Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Northern Michigan University

Theses/Dissertations

Articles 1 - 30 of 77

Full-Text Articles in Medicine and Health Sciences

The Impact Of Brief Electronic Guided Mindfulness Meditation On Anxiety Scores, Sierra King Feb 2024

The Impact Of Brief Electronic Guided Mindfulness Meditation On Anxiety Scores, Sierra King

DNP Scholarly Projects

In the United States, anxiety rates are on the rise for the general population (Goodwin et al., 2020a). Prolonged and frequent anxiety can become unprompted and problematic (American Psychiatric Association, 2021). Management of anxiety is crucial for overall wellbeing. Access to treatment and resources for anxiety may be limited in rural geographical locations (Morales et al., n.d.). This DNP project sought to determine whether a brief intervention of electronic guided mindfulness meditation (MM) by Insight Timer is effective in decreasing anxiety in a rural populous. Convenience sampling recruited a final total of 11 rural participants who participated in seven sessions …


Effects Of Static Versus Dynamic Cupping On Ankle Dorsiflexion, Alexandria N. Schaub Aug 2023

Effects Of Static Versus Dynamic Cupping On Ankle Dorsiflexion, Alexandria N. Schaub

All NMU Master's Theses

PURPOSE: Cupping therapy involves lifting and separating fascial tissue to facilitate stretching and promote blood flow. Although cupping is a common treatment modality for pain, studies are inconsistent in regards to whether cupping improves other outcomes, like range of motion. Possessing a limited range of motion can lead to musculoskeletal injury. The aim of this research is to determine the acute effect of different methods of cupping therapy on ankle dorsiflexion. METHODS: A total of 35 healthy adults (age: 22.1±4.52 years) with an average ankle ROM of 34.68±4.22° at baseline were included in the study. Participants were randomly …


Effect Of Covid-Protocols On Athletic Training Burnout, Harrison C. Garcia Apr 2023

Effect Of Covid-Protocols On Athletic Training Burnout, Harrison C. Garcia

All NMU Master's Theses

Burnout is a psychological condition consisting of emotional exhaustion, depersonalization, and a decreased sense of personal accomplishment and identity. Since the start of the pandemic, a significant increase in burnout has been reported by healthcare professionals, however, there is little known regarding the experiences of athletic trainers (ATs). PURPOSE: The purpose of our study was to investigate the association between burnout and COVID-19 related factors among ATs. METHODS: An electronic survey grouped by the Maslach Burnout Inventory – Human Services Survey, COVID-19 related workplace policies, and demographics was sent to 1,000 ATs through the National Athletic Trainer’s Association email listserv; …


Concussion And Mental Health: Case Series, Haley M. Clark Aug 2022

Concussion And Mental Health: Case Series, Haley M. Clark

All NMU Master's Theses

Concussion is the most common traumatic brain injury in the United States, and is thought to lead to adverse effects on mental health. No studies to date have examined mental health throughout concussion recovery. This project examined the effect of concussion on three aspects of mental health: anxiety (Hamilton Anxiety Rating Scale), depression (Beck’s Depression Inventory), and aggression, (Buss-Perry Aggression Questionnaire) at three time points (baseline, mid-season, and postseason) and if the athlete had a concussion, they completed the questionnaire once upon diagnosis, bi-weekly until return-to-play, and bi-weekly for two weeks after being cleared for participation. Each concussion showed an …


Management Of Youth Sport-Related Concussion By Urban And Rural Practitioners: A Pilot Study, Brett R. Fox Aug 2022

Management Of Youth Sport-Related Concussion By Urban And Rural Practitioners: A Pilot Study, Brett R. Fox

All NMU Master's Theses

Sport-related concussions (SRC) occur at alarming rates among high school athletes (ages 13-18), which made the Center for Disease Control and Prevention and other agencies classify it as an “epidemic”. If improperly managed, physical, mental, and emotional consequences can occur for SRC patients. Due to these consequences all 50 states in the US have passed legislation requiring medical release from a practitioner before a student-athlete can return to athletics following an SRC, yet there is no universally accepted consensus on how to medically manage this common injury. A 22-item, validated survey was distributed to Michigan practitioners who sign off on …


Effects Of Education On Correcting Misconceptions And Acceptance Of The Influenza Vaccination Among A College Campus, Travis E. Fairbanks Jul 2022

Effects Of Education On Correcting Misconceptions And Acceptance Of The Influenza Vaccination Among A College Campus, Travis E. Fairbanks

DNP Scholarly Projects

Educating patients on the influenza vaccination is an important goal for health care providers. It fosters a working relationship between provider and patient and allows patients to make an informed decision on their health care needs. The percentage of individuals who receive the influenza vaccine in the United States has been consistently below goals set by the committee for Healthy People 2020. This DNP scholarly project aimed to determine whether the introduction of education was effective at increasing individuals’ choice to vaccinate against the influenza virus among college campus students. The study was a non-experimental, non-randomized control trial that utilized …


Implementing Faculty Development Modules To Increase Readiness For Addressing Social Determinants Of Health, Implicit Bias And Equity In Course Content, Claudia Ngafeeson Jul 2022

Implementing Faculty Development Modules To Increase Readiness For Addressing Social Determinants Of Health, Implicit Bias And Equity In Course Content, Claudia Ngafeeson

DNP Scholarly Projects

Implicit bias is viewed as an unconscious and involuntary attitude that lies below the surface of consciousness but can influence behavior, and cognitive processes (Maina et al., 2018). Social determinants of health are considered to be the conditions in which people are born, grow, live, work, and age; these circumstances are usually shaped by the distribution of money, power, and resources at global, national, and local levels, which in turns determines the distribution of the value of medical care. Existing literature on implicit bias has been fragmented in different fields such as; cognitive psychology, business ethics, and higher education, but …


Implementation Of An Advanced Operating Room Schedule To Increase Compliance With Clinical Practice Guidelines For Preoperative Antibiotic Selection And Timing: A Quality Improvement Project, Shelby Lynne Adams Jul 2022

Implementation Of An Advanced Operating Room Schedule To Increase Compliance With Clinical Practice Guidelines For Preoperative Antibiotic Selection And Timing: A Quality Improvement Project, Shelby Lynne Adams

DNP Scholarly Projects

Surgical site infection (SSI) is a major cause of morbidity and mortality in operative patients worldwide. The American Society for Health-System Pharmacists (ASHP) published the most recent clinical practice guidelines for antimicrobial prophylaxis in surgery. These guidelines are based upon the available evidence and provide a standardized approach for the safe and effective selection, dosing, and administration of antibiotics for the prevention of SSI (Bratzler et al., 2013). This Doctor of Nursing Practice (DNP) project aimed to determine if incorporating an advanced operating room (OR) schedule, inclusive of ASHP presurgical antibiotics, increased compliance with ASHP standards of antibiotic selection and …


Effects Of Evidence-Based Discharge Instructions On Follow-Up With A Healthcare Provider In Patients Presenting With Mtbi-Like Symptoms To A Health Clinic At A Rural Sports Camp In The Pacific Northwest In The U.S., Eva G. Bergner May 2022

Effects Of Evidence-Based Discharge Instructions On Follow-Up With A Healthcare Provider In Patients Presenting With Mtbi-Like Symptoms To A Health Clinic At A Rural Sports Camp In The Pacific Northwest In The U.S., Eva G. Bergner

DNP Scholarly Projects

Mild traumatic brain injury (mTBI) is a major public health burden affecting both children and adults in the U. S. (Sarmiento et al., 2019; Schuchat, Houry, & Baldwin, 2018). The management of mTBI at summer camps is not well characterized in the literature. Epidemiologic studies on summer camps have reported that 25% of all injuries were to the head, face and/or neck (Kolberg et al., 2020; Robinson, Arbogast, Garst & Corwin 2019). The purpose of this project was to evaluate the impact of evidence-based instructions for follow-up with a healthcare provider in patients presenting with mTBI-like symptoms to a health …


A Systematic Review: The Effect Of Prophylactic Braces On Reducing Risk Factors Related To Acl Injury In Athletes, Zak Linczeski Apr 2022

A Systematic Review: The Effect Of Prophylactic Braces On Reducing Risk Factors Related To Acl Injury In Athletes, Zak Linczeski

All NMU Master's Theses

Purpose: Anterior cruciate ligament (ACL) injuries are one of the most common sports-related injuries as they account for around 100,000 injuries per year. This study sought to review research on prophylactic knee bracing (PKB) for the reduction of the risk factors related to injury of the ACL.

Methods: An extensive search of articles from 1990-2021 was performed with inclusion criteria of no previous ACL injury, no knee injury or surgery in the past 6 months, the use of a hinged knee brace, and use of kinetic, kinematic, and proprioceptive variables. All studies underwent a PEDro score evaluation to determine article …


Increase In 1rm Back Squat After Abdominal Stabilizing Maneuvers, Caro Els Apr 2022

Increase In 1rm Back Squat After Abdominal Stabilizing Maneuvers, Caro Els

All NMU Master's Theses

Increasing intra-abdominal pressure (IAP) during free weight exercises can protect the lumbar spine from excess movement; a cause of lower back pain. Abdominal bracing (AB) and abdominal hollowing (AH) are two stabilizing maneuvers that increase IAP. Previous literature primarily compared AH and AB in therapy settings on bodyweight single joint movements. The effect of AB and AH during a multi-joint movement involving a maximum or near maximum external load is unknown. The purpose of this study was to compare the effect of AB and AH on lower limb muscle activity and the maximum amount of external weight lifted during a …


Reducing Central Line-Associated Bloodstream Infections At A Rural Midwestern Hospital Through An Evidence-Based Nurse-Led Practice Change Intervention, Crystal B. Lavalley Apr 2022

Reducing Central Line-Associated Bloodstream Infections At A Rural Midwestern Hospital Through An Evidence-Based Nurse-Led Practice Change Intervention, Crystal B. Lavalley

DNP Scholarly Projects

Central line-associated bloodstream infections (CLABSIs) are responsible for increased patient morbidity, mortality, and healthcare costs, despite being a preventable harm (Barnes et al., 2015; Furuya et al., 2016). Evidence-based (EB) research suggests that the use of central line bundles is the most effective way to reduce CLABSIs in hospitals (Barnes et al., 2015; Furuya et al., 2016). Researchers have also found a statistically significant correlation between nurse compliance with bundle components and CLABSI rates (Aloush & Alsaraireh, 2018; Furuya et al., 2016). The purpose of this study was to determine if a nurse-led collaborative that focused on CLABSI reduction using …


The Impact Of Early Goal Directed Sepsis Bundle Sets In The Emergency Department And The Impact Of Sep-1 Compliance Rates, Christie L. Ferrari Mar 2022

The Impact Of Early Goal Directed Sepsis Bundle Sets In The Emergency Department And The Impact Of Sep-1 Compliance Rates, Christie L. Ferrari

DNP Scholarly Projects

Sepsis is a medical emergency that is prevalent throughout hospitals everywhere. Due to the growing crisis, the Centers for Medicare and Medicaid Services (CMS) in collaboration with the Surviving Sepsis Campaign (SSC) adopted core measures for sepsis (SEP-1) which aim at improving overall compliance of evidence-based treatment standards for sepsis. The purpose of this Doctor of Nursing Practice (DNP) project was to determine if incorporating early goal directed sepsis bundles in a rural Midwestern ED was effective in increasing compliance with SEP-1 rates. The secondary purpose evaluated how nursing knowledge, awareness, and compliance with sepsis bundles affects SEP-1 compliance rates. …


Implementation Of An Evidence-Based Bundle To Reduce Hospital Acquired Pressure Injury Harm Rates In The Intensive Care Unit: A Quality Improvement Project, Jessica Tripp Mar 2022

Implementation Of An Evidence-Based Bundle To Reduce Hospital Acquired Pressure Injury Harm Rates In The Intensive Care Unit: A Quality Improvement Project, Jessica Tripp

DNP Scholarly Projects

A pressure injury (PI) is a condition in which prolonged pressure or shear causes localized damage to the soft tissue and skin and is usually over a bony prominence (National Pressure Ulcer Advisory Panel (NPUAP), 2016). PIs can increase morbidity and mortality, increase length of stay, increase infection rates, increase healthcare costs and decrease quality of life (Agency for Healthcare Research and Quality (AHRQ), n.d.; Coyer et al., 2017). PIs are largely preventable yet continue to occur, despite the growing number of high-quality research articles that focus on this problem. Quality improvement initiatives are an effective way to translate evidence-based …


Evaluation Of A Hands-On Cooking Class And Its Effects On Self-Efficacy In Relation To Healthy Eating In Type 2 Diabetics, Codi A. Jenshak-Gorzinski Mar 2022

Evaluation Of A Hands-On Cooking Class And Its Effects On Self-Efficacy In Relation To Healthy Eating In Type 2 Diabetics, Codi A. Jenshak-Gorzinski

DNP Scholarly Projects

The prevalence of Type 2 diabetes is alarming and poses a great threat to U.S. national health. Chronic diabetes can lead to serious conditions such as heart attack and stroke, and can result in premature mortality (World Health Organization, 2018). Diabetes can be prevented or treated by eating a healthy diet. Cooking classes are a potential way to improve American’s knowledge of nutritional principles and help them become confident that they have the capacity to eat a healthy diet. The purpose of this DNP project was to determine if participation in cooking classes enhanced self-efficacy as it pertains to healthy …


Utilization Of The Calm Apparatus To Adult Men And Women With Atrial Fibrillation To Decrease Emergency Department Visits For Atrial Fibrillation, Ami Klein Feb 2022

Utilization Of The Calm Apparatus To Adult Men And Women With Atrial Fibrillation To Decrease Emergency Department Visits For Atrial Fibrillation, Ami Klein

DNP Scholarly Projects

The purpose of this project is two-fold. The first is to determine if the CALM APP use by adult men and women with atrial fibrillation (AF) will decrease anxiety. The second is to determine if decreased anxiety utilizing the CALM APP will deter admissions to the emergency department (ED) for AF in the first month post-catheter ablation of AF. The Zung SAS was used to determine the pre- and post-anxiety scores. The Seven Days of Calm (free app) was used to teach deep breathing and meditation. This study showed a moderate decrease in ED visits with use of the Calm …


Representation Matters: An Examination In To How The Patient Experience Is Impacted By The Inclusion Of Sexual Orientation And Gender Identity Questions On A Health History Intake Form, Meghan N. Digneit Jan 2022

Representation Matters: An Examination In To How The Patient Experience Is Impacted By The Inclusion Of Sexual Orientation And Gender Identity Questions On A Health History Intake Form, Meghan N. Digneit

DNP Scholarly Projects

The disclosure of one’s sexual orientation and gender identity (SOGI) status is an extremely personal decision subject to a variety of internal and external factors. The disclosure of this status in the healthcare setting is an important topic that continues to be subject to discussion, research, education, and mutual understanding between the patient and provider. The purpose of this DNP project is to explore how answering SOGI questions on a general intake form impacts patient attitudes regarding the impending visit. This was a mixed-methods research study that included demographic questions, nominal data in the form of yes/no questions, and two …


Coordination Variability And Injury Risk In Experienced Collegiate Dancers, Emily Klinkman Oct 2021

Coordination Variability And Injury Risk In Experienced Collegiate Dancers, Emily Klinkman

All NMU Master's Theses

Dance is a sport that places a number of physical demands upon the human body, and injuries are a common occurrence in the sport. While it has not yet been linked to dance-related injury, coordination variability (CV) is a measure of how much movement strategy changes between repetitions of a task and low levels of CV have been linked to injury in other sports. This study aimed to determine the relationship between CV and dance injury in collegiate dancers. Eight (8) undergraduate student subjects were recruited from the dance major and minor, BFA major and minor, and recreational dancers who …


Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell Jul 2021

Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell

All NMU Master's Theses

Anxiety and anxiety related disorders are increasing at a drastic rate in the past decade, with the NIMH reporting that 31.1% of U.S. adults will experience an anxiety disorder at some point in their lives. Anxiety is commonly characterized by increased attention bias to threat. Attention Bias Modification (ABM) is a new treatment used to reduce individual’s attention bias towards threat. The extent to which ABM leads to underlying neural changes is still unknown. The cerebellum is a neglected brain structure, with new research provides evidence that cerebellum’s functional connectivity and shared networks with threat processing regions has a direct …


The Impact Of Participation In A Mentored Cycling Program, Dana Bolduc Jun 2021

The Impact Of Participation In A Mentored Cycling Program, Dana Bolduc

DNP Scholarly Projects

Physical activity (PA) has the potential to have a positive impact on mental health conditions such as anxiety, depression and self-esteem. In particular, this project focused on self-esteem because low self-esteem can lead to increased risk of developing anxiety or depression. In contrast, high self-esteem can have a protective effect against anxiety and depression. Group PA programs combined with mentorship have been shown to build relationships and enhance self-esteem. The purpose of this DNP project was to determine the impact of participation in a rural midwestern, mentored cycling program on self-esteem in an at-risk adolescent population. Self-esteem was measured using …


The Physiological Effects Of Therapy Dogs During Exercise For Sedentary Adults, Josie Lynne Mazzone May 2021

The Physiological Effects Of Therapy Dogs During Exercise For Sedentary Adults, Josie Lynne Mazzone

All NMU Master's Theses

Previous research has shown therapy dogs may be utilized to attenuate heart rate (HR) and blood pressure (BP) responses during various types of stressors due to an increase in oxytocin (OT) and decrease in cortisol (CL) production. These hormonal changes have also been shown to enhance exercise performance. Purpose: This study aimed to determine if physiological responses to exercise changed in the presence of a therapy dog for sedentary adults. Methods: Seven adult subjects (mean age of 30.86 ± 14.07 years) who self-reported less than 150 min of physical activity per week participated in a graded walking test with a …


Nitroglycerin Safety In Inferior St Elevation Myocardial Infarction (Stemi) Patients: A Retrospective Review, Olivia Montgomery May 2021

Nitroglycerin Safety In Inferior St Elevation Myocardial Infarction (Stemi) Patients: A Retrospective Review, Olivia Montgomery

DNP Scholarly Projects

Nitroglycerin (NTG) is medication used to reduce chest pain (Boden et al., 2015) and is the suggested analgesic for angina associated with ST elevation myocardial infarction (STEMI) (de Alencar Neto, 2018). Due to the potential for right ventricular (RV) infarct and hemodynamic collapse in inferior STEMI patients (Nagam, Vinson, & Levis, 2017), the American Heart Association (AHA) recommends avoidance of NTG in patients with suspected RV infarct (Antman et al., 2004). The purpose of this DNP project was to explore the safety of NTG use in the treatment of patients diagnosed with STEMI by evaluating the effects of NTG on …


An Examination Of The Impact Of Health Literacy Assessment On Incarcerated Individuals With A Diagnosis Of Type 2 Diabetes, Josi Rotunno May 2021

An Examination Of The Impact Of Health Literacy Assessment On Incarcerated Individuals With A Diagnosis Of Type 2 Diabetes, Josi Rotunno

DNP Scholarly Projects

Low health literacy levels limit healthcare outcomes in a variety of diagnoses. Having a low health literacy level can significantly impact an individual’s ability to manage their condition. Among these individuals are incarcerated individuals, who are especially vulnerable to low health literacy levels. Due to regulations of the correctional facility, along with the vulnerability of the population, it is often difficult to get approval for studies and to make changes within this setting[TMD1] . The stigma of incarceration, along with the difficulty in navigating the correctional setting regulations, often create barriers to making changes that could improve the health …


Evaluating Soluble Axl As A Biomarker For Glioblastoma, Daniel Raymond Aug 2020

Evaluating Soluble Axl As A Biomarker For Glioblastoma, Daniel Raymond

All NMU Master's Theses

AXL, a receptor tyrosine kinase, is known to promote malignant phenotypes in various types of cancer. AXL overexpression is commonly observed in glioblastoma and correlates with a worse prognosis. Detectable in most biological fluids, the extracellular domain of AXL, sAXL, is the product of enzymatic cleavage by ADAM10/17. Here we used ELISA, BCA and BCG assays to characterize blood serum from 23 newly diagnosed GBM patients which was collected roughly 24 hours before and after surgery as well as every three months post-surgery, corresponding to follow-up treatment visits. Immunoblotting was used to determine relative AXL expression in 13 patient tumor …


The Physiological And Psychological Effects Of Indoor Versus Outdoor Aerobic Exercise In Female Cancer Survivors: A Literature Review, Emily Ferroni May 2020

The Physiological And Psychological Effects Of Indoor Versus Outdoor Aerobic Exercise In Female Cancer Survivors: A Literature Review, Emily Ferroni

All NMU Master's Theses

Moderate aerobic exercise is advantageous to physiological and psychological well-being among healthy and diseased populations. Investigating the physiological and psychological effects of indoor and outdoor aerobic training on ROS, antioxidants, QOL, vitamin D, estrogen, kynurenine, cardiovascular disease, obesity, and the immune system within cancer patients and survivors may be imperative to their recovery and survival. Outdoor aerobic exercise within a greenery-rich environment elicits greater positive changes within overall well-being compared to outdoor exercise in an urban setting or indoor exercise. However, both indoor and outdoor aerobic exercise produce benefits in mood state, the immune system, cardiovascular health, bone health, and …


Effectiveness Of An Aquatic Exercise Program For Reducing Weight, Body Fat And Chronic Low Back And Joint Pain, Terilyn Darley Apr 2020

Effectiveness Of An Aquatic Exercise Program For Reducing Weight, Body Fat And Chronic Low Back And Joint Pain, Terilyn Darley

DNP Scholarly Projects

According to the World Health Organization (WHO), obesity has risen at an alarming rate and has reached epidemic proportions throughout the world (WHO, 2017). In the U. S., approximately 93.3 million U.S. adults are obese with an overall prevalence of 39.8 %. Chronic pain is another public health issue in the U.S, affecting almost 100 million people and is associated with significant annual healthcare costs and lost productivity (National Center for Complementary and Integrative Health [NCCIH], 2017). Exercise is considered one of the most effective prevention strategies for reducing obesity and has been documented to decrease chronic pain. The purpose …


A Comparison Of The National Football League Coaches Strength And Conditioning Practices 1997-1998 To 2018, Corey Fitzgerald Mar 2020

A Comparison Of The National Football League Coaches Strength And Conditioning Practices 1997-1998 To 2018, Corey Fitzgerald

All NMU Master's Theses

This study describes the results of a survey of the strength and conditioning practices of the National Football League’s (NFL) strength and conditioning (S&C) coaches. The primary purpose was to identify the common and unique aspects of the NFL S&C practices during 2018. A secondary purpose was to compare those results to 1997-1998 (‘97-98) to determine differences across years. The survey response rate was 28.1% (9 of 32 NFL teams) agreeing to participate. The survey instrument was a 150 item assessment divided into 10 sections examining the entire training program. Results revealed that subjects test 6.8 ± 3.1 fitness variables …


Successful Shot Locations And Shot Types Used In Ncaa Men’S Division I Basketball, Olivia D. Perrin Aug 2019

Successful Shot Locations And Shot Types Used In Ncaa Men’S Division I Basketball, Olivia D. Perrin

All NMU Master's Theses

The primary purpose of the current study was to investigate the effect of court location (distance and angle from basket) and shot types used on shot success in NCAA Men’s DI basketball during the 2017-18 season. A secondary purpose was to further expand the analysis based on two additional factors: player position (guard, forward, or center) and team ranking. All statistical analyses were completed in RStudio and three binomial logistic regression analyses were performed to evaluate factors that influence shot success; one for all two and three point shot attempts, one for only two point attempts, and one for only …


General Strength And Muscular Endurance: Relationship To V1- And V2-Skate Skiing Economy In Collegiate Cross-Country Skiers, Ian Torchia Jul 2019

General Strength And Muscular Endurance: Relationship To V1- And V2-Skate Skiing Economy In Collegiate Cross-Country Skiers, Ian Torchia

All NMU Master's Theses

Introduction Cross-country skiing is a power-endurance sport requiring upper and lower body activation for propulsion across the ground. While high aerobic markers such as VO2max and lactate threshold are important performance indicators, recent research has demonstrated the importance of full-body general strength and muscular endurance in skiing success. The purpose of this study was to examine the relationship of strength indices via a full-body series of muscular endurance tests, as well as a general 1-RM strength test, to VO2 skiing economy utilizing the V1- and V2-skate technique.

Methods Oxygen uptake was measured during baseline and economy testing on …


Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander Jul 2019

Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander

All NMU Master's Theses

This study attempted to further explore the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to discriminate 1.25 mg/kg clozapine from vehicle were able to acquire the discrimination in 19.1 sessions. The clozapine cue partially generalized (63.13% drug lever responding [SEM = ± 18.91]) to the antimalarial drug methylene blue at the 7.5 mg/kg dose, but not to the antimalarial quinacrine. …