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Articles 1 - 30 of 7397

Full-Text Articles in Medicine and Health Sciences

Chitosan-Adjuvanted Salmonella Subunit Nanoparticle Vaccine For Poultry Delivered Through Drinking Water And Feed, Sankar Renu, Yi Han, Santosh Dhakal, Yashavanth S. Lakshmanappa, Ninoshkaly Feliciano-Ruiz, Sujata Senapati, Balaji Narasimhan, Ramesh Selvaraj, Gourapura J. Renukaradhya May 2020

Chitosan-Adjuvanted Salmonella Subunit Nanoparticle Vaccine For Poultry Delivered Through Drinking Water And Feed, Sankar Renu, Yi Han, Santosh Dhakal, Yashavanth S. Lakshmanappa, Ninoshkaly Feliciano-Ruiz, Sujata Senapati, Balaji Narasimhan, Ramesh Selvaraj, Gourapura J. Renukaradhya

Chemical and Biological Engineering Publications

Poor induction of mucosal immunity in the intestines by current Salmonella vaccines is a challenge to the poultry industry. We prepared and tested an oral deliverable Salmonella subunit vaccine containing immunogenic outer membrane proteins (OMPs) and flagellin (F) protein loaded and F-protein surface coated chitosan nanoparticles (CS NPs) (OMPs-F-CS NPs). The OMPs-F-CS NPs had mean particle size distribution of 514 nm, high positive charge and spherical in shape. In vitro and in vivo studies revealed the F-protein surface coated CS NPs were specifically targeted to chicken immune cells. The OMPs-F-CS NPs treatment of chicken immune cells upregulated TLRs, and Th1 ...


Evaluation Of Locally Injected Mycobacterium Cell Wall Fraction In Horses With Sarcoids, Stephanie S. Caston, Brett A. Sponseller, Katarzyna A. Dembek, Jesse M. Hostetter Apr 2020

Evaluation Of Locally Injected Mycobacterium Cell Wall Fraction In Horses With Sarcoids, Stephanie S. Caston, Brett A. Sponseller, Katarzyna A. Dembek, Jesse M. Hostetter

Veterinary Clinical Sciences Publications

A reformulation of Mycobacterium cell wall fraction immunotherapeutic can be used to successfully treat sarcoids in horses. Sarcoids are reported to be the most common equine skin tumors with tumor type and location influencing the choice of treatment. Wide surgical excision is curative for many tumors, but may not always be feasible. Previous studies have reported sarcoid regression after injection with mycobacterial cell wall immunotherapeutics. A new formulation of the Mycobacterium phlei cell wall fraction immunostimulant (Immunocidin® Equine) was utilized to treat cutaneous tumors in horses. Equids with skin tumors diagnosed as sarcoids were enrolled in the study. Sarcoids were ...


Recapitulation Of The Accessible Interface Of Biopsy-Derived Canine Intestinal Organoids To Study Epithelial-Luminal Interactions, Yoko M. Ambrosini, Yejin Park, Albert E. Jergens, Woojung Shin, Soyoun Min, Todd Atherly, Dana C. Borcherding, Jinah Jang, Karin Allenspach, Jonathan P. Mochel, Hyun Jung Kim Apr 2020

Recapitulation Of The Accessible Interface Of Biopsy-Derived Canine Intestinal Organoids To Study Epithelial-Luminal Interactions, Yoko M. Ambrosini, Yejin Park, Albert E. Jergens, Woojung Shin, Soyoun Min, Todd Atherly, Dana C. Borcherding, Jinah Jang, Karin Allenspach, Jonathan P. Mochel, Hyun Jung Kim

Biomedical Sciences Publications

Recent advances in canine intestinal organoids have expanded the option for building a better in vitro model to investigate translational science of intestinal physiology and pathology between humans and animals. However, the three-dimensional geometry and the enclosed lumen of canine intestinal organoids considerably hinder the access to the apical side of epithelium for investigating the nutrient and drug absorption, host-microbiome crosstalk, and pharmaceutical toxicity testing. Thus, the creation of a polarized epithelial interface accessible from apical or basolateral side is critical. Here, we demonstrated the generation of an intestinal epithelial monolayer using canine biopsy-derived colonic organoids (colonoids). We optimized the ...


Whole Genome Sequencing For Mutation Discovery In A Single Case Of Lysosomal Storage Disease (Mps Type 1) In The Dog, Tamer A. Mansour, Kevin D. Woolard, Karen L. Vernau, Devin M. Ancona, Sara M. Thomasy, Lionel Sebbag, Bret A. Moore, Marguerite F. Knipe, Haitham A. Seada, Tina M. Cowan, Miriam Aguilar, C. Titus Brown, Danika L. Bannasch Apr 2020

Whole Genome Sequencing For Mutation Discovery In A Single Case Of Lysosomal Storage Disease (Mps Type 1) In The Dog, Tamer A. Mansour, Kevin D. Woolard, Karen L. Vernau, Devin M. Ancona, Sara M. Thomasy, Lionel Sebbag, Bret A. Moore, Marguerite F. Knipe, Haitham A. Seada, Tina M. Cowan, Miriam Aguilar, C. Titus Brown, Danika L. Bannasch

Veterinary Clinical Sciences Publications

Mucopolysaccharidosis (MPS) is a metabolic storage disorder caused by the deficiency of any lysosomal enzyme required for the breakdown of glycosaminoglycans. A 15-month-old Boston Terrier presented with clinical signs consistent with lysosomal storage disease including corneal opacities, multifocal central nervous system disease and progressively worsening clinical course. Diagnosis was confirmed at necropsy based on histopathologic evaluation of multiple organs demonstrating accumulation of mucopolysaccharides. Whole genome sequencing was used to uncover a frame-shift insertion affecting the alpha-L-iduronidase (IDUA) gene (c.19_20insCGGCCCCC), a mutation confirmed in another Boston Terrier presented 2 years later with a similar clinical picture. Both dogs were homozygous ...


(-)-Α-Pinene Reduces Quorum Sensing And Campylobacter Jejuni Colonization In Broiler Chickens, Katarina Šimunović, Orhan Sahin, Jasna Kovač, Zhangqi Shen, Anja Klančnik, Qijing Zhang, Sonja Smole Možina Apr 2020

(-)-Α-Pinene Reduces Quorum Sensing And Campylobacter Jejuni Colonization In Broiler Chickens, Katarina Šimunović, Orhan Sahin, Jasna Kovač, Zhangqi Shen, Anja Klančnik, Qijing Zhang, Sonja Smole Možina

Veterinary Microbiology and Preventive Medicine Publications

Campylobacter jejuni is one of the most prevalent causes of bacterial gastroenteritis worldwide, and it is largely associated with consumption of contaminated poultry. Current Campylobacter control measures at the poultry production level remain insufficient, and hence there is the need for alternative control strategies. We evaluated the potential of the monoterpene (-)-α-pinene for control of C. jejuni in poultry. The antibacterial and resistance-modulatory activities of (-)-α-pinene were also determined against 57 C. jejuni strains. In addition, the anti-quorum-sensing activity of (-)-α-pinene against C. jejuni NCTC 11168 was determined for three subinhibitory concentrations (125, 62.5, 31.25 mg/L) over ...


Swine Disease Reporting: Report #25, Giovani Trevisan, Daniel Linhares, Edison Magalhaes, Leticia Linhares, Bret Crim, Poonam Dubey, Kent Schwartz, Eric Burrough, Phillip Gauger, Rodger Main, Mary Thrun, Paulo Lages, Cesar Corzo, Jerry Torrison, Rob Mcgaughey, Eric Herrman, Giselle Cino, Jamie Henningson, Jon Greseth, Travis Clement, Jane C. Hennings Mar 2020

Swine Disease Reporting: Report #25, Giovani Trevisan, Daniel Linhares, Edison Magalhaes, Leticia Linhares, Bret Crim, Poonam Dubey, Kent Schwartz, Eric Burrough, Phillip Gauger, Rodger Main, Mary Thrun, Paulo Lages, Cesar Corzo, Jerry Torrison, Rob Mcgaughey, Eric Herrman, Giselle Cino, Jamie Henningson, Jon Greseth, Travis Clement, Jane C. Hennings

Swine Disease Reporting System

SDRS includes multiple projects that aggregates data from participating veterinary diagnostic laboratories (VDLs) in the United States of America, and reports the major findings to the swine industry. Our goal is to share information on endemic and emerging diseases affecting the swine population in the USA, assisting veterinarians and producers to make informed decisions on disease prevention, detection and management. After aggregating information from participating VDLs and summarizing the data, we ask the input of our advisory group, which consists of veterinarians and producers across the USA swine industry. The intent is to provide interpretation of the data observed, and ...


Measuring Cmi Responses Using The Primeflow Rna Assay: A New Method Of Evaluating Bvdv Vaccination Response In Cattle, Shollie M. Falkenberg, Rohana P. Dassanayake, John D. Neill, Paul H. Walz, Eduardo Casas, Julia F. Ridpath, James A. Roth Mar 2020

Measuring Cmi Responses Using The Primeflow Rna Assay: A New Method Of Evaluating Bvdv Vaccination Response In Cattle, Shollie M. Falkenberg, Rohana P. Dassanayake, John D. Neill, Paul H. Walz, Eduardo Casas, Julia F. Ridpath, James A. Roth

Veterinary Microbiology and Preventive Medicine Publications

Current methods for evaluating bovine viral diarrhea virus (BVDV) vaccination response typically rely on measurement of humoral responses as determined by virus neutralizing antibody titers (VNT) against BVDV. While VNT are correlated with increased protection, research has also shown that cell mediated immunity (CMI) is an important component of a protective response against BVDV. For example, improved protection against BVDV by modified-live viral (MLV) vaccines as compared to killed vaccines is thought to be due to better CMI induced by the MLV. The goal of this work was to evaluate the cell mediated response in vaccinated calves using a novel ...


A Brief Report On A Facilitated Approach To Connect Cooperative Extension Southern Region State-Level Health Specialists, Samantha M. Harden, Lisa Washburn, Alison Berg, Ninfa Pena-Purcell, Heather Norman-Burgdolf, Nancy K. Franz Mar 2020

A Brief Report On A Facilitated Approach To Connect Cooperative Extension Southern Region State-Level Health Specialists, Samantha M. Harden, Lisa Washburn, Alison Berg, Ninfa Pena-Purcell, Heather Norman-Burgdolf, Nancy K. Franz

Education Publications

Improving the nation’s health will require collaboration among many stakeholders and systems, including representatives from Cooperative Extension Services (CES). This paper describes the process of establishing a multi state collaboration and discusses initial outcomes of a third-party facilitated participatory planning meeting. State-level specialists with expertise and responsibilities in“health”promotion participated. Satisfaction with meeting format;feasibility, acceptability, and appropriateness of the proposed approach to public health impact;and general meeting feedback were collected through a survey and cultural artifacts (e.g., notes, worksheets). Preparation and attendance costs were captured. Seventeen of the 20 attendees (85%) responded to the survey ...


Serum Vitamin B12, And Related Mtrr And Cubilin Genotypes, Predict Neural Outcomes Across The Ad Spectrum, K. E. Mcliman, A. D. Collazo Martinez, Jonathan P. Mochel, Karin D. Allenspach, Auriel A. Willette Mar 2020

Serum Vitamin B12, And Related Mtrr And Cubilin Genotypes, Predict Neural Outcomes Across The Ad Spectrum, K. E. Mcliman, A. D. Collazo Martinez, Jonathan P. Mochel, Karin D. Allenspach, Auriel A. Willette

Biomedical Sciences Publications

Epidemiological studies show mixed findings for serum vitamin B12 and both cognitive and regional volume outcomes. No studies to date have comprehensively examined, in non-supplemented individuals, serum B12 level associations with neurodegeneration, hypometabolism, and cognition across the Alzheimer's disease (AD) spectrum. Serum vitamin B12 was assayed from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Voxel-wise analyses regressed B12 levels against regional gray matter (GM) volume and glucose metabolism (p


The Effect Of Intravenous Maropitant On Blood Pressure In Healthy Awake And Anesthetized Dogs, Ting-Ting Chi, Bonnie L. Hay Kraus Feb 2020

The Effect Of Intravenous Maropitant On Blood Pressure In Healthy Awake And Anesthetized Dogs, Ting-Ting Chi, Bonnie L. Hay Kraus

Veterinary Clinical Sciences Publications

Objective To evaluate the effects of intravenous maropitant on arterial blood pressure in healthy dogs while awake and under general anesthesia.

Design Experimental crossover study.

Animals Eight healthy adult Beagle dogs.

Procedure All dogs received maropitant (1 mg kg-1) intravenously under the following conditions: 1) awake with non-invasive blood pressure monitoring (AwNIBP), 2) awake with invasive blood pressure monitoring (AwIBP), 3) premedication with acepromazine (0.005 mg kg-1) and butorphanol (0.2 mg kg-1) intramuscularly followed by propofol induction and isoflurane anesthesia (GaAB), and 4) premedication with dexmedetomidine (0.005 mg kg-1) and butorphanol (0.2 mg kg-1) intramuscularly followed ...


Population Modeling Of Tumor Growth Curves And The Reduced Gompertz Model Improve Prediction Of The Age Of Experimental Tumors, Cristina Vaghi, Anne Rodallec, Raphaelle Fanciullin, Joseph Ciccolini, Jonathan P. Mochel, Michalis Mastri, Clair Poignard, John M. L. Ebos, Sebastien Benzekry Feb 2020

Population Modeling Of Tumor Growth Curves And The Reduced Gompertz Model Improve Prediction Of The Age Of Experimental Tumors, Cristina Vaghi, Anne Rodallec, Raphaelle Fanciullin, Joseph Ciccolini, Jonathan P. Mochel, Michalis Mastri, Clair Poignard, John M. L. Ebos, Sebastien Benzekry

Biomedical Sciences Publications

Tumor growth curves are classically modeled by means of ordinary differential equations. In analyzing the Gompertz model several studies have reported a striking correlation between the two parameters of the model, which could be used to reduce the dimensionality and improve predictive power. We analyzed tumor growth kinetics within the statistical framework of nonlinear mixed-effects (population approach). This allowed the simultaneous modeling of tumor dynamics and inter-animal variability. Experimental data comprised three animal models of breast and lung cancers, with 833 measurements in 94 animals. Candidate models of tumor growth included the exponential, logistic and Gompertz models. The exponential and ...


Comparison Of Productivity Losses Between Swine Breeding Herds Adopting Killed Or Attenuated Prrs Virus Vaccination Protocols Following Prrs Outbreaks, Gaurav Rawal, Christopher Rademacher, Daniel Linhares Feb 2020

Comparison Of Productivity Losses Between Swine Breeding Herds Adopting Killed Or Attenuated Prrs Virus Vaccination Protocols Following Prrs Outbreaks, Gaurav Rawal, Christopher Rademacher, Daniel Linhares

Veterinary Diagnostic and Production Animal Medicine Publications

Porcine reproductive and respiratory syndrome virus (PRRSv) has been endemic for more than 30 years in most pig producing countries across the globe, and is still one of the most economically important pathogens affecting swine. The use of modified live vaccines (MLV) on breeding herds has been reported by several investigators and is a common practice in the industry for the control of PRRSv. There is limited published information on efficacy of killed virus (KV) vaccines as part of PRRS control programs in breeding herds. Thus, the objective of this study was to describe productivity losses in breeding herds following ...


Vaginal Microbiota Diverges In Sows With Low And High Reproductive Performance After Porcine Reproductive And Respiratory Syndrome Vaccination, L. P. Sanglard, S. Schmitz-Esser, K. A. Gray, D. C. L. Linhares, C. J. Yeoman, J. C. M. Dekkers, M. C. Niederwerder, N. V. L. Serão Feb 2020

Vaginal Microbiota Diverges In Sows With Low And High Reproductive Performance After Porcine Reproductive And Respiratory Syndrome Vaccination, L. P. Sanglard, S. Schmitz-Esser, K. A. Gray, D. C. L. Linhares, C. J. Yeoman, J. C. M. Dekkers, M. C. Niederwerder, N. V. L. Serão

Animal Science Publications

Previous studies have demonstrated evidence for a relationship between the vaginal microbiome and reproductive performance, suggesting the vaginal microbiota may serve as a tool to predict farrowing outcomes in commercial pigs. In this study, we compared the vaginal microbiome in sows with low and high farrowing performance and used it to classify animals with contrasting reproductive outcomes in commercial sows following immune challenge with porcine respiratory and reproductive syndrome (PRRS) vaccination. Eighteen microbes were differentially abundant (q-value < 0.05) between the Low and High farrowing performance groups. Among them, Campylobacter, Bacteroides, Porphyromonas, Lachnospiraceae unclassified, Prevotella, and Phascolarctobacterium were also selected in the discriminant and linear regression analyses, and could be used ...


A Single Dose Polyanhydride-Based Nanovaccine Against Paratuberculosis Infection, Akanksha Thukral, Kathleen Ross, Chungyi Hansen, Yashdeep Phanse, Balaji Narasimhan, Howard Steinberg, Adel M. Talaat Feb 2020

A Single Dose Polyanhydride-Based Nanovaccine Against Paratuberculosis Infection, Akanksha Thukral, Kathleen Ross, Chungyi Hansen, Yashdeep Phanse, Balaji Narasimhan, Howard Steinberg, Adel M. Talaat

Chemical and Biological Engineering Publications

Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) causes Johne’s disease in ruminants and is characterized by chronic gastroenteritis leading to heavy economic losses to the dairy industry worldwide. The currently available vaccine (inactivated bacterin in oil base) is not effective in preventing pathogen shedding and is rarely used to control Johne’s disease in dairy herds. To develop a better vaccine that can prevent the spread of Johne’s disease, we utilized polyanhydride nanoparticles (PAN) to encapsulate mycobacterial antigens composed of whole cell lysate (PAN-Lysate) and culture filtrate (PAN-Cf) of M. paratuberculosis. These nanoparticle-based vaccines (i.e., nanovaccines) were well ...


Beef Cattle That Respond Differently To Fescue Toxicosis Have Distinct Gastrointestinal Tract Microbiota, Lucas R. Koester, Daniel H. Poole, Nick V. L. Serão, Stephan Schmitz-Esser Feb 2020

Beef Cattle That Respond Differently To Fescue Toxicosis Have Distinct Gastrointestinal Tract Microbiota, Lucas R. Koester, Daniel H. Poole, Nick V. L. Serão, Stephan Schmitz-Esser

Animal Science Publications

Tall fescue (Lolium arundinaceum) is a widely used forage grass which shares a symbiosis with the endophytic fungus Epichloë coenophiala. The endophyte produces an alkaloid toxin that provides herbivory, heat and drought resistance to the grass, but can cause fescue toxicosis in grazing livestock. Fescue toxicosis can lead to reduced weight gain and milk yields resulting in significant losses to the livestock industry. In this trial, 149 Angus cows across two farms were continuously exposed to toxic, endophyte-infected, fescue for a total of 13 weeks. Of those 149 cows, 40 were classified into either high (HT) or low (LT) tolerance ...


Swine Disease Reporting: Report #24, Giovani Trevisan, Daniel Linhares, Edison Magalhaes, Leticia Linhares, Bret Crim, Poonam Dubey, Kent Schwartz, Eric Burrough, Phillip Gauger, Rodger Main, Mary Thurn, Paulo Lages, Cesar Corzo, Jerry Torrison, Rob Mcgaughey, Eric Herrman, Giselle Cino, Jamie Henningson, Jon Greseth, Travis Clement, Jane C. Hennings Feb 2020

Swine Disease Reporting: Report #24, Giovani Trevisan, Daniel Linhares, Edison Magalhaes, Leticia Linhares, Bret Crim, Poonam Dubey, Kent Schwartz, Eric Burrough, Phillip Gauger, Rodger Main, Mary Thurn, Paulo Lages, Cesar Corzo, Jerry Torrison, Rob Mcgaughey, Eric Herrman, Giselle Cino, Jamie Henningson, Jon Greseth, Travis Clement, Jane C. Hennings

Swine Disease Reporting System

SDRS includes multiple projects that aggregates data from participating veterinary diagnostic laboratories (VDLs) in the United States of America, and reports the major findings to the swine industry. Our goal is to share information on endemic and emerging diseases affecting the swine population in the USA, assisting veterinarians and producers to make informed decisions on disease prevention, detection and management. After aggregating information from participating VDLs and summarizing the data, we ask the input of our advisory group, which consists of veterinarians and producers across the USA swine industry. The intent is to provide interpretation of the data observed, and ...


Multimodal Multiplexed Immunoimaging With Nanostars To Detect Multiple Immunomarkers And Monitor Response To Immunotherapies, Yu-Chuan Ou, Xiaona Wen, Christopher A. Johnson, Daniel Shae, Oscar D. Ayala, Joseph A. Webb, Eugene C. Lin, Rossane C. Delapp, Kelli L. Boyd, Ann Richmond, Anita Mahadevan-Jansen, Marjan Rafat, John T. Wilson, Justin M. Balko, Mohammed N. Tantawy, Anna E. Vilgelm, Rizia Bardhan Jan 2020

Multimodal Multiplexed Immunoimaging With Nanostars To Detect Multiple Immunomarkers And Monitor Response To Immunotherapies, Yu-Chuan Ou, Xiaona Wen, Christopher A. Johnson, Daniel Shae, Oscar D. Ayala, Joseph A. Webb, Eugene C. Lin, Rossane C. Delapp, Kelli L. Boyd, Ann Richmond, Anita Mahadevan-Jansen, Marjan Rafat, John T. Wilson, Justin M. Balko, Mohammed N. Tantawy, Anna E. Vilgelm, Rizia Bardhan

Chemical and Biological Engineering Publications

The overexpression of immunomarker programmed cell death protein 1 (PD-1) and engagement of PD-1 to its ligand, PD-L1, are involved in the functional impairment of cluster of differentiation 8+ (CD8+) T cells, contributing to cancer progression. However, heterogeneities in PD-L1 expression and variabilities in biopsy-based assays render current approaches inaccurate in predicting PD-L1 status. Therefore, PD-L1 screening alone is not predictive of patient response to treatment, which motivates us to simultaneously detect multiple immunomarkers engaged in immune modulation. Here, we have developed multimodal probes, immunoactive gold nanostars (IGNs), that accurately detect PD-L1+ tumor cells and CD8+ T cells simultaneously in ...


Albumin Levels In Tear Film Modulate The Bioavailability Of Medically-Relevant Topical Drugs, Lionel Sebbag, Leah M. Moody, Jonathan P. Mochel Jan 2020

Albumin Levels In Tear Film Modulate The Bioavailability Of Medically-Relevant Topical Drugs, Lionel Sebbag, Leah M. Moody, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

The breakdown of blood-tear barrier that occurs with ocular pathology allows for large amounts of albumin to leak into the tear fluid. This process likely represents an important restriction to drug absorption in ophthalmology, as only the unbound drug is transported across the ocular tissue barriers to exert its pharmacologic effect. We aimed to investigate the effects of albumin levels in tears on the bioavailability of two commonly used ophthalmic drugs: tropicamide, an antimuscarinic that produces mydriasis and cycloplegia, and latanoprost, a PGF2α analog used for the treatment of glaucoma. Eight female beagle dogs underwent a randomized, vehicle-controlled crossover trial ...


Lungworm Infection In A Central Iowa Beef Herd, Joe Smith, Jeff Olivarez, Matt T. Brewer, Mitch R. Hiscocks, Claire B. Andreasen Jan 2020

Lungworm Infection In A Central Iowa Beef Herd, Joe Smith, Jeff Olivarez, Matt T. Brewer, Mitch R. Hiscocks, Claire B. Andreasen

Veterinary Diagnostic and Production Animal Medicine Publications

A beef herd presented four calves, aged 8–9 months, in late September for evaluation of respiratory disease of 2 months duration that was non-responsive to antimicrobial treatment. Calves were housed on a marshy pasture and similar signs occurred in calves during the same months the previous 2 years. The owner reported greater than 50% of calves were affected with a significantly decreased rate of gain. Physical examination revealed tachypnea and cough. Transtracheal wash cytology, viral respiratory PCR panel and bacterial culture were performed. The viral respiratory PCR panel was negative, and bacterial cultures identified commensal bacteria.


A Case Of A Linear Foreign Body Removal In A Miniature Companion Pig, Alison Cain, Jordan Kirkpatrick, Ryan Breuer, Robin White, Joe Smith Jan 2020

A Case Of A Linear Foreign Body Removal In A Miniature Companion Pig, Alison Cain, Jordan Kirkpatrick, Ryan Breuer, Robin White, Joe Smith

Veterinary Diagnostic and Production Animal Medicine Publications

Despite the recent rise in popularity of miniature pigs as companion animals, there are few published reports available regarding gastrointestinal surgery in these animals. This case report describes a 4-year-old castrated male companion potbellied pig who was diagnosed with a small bowel linear foreign body and associated pyloric outflow obstruction. A gastrotomy and three enterotomies involving the proximal and mid-jejunum and proximal centripetal loop of the spiral colon were performed to remove the linear foreign body. The surgical techniques and post-operative care described in this case report provided effective treatment of the linear foreign body and adequately prevented clinical evidence ...


Privacy Concerns Regarding Wearable Iot Devices: How It Is Influenced By Gdpr?, Chinju Paul, Kevin P. Scheibe, Sree Nilakanta Jan 2020

Privacy Concerns Regarding Wearable Iot Devices: How It Is Influenced By Gdpr?, Chinju Paul, Kevin P. Scheibe, Sree Nilakanta

Supply Chain and Information Management Conference Papers, Posters and Proceedings

Internet of Things (IoT) devices have implications for health and fitness. Fitness wearables can promote healthy behavior and improve an individual’s overall health and quality of life. Even though fitness wearables have various benefits, privacy concerns regarding the data collected remain as a major barrier to adoption of fitness wearables. Intrinsic factors like disposition to value privacy and extrinsic factors like privacy policies and General Data Protection Regulation (GDPR) can influence users’ privacy concerns. This research uses experimental design to understand how these factors influence privacy concerns. The results suggest that GDPR reduces the average privacy concerns of users ...


Swine Disease Reporting: Report #23, Giovani Trevisan, Daniel Linhares, Edison Magalhaes, Leticia Linhares, Bret Crim, Poonam Dubey, Kent Schwartz, Eric Burrough, Philip Gauger, Rodger Main, Mary Thurn, Paulo Lages, Cesar Corzo, Jerry Torrison, Rob Mcgaughey, Eric Herrman, Giselle Cino, Jamie Henningson, Jon Greseth, Travis Clement, Jane C. Hennings Jan 2020

Swine Disease Reporting: Report #23, Giovani Trevisan, Daniel Linhares, Edison Magalhaes, Leticia Linhares, Bret Crim, Poonam Dubey, Kent Schwartz, Eric Burrough, Philip Gauger, Rodger Main, Mary Thurn, Paulo Lages, Cesar Corzo, Jerry Torrison, Rob Mcgaughey, Eric Herrman, Giselle Cino, Jamie Henningson, Jon Greseth, Travis Clement, Jane C. Hennings

Swine Disease Reporting System

SDRS includes multiple projects that aggregates data from participating veterinary diagnostic laboratories (VDLs) in the United States of America, and reports the major findings to the swine industry. Our goal is to share information on endemic and emerging diseases affecting the swine population in the USA, assisting veterinarians and producers to make informed decisions on disease prevention, detection and management. After aggregating information from participating VDLs and summarizing the data, we ask the input of our advisory group, which consists of veterinarians and producers across the USA swine industry. The intent is to provide interpretation of the data observed, and ...


Small Non-Coding Rna Cjnc110 Influences Motility, Autoagglutination, Ai-2 Localization, And Chicken Colonization In Campylobacter Jejuni, Amanda J. Kreuder, Brandon Ruddell, Kathy Mou, Alan Hassall, Qijing Zhang, Paul J. Plummer Jan 2020

Small Non-Coding Rna Cjnc110 Influences Motility, Autoagglutination, Ai-2 Localization, And Chicken Colonization In Campylobacter Jejuni, Amanda J. Kreuder, Brandon Ruddell, Kathy Mou, Alan Hassall, Qijing Zhang, Paul J. Plummer

Veterinary Microbiology and Preventive Medicine Publications

Small non-coding RNAs are involved in many important physiological functions in pathogenic microorganisms. Previous studies have identified the presence of non-coding RNAs in the major zoonotic pathogen Campylobacter jejuni, however, few have been functionally characterized to date. CjNC110 is a conserved ncRNA in C. jejuni, located downstream of the luxS gene which is responsible for the production of the quorum-sensing molecule autoinducer-2 (AI-2). In this study, we utilized strand specific high-throughput RNAseq to identify potential targets or interactive partners of CjNC110 in a sheep abortion clone of C. jejuni. This data was utilized to focus further phenotypic evaluation of the ...


Epidemiology, Detection, And Intervention/Control Of Cyclospora Cayetanensis: A Scoping Review Protocol, Sarah C. Totton, Annette M. O'Connor, Mary E. Torrence, Jan M. Sargeant Jan 2020

Epidemiology, Detection, And Intervention/Control Of Cyclospora Cayetanensis: A Scoping Review Protocol, Sarah C. Totton, Annette M. O'Connor, Mary E. Torrence, Jan M. Sargeant

Veterinary Diagnostic and Production Animal Medicine Reports

Background: Cyclosporiasis is a food- and waterborne illness in humans caused by the consumption of contaminated food or water. As the causative agent, Cyclospora cayetanensis, has only been recently described, the published literature is limited and no scoping reviews on this topic have yet been conducted.

Objectives: Our objective is to conduct a scoping review of the epidemiology, detection in matrix, and intervention/control of C. cayetanensis worldwide in humans, plant-based food, and in the environment with the aim of identifying gaps in the literature, potential areas where there may be sufficient literature to warrant a systematic review, and prioritizing ...


The Code Of The Street Fights Back! Significant Associations With Arrest, Delinquency, And Violence Withstand Psychological Confound, Kyle A. Burgason, Matt Delisi, Mark H. Heirigs, Abdi Kusow, Jacob H. Erickson, Michael G. Vaughn Jan 2020

The Code Of The Street Fights Back! Significant Associations With Arrest, Delinquency, And Violence Withstand Psychological Confound, Kyle A. Burgason, Matt Delisi, Mark H. Heirigs, Abdi Kusow, Jacob H. Erickson, Michael G. Vaughn

Sociology Publications

Since Anderson’s now classic, Code of the Street: Decency, Violence, and the Moral Life of the Inner City, an increasing number of researchers have found a significant association between the code of the street and antisocial behavior. Less researched, however, is the relationship between the code of the street and cognate psychological factors. Building on the hypothesis that the code of the street is simply a reflection of elements of the population who exhibit antisocial traits, our aim in this study is to empirically test whether the observed association between the code of the street and antisocial behavior can ...


Diagnosis And Treatment Of Ocular Proptosis, Braidee C. Foote, Lionel Sebbag Jan 2020

Diagnosis And Treatment Of Ocular Proptosis, Braidee C. Foote, Lionel Sebbag

Veterinary Clinical Sciences Publications

Proptosis, or traumatic forward displacement of the globe out of the orbit, is a serious ocular emergency that requires immediate attention to minimize discomfort and damage to the eye (Figure 1). With proptosis, the eyelid margins are trapped behind the equator of the globe and, together with profound tissue swelling in the orbit, prevent the eyeball from returning to a normal position.


Experimental Study Using Multiple Strains Of Prion Disease In Cattle Reveals An Inverse Relationship Between Incubation Time And Misfolded Prion Accumulation, Neuroinflammation And Autophagy, Najiba Mammadova, M. Heather West Greenlee, S. Jo Moore, Donald S. Sakaguchi, Justin J. Greenlee Jan 2020

Experimental Study Using Multiple Strains Of Prion Disease In Cattle Reveals An Inverse Relationship Between Incubation Time And Misfolded Prion Accumulation, Neuroinflammation And Autophagy, Najiba Mammadova, M. Heather West Greenlee, S. Jo Moore, Donald S. Sakaguchi, Justin J. Greenlee

Genetics, Development and Cell Biology Publications

Proteinopathies result from aberrant folding and accumulation of specific proteins. Currently, there is a lack of knowledge about the factors that influence disease progression making this a key challenge for the development of therapies for proteinopathies. Due to the similarities between transmissible spongiform encephalopathies (TSEs) and other protein misfolding diseases, TSEs can be used to understand other proteinopathies. Bovine spongiform encephalopathy (BSE) is a TSE that occurs in cattle and can be subdivided into three strains: classical BSE, and atypical BSEs (H-type and L-type) that have shorter incubation periods. The NLRP3 inflammasome is a critical component of the innate immune ...


Cholinergic Receptors On Intestine Cells Of Ascaris Suum And Activation Of Nachrs By Levamisole, Mark Mchugh, Paul Williams, Saurabh Verma, Jo Anne Powell-Coffman, Alan P. Robertson, Richard J. Martin Jan 2020

Cholinergic Receptors On Intestine Cells Of Ascaris Suum And Activation Of Nachrs By Levamisole, Mark Mchugh, Paul Williams, Saurabh Verma, Jo Anne Powell-Coffman, Alan P. Robertson, Richard J. Martin

Genetics, Development and Cell Biology Publications

Cholinergic agonists, like levamisole, are a major class of anthelmintic drug that are known to act selectively on nicotinic acetylcholine receptors (nAChRs) on the somatic muscle and nerves of nematode parasites to produce their contraction and spastic paralysis. Previous studies have suggested that in addition to the nAChRs found on muscle and nerves, there are nAChRs on non-excitable tissues of nematode parasites. We looked for evidence of nAChRs expression in the cells of the intestine of the large pig nematode, Ascaris suum, using RT-PCR and RNAscope in situ hybridization and detected mRNA of nAChR subunits in the cells. These subunits ...


Sensor-As-A-Service: Convergence Of Sensor Analytic Point Solutions (Snaps) And Pay-A-Penny-Per-Use (Pappu) Paradigm As A Catalyst For Democratization Of Healthcare In Underserved Communities, Victoria Morgan, Lisseth Casso-Hartmann, David Bahamon-Pinzon, Kelli Mccourt, Robert G. Hjort, Sahar Bahramzadeh, Irene Velez-Torres, Eric Mclamore, Carmen Gomes, Evangelyn C. Alocilja, Nirajan Bhusal, Sunaina Shrestha, Nisha Pote, Ruben Kenny Briceno, Shoumen Palit Austin Datta, Diana C. Vanegas Jan 2020

Sensor-As-A-Service: Convergence Of Sensor Analytic Point Solutions (Snaps) And Pay-A-Penny-Per-Use (Pappu) Paradigm As A Catalyst For Democratization Of Healthcare In Underserved Communities, Victoria Morgan, Lisseth Casso-Hartmann, David Bahamon-Pinzon, Kelli Mccourt, Robert G. Hjort, Sahar Bahramzadeh, Irene Velez-Torres, Eric Mclamore, Carmen Gomes, Evangelyn C. Alocilja, Nirajan Bhusal, Sunaina Shrestha, Nisha Pote, Ruben Kenny Briceno, Shoumen Palit Austin Datta, Diana C. Vanegas

Mechanical Engineering Publications

In this manuscript, we discuss relevant socioeconomic factors for developing and implementing sensor analytic point solutions (SNAPS) as point-of-care tools to serve impoverished communities. The distinct economic, environmental, cultural, and ethical paradigms that affect economically disadvantaged users add complexity to the process of technology development and deployment beyond the science and engineering issues. We begin by contextualizing the environmental burden of disease in select low-income regions around the world, including environmental hazards at work, home, and the broader community environment, where SNAPS may be helpful in the prevention and mitigation of human exposure to harmful biological vectors and chemical agents ...


Development Of A Subcutaneous Ear Implant To Deliver An Anaplasmosis Vaccine To Dairy Steers, Andrew K. Curtis, Kathryn E. Reif, Michael D. Kleinhenz, Miriam S. Martin, Brandt Skinner, Sean M. Kelly, Douglas E. Jones, Emily J. Reppert, Shawnee R. Montgomery, Balaji Narasimhan, Tippawan Anantatat, Majid Jaberi-Douraki, Johann F. Coetzee Dec 2019

Development Of A Subcutaneous Ear Implant To Deliver An Anaplasmosis Vaccine To Dairy Steers, Andrew K. Curtis, Kathryn E. Reif, Michael D. Kleinhenz, Miriam S. Martin, Brandt Skinner, Sean M. Kelly, Douglas E. Jones, Emily J. Reppert, Shawnee R. Montgomery, Balaji Narasimhan, Tippawan Anantatat, Majid Jaberi-Douraki, Johann F. Coetzee

Chemical and Biological Engineering Publications

Bovine anaplasmosis is the most prevalent tick-transmitted disease of cattle worldwide and a major obstacle to profitable beef production. Use of chlortetracycline-medicated feed to control active anaplasmosis infections during the vector season has raised concerns about the potential emergence of antimicrobial resistance in bacteria that may pose a risk to human health. Furthermore, the absence of effectiveness data for a commercially available, conditionally licensed anaplasmosis vaccine is a major impediment to implementing anaplasmosis control programs. The primary objective of this study was to develop a single-dose vaccine delivery platform to produce long-lasting protective immunity against anaplasmosis infections. Twelve Holstein steers ...