant Prostate Cancer (CRPC). There is currently no known cure for CRPC. In this study, the androgensensitive LNCaP cells served as an in vitro …

Is Brimonidine Tartrate Gel .5% Effective In Reducing Facial Erythema Of Rosacea?, Meeta Aggarwal

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective Evidence Based Medicine (EBM) review is to determine whether or not “Is Brimonidine Tartrate gel 0.5% effective in reducing facial erythema of Rosacea?”

STUDY DESIGN: Review of two randomized controlled trials (RCT), and one 1-year longitudinal open-label study.

DATA SOURCES: All studies were published in peer-reviewed journals found via the use of PubMed or Medline.

OUTCOMES MEASURED: Patients were divided into two groups: those who received the Brimonidine Tartrate gel and those who received the vehicle (placebo) gel. Efficacy of Brimonidine tartrate gel was compared to the efficacy of the vehicle gel. Outcomes were …

Does Routine Use Of Medical Cannabis (Marijuana) Decrease The Intensity Of Chronic Neuropathic Pain In Adults?, Ben Arpin

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM was to investigate the question, “Does routine use of medical cannabis (marijuana) decrease the intensity of neuropathic chronic pain in adults?

STUDY DESIGN: systematic review of 3 English language primary studies, published between 2005 and 2009.

DATA SOURCES: Three Randomized Controlled Trials (RTC’s) published on or after 2005 were selected based on their relevance to the proposed question via PubMed. All three RTC’s compared cannabis use vs. placebo for chronic neuropathic pain, with two RTC’s focusing on HIV neuropathic pain and the third focusing on MS.

OUTCOMES MEASURED: The outcomes measured in these …

Does Nebulized Hypertonic Saline Solution Decrease Hospital Admission Rates When Compared To Nebulized Normal Saline In Children Less Than Or Equal To 24 Months Old With Bronchiolitis?, Korie Alecxih

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not nebulized hypertonic saline solution reduces hospital admission rates when compared to nebulized normal saline solution in children less than or equal to 24 months of age diagnosed with acute bronchiolitis in the emergency department setting.

STUDY DESIGN: Systematic review of three randomized, double-blind, placebo controlled trials in the English language all published in 2014.

DATA SOURCES: Data sources obtained for this review were articles published in peerreviewed journals found using PubMed Database.

OUTCOMES MEASURED: The outcome measured was hospital admission rate. Hospital admission rate is calculated …

Is Viscosupplementation Effective In Reducing Osteoarthritis Knee Pain?, Amalia Antonoplos

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not viscosupplementation is effective in reducing osteoarthritis knee pain

STUDY DESIGN: Review of three randomized, double blind, placebo control trials between 2009- 2010

DATA SOURCES: Three randomized, double blind, placebo control trials were found via PubMed and NCBI

OUTCOMES MEASURED: Each randomized control trial measured knee pain and/or patient satisfaction following their intervention (placebo or hyaluronic acid) in patients with knee osteoarthritis, which was measured via WOMAC pain scale and patient global assessment forms.

RESULTS: (P<0.05) for change in pain at 14-26 weeks after injection (NNT=6- 8 for Chevalier et al and 4 for Kul-Panza & Berker). Patient satisfaction was higher in the experimental groups as compared to the control with conclusions of NNT between 11 and 20 for Chevalier et al and Kul-Panza & Berker respectively. Chavelier et al found adverse events such as arthralgias and joint effusion in <10% of their study population (NNH=39). No dichotomous data was presented in Diacoglu et al; however an ANOVA was deemed statistically significant (p<0.01).

CONCLUSION: Review of these articles concludes that the use of hyaluronic …