Medicine and Health Sciences Commons^™

Eaat4-Dependent Effects On Glutamatergic Signaling In The Cerebellar Molecular Layer, Christopher Chen

Dissertations (1934 -)

Glutamatergic signaling is fundamental to human behavior and its dysfunction is implicated in a wide range of neurological and neurodegenerative disorders. Excitatory amino-acid transporters (EAATs) – of which four primary subtypes (EAAT1, EAAT2, EAAT3, and EAAT4) exist in the human brain – are primary regulators of glutamate signaling. Endogenously-expressed at either low (EAAT4-low) or high (EAAT4-high) concentration in cerebellar Purkinje cells, EAAT4 has been shown to regulate Purkinje cell activity in the cerebellar molecular layer. However, differences in glutamatergic signaling at the circuit and single-synaptic levels in EAAT4-low and EAAT4-high regions are poorly understood. To characterize EAAT4-specific effects on excitatory …

Process Of Maintaining Self In Individuals Living With Systemic Sclerosis: A Grounded Theory Study Of American Women, Donald D. Miller, Jennifer J. Doering

College of Nursing Faculty Research and Publications

Background: People with chronic illnesses may struggle to adapt psychologically to the illness experience and have feelings of identity loss, self-diminishment, and biographical disruption. This may limit people’s ability to engage in optimal selfmanagement. Systemic sclerosis is a debilitating, stigmatizing, and life-limiting progressive chronic illness with significant disfiguring effects. Little is known about the identity management process in people with disfiguring and debilitating conditions such as systemic sclerosis.

Purpose: The purpose of this study was to generate a grounded theory explicating the process of maintaining a sense of self in people living with systemic sclerosis.

Methods: Fifteen women with systemic …

Application Of The Social Determinants Of Health To Geriatric Patients By Nurse Practitioner Students, Theresa Marie Gruenke Schnable

Dissertations (1934 -)

ABSTRACT APPLICATION OF THE SOCIAL DETERMINANTS OF HEALTH TO GERIATRIC PATIENTS BY NURSE PRACTITIONER STUDENTS Patient outcomes are influenced by the social determinants of health (SDOH), which influence differing exposures to opportunities or health risks. Holistic care of geriatric patients includes considering SDOH in patient assessment, diagnosis, and care delivery. Understanding how NP students care for geriatric patients using a SDOH lens provides insight into their practice behaviors and helps educators understand how to strengthen NP programs to achieve better patient outcomes and advance health equity for the geriatric population. The purpose of this study was to describe how NP …

Alveolar Bone Remodeling In Response To Orthodontic Tooth Movement, Matthew Raymond Mcgrady

Master's Theses (2009 -)

Objective: Dental protrusion and retrusion are common malocclusions in clinical orthodontics. When teeth are moved orthodontically, the alveolar bone surrounding the teeth remodels. In the past, incisor retraction-associated alveolar bone remodeling has been studied. However, less is known about the alveolar bone remodeling after incisors are proclined. This study aimed to assess the changes in alveolar bone thickness after proclination of maxillary incisors. The null hypothesis was that there is no difference in the surrounding alveolar bone thickness after orthodontic tooth movement. Materials and Methods: Patients were selected under the inclusion criteria of moderate-to-severe bimaxillary dental retrusion (U1-SN < 97°, L1-MP < 88.0°), absence of craniofacial anomalies, non-extraction, absence of missing teeth, with quality pre-and post-treatment lateral cephalometric images. Nineteen patients (10 males, 9 females; mean age 14.7 years) were selected, and their pre-treatment and post-treatment lateral cephalograms were digitally traced using a customized cephalometric analysis to compare changes in labial and lingual alveolar bone thickness (ABT) after orthodontic treatment. A two-sample t-test with R statistical software version 4.1.2 was used to measure the differences between the pre- and post-treatment cephalometric measurements. A p value less than 0.05 was considered statistically significant. Results: According to the SN-7° measurement method, ABT increased at the labial(b) SN-7 (0.27mm ± 0.70; p<0.05) and U1 labial(c) SN-7 (0.79mm ± 1.56; p<0.05) levels; however, ABT decreased at the U1 lingual (c) SN-7 (1.13mm ± 1.35; p<0.05) level. According to the perpendicular of the long axis of U1 root measurement method, ABT increased at the U1 labial(c) ⊥U1 (0.55mm ± 1.35; p<0.05) level while ABT decreased at the U1 lingual (b) ⊥U1 (0.79mm ± 1.03; p<0.05) and U1 lingual (c) ⊥U1 (1.61mm ±1.39; p<0.05) levels. Statistically significant changes were also found in post-treatment incisor angulation U1-SN° (8.05° ± 8.25; p<0.05), U1 – NA° (7.44° ± 8.08; p < 0.05) and post-treatment incisor position U1 – NA (mm) (1.64mm ± 2.63; p<0.05). Conclusion:The null hypothesis was rejected based on our results. There are statistically significant changes to the labial and lingual alveolar bone (ABT) after proclination of the maxillary incisors. Our data support previous findings in orthodontics literature. Further studies should be conducted that can employ larger sample sizes with imaging methods that overcome the limitations of conventional two-dimensional imaging.

Why We Work: Exploring The Relationships Between Work Rewards, Burnout, And Intention To Leave For Professional Nurses, Jacqueline Christianson

Dissertations (1934 -)

Nurse burnout leads to attrition from hospital nursing positions and the nursing profession prior to typical retirement age. Yet some nurses choose to stay despite burnout. Previous research indicates that nurses stay due to the rewards they receive from work but the relationships between different types of work rewards, work-related burnout, and intention to leave are poorly described. The ability to implement or execute altruistic behaviors may also represent an under-recognized work reward. Thus, the purpose of this study is to investigate the relationships between work rewards, work-related burnout, and intention to leave nursing positions and the nursing profession and …

Maxillary And Mandibular Incisor And Molar Dentoalveolar Heights In Untreated Subjects Presenting Class I And Class Ii Malocclusion, Samantha Zavada Cardinal

Master's Theses (2009 -)

Objective : Class II malocclusion has been extensively studied, however there are many unanswered questions. This study analyzed the difference in incisor and molar dentoalveolar heights of untreated subjects presenting with Class I and Class II malocclusion. Dentialveolar heights are an aspect of the craniofacial complex that changes with growth and development and are manipulated by orthodontists. These changes hold important clinical implications for the development, maintenance and treatment of malocclusions. Methods : A sample of 96 untreated Class I and Class II subjects, with a total of 611 cephalograms was drawn from the archives of the University of Michigan …

Improving Communication Access With Deaf People Through Nursing Simulation: A Cross-Disciplinary Collaboration, Jamie L. Mccartney Ph.D., Tracy Gidden, Jennifer Biggs, Kathy Geething, Karl Kosko Ph.D.

Journal of Gender, Ethnic, and Cross-Cultural Studies

Baccalaureate nursing and sign language interpreting students participated in a pediatric discharge simulation with a deaf person playing the role of the baby’s parent. At the conclusion of the simulation, participants were emailed a consent letter and a link to a 17-item questionnaire developed by the authors. Responses were analyzed both quantitatively and qualitatively, whereby nonparametric statistics were calculated to examine Likert-scale items. A Mann-Whitney test statistic was calculated, instead of an independent samples t-test, given the smaller sample in the current study (n = 26). A question was posed to participants that evaluated their self-perception of the effectiveness of …

Blindness And The Beast: Disability, Fairy Tale And Myth In Wilkie Collins’ Poor Miss Finch, György Kiss

Journal of Gender, Ethnic, and Cross-Cultural Studies

The paper offers a close reading of Wilkie Collins’ 1872 novel, Poor Miss Finch through the lens of fairy tales, gender, and disability studies. In Poor Miss Finch, we follow the life of a young blind woman, Lucilla Finch, who falls in love with a man named Oscar Dubourg, whose appearance can be described as “monstrous”. This plot evokes the popular tale of ‘Beauty and the Beast’, which the paper argues is the inspiration of Poor Miss Finch. In his work, Collins incorporates and rethinks many elements of the fairy tale to fit them into the 19^{th …}

“Handicap Removed”: An Alternative Path To The Social Model, Craig M. Rustici

Journal of Gender, Ethnic, and Cross-Cultural Studies

This article identifies an expression of a social model of disability in a 1966 film promoting Hofstra University’s Program for the Higher Education of the Handicapped and traces that model back to books published by the pioneering rehabilitation physician Henry H. Kessler in 1935 and 1947, decades before the UPIAS (Union of the Physically Impaired against Segregation) Fundamental Principles of Disability (1976). In light of Kessler’s articulation of social and minority models, identification of contrasting religious, charity and medical models, and discussion of disability stigma, this article reassesses Ruth O’Brien’s critique, in Crippled Justice (2001), of Kessler and the twentieth-century …

The Influence Of Peri-Cervical Dentin Conservation On The Propagation Of Cracks In Mandibular Molars, Hassanain Zaheer

Master's Theses (2009 -)

Introduction: The objective of this study was to investigate the effect of peri-cervical dentin conservation during root canal treatment on the longitudinal propagation of cracks, utilizing the finite element method. Methods: Two 3D printed mandibular molars were subjected to a simulated root canal therapy protocol. The teeth were divided into two test groups: Group 1: Instrumented with using Protaper Gold (PTG) rotary files. Group 2: Instrumented with using TruNatomy. Each access was restored with composite at the level of the CEJ to the occlusal surface. The two teeth were digitized using a high-resolution micro–computed tomographic scan to create 3-D models …

A Digital Assessment Of Centric Relation Precision, Christine Roenitz

Master's Theses (2009 -)

Objective: Recording the centric relation position is a critical step in diagnosis and treatment in prosthodontics. There are various methods that can be used to position a patient’s mandible into centric relation. Among these are: swallow technique (unguided closure), chin-point guidance, and bimanual manipulation. The precision of these methods has previously been studied by traditional methods. Data is lacking on the precision of virtual recordings of these methods taken by an intraoral scanner. The purpose of this study was to assess the digital precision of the swallow, chin-point guidance, and bimanual manipulation centric relation positioning techniques.Materials and Methods: Ten participants …

The Influence Of Peri-Cervical Dentin Conservation On The Propagation Of Cracks In Mandibular Molars, Hassanain Zaheer

Master's Theses (1922-2009) Access restricted to Marquette Campus

Introduction: The objective of this study was to investigate the effect of peri-cervical dentin conservation during root canal treatment on the longitudinal propagation of cracks, utilizing the finite element method. Methods: Two 3D printed mandibular molars were subjected to a simulated root canal therapy protocol. The teeth were divided into two test groups: Group 1: Instrumented with using Protaper Gold (PTG) rotary files. Group 2: Instrumented with using TruNatomy. Each access was restored with composite at the level of the CEJ to the occlusal surface. The two teeth were digitized using a high-resolution micro–computed tomographic scan to create 3-D models …

Generalized Joint Hypermobility And Lower Extremity Musculoskeletal Biomechanics In Female Athletes, Christopher F. Geiser

Dissertations (1934 -)

Generalized Joint Hypermobility (GJH), in lay terms being “double-jointed”, affects 5 to 43 percent of the general population. In severe forms, GJH impacts systems across the body, with cardiovascular, ocular, and musculoskeletal effects that can be quite debilitating. Most of the literature examining GJH is in this severely impacted group of people. However less severe forms of GJH are present in the athlete population in the same proportions, and athletes with GJH are more likely to be injured while participating in activities. They also experience greater time-loss injuries while participating in athletic activities. The movement biomechanics of those with severe …

Examining Relationships Among Nursing Students' Views Of Suffering, Positive Thinking, And Professional Quality Of Life, Ruth Anne Engbers

Dissertations (1934 -)

Despite the association between nursing students’ exposure to suffering and the development of compassion fatigue, little research exists regarding promoting nursing students’ adaptation to caring for suffering patients and families. As a possible nursing shortage is projected, it is imperative to better understand the factors that impact this adaptation to ensure that nursing students can successfully transition into their nursing role. Although beliefs about the reasons for human suffering affect their ability to cope with their exposure to the suffering of others, there is no empirical data regarding nursing students’ views of suffering. Nursing students also report using positive reframing …

Work-Related Burnout, Compassion Fatigue, And Nurse Intention To Leave The Profession During Covid-19, Jacqueline Christianson, Norah L. Johnson, Amanda Nelson, Maharaj Singh

College of Nursing Faculty Research and Publications

The purpose of this mixed-method study was to understand the relationships between work-related burnout (WRB), compassion fatigue (CF), and intention to leave the nursing profession. The Job Demands-Resources model was used to predict intention to leave as a function of WRB, CF, and caring for COVID-19 patients in a sample of 1299 US nurses. Greater WRB and CF scores were associated with intention to leave the profession. Contrary to prior research, working with COVID-19 patients was associated with greater intention to stay in nursing. Personal finances may represent the rationale for nurses to choose to stay nurses despite burnout.

Mechanisms Of The Age-Related Power Reduction In The Knee Extensor Muscles Of Men And Women, David Wrucke

Master's Theses (2009 -)

The mechanisms for the loss in limb muscle power output in old (60-79 years) and very old adults (≥80 years) and whether these mechanisms differ between older men and women are not well-understood. The aims of the thesis are to 1) compare peak power output of the knee extensor muscles between young, old, and very old adults and 2) determine the physiological mechanisms for the age-related loss of power in men compared with women. 31 young (22.9±3.0 years, 16 men), 83 old (70.4±4.9 years, 44 men), and 16 very old adults (85.8±4.2 years, 7 men) performed maximal isokinetic contractions at …

The Influence Of The Digitization Method On The Assessment Of Accuracy And Reliability Of Implant Placements, Ajitesh Singh

Master's Theses (2009 -)

Purpose: Studies investigating the accuracy of implant placement are utilizing different methods to digitize the post-operative implant position to compare it with the planned reference position. This study aimed to compare the influence on radiographic and digital methods in the accuracy of static computer-assisted and free hand implant placement.Methods: In total, n=40 implants were placed either fully guided (n=20) or free-handed (n=20) in standardized mandible replicas. A static surgical guide was planned for the fully guided surgery group (FG) for an implant at the lower right first molar site and 3D printed. In the free-hand group (FH) the implant surgery …

Immediate Postoperative Dimensional Changes Following Implant Placement, Juan Felipe Valencia Rincon

Master's Theses (2009 -)

Objective: Hard tissue outcomes after implant placement have been well documented. However, there is scarce evidence on immediate soft tissue and patient-centered outcomes. The aim of this prospective study is to quantify post-implant placement edema and to correlate it with oral health-related quality of life. Methods: Patients undergoing a standardized two-stage implant placement at a single tooth-bound site were recruited (n=26; 54.13.3 years, 14 males). Soft tissue edema was recorded by using intraoral scans immediately pre- (PS) and post-operatively (IP), at 2 (2D), 7 (7D) and 14 days (14D) and 2 months (2M). After scan registration, ridge width, maximum height, …

Randomized Controlled Trial Of The Behavioral Intervention For Increasing Physical Activity In Multiple Sclerosis Project: Secondary, Patient-Reported Outcomes, Robert W. Motl, Brian M. Sandroff, Lara A. Pilutti, Gary R. Cutter, Roberto Aldunate, Ariel Kidwell, Rachel E. Bollaert

Exercise Science Faculty Research and Publications

Background

We undertook a randomized controlled trial (RCT) that investigated the effectiveness of a theory-based, Internet-delivered, behavioral intervention focusing on physical activity promotion for immediate and sustained improvements in secondary, patient-reported outcomes (PROs) of function, symptoms, and quality of life (QOL) in multiple sclerosis (MS).

Method

Persons with MS (N = 318) were recruited from throughout the United States and randomized into behavioral intervention (n = 159) or attention/social contact control (n = 159) conditions. The conditions were administered over a 6-month period by persons who were uninvolved in screening, recruitment, random assignment, and outcome assessment. There …

Who Was Wearing A Mask In 2021? Update On Gender-, Age-, And Location-Related Differences During The Covid-19 Pandemic, Michael H. Haischer, Rachel Beilfuss, Meggie Rose Hart, Lauren Opielinski, Emma Schmit, David Wrucke, Helena Zhao, Toni D. Uhrich, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Previous observational work from 2020 demonstrated gender-, age-, and location-related differences in mask-wearing behavior, despite the efficacy and public health messaging that emphasized face coverings in combatting the spread of COVID-19. In 2021, COVID-19 vaccinations and a corresponding change in public health policy became new considerations in deciding personal protective behaviors. To provide an update on mask wearers and resistors approximately one year after our initial study, we observed shoppers (n = 6,118) entering retail stores using the same experimental methodology. Approximately 26% of individuals wore a mask. Mask wearing has decreased across demographic groups compared to 2020. Aligning …

Cost-Effectiveness Analysis Of Overground Robotic Training Versus Conventional Locomotor Training In People With Spinal Cord Injury, Daniel Pinto, Allen W. Heinemann, Shuo-Hsiu Chang, Susan Charlifue, Edelle C. Field-Fote, Catherine L. Furbish, Arun Jayaraman, Candy Tefertiller, Heather B. Taylor, Dustin D. French

Physical Therapy Faculty Research and Publications

Background

Few, if any estimates of cost-effectiveness for locomotor training strategies following spinal cord injury (SCI) are available. The purpose of this study was to estimate the cost-effectiveness of locomotor training strategies following spinal cord injury (overground robotic locomotor training versus conventional locomotor training) by injury status (complete versus incomplete) using a practice-based cohort.

Methods

A probabilistic cost-effectiveness analysis was conducted using a prospective, practice-based cohort from four participating Spinal Cord Injury Model System sites. Conventional locomotor training strategies (conventional training) were compared to overground robotic locomotor training (overground robotic training). Conventional locomotor training included treadmill-based training with body weight …

Learning A Healthy Rhythm: An Intervention To Increase Children’S Resources For Stress Management, Kristin Haglund, Amanda L. King, Abir K. Bekhet, Mauricio Garnier-Villarreal, Karen Olson, Rashs Atshan, Angela Ortiz, Johanna De Los Santos, Ruth Ann Belknap

College of Nursing Faculty Research and Publications

This article describes a pilot test of a community engaged, culturally relevant, arts-based intervention. The purpose was to increase children’s personal protective buffering resources. Protective buffering resources help children cope with stressful stimuli, reduce activation of their systemic stress response, mitigate allostatic load, and promote optimal health. The “Learning a Healthy Rhythm” intervention included a stress management component and an ongoing Afro-Latino percussion program for 18 children ages 9–11. The stress management component included educational content about stress, self-assessment of stress symptoms, and stress management techniques. A mixed-method intervention evaluation design was used. Qualitative data, quantitative data, and biometrics including …

A Randomized Controlled Trial Of An Oral Probiotic To Reduce Antepartum Group B Streptococcus Colonization And Gastrointestinal Symptoms, Lisa Hanson, Leona Vandevusse, Marie Forgie, Emily Malloy, Maharaj Singh, Maryanne Scherer, Diana Kleber, Jonah Dixon, Andrew J. Hryckowian, Nasia Safdar

College of Nursing Faculty Research and Publications

BACKGROUND

Probiotics have been suggested as a strategy to reduce antenatal group B Streptococcus colonization. Although probiotics are known to improve gastrointestinal symptoms, this has not been studied during pregnancy.

OBJECTIVE

This study aimed to evaluate the efficacy of a probiotic to reduce: (1) standard-of-care antenatal group B Streptococcus colonization and colony counts and (2) gastrointestinal symptoms of pregnancy.

STUDY DESIGN

In a double-blind fashion, 109 healthy adult pregnant people were randomized to Florajen3 probiotic or placebo capsules once daily from 28 weeks’ gestation until labor onset. Baseline vaginal and rectal study swabs for group B Streptococcus colony-forming units and …

Theoretical Substruction Of Resilience Theory: Dementia Caregivers' Burden And Their Care Recipients' Behavior, Abir K. Bekhet

College of Nursing Faculty Research and Publications

Theoretical substruction is vital in clarifying models and guiding research. In this article, the process of theoretical substruction was examined through resilience theory to provide an example of the congruence between theoretical and operational definitions in nursing research. The author examines the significance of resilience theory in the context of dementia caregivers’ burden and their care recipients’ behavioral problems. The steps of theoretical substruction are included, and a model of resilience is presented that includes middle-range concepts, relational statements, and propositions derived from the research literature. The rigorous process of theoretical substruction provides an example of a theoretically sound basis …

Experiences Of Sex Workers In Chicago During Covid-19: A Qualitative Study, Randi Beth Singer, Sarah Abboud, Amy K. Johnson, Jessica L. Zemlak, Natasha Crooks, Sangeun Lee, Johannes Wilson, Della Gorvine, Jahari Stamps, Douglas Bruce, Susan G. Sherman, Alicia K. Matthews, Crystal L. Patil

College of Nursing Faculty Research and Publications

COVID-19 exacerbated health disparities, financial insecurity, and occupational safety for many within marginalized populations. This study, which took place between 2019 and 2022, aimed to explore the way in which sex workers (n = 36) in Chicago were impacted by COVID-19. We analyzed the transcripts of 36 individual interviews with a diverse group of sex workers using thematic analysis. Five general themes emerged regarding the detrimental impact of COVID-19 on sex workers: (1) the impact of COVID-19 on physical health; (2) the economic impact of COVID-19; (3) the impact of COVID-19 on safety; (4) the impact of COVID-19 on …

Patient Engagement, Involvement, Or Participation -- Entrapping Concepts In Nurse-Patient Interactions: A Critical Discussion, Teresa Jerofke-Owen, Georgia Tobiano, Ann C. Eldh

College of Nursing Faculty Research and Publications

The importance of patients taking an active role in their healthcare is recognized internationally, to improve safety and effectiveness in practice. There is still, however, some ambiguity about the conceptualization of that patient role; it is referred to interchangeably in the literature as engagement, involvement, and participation. The aim of this discussion paper is to examine and conceptualize the concepts of patient engagement, involvement, and participation within healthcare, particularly nursing. The concepts were found to have semantic differences and similarities, although, from a nursing perspective, they can be summoned to illustrate the establishment of a mutual partnership between a patient …

Lived Experiences Of American Adults Who Survive Covid-19: Implications For Physical Activity And Interpersonal Stress, Linda B. Piacentine, Hannah C. Barbosa, Kristin Haglund, Lauren Opielinski, Sandra K. Hunter, Paula E. Papanek, Marie K. Hoeger Bement, Norah L. Johnson

College of Nursing Faculty Research and Publications

Introduction: The cumulative number of COVID-19 cases has surpassed 579 million globally. Symptoms during and after COVID-19 infection vary from mild cold symptoms to severe multisystem illness. Given the wide range of symptom presentations and complications post COVID-19, the purpose of this study was to describe the lived experience of American adults surviving COVID-19.

Method: This study employed an exploratory qualitative description design. Semi-structured interviews were conducted with a sample of 35 individuals, [white (94%), female (71%), mean age = 43.7 years], with proximity to a university in an urban Midwest American city. Interviews occurred between May and …

A Comparison Of Two Hormonal Fertility Monitoring Systems For Ovulation Detection: A Pilot Study, Qiyan Mu, Richard J. Fehring

College of Nursing Faculty Research and Publications

Background and Objectives: Accuracy in detecting ovulation and estimating the fertile window in the menstrual cycle is essential for women to avoid or achieve pregnancy. There has been a rapid growth in fertility apps and home ovulation testing kits in recent years. Nevertheless, there lacks information on how well these apps perform in helping users understand their fertility in the menstrual cycle. This pilot study aimed to evaluate and compare the beginning, peak, and length of the fertile window as determined by a new luteinizing hormone (LH) fertility tracking app with the Clearblue Fertility Monitor (CBFM).

Materials and Methods: A …

Case Reports From Women Using A Quantitative Hormone Monitor To Track The Perimenopause Transition, Maria Meyers, Richard J. Fehring, Mary Schneider

College of Nursing Faculty Research and Publications

The fertility tracking of menstrual cycles during perimenopause with a quantitative hormone monitor is a novel undertaking. Women in regular menstrual cycles have been tracking their fertility using different biomarkers since the 1960′s. Presently, there are newer electronic hormonal devices used to track fertility that provide more exact and objective data to help delineate the fertile time frame of a woman’s cycle. These devices measure quantitative levels of estrogen, the luteinizing hormone, progesterone, and follicle-stimulating hormone, all of which occur at varying levels during the menstrual cycle. As women advance toward menopause, their cycles vary in length, and their hormones …

Moderate-To-Vigorous Physical Activity Is Related With Retinal Neuronal And Axonal Integrity In Persons With Multiple Sclerosis, Jeongwoon Kim, Rachel E. Bollaert, Jonathan Cerna, Brynn C. Adamson, Connor M. Robbs, Naiman A. Khan, Robert W. Motl

Exercise Science Faculty Research and Publications

Background

Moderate-to-vigorous physical activity (MVPA) may confer benefits for axonal and/or neuronal integrity in adults with multiple sclerosis (MS).

Purpose

Examine the association between device-measured MVPA with optical coherence tomography (OCT) metrics of retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in persons with and without MS.

Methods

Adults with MS (N = 41), along with sex-matched healthy control (HC) participants (N = 79), underwent measurements of retinal morphology via OCT and wore an accelerometer for a period of 7 days as a measure of MVPA.

Results

Persons with MS had significantly lower MVPA, RNFL thickness, and …