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Full-Text Articles in Medicine and Health Sciences

Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery Of Antigen And Improve Vaccine Efficacy While Inducing Low Inflammation, Sujata Senapati, Ross J. Darling, Darren Loh, Ian C. Schneider, Michael J. Wannemeuhler, Balaji Narasimhan, Surya K. Mallapragada Feb 2019

Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery Of Antigen And Improve Vaccine Efficacy While Inducing Low Inflammation, Sujata Senapati, Ross J. Darling, Darren Loh, Ian C. Schneider, Michael J. Wannemeuhler, Balaji Narasimhan, Surya K. Mallapragada

Chemistry Publications

As the focus has shifted from traditional killed or live, attenuated vaccines towards subunit vaccines, improvements in vaccine safety have been confronted with low immunogenicity of protein antigens. This issue has been addressed by synthesizing and designing a wide variety of antigen carriers and adjuvants, such as Toll-like receptor agonists (e.g., MPLA, CpG). Studies have focused on optimizing adjuvants for improved cellular trafficking, cytosolic availability, and improved antigen presentation. In this work, we describe the design of novel amphiphilic pentablock copolymer (PBC) adjuvants that exhibit high biocompatibility and reversible pH- and temperature-sensitive micelle formation. We demonstrate improved humoral immunity ...


Optimal Scheduling Of Bevacizumab And Pemetrexed/Cisplatin Dosing In Non-Small Cell Lung Cancer, Benjamin K. Schneider, Arnaud Boyer, Joseph Ciccolini, Fabrice Barlesi, Kenneth Wang, Sebastien Benzekry, Jonathan P. Mochel Feb 2019

Optimal Scheduling Of Bevacizumab And Pemetrexed/Cisplatin Dosing In Non-Small Cell Lung Cancer, Benjamin K. Schneider, Arnaud Boyer, Joseph Ciccolini, Fabrice Barlesi, Kenneth Wang, Sebastien Benzekry, Jonathan P. Mochel

Biomedical Sciences Publications

Bevacizumab-pemetrexed/cisplatin (BEV-PEM/CIS) is a first line therapeutic for advanced non-squamous non-small cell lung cancer (NSCLC). Bevacizumab potentiates PEM/CIS cytotoxicity by inducing transient tumor vasculature normalization. BEV-PEM/CIS has a narrow therapeutic window. Therefore, it is an attractive target for administration schedule optimization. The present study leverages our previous work on BEV-PEM/CIS pharmacodynamic modeling in NSCLC-bearing mice to estimate the optimal gap in the scheduling of sequential BEV-PEM/CIS. We predicted the optimal gap in BEV-PEM/CIS dosing to be 2.0 days in mice and 1.2 days in humans. Our simulations suggest that the efficacy ...


Data Evidencing Slow Anaerobic Digestion In Emergency Treatment And Disposal Of Infectious Animal Carcasses, Jacek A. Koziel, Heekwon Ahn, Thomas D. Glanville, Timothy S. Frana, J. (Hans) Van Leeuwen, Lam T. Nguyen Feb 2019

Data Evidencing Slow Anaerobic Digestion In Emergency Treatment And Disposal Of Infectious Animal Carcasses, Jacek A. Koziel, Heekwon Ahn, Thomas D. Glanville, Timothy S. Frana, J. (Hans) Van Leeuwen, Lam T. Nguyen

Agricultural and Biosystems Engineering Publications

Burial of infectious and potentially infectious livestock and poultry animals is the most common response to an emergency situation. The data set summarizes 22-week-long experiment that simulates the environment found within conventional burial trenches for emergency disposal of animal carcasses, worldwide, sometimes with a topical application of quicklime as it is required in the Republic of Korea. This data set shows the rarely presented evidence of the extremely slow decay of animal carcasses. Besides visual evidence of no visible breakdown of carcass material, i.e., carcass (or carcass quarters and coarse cuts) still resembled the initial material at the end ...


Human Survival Motor Neuron Genes Generate A Vast Repertoire Of Circular Rnas, Eric W. Ottesen, Diou Luo, Joonbae Seo, Natalia N. Singh, Ravindra N. Singh Jan 2019

Human Survival Motor Neuron Genes Generate A Vast Repertoire Of Circular Rnas, Eric W. Ottesen, Diou Luo, Joonbae Seo, Natalia N. Singh, Ravindra N. Singh

Biomedical Sciences Publications

Circular RNAs (circRNAs) perform diverse functions, including the regulation of transcription, translation, peptide synthesis, macromolecular sequestration and trafficking. Inverted Alu repeats capable of forming RNA:RNA duplexes that bring splice sites together for backsplicing are known to facilitate circRNA generation. However, higher limits of circRNAs produced by a single Alu-rich gene are currently not predictable due to limitations of amplification and analyses. Here, using a tailored approach, we report a surprising diversity of exon-containing circRNAs generated by the Alu-rich Survival Motor Neuron (SMN) genes that code for SMN, an essential multifunctional protein in humans. We show that expression of the ...


The Role Of The Gut-Brain Axis In Neurodegenerative Diseases And Relevance Of The Canine Model: A Review, Yoko Ambrosini, Dana Borcherding, Anumantha Kanthasamy, Hyun Jung Kim, Albert Jergens, Karin Allenspach, Jonathan Mochel Jan 2019

The Role Of The Gut-Brain Axis In Neurodegenerative Diseases And Relevance Of The Canine Model: A Review, Yoko Ambrosini, Dana Borcherding, Anumantha Kanthasamy, Hyun Jung Kim, Albert Jergens, Karin Allenspach, Jonathan Mochel

Biomedical Sciences Publications

Identifying appropriate animal models is critical in developing translatable in vitro and in vivo systems for therapeutic development and investigating disease pathophysiology. These animal models should have direct biological and translational relevance to the underlying disease they are supposed to mimic. Aging dogs naturally develop a cognitive decline in many aspects including learning and memory, but also exhibit human-like individual variability in the aging process. Neurodegenerative processes that can be observed in both human and canine brains include the progressive accumulation of β-amyloid (Aβ) found as diffuse plaques in the prefrontal cortex, including the gyrus proreus, the hippocampus, and in ...


Use Of Flexible Sensor To Characterize Biomechanics Of Canine Skin, Austin R. J. Downey, Jin Yan, Eric M. Zellner, Karl H. Kraus, Iris V. Rivero, Simon Laflamme Jan 2019

Use Of Flexible Sensor To Characterize Biomechanics Of Canine Skin, Austin R. J. Downey, Jin Yan, Eric M. Zellner, Karl H. Kraus, Iris V. Rivero, Simon Laflamme

Civil, Construction and Environmental Engineering Publications

Background: Suture materials and techniques are frequently evaluated in ex vivo studies by comparing tensile strengths. However, the direct measurement techniques to obtain the tensile forces in canine skin are not available, and, therefore, the conditions suture lines undergo is unknown. A soft elastomeric capacitor is used to monitor deformation in the skin over time by sensing strain. This sensor was applied to a sample of canine skin to evaluate its capacity to sense strain in the sample while loaded in a dynamic material testing machine. The measured strain of the sensor was compared with the strain measured by the ...


A Latent Spatial Piecewise Exponential Model For Interval-Censored Disease Surveillance Data With Time-Varying Covariates And Misclassification, Yaxuan Sun, Chong Wang, William Q. Meeker, Max Morris, Marisa L. Rotolo, Jeffery Zimmerman Jan 2019

A Latent Spatial Piecewise Exponential Model For Interval-Censored Disease Surveillance Data With Time-Varying Covariates And Misclassification, Yaxuan Sun, Chong Wang, William Q. Meeker, Max Morris, Marisa L. Rotolo, Jeffery Zimmerman

Veterinary Diagnostic and Production Animal Medicine Publications

Understanding the dynamics of disease spread is critical to achieving effective animal disease surveillance. A major challenge in modeling disease spread is the fact that the true disease status cannot be known with certainty due to the imperfect diagnostic sensitivity and specificity of the tests used to generate the disease surveillance data. Other challenges in modeling such data include interval censoring, relating disease spread to distance between units, and incorporating time-varying covariates, which are the unobserved disease statuses. We propose a latent spatial piecewise exponential model (PEX) with misclassification of events to address the challenges in modeling such disease surveillance ...


Collaborative Efforts To Forecast Seasonal Influenza In The United States, 2015–2016, Craig J. Mcgowan, Jarad Niemi, Nehemias Ulloa, Katie Will, Et Al. Jan 2019

Collaborative Efforts To Forecast Seasonal Influenza In The United States, 2015–2016, Craig J. Mcgowan, Jarad Niemi, Nehemias Ulloa, Katie Will, Et Al.

Statistics Publications

Since 2013, the Centers for Disease Control and Prevention (CDC) has hosted an annual influenza season forecasting challenge. The 2015–2016 challenge consisted of weekly probabilistic forecasts of multiple targets, including fourteen models submitted by eleven teams. Forecast skill was evaluated using a modified logarithmic score. We averaged submitted forecasts into a mean ensemble model and compared them against predictions based on historical trends. Forecast skill was highest for seasonal peak intensity and short-term forecasts, while forecast skill for timing of season onset and peak week was generally low. Higher forecast skill was associated with team participation in previous influenza ...


Effects Of Litter Floor Access And Inclusion Of Experienced Hens In Aviary Housing On Floor Eggs, Litter Condition, Air Quality, And Hen Welfare, Jofran L. Oliveira, Hongwei Xin, Lilong Chai, Suzanne T. Millman Dec 2018

Effects Of Litter Floor Access And Inclusion Of Experienced Hens In Aviary Housing On Floor Eggs, Litter Condition, Air Quality, And Hen Welfare, Jofran L. Oliveira, Hongwei Xin, Lilong Chai, Suzanne T. Millman

Agricultural and Biosystems Engineering Publications

To better understand how relevant intensive systems’ characteristics simultaneously affect the performance and welfare of broiler chickens, a meta-analysis of recent literature was carried out. The study determined the effects of gender, genetics, experimental initial age (EIA, d), stocking density (SD; kg/m2), group size (GS; n), bedding material (yes/no), duration of photoperiod (DP; h), divided scotoperiod (yes/no), feeding phases (1/2/3/>3), environmental control (EC; yes/no), environmental enrichment (yes/no), use of vaccines and other medications (yes/no), experimental duration (d), and relevant 2-way interactions on average daily gain (g/d), average daily feed intake ...


Domain Description: Validating The Interpretation Of The Toefl Ibt® Speaking Scores For International Teaching Assistant Screening And Certification Purposes, Elena Cotos, Yoo-Ree Chung Dec 2018

Domain Description: Validating The Interpretation Of The Toefl Ibt® Speaking Scores For International Teaching Assistant Screening And Certification Purposes, Elena Cotos, Yoo-Ree Chung

English Publications

In the past 2 decades, there has been an increasing tendency to use scores from the TOEFL iBT® Speaking test for decisions regarding the certification of international graduate students as teaching assistants at North American universities. To obtain validity evidence in support of the usefulness of the speaking scores for this secondary use of the test, this study adopted the argument‐based approach to validation. Focusing on the domain description inference in the TOEFL interpretive argument, the study investigated whether the language functions elicited by TOEFL iBT Speaking tasks can be identified in authentic discourse produced by international teaching assistants ...


High-Affinity Rna Targets Of The Survival Motor Neuron Protein Reveal Diverse Preferences For Sequence And Structural Motifs, Eric W. Ottesen, Natalia N. Singh, Diou Luo, Ravindra N. Singh Nov 2018

High-Affinity Rna Targets Of The Survival Motor Neuron Protein Reveal Diverse Preferences For Sequence And Structural Motifs, Eric W. Ottesen, Natalia N. Singh, Diou Luo, Ravindra N. Singh

Biomedical Sciences Publications

The Survival Motor Neuron (SMN) protein is essential for survival of all animal cells. SMN harbors a nucleic acid-binding domain and plays an important role in RNA metabolism. However, the RNA-binding property of SMN is poorly understood. Here we employ iterative in vitro selection and chemical structure probing to identify sequence and structural motif(s) critical for RNA–SMN interactions. Our results reveal that motifs that drive RNA–SMN interactions are diverse and suggest that tight RNA–SMN interaction requires presence of multiple contact sites on the RNA molecule. We performed UV crosslinking and immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP ...


Clinical Features Of Cats With Aqueous Tear Deficiency: A Retrospective Case Series Of 10 Patients (17 Eyes), Lisa K. Uhl, Akihiko Saito, Hiroko Iwashita, David J. Maggs, Jonathan P. Mochel, Lionel Sebbag Nov 2018

Clinical Features Of Cats With Aqueous Tear Deficiency: A Retrospective Case Series Of 10 Patients (17 Eyes), Lisa K. Uhl, Akihiko Saito, Hiroko Iwashita, David J. Maggs, Jonathan P. Mochel, Lionel Sebbag

Veterinary Clinical Sciences Publications

Objectives

The aim of this study was to describe the clinical findings, diagnostic test results and response to therapy of cats with Schirmer tear test 1 (STT-1) values below the reference interval.

Methods

The medical records of three institutions were searched for cats with ocular surface disease and STT-1 values/min, confirmed at two or more separate visits.

Results

Ten cats (17 eyes) were included. The mean ± SD (range) age and STT-1 values in affected eye(s) were 6.1 ± 5.7 (0.2–16) years and 2.4 ± 3.1 (0–8) mm/min, respectively. Concurrent ocular surface disease ...


Project Resilience: A Community-Based Resilience Initiative To Engage Rural Adolescents Towards Healthy Functioning, Anthony J. Hill, Joshua Kirven Nov 2018

Project Resilience: A Community-Based Resilience Initiative To Engage Rural Adolescents Towards Healthy Functioning, Anthony J. Hill, Joshua Kirven

Journal of Critical Thought and Praxis

Project Resilience: A community-based Resilience Initiative to engage rural adolescents towards healthy functioning

Project Resilience, a community-based resilience initiative was developed to address public concern. In the first part of the year of 2012 in a rural Mid-Atlantic state, eight adolescents and young adults died by suicide. Concerned public officials asked the Centers for Disease Control and Prevention (CDC) to assist with the epidemiologic investigation of these deaths. Mental health problems were found to be a significant contributing factor to the fatal suicide attempts. The scope of this paper will explore the potential influence of rural stress, trauma and violence ...


Cultural Competency Training: How Do We Measure Outcomes?, Timothy Lee, Sean Ervin Dr. Nov 2018

Cultural Competency Training: How Do We Measure Outcomes?, Timothy Lee, Sean Ervin Dr.

Journal of Critical Thought and Praxis

Background

The term “cultural competency” in healthcare is meant to convey an understanding of cultural and linguistic differences that exist within and between distinct social groups and a sensitivity to these differences that may allow for improved health care outcomes to occur. The medical literature has validated the importance of cultural competency training to medical education and its possible influence on patient health status and outcomes. Many pre-licensure cultural competency training programs have emerged due to the perceived benefits for healthcare delivery and outcomes. However, few studies have evaluated the clinical impact and success of these training programs. In this ...


Health Justice And Kinesiology Research: An Interview With Dr. Scherezade K. Mama, Scherezade K. Mama, Tyanez Jones Nov 2018

Health Justice And Kinesiology Research: An Interview With Dr. Scherezade K. Mama, Scherezade K. Mama, Tyanez Jones

Journal of Critical Thought and Praxis

The Journal of Critical Thought and Praxis has traditionally published interviews with individuals who have strong connections to our special issue topics. We believe that interviews are important ways to contribute to the conversation surrounding critical issues in social justice.


Health Justice - Letter From The Senior Editor, Tyanez Jones Nov 2018

Health Justice - Letter From The Senior Editor, Tyanez Jones

Journal of Critical Thought and Praxis

Tyanez C. Jones is the Senior Editor of the Journal of Critical Thought and Praxis.


Writing Ourselves Into Existence: Healing Through Collaborative Curriculum Development, Bianca Ivette Laureano, Sara C. Flowers Drph Nov 2018

Writing Ourselves Into Existence: Healing Through Collaborative Curriculum Development, Bianca Ivette Laureano, Sara C. Flowers Drph

Journal of Critical Thought and Praxis

Here we offer an open exchange / evaluation of our experience as facilitator and editor (Bianca) and writer and collaborator (Sara) during the inaugural Women of Color Sexual Health Network Curriculum Lab which took place November 2017 in New Orleans, LA. In two months, 7 women and femmes of color who are sexuality educators wrote a robust curriculum for our communities that centers pleasure, social emotional learning competencies as early Freedom Schools implemented, sex and pleasure positive, using an intersectional framework and praxis, disability justice framework, inclusive of LGBTQ communities, and does not assume HIV negative status. This is one of ...


Reclaiming Health For Black Women And Girls: A Conversation With Dr. Jameta Nicole Barlow, Jameta N. Barlow, Tyanez Jones Nov 2018

Reclaiming Health For Black Women And Girls: A Conversation With Dr. Jameta Nicole Barlow, Jameta N. Barlow, Tyanez Jones

Journal of Critical Thought and Praxis

The Journal of Critical Thought and Praxis has traditionally published interviews with individuals who have strong connections to our special issue topics. We believe that interviews are important ways to contribute to the conversation surrounding critical issues in social justice.


Handwriting At Different Paces And Sizes With Visual Cues In Persons With Parkinson’S Disease, Andrew Zaman, Elizabeth L. Stegemoller Nov 2018

Handwriting At Different Paces And Sizes With Visual Cues In Persons With Parkinson’S Disease, Andrew Zaman, Elizabeth L. Stegemoller

Kinesiology Publications

Background: Persons with Parkinson’s disease (PD) typically have small handwriting, especially when writing faster and/or larger. However, visual cues can help persons with PD increase their handwriting size. This study tested if lined paper would improve handwriting in persons with PD, even when writing faster and/or larger. Secondarily, we wanted determine if persons with PD perceived handwriting as stressful, and if perceived stress was associated with writing performance.

Methods: The study included 22 subjects with Parkinson’s disease and 11 age-gender-matched controls. Participants completed eight trials (2 × 2 × 2) of printing a “P” and “d”, at a ...


A Phage-Based Assay For The Rapid, Quantitative, And Single Cfu Visualization Of E. Coli (Ecor #13) In Drinking Water, Troy C. Hinkely, S. Singh, Spencer Garing, Anne-Laure M. Le Ny, Kevin P. Nichols, Joseph E. Peters, Joey N. Talbert, Sam R. Nugen Oct 2018

A Phage-Based Assay For The Rapid, Quantitative, And Single Cfu Visualization Of E. Coli (Ecor #13) In Drinking Water, Troy C. Hinkely, S. Singh, Spencer Garing, Anne-Laure M. Le Ny, Kevin P. Nichols, Joseph E. Peters, Joey N. Talbert, Sam R. Nugen

Food Science and Human Nutrition Publications

Drinking water standards in the United States mandate a zero tolerance of generic E. coli in 100mL of water. The presence of E. coli in drinking water indicates that favorable environmental conditions exist that could have resulted in pathogen contamination. Therefore, the rapid and specifc enumeration of E. coli in contaminated drinking water is critical to mitigate signifcant risks to public health. To meet this challenge, we developed a bacteriophage-based membrane fltration assay that employs novel fusion reporter enzymes to fully quantify E. coli in less than half the time required for traditional enrichment assays. A luciferase and an alkaline ...


Nanoparticle Microarray For High-Throughput Microbiome Metabolomics Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry, Rebecca L. Hansen, Maria Emilia Duenas, Torey Looft, Young Jin Lee Oct 2018

Nanoparticle Microarray For High-Throughput Microbiome Metabolomics Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry, Rebecca L. Hansen, Maria Emilia Duenas, Torey Looft, Young Jin Lee

Chemistry Publications

A high-throughput matrix-assisted laser desorption/ionization mass spectrometry (MALDI)-MS-based metabolomics platform was developed using a pre-fabricated microarray of nanoparticles and organic matrices. Selected organic matrices, inorganic nanoparticle (NP) suspensions, and sputter coated metal NPs, as well as various additives, were tested for metabolomics analysis of the turkey gut microbiome. Four NPs and one organic matrix were selected as the optimal matrix set: α-cyano-4-hydroycinnamic acid, Fe3O4 and Au NPs in positive ion mode with 10 mM sodium acetate, and Cu and Ag NPs in negative ion mode with no additive. Using this set of five matrices, over two thousand unique ...


Photography-Based Method For Assessing Fluorescein Clearance Test In Dogs, Arianne Pontes Oriá, Miriam Flores Rebouças, Emanoel Martins Filho, Francisco De Assis Dórea Neto, Ana Cláudia Raposo, Lionel Sebbag Sep 2018

Photography-Based Method For Assessing Fluorescein Clearance Test In Dogs, Arianne Pontes Oriá, Miriam Flores Rebouças, Emanoel Martins Filho, Francisco De Assis Dórea Neto, Ana Cláudia Raposo, Lionel Sebbag

Veterinary Clinical Sciences Publications

Background: The fluorescein clearance test (FCT) provides insight into the tear film dynamics. The purpose of this study was to describe an inexpensive and practical method for assessing FCT in dogs, using photography and software analysis, and to assess the retention time of 1 vs. 2 eye drops on the canine ocular surface.

Methods: (i) In vivo - Eight healthy German Shepherd dogs were recruited. Following topical anesthesia with 0.5% proxymetacaine, each eye sequentially received (1 week apart) either 1 drop (35 μL) or 2 drops (70 μL) of 0.5% fluorescein. A Schirmer strip was inserted in the ventral ...


Changes In Sedentary Time Are Associated With Changes In Mental Wellbeing Over 1 Year In Young Adults, Laura D. Ellingson, Jacob Meyer, Robin P. Shook, Philip M. Dixon, Gregory A. Hand, Michael D. Wirth, Amanda E. Paluch, Stephanie Burgess, James R. Hebert, Steven N. Blair Sep 2018

Changes In Sedentary Time Are Associated With Changes In Mental Wellbeing Over 1 Year In Young Adults, Laura D. Ellingson, Jacob Meyer, Robin P. Shook, Philip M. Dixon, Gregory A. Hand, Michael D. Wirth, Amanda E. Paluch, Stephanie Burgess, James R. Hebert, Steven N. Blair

Kinesiology Publications

Excessive sedentary time is related to poor mental health. However, much of the current literature uses crosssectional data and/or self-reported sedentary time, and does not assess factors such as sedentary bout length. To address these limitations, the influence of objectively measured sedentary time including sedentary bout length (i.e. < 30 min, ≥30 min) on mood, stress, and sleep, was assessed in 271 healthy adults (49% women; age 27.8 ± 3.7) across a 1-year period between 2011 and 2013 in Columbia, SC. Participants completed the Profile of Mood States and the Perceived Stress Scale, and wore a Sensewear Armband to assess sedentary time, physical activity, and sleep for ten days at baseline and one year. A series of fixed-effects regressions was used to determine the influence of both baseline levels and changes in daily sedentary time (total and in bouts) and physical activity on changes in mood, stress, and sleep over one year. Results showed that across the year, decreases in total sedentary time, and time in both short and long bouts, were associated with improvements in mood, stress and sleep (p < 0.05). Increases in physical activity were only significantly predictive of increases in sleep duration (p < 0.05). Thus, reductions in sedentary time, regardless of bout length, positively influenced mental wellbeing. Specifically, these results suggest that decreasing daily sedentary time by 60 min may significantly attenuate the negative effects of high levels of pre-existing sedentary time on mental wellbeing. Interventions manipulating sedentary behavior are needed to determine a causal link with wellbeing and further inform recommendations.


Relationship Of The Mucosal Microbiota To Gastrointestinal Inflammation And Small Cell Intestinal Lymphoma In Cats, Kayode Garraway, Chad M. Johannes, Angela Bryan, John Peauroi, Giacomo Rossi, Min Zhang, Chong Wang, Karin Allenspach, Albert E. Jergens Aug 2018

Relationship Of The Mucosal Microbiota To Gastrointestinal Inflammation And Small Cell Intestinal Lymphoma In Cats, Kayode Garraway, Chad M. Johannes, Angela Bryan, John Peauroi, Giacomo Rossi, Min Zhang, Chong Wang, Karin Allenspach, Albert E. Jergens

Veterinary Diagnostic and Production Animal Medicine Publications

Background: The gastrointestinal (GI) microbiota in healthy cats is altered in IBD. Little research has been performed to identify whether specific bacterial groups are associated with small cell GI lymphoma (LSA).

Hypothesis: Mucosal bacteria, including Enterobacteriaceae and Fusobacterium spp., are abundant in intestinal biopsies of cats with small cell GI LSA compared to cats with IBD.

Animals: Fourteen cats with IBD and 14 cats with small cell GI LSA.

Methods: Retrospective case control study. A search of the medical records was performed to identify cats diagnosed with IBD and with GI LSA. Bacterial groups identified by FISH in GI biopsies ...


Global And Entrepreneurial Perspectives For Enhancing Retailing Education: Development Of A Hybrid Graduate Course Focused On U.S. And Indian Small Businesses., Ann M. Fiore, Jessica L. Hurst, Linda S. Niehm, Telin Chung, Elena E. Karpova, Amrut Sadachar, Sanjukta Pookulangara, Danielle S. Testa Aug 2018

Global And Entrepreneurial Perspectives For Enhancing Retailing Education: Development Of A Hybrid Graduate Course Focused On U.S. And Indian Small Businesses., Ann M. Fiore, Jessica L. Hurst, Linda S. Niehm, Telin Chung, Elena E. Karpova, Amrut Sadachar, Sanjukta Pookulangara, Danielle S. Testa

Apparel, Events and Hospitality Management Publications

This paper provides an approach, based on global and entrepreneurial perspectives, to enhance retailing education. The approach was operationalized through a hybrid graduate course, co-taught by U.S. and Indian faculty members, which focused on engaging Bloom's higher order cognitive skills in learning about the operation of small retail businesses in U.S. and Indian cultural contexts. The courseincluded interactive learning modules, learning activities, and a student service-learning project. The project required the application of module content in the development of business enhancement plans for small retail businesses and in assessing the plans applicability to small businesses in ...


Surveillance For Respiratory And Diarrheal Pathogens At The Human-Pig Interface In Sarawak, Malaysia, Laura K. Borkenhagen, Kerry A. Mallinson, Rick W. Tsao, Siaw-Jing Ha, Wei-Honn Lim, Teck-Hock Toh, Benjamin D. Anderson, Jane K. Fieldhouse, Sarah E. Philo, Kuek-Sen Chong, William G. Lindsley, Alejandro Ramirez, James F. Lowe, Kristen K. Coleman, Gregory C. Gray Jul 2018

Surveillance For Respiratory And Diarrheal Pathogens At The Human-Pig Interface In Sarawak, Malaysia, Laura K. Borkenhagen, Kerry A. Mallinson, Rick W. Tsao, Siaw-Jing Ha, Wei-Honn Lim, Teck-Hock Toh, Benjamin D. Anderson, Jane K. Fieldhouse, Sarah E. Philo, Kuek-Sen Chong, William G. Lindsley, Alejandro Ramirez, James F. Lowe, Kristen K. Coleman, Gregory C. Gray

Veterinary Diagnostic and Production Animal Medicine Publications

Background The large livestock operations and dense human population of Southeast Asia are considered a hot-spot for emerging viruses.

Objectives To determine if the pathogens adenovirus (ADV), coronavirus (CoV), encephalomyocarditis virus (EMCV), enterovirus (EV), influenza A-D (IAV, IBV, ICV, and IDV), porcine circovirus 2 (PCV2), and porcine rotaviruses A and C (RVA and RVC), are aerosolized at the animal-interface, and if humans working in these environments are carrying these viruses in their nasal airways.

Study This cross-sectional study took place in Sarawak, Malaysia among 11 pig farms, 2 abattoirs, and 3 animal markets in June and July of 2017. Pig ...


Water And Sediment Microbial Quality Of Mountain And Agricultural Streams, Pramod Pandey, Michelle L. Soupir, Yi Wang, Wenlong Cao, Sagor Biswas, Venkata Vaddella, Robert Atwill, Venkatesh Merwade, Gregory Pasternack Jul 2018

Water And Sediment Microbial Quality Of Mountain And Agricultural Streams, Pramod Pandey, Michelle L. Soupir, Yi Wang, Wenlong Cao, Sagor Biswas, Venkata Vaddella, Robert Atwill, Venkatesh Merwade, Gregory Pasternack

Agricultural and Biosystems Engineering Publications

Increased public health risk caused by pathogen contamination in streams is a serious issue, and mitigating the risk requires improvement in existing microbial monitoring of streams. To improve understanding of microbial contamination in streams, we monitored Escherichia coli in stream water columns and streambed sediment. Two distinct streams and their subwatersheds were studied: (i) a mountain stream (Merced River, California), which represents pristine and wild conditions, and (ii) an agricultural stream (Squaw Creek, Iowa), which represents an agricultural setting (i.e., crop, manure application, cattle access). Stream water column and sediment samples were collected in multiple locations in the Merced ...


Impact Of Flow Rate, Collection Devices, And Extraction Methods On Tear Concentrations Following Oral Administration Of Doxycycline In Dogs And Cats, Lionel Sebbag, Lucas Showman, Emily M. Mcdowell, Ann Perera, Jonathan P. Mochel Jul 2018

Impact Of Flow Rate, Collection Devices, And Extraction Methods On Tear Concentrations Following Oral Administration Of Doxycycline In Dogs And Cats, Lionel Sebbag, Lucas Showman, Emily M. Mcdowell, Ann Perera, Jonathan P. Mochel

Veterinary Diagnostic and Production Animal Medicine Publications

Purpose: Compare the precision of doxycycline quantification in tear fluid collected with either Schirmer strips or polyvinyl acetal (PVA) sponges following oral drug administration.

Methods: Three dogs and 3 cats were administered doxycycline orally at a dose of 4.2–5 mg/kg every 12 h for 6 consecutive days. At day 5 and 6, blood and tear fluid were sampled to capture doxycycline trough and maximal concentrations. Tear fluid was collected 3 times (spaced 10 min apart) at each session with the absorbent material placed in the lower conjunctival fornix until the 20-mm mark was reached (Schirmer strip, one ...


The Study Design Elements Employed By Researchers In Preclinical Animal Experiments From Two Research Domains And Implications For Automation Of Systematic Reviews, Annette M. O'Connor, Sarah C. Totton, Jonah C. Cullen, Mahmood Ramezani, Vijay Kalivarapu, Chaohui Yuan, Stephen B. Gilbert Jun 2018

The Study Design Elements Employed By Researchers In Preclinical Animal Experiments From Two Research Domains And Implications For Automation Of Systematic Reviews, Annette M. O'Connor, Sarah C. Totton, Jonah C. Cullen, Mahmood Ramezani, Vijay Kalivarapu, Chaohui Yuan, Stephen B. Gilbert

Veterinary Diagnostic and Production Animal Medicine Publications

Systematic reviews are increasingly using data from preclinical animal experiments in evidence networks. Further, there are ever-increasing efforts to automate aspects of the systematic review process. When assessing systematic bias and unit-of-analysis errors in preclinical experiments, it is critical to understand the study design elements employed by investigators. Such information can also inform prioritization of automation efforts that allow the identification of the most common issues. The aim of this study was to identify the design elements used by investigators in preclinical research in order to inform unique aspects of assessment of bias and error in preclinical research. Using 100 ...


Transcranial Magnetic Stimulation: Design Of A Stimulator And A Focused Coil For The Application Of Small Animals, Jayaprakash Selvaraj, Priyam Rastogi, Neelam G. Prabhu Gaunkar, Ravi L. Hadimani, Mani Mina Jun 2018

Transcranial Magnetic Stimulation: Design Of A Stimulator And A Focused Coil For The Application Of Small Animals, Jayaprakash Selvaraj, Priyam Rastogi, Neelam G. Prabhu Gaunkar, Ravi L. Hadimani, Mani Mina

Electrical and Computer Engineering Publications

Transcranial magnetic stimulation (TMS) is a non-invasive, safe, effective, and food and drug administration approved treatment for major depressive disorder. TMS relies on time-varying magnetic fields to induce an electric field in the brain, resulting in depolarization or hyperpolarization of the neurons. Recently, there has been extensive research to improve the magnetic coil design, effectiveness of TMS treatment, and improvement in the computer modeling of human brains, yet little development is reported on the TMS pulse generators and coil design for small animals. TMS pulse generators, or stimulators, are the circuits which provides pulse current to drive the inductive coils ...