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Articles 1 - 30 of 3565
Full-Text Articles in Medicine and Health Sciences
Co-Design Of A Personalised Digital Intervention To Improve Vegetable Intake In Adults Living In Australian Rural Communities, Katherine M. Livingstone, Jonathan C. Rawstorn, Laura Alston, Stephanie R. Partridge, Amber Bastian, Kate Dullaghan, Sarah A. Mcnaughton, Gilly A. Hendrie, Lauren C. Blekkenhorst, Ralph Maddison, Yuxin Zhang, Scott Barnett, John C. Mathers, Stephanie L. Godrich
Co-Design Of A Personalised Digital Intervention To Improve Vegetable Intake In Adults Living In Australian Rural Communities, Katherine M. Livingstone, Jonathan C. Rawstorn, Laura Alston, Stephanie R. Partridge, Amber Bastian, Kate Dullaghan, Sarah A. Mcnaughton, Gilly A. Hendrie, Lauren C. Blekkenhorst, Ralph Maddison, Yuxin Zhang, Scott Barnett, John C. Mathers, Stephanie L. Godrich
Research outputs 2022 to 2026
Background: Diets low in vegetables are a main contributor to the health burden experienced by Australians living in rural communities. Given the ubiquity of smartphones and access to the Internet, digital interventions may offer an accessible delivery model for a dietary intervention in rural communities. However, no digital interventions to address low vegetable intake have been co-designed with adults living in rural areas. This paper describes the co-design of a digital intervention to improve vegetable intake with rural community members and research partners. Methods: Active participants in the co-design process were adults ≥ 18 years living in three rural Australian …
The Effects Of Short-Term, Progressive Exercise Training On Disease Activity In Smouldering Multiple Myeloma And Monoclonal Gammopathy Of Undetermined Significance: A Single-Arm Pilot Study, A. Emery, S. Moore, J. Crowe, J. Murray, O. Peacock, D. Thompson, F. Betts, S. Rapps, L. Ross, D. Rothschild-Rodriguez, A. A. Echarri, R. Davies, R. Lewis, D. X. Augustine, A. Whiteway, Z. Afzal, J. L. J. Heaney, M. T. Drayson, J. E. Turner, John P. Campbell
The Effects Of Short-Term, Progressive Exercise Training On Disease Activity In Smouldering Multiple Myeloma And Monoclonal Gammopathy Of Undetermined Significance: A Single-Arm Pilot Study, A. Emery, S. Moore, J. Crowe, J. Murray, O. Peacock, D. Thompson, F. Betts, S. Rapps, L. Ross, D. Rothschild-Rodriguez, A. A. Echarri, R. Davies, R. Lewis, D. X. Augustine, A. Whiteway, Z. Afzal, J. L. J. Heaney, M. T. Drayson, J. E. Turner, John P. Campbell
Research outputs 2022 to 2026
Background: High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting. A case study (N = 1) of a former elite athlete aged 44 years previously indicated that a multi-modal exercise programme reversed SMM disease activity. To build from this prior case study, the present pilot study firstly examined if short-term exercise training was feasible and safe for a group of MGUS and SMM patients, and secondly …
Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu
Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu
Research outputs 2022 to 2026
Background: Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the association between systemic inflammation assessed by joint cumulative high-sensitivity C-reactive protein (CumCRP) and monocyte to high-density lipoprotein ratio (CumMHR) and incident type 2 diabetes (T2D) and their predictive value for T2D in a general population. Methods: A total of 40,813 nondiabetic participants from a prospective real-life cohort (Kailuan Study, China) were followed biennially from 2010/2011 until December 31, 2020. Multivariable Cox regression analyses were conducted to evaluate the adjusted hazard ratios (aHRs) of …
Simultaneous Extraction And Quantitative Analysis Of S-Methyl-L-Cysteine Sulfoxide, Sulforaphane And Glucosinolates In Cruciferous Vegetables By Liquid Chromatography Mass Spectrometry, Armaghan Shafaei, Caroline R. Hill, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Mary C. Boyce
Simultaneous Extraction And Quantitative Analysis Of S-Methyl-L-Cysteine Sulfoxide, Sulforaphane And Glucosinolates In Cruciferous Vegetables By Liquid Chromatography Mass Spectrometry, Armaghan Shafaei, Caroline R. Hill, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Mary C. Boyce
Research outputs 2022 to 2026
Sulfur containing compounds including glucosinolates (GLS), sulforaphane (SFN) and S-methyl-L-cysteine sulfoxide (SMCSO) have been proposed to be partly responsible for the beneficial health effects of cruciferous vegetables. As such, greater understanding of their measurements within foods is important to estimate intake in humans and to inform dietary intervention studies. Herein is described a simple and sensitive method for simultaneous analysis of 20 GLS, SFN and SMCSO by liquid chromatography mass spectrometry. Analytes were effectively retained and resolved on an Xbridge C18 column. Detection can be achieved using high resolution or unit resolution mass spectrometry; the latter making the method more …
What Resilience (Strength) Means For Australian Aboriginal And Torres Strait Islander Health Professionals And Practitioners: An Exploratory Study, Eileen Willis, Amy-Louise J. Byrne, Sandy Mclellan, Venessa Curnow, Harvey Clare, Janie Brown, Amelia Britton
What Resilience (Strength) Means For Australian Aboriginal And Torres Strait Islander Health Professionals And Practitioners: An Exploratory Study, Eileen Willis, Amy-Louise J. Byrne, Sandy Mclellan, Venessa Curnow, Harvey Clare, Janie Brown, Amelia Britton
Journal of the Australian Indigenous HealthInfoNet
This article explores the concept of resilience from the perspective of Australian Aboriginal and Torres Strait Islander health professionals and practitioners, with the aim of describing what it is and how it is practiced in the workplace. Interviews in the form of Yarns were conducted with ten Aboriginal and Torres Strait Islander health professionals in regional North Queensland. We found that for Aboriginal and Torres Strait Islander health professionals and practitioners, resilience encompasses cultural identity and an ability to manage both Indigenous and western cultures and structures. Resilience, understood as ‘Strength’, draws on strong relationships to family and Country, often …
Use Of A Primary Care Dataset To Describe ‘The Real Picture’ Of Diabetes In Kimberley Aboriginal Communities, Caitlyn S. White, Kimberley Seear, Lorraine Anderson, Emma Griffiths
Use Of A Primary Care Dataset To Describe ‘The Real Picture’ Of Diabetes In Kimberley Aboriginal Communities, Caitlyn S. White, Kimberley Seear, Lorraine Anderson, Emma Griffiths
Journal of the Australian Indigenous HealthInfoNet
Objective
Aboriginal communities are impacted by high rates of diabetes, however these are currently underestimated by national data sources used by policy and decision makers to inform allocation of health resources. We aimed to estimate diabetes prevalence and screening coverage using primary care electronic medical record data.
Methods
A cross-sectional audit was conducted using primary care data from Aboriginal regular Aboriginal Community Controlled Health Service (ACCHS) clinic attendees aged 15 years and over (n=1763) in five remote communities in the Kimberley region. Main outcome measures were overall diabetes prevalence; age-specific diabetes prevalence; prevalence of pre-diabetes; and screening rates among patients …
The Inequitable Burden Of Infectious Diseases Among Remote-Living Aboriginal And Torres Strait Islander Australians: A Product Of History, Stephanie L. Enkel, Rebecca Famlonga, Hannah M. M. Thomas, Nina Lansbury, Jonathan R. Carapetis, Glenn Pearson, Asha C. Bowen
The Inequitable Burden Of Infectious Diseases Among Remote-Living Aboriginal And Torres Strait Islander Australians: A Product Of History, Stephanie L. Enkel, Rebecca Famlonga, Hannah M. M. Thomas, Nina Lansbury, Jonathan R. Carapetis, Glenn Pearson, Asha C. Bowen
Journal of the Australian Indigenous HealthInfoNet
Insufficient and poorly maintained housing and plumbing in many remote Australian Indigenous communities in Australia results in reduced capacity to maintain personal hygiene, contributing to infectious disease inequalities. Infections from Streptococcus pyogenes (Strep A) and sequalae are often noted to be the result of contextual poverty; a product of over 230 years of discriminatory practice that has excluded Indigenous people from the basic human rights of healthy, maintained housing afforded to most in the nation. The solutions for eliminating diseases of inequity among Australian Indigenous population are known, their success is historically documented, and yet they are to be comprehensively …
The Koolungar Moorditj Healthy Skin Project: Elder And Community Led Resources Strengthen Aboriginal Voice For Skin Health, Bernadette M. Ricciardo, Jacinta Walton, Noel Nannup, Dale Tilbrook, Heather-Lynn Kessaris, Carol Michie, Brad Farrant, Roni Forrest, Annette Garlett, Joanne Hill, Larissa Jones, Natasha Kickett, Sally Smith, Delys Walton, Taleah Ugle, Nadia Rind, Richelle Douglas, Jodie Ingrey, Brenda Carter, Ainslie Poore, Ingrid Amgarth-Duff, Hannah Thomas, Prasad S. Kumarasinghe, Jonathan R. Carapetis, Asha C. Bowen
The Koolungar Moorditj Healthy Skin Project: Elder And Community Led Resources Strengthen Aboriginal Voice For Skin Health, Bernadette M. Ricciardo, Jacinta Walton, Noel Nannup, Dale Tilbrook, Heather-Lynn Kessaris, Carol Michie, Brad Farrant, Roni Forrest, Annette Garlett, Joanne Hill, Larissa Jones, Natasha Kickett, Sally Smith, Delys Walton, Taleah Ugle, Nadia Rind, Richelle Douglas, Jodie Ingrey, Brenda Carter, Ainslie Poore, Ingrid Amgarth-Duff, Hannah Thomas, Prasad S. Kumarasinghe, Jonathan R. Carapetis, Asha C. Bowen
Journal of the Australian Indigenous HealthInfoNet
In partnership with local Aboriginal Community Controlled Health Organisations, the Elder-led co-designed Koolungar Moorditj Healthy Skin project is guided by principles of reciprocity, capacity building, respect, and community involvement. Through this work, the team of Elders, community members, clinicians and research staff have gained insight into the skin health needs of urban-living Aboriginal koolungar (children); and having identified a lack of targeted and culturally appropriate health literacy and health promotion resources on moorditj (strong) skin, prioritised development of community-created healthy skin resources. Community members self-appointed to Aboriginal Community Advisory Groups (CAG) on Whadjuk (Perth) …
Communities Of Practice To Facilitate Change In Health Professions Education: A Realist Synthesis, Gemma Jenkins, Claire Palermo, Alexander M. Clark, Leesa Costello
Communities Of Practice To Facilitate Change In Health Professions Education: A Realist Synthesis, Gemma Jenkins, Claire Palermo, Alexander M. Clark, Leesa Costello
Research outputs 2022 to 2026
Background: Communities of practice could contribute to transformations in health professions education to meet complex and emerging challenges. However, little is known about the underlying mechanisms of communities of practice in this setting, and how context influences outcomes. Objective: To understand when, why and how communities of practice with health professions education faculty work to facilitate higher education change. Design: A realist synthesis according to the RAMESES standards and steps described by Pawson and colleagues. Review methods: Early scoping of the literature informed the development of an initial program theory to describe underlying assumptions about how communities of practice in …
Consensus-Based Recommendations For The Care Of Women With A Breech Presenting Fetus, Sara Morris, Sadie Geraghty, Deborah Sundin
Consensus-Based Recommendations For The Care Of Women With A Breech Presenting Fetus, Sara Morris, Sadie Geraghty, Deborah Sundin
Research outputs 2022 to 2026
Objective: To establish consensus related to aspects of breech presentation and care. Design: A multinational, three round e-Delphi study. Participants: A panel of 15 midwives, four obstetricians and an academic with knowledge and/or experience of caring for women with a breech presenting fetus. Methods: An initial survey of 45 open-ended questions. Answers were coded and amalgamated to form 448 statements in the second round and three additional statements in the third round. Panellists were asked to provide their level of agreement for each statement using a 5-point Likert scale. Consensus was deemed met if 70% of panellists responded with strongly …
Large Airway T Cells In Adults With Former Bronchopulmonary Dysplasia, Jing Gao, Petra Um-Bergström, Melvin Pourbazargan, Eva Berggren-Broström, Chuan X. Li, Heta Merikallio, Riitta Kaarteenaho, Nichole S. Reinke, Craig E. Wheelock, Erik Melén, Lindén Anders, Åsa M. Wheelock, Georgios Rassidakis, Cristian Ortiz-Villalon, Magnus C. Sköld
Large Airway T Cells In Adults With Former Bronchopulmonary Dysplasia, Jing Gao, Petra Um-Bergström, Melvin Pourbazargan, Eva Berggren-Broström, Chuan X. Li, Heta Merikallio, Riitta Kaarteenaho, Nichole S. Reinke, Craig E. Wheelock, Erik Melén, Lindén Anders, Åsa M. Wheelock, Georgios Rassidakis, Cristian Ortiz-Villalon, Magnus C. Sköld
Research outputs 2022 to 2026
BACKGROUND: Bronchopulmonary Dysplasia (BPD) in infants born prematurely is a risk factor for chronic airway obstruction later in life. The distribution of T cell subtypes in the large airways is largely unknown. OBJECTIVE: To characterize cellular and T cell profiles in the large airways of young adults with a history of BPD. METHODS: Forty-three young adults born prematurely (preterm (n = 20), BPD (n = 23)) and 45 full-term-born (asthma (n = 23), healthy (n = 22)) underwent lung function measurements, and bronchoscopy with large airway bronchial wash (BW). T-cells subsets in BW were analyzed by immunocytochemistry. RESULTS: The proportions …
Investigating The Genetic Makeup Of The Major Histocompatibility Complex (Mhc) In The United Arab Emirates Population Through Next-Generation Sequencing, Nour A. D. Marzouka, Halima Alnaqbi, Amira Al-Aamri, Guan Tay, Habiba Alsafar
Investigating The Genetic Makeup Of The Major Histocompatibility Complex (Mhc) In The United Arab Emirates Population Through Next-Generation Sequencing, Nour A. D. Marzouka, Halima Alnaqbi, Amira Al-Aamri, Guan Tay, Habiba Alsafar
Research outputs 2022 to 2026
The Human leukocyte antigen (HLA) molecules are central to immune response and have associations with the phenotypes of various diseases and induced drug toxicity. Further, the role of HLA molecules in presenting antigens significantly affects the transplantation outcome. The objective of this study was to examine the extent of the diversity of HLA alleles in the population of the United Arab Emirates (UAE) using Next-Generation Sequencing methodologies and encompassing a larger cohort of individuals. A cohort of 570 unrelated healthy citizens of the UAE volunteered to provide samples for Whole Genome Sequencing and Whole Exome Sequencing. The definition of the …
Arterial Stiffness And Obesity As Predictors Of Diabetes: Longitudinal Cohort Study, Cancan Cui, Zhiyuan Wu, Jia Zheng, Jiaqi Chu, Jiajing Zhu, Yitian Qi, Zhenming Zhang, Zhijia Wang, Mengchao Zhang, Zhanhao Mo, Liangkai Cheng, Lei Ding, Xiaoping Kang, Lin Liu, Te Zhang
Arterial Stiffness And Obesity As Predictors Of Diabetes: Longitudinal Cohort Study, Cancan Cui, Zhiyuan Wu, Jia Zheng, Jiaqi Chu, Jiajing Zhu, Yitian Qi, Zhenming Zhang, Zhijia Wang, Mengchao Zhang, Zhanhao Mo, Liangkai Cheng, Lei Ding, Xiaoping Kang, Lin Liu, Te Zhang
Research outputs 2022 to 2026
BACKGROUND: Previous studies have confirmed the separate effect of arterial stiffness and obesity on type 2 diabetes; however, the joint effect of arterial stiffness and obesity on diabetes onset remains unclear. OBJECTIVE: This study aimed to propose the concept of arterial stiffness obesity phenotype and explore the risk stratification capacity for diabetes. METHODS: This longitudinal cohort study used baseline data of 12,298 participants from Beijing Xiaotangshan Examination Center between 2008 and 2013 and then annually followed them until incident diabetes or 2019. BMI (waist circumference) and brachial-ankle pulse wave velocity were measured to define arterial stiffness abdominal obesity phenotype. The …
Living With Myocardial Ischaemia And No Obstructive Coronary Arteries: A Qualitative Study, Helen Humphreys, Danielle Paddock, Sarah Brown, Colin Berry, Aynsley Cowie, Susan Dawkes, Simon Nichols
Living With Myocardial Ischaemia And No Obstructive Coronary Arteries: A Qualitative Study, Helen Humphreys, Danielle Paddock, Sarah Brown, Colin Berry, Aynsley Cowie, Susan Dawkes, Simon Nichols
Research outputs 2022 to 2026
Objective To explore the lived experience of people with myocardial ischaemia with no obstructive arteries. Design Qualitative study using semistructured interviews. Setting Telephone interviews with 17 participants living in the UK. Participants 17 people (2 males, 15 females; aged 31–69 years) with a presumed or confirmed diagnosis of myocardial ischaemia with no obstructive arteries, recruited via social media and online patient-led support forums. Results Five themes were generated. Theme 1 describes the wide range of experiences that participants described, particularly the frequency and intensity of symptoms, and the uncertainty and fear that symptoms commonly provoked. Theme 2 describes the major …
Assessing Suboptimal Health Status In The Saudi Population: Translation And Validation Of The Shsq-25 Questionnaire, Mohamed A. Alzain, Collins O. Asweto, Sehar-Un-Nisa Hassan, Mohammed E. Saeed, Ahmed Kassar, Kamal E. M. Ali, Mouna Ghorbel, Rafat Zrieq, Bandar Alsaif, Wei Wang
Assessing Suboptimal Health Status In The Saudi Population: Translation And Validation Of The Shsq-25 Questionnaire, Mohamed A. Alzain, Collins O. Asweto, Sehar-Un-Nisa Hassan, Mohammed E. Saeed, Ahmed Kassar, Kamal E. M. Ali, Mouna Ghorbel, Rafat Zrieq, Bandar Alsaif, Wei Wang
Research outputs 2022 to 2026
Background: Suboptimal Health Status (SHS) is realised as a vital feature for improving global health. However, the Arabian world does not have a validated instrument for screening SHS in their population. Therefore, the study aimed to evaluate the psychometric properties of Arabic-translated SHS (ASHSQ-25) in the Saudi Arabian population. Methods: We conducted a cross-sectional study among the conveniently sampled 1590 participants from the Saudi population (with a 97.4% response rate). The data was gathered through an online survey and then exported into SPSS and AMOS version 26.0 for analysis. Mann-Whitney and Kruskal-Wallis tests were used to identify the median difference …
Analysis Of The Outer Retinal Bands In Abca4 And Prph2-Associated Retinopathy Using Oct, Rachael C. Heath Jeffery, Johnny Lo, Jennifer A. Thompson, Tina M. Lamey, Terri L. Mclaren, John N. De Roach, Lauren N. Ayton, Andrea L. Vincent, Abhishek Sharma, Fred K. Chen
Analysis Of The Outer Retinal Bands In Abca4 And Prph2-Associated Retinopathy Using Oct, Rachael C. Heath Jeffery, Johnny Lo, Jennifer A. Thompson, Tina M. Lamey, Terri L. Mclaren, John N. De Roach, Lauren N. Ayton, Andrea L. Vincent, Abhishek Sharma, Fred K. Chen
Research outputs 2022 to 2026
Purpose: To evaluate the outer retinal bands using OCT in ABCA4- and PRPH2-associated retinopathy and develop a novel imaging biomarker to differentiate between these 2 genotypes. Design: Multicenter case-control study. Participants: Patients with a clinical and genetic diagnosis of ABCA4- or PRPH2-associated retinopathy and an age-matched control group. Methods: Macular OCT was used to measure the thickness of the outer retinal bands 2 and 4 by 2 independent examiners at 4 retinal loci. Main Outcome Measures: Outcome measures included the thicknesses of band 2, band 4, and the band 2/band 4 ratio. Linear mixed modeling was used to make comparisons …
Dropout From Exercise Trials Among Cancer Survivors—An Individual Patient Data Meta-Analysis From The Polaris Study, Benedikte Western, Andreas Ivarsson, Ingvild Vistad, Ingrid Demmelmaier, Neil K. Aaronson, Gillian Radcliffe, Marc Van Beurden, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvão, Rachel Garrod, Martine M. Goedendorp, Kathleen A. Griffith, Wim H. Van Harten, Sandi C. Hayes, Fernando Herrero-Roman, Anouk E. Hiensch, Melinda L. Irwin, Erica James, Marlou-Floor Kenkhuis, Marie J. Kersten, Hans Knoop, Alejandro Lucia, Anne M. May, Alex Mcconnachie, Willem Van Mechelen, Nanette Mutrie, Robert U. Newton, Frans Nollet, Hester S. Oldenburg, Ron Plotnikoff, Martina E. Schmidt, Katie H. Schmitz, Karl-Heinz Schulz, Camille E. Short, Gabe S. Sonke, Karen Steindorf, Martijn M. Stuiver, Dennis R. Taaffe, Lene Thorsen, Miranda J. Velthuis, Jennifer Wenzel, Kerri M. Winters-Stone, Joachim Wiskemann, Sveinung Berntsen, Laurien M. Buffart
Dropout From Exercise Trials Among Cancer Survivors—An Individual Patient Data Meta-Analysis From The Polaris Study, Benedikte Western, Andreas Ivarsson, Ingvild Vistad, Ingrid Demmelmaier, Neil K. Aaronson, Gillian Radcliffe, Marc Van Beurden, Martin Bohus, Kerry S. Courneya, Amanda J. Daley, Daniel A. Galvão, Rachel Garrod, Martine M. Goedendorp, Kathleen A. Griffith, Wim H. Van Harten, Sandi C. Hayes, Fernando Herrero-Roman, Anouk E. Hiensch, Melinda L. Irwin, Erica James, Marlou-Floor Kenkhuis, Marie J. Kersten, Hans Knoop, Alejandro Lucia, Anne M. May, Alex Mcconnachie, Willem Van Mechelen, Nanette Mutrie, Robert U. Newton, Frans Nollet, Hester S. Oldenburg, Ron Plotnikoff, Martina E. Schmidt, Katie H. Schmitz, Karl-Heinz Schulz, Camille E. Short, Gabe S. Sonke, Karen Steindorf, Martijn M. Stuiver, Dennis R. Taaffe, Lene Thorsen, Miranda J. Velthuis, Jennifer Wenzel, Kerri M. Winters-Stone, Joachim Wiskemann, Sveinung Berntsen, Laurien M. Buffart
Research outputs 2022 to 2026
Introduction: The number of randomized controlled trials (RCTs) investigating the effects of exercise among cancer survivors has increased in recent years; however, participants dropping out of the trials are rarely described. The objective of the present study was to assess which combinations of participant and exercise program characteristics were associated with dropout from the exercise arms of RCTs among cancer survivors. Methods: This study used data collected in the Predicting OptimaL cAncer RehabIlitation and Supportive care (POLARIS) study, an international database of RCTs investigating the effects of exercise among cancer survivors. Thirty-four exercise trials, with a total of 2467 patients …
The Role Of Diet And Gut Microbiota In Alzheimer’S Disease, D. M.Sithara Dissanayaka, Vijay Jayasena, Stephanie R. Rainey-Smith, Ralph N. Martins, W. M.A.D.Binosha Fernando
The Role Of Diet And Gut Microbiota In Alzheimer’S Disease, D. M.Sithara Dissanayaka, Vijay Jayasena, Stephanie R. Rainey-Smith, Ralph N. Martins, W. M.A.D.Binosha Fernando
Research outputs 2022 to 2026
Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (A ) plaques and hyperphosphorylated tau tangles. Currently, Alzheimer’s disease (AD) impacts 50 million individuals, with projections anticipating an increase to 152 million by the year 2050. Despite the increasing global prevalence of AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis and treatment. Recent research suggests a link between gut dysbiosis and the aggregation of A , the development of tau proteins, and the occurrence of neuroinflammation and oxidative stress are associated with AD. However, investigations into the gut–brain axis …
Challenging The Nuances Of Pain Assessment With Co-Designed Audio-Visual Simulations In Nursing Education: A Descriptive Study, Michelle A. Kelly, Susan Slatyer, Naomi Tutticci, Joanne Ramsbotham, Sandra Johnston, Irene Ngune, Karen A. Theobald
Challenging The Nuances Of Pain Assessment With Co-Designed Audio-Visual Simulations In Nursing Education: A Descriptive Study, Michelle A. Kelly, Susan Slatyer, Naomi Tutticci, Joanne Ramsbotham, Sandra Johnston, Irene Ngune, Karen A. Theobald
Research outputs 2022 to 2026
Background: Appropriate management of pain remains a challenging issue. Surfacing nurses’ inherent assumptions about pain may lead to better pain management. This study developed and evaluated new audio-visual (AV) simulations for nursing students showcasing patient characteristics that may influence pain assessment. Methods: Descriptive pre/post intervention study informed by the STROBE framework. Participants were drawn from two Australian universities. Three AV simulations were codesigned by clinicians, educators, and health consumers. Data included: demographics, previous experiences of pain assessment; compassion scale, feasibility, and relevance of AV simulations. Quantile regression and content analyses were applied. Results: Full data sets of 491 participants (314 …
Pre-Eclampsia Training Needs Of Midwives In A Ghanaian Tertiary Hospital: A Cross-Sectional Study, Isabella Garti, Michelle Gray, Angela Bromley, Jing-Yu (Benjamin) Tan
Pre-Eclampsia Training Needs Of Midwives In A Ghanaian Tertiary Hospital: A Cross-Sectional Study, Isabella Garti, Michelle Gray, Angela Bromley, Jing-Yu (Benjamin) Tan
Research outputs 2022 to 2026
Aim: This study aimed to assess the specific clinical and non-clinical training needs of midwives and determine their preferred approach to enhancing performance. Background: Pre-eclampsia remains one of the leading causes of maternal deaths in low and middle-income countries. Pre-eclampsia-related deaths may be due to reduced midwifery knowledge and inadequate management. Therefore, a training needs assessment is vital in identifying gaps in practice, especially, in poorly resourced settings for maximal use of training resources. Design: A hospital-based cross-sectional study. Setting: The largest tertiary hospital in Ghana. Methods: An online version of the validated WHO Hennessy-Hicks Training Needs Analysis questionnaire was …
The Psychosocial Beliefs, Experiences And Expectations Of Children Living With Obesity, Lisa Newson, Nicola Sides, Amineh Rashidi
The Psychosocial Beliefs, Experiences And Expectations Of Children Living With Obesity, Lisa Newson, Nicola Sides, Amineh Rashidi
Research outputs 2022 to 2026
Background: Childhood obesity has been shown to impair psychological health. However, psychological factors are often overlooked in both research evaluations and treatment interventions, and children's perspectives on managing obesity are underexplored. Neglecting psychosocial factors might undermine interventions. This research explored the psychological beliefs, expectations and experiences of children living with obesity (range 7–13) and attending a weight management programme (WMP). Methods: Thirty-four participants (19 females, 15 males, average age 9.5 years) completed a semistructured interview. Recorded interviews were transcribed verbatim and analysed using thematic analysis. Results: Four overarching themes were developed: (1) defining health and self-recognition; (2) external influence; feedback, …
Failure To Progress Or Just Normal? A Constructivist Grounded Theory Of Physiological Plateaus During Childbirth, Marina Weckend, Kylie Mccullough, Christine Duffield, Sara Bayes, Clare Davison
Failure To Progress Or Just Normal? A Constructivist Grounded Theory Of Physiological Plateaus During Childbirth, Marina Weckend, Kylie Mccullough, Christine Duffield, Sara Bayes, Clare Davison
Research outputs 2022 to 2026
Background and problem: During childbirth, one of the most common diagnoses of pathology is ‘failure to progress’, frequently resulting in labour augmentation and intervention cascades. However, failure to progress is poorly defined and evidence suggests that some instances of slowing, stalling and pausing labour patterns may represent physiological plateaus. Aim: To explore how midwives conceptualise physiological plateaus and the significance such plateaus may have for women's labour trajectory and birth outcome. Methods: Twenty midwives across Australia participated in semi-structured interviews between September 2020 and February 2022. Constructivist grounded theory methodology was applied to analyse data, including multi-phasic coding and application …
Audit Tools For Culturally Safe And Responsive Healthcare Practices With Aboriginal And Torres Strait Islander People: A Scoping Review, Jessica Muller, Susan Devine, Lynore Geia, Alice Cairns, Kylie Stothers, Paul Gibson, Donna Murray
Audit Tools For Culturally Safe And Responsive Healthcare Practices With Aboriginal And Torres Strait Islander People: A Scoping Review, Jessica Muller, Susan Devine, Lynore Geia, Alice Cairns, Kylie Stothers, Paul Gibson, Donna Murray
Research outputs 2022 to 2026
Aboriginal and Torres Strait Islander people in Australia face disparities in accessing culturally safe and appropriate health services. While current cultural safety and responsiveness frameworks set standards for improving healthcare practices, ensuring accountability and sustainability of changes, necessitates robust mechanisms for auditing and monitoring progress. This study examined existing cultural safety audit tools, and facilitators and barriers to implementation, in the context of providing culturally safe and responsive healthcare services with Aboriginal and Torres Strait Islander people. This will assist organisations, interested in developing tools, to assess culturally responsive practice. A scoping review was undertaken using Medline, Scopus, CINAHL, Informit …
Determining The Feasibility Of A Codesigned And Personalised Intervention (Veg4me) To Improve Vegetable Intake In Young Adults Living In Rural Australian Communities: Protocol For A Randomised Controlled Trial, Katherine M. Livingstone, Jonathan C. Rawstorn, Stephanie R. Partridge, Yuxin Zhang, Eric O, Stephanie L. Godrich, Sarah A. Mcnaughton, Gilly A. Hendrie, Kate Dullaghan, Gavin Abbott, Lauren C. Blekkenhorst, Ralph Maddison, Scott Barnett, John C. Mathers, Laura Alston
Determining The Feasibility Of A Codesigned And Personalised Intervention (Veg4me) To Improve Vegetable Intake In Young Adults Living In Rural Australian Communities: Protocol For A Randomised Controlled Trial, Katherine M. Livingstone, Jonathan C. Rawstorn, Stephanie R. Partridge, Yuxin Zhang, Eric O, Stephanie L. Godrich, Sarah A. Mcnaughton, Gilly A. Hendrie, Kate Dullaghan, Gavin Abbott, Lauren C. Blekkenhorst, Ralph Maddison, Scott Barnett, John C. Mathers, Laura Alston
Research outputs 2022 to 2026
INTRODUCTION: Diets low in vegetables are a main contributor to the health burden experienced by young adults in rural communities. Digital health interventions provide an accessible delivery model that can be personalised to meet the diverse preferences of young adults. A personalisable digital vegetable intake intervention (Veg4Me) was codesigned to meet the needs of young adults living in rural communities. This study will determine the feasibility of delivering a personalised Veg4Me programme and compare preliminary effects with a non-personalised Veg4Me (control). METHODS AND ANALYSIS: A 12-week assessor-blinded, two-arm, parallel randomised controlled trial will be undertaken from August 2023 until April …
Are Remote Health Clinics Primary Health Care Focused? Validation Of The Primary Health Care Engagement (Phce) Scale For The Australian Remote Primary Health Care Setting, Kylie Mccullough, Gemma Doleman, Melissa Dunham, Lisa Whitehead, Davina Porock
Are Remote Health Clinics Primary Health Care Focused? Validation Of The Primary Health Care Engagement (Phce) Scale For The Australian Remote Primary Health Care Setting, Kylie Mccullough, Gemma Doleman, Melissa Dunham, Lisa Whitehead, Davina Porock
Research outputs 2022 to 2026
AIM: To test and validate a measure of primary health care (PHC) engagement in the Australian remote health context. BACKGROUND: PHC principles include quality improvement, community participation and orientation of health care, patient-centred continuity of care, accessibility, and interdisciplinary collaboration. Measuring the alignment of services with the principles of PHC provides a method of evaluating the quality of care in community settings. METHODS: A two-stage design of initial content and face validity evaluation by a panel of experts and then pilot-testing the instrument via survey methods was conducted. Twelve experts from clinical, education, management and research roles within the remote …
Development Of A Regional Climate Change Model For Aedes Vigilax And Aedes Camptorhynchus (Diptera: Culicidae) In Perth, Western Australia, Kerry Staples, Peter J. Neville, Steven Richardson, Jacques Oosthuizen
Development Of A Regional Climate Change Model For Aedes Vigilax And Aedes Camptorhynchus (Diptera: Culicidae) In Perth, Western Australia, Kerry Staples, Peter J. Neville, Steven Richardson, Jacques Oosthuizen
Research outputs 2022 to 2026
Mosquito-borne disease is a significant public health issue and within Australia Ross River virus (RRV) is the most reported. This study combines a mechanistic model of mosquito development for two mosquito vectors; Aedes vigilax and Aedes camptorhynchus, with climate projections from three climate models for two Representative Concentration Pathways (RCPs), to examine the possible effects of climate change and sea-level rise on a temperate tidal saltmarsh habitat in Perth, Western Australia. The projections were run under no accretion and accretion scenarios using a known mosquito habitat as a case study. This improves our understanding of the possible implications of sea-level …
Association Of Abnormal Lung Function And Its Subtypes With Arterial Stiffness: A Longitudinal Cohort Study, Zhiyuan Wu, Haiping Zhang, Yue Jiang, Zhiwei Li, Yutao Wang, Yixing Tian, Zheng Guo, Yulu Zheng, Xia Li, Lixin Tao, Xiuhua Guo
Association Of Abnormal Lung Function And Its Subtypes With Arterial Stiffness: A Longitudinal Cohort Study, Zhiyuan Wu, Haiping Zhang, Yue Jiang, Zhiwei Li, Yutao Wang, Yixing Tian, Zheng Guo, Yulu Zheng, Xia Li, Lixin Tao, Xiuhua Guo
Research outputs 2022 to 2026
BACKGROUND: Prior studies have reported the cross-sectional relationship between lung function and arterial stiffness, while the longitudinal association remains unclear to date. This study aimed to investigate whether abnormal lung function and its subtypes at baseline are associated with increased arterial stiffness using a cohort. METHODS AND RESULTS: This was a secondary analysis extracting 2461 participants from Beijing Health Management Cohort as baseline and annually followed for development of arterial stiffness. Abnormal lung function was defined by forced expiratory volume in 1s < 80% of the predicted value, forced vital capacity of the predicted value, or forced expiratory volume in 1s/ forced vital capacity ratio < 70%. Increased arterial stiffness was determined by brachial-ankle pulse wave velocity ≥ 1400 cm/s. Cox proportional hazards model was used to calculate the hazard ratio and population attributable fraction. The mean age was 42.8±8.1 years, and 444 (18.0%) cases developed increased arterial stiffness during a median follow-up of 3.0 years. The adjusted hazard ratio (95% CI) of arterial stiffness was 1.47 (95% CI, 1.10–1.96) for abnormal lung function, with a population attributable fraction of 3.9% (95% CI, 0.8–7.1). Of subtypes, only obstructive ventilatory dysfunction was significantly associated with arterial stiffness (adjusted hazard ratio, 2.06 [95% CI, 1.27–3.36]), not restricted ventilatory dysfunction (adjusted hazard ratio, 0.95 [95% CI, 0.54–1.65]). Consistent results were observed on multiple sensitivity analyses. CONCLUSIONS: Our study indicated a longitudinal association of abnormal lung function with increased arterial stiffness using a large cohort, especially for the obstructive ventilatory dysfunction.
Dose-Response Effects Of Exercise On Mental Health In Community-Dwelling Older Adults: Exploration Of Genetic Moderators, Swathi Gujral, Marcia Burns, Kirk I. Erickson, Dana Rofey, Jeremiah J. Peiffer, Simon M. Laws, Belinda Brown
Dose-Response Effects Of Exercise On Mental Health In Community-Dwelling Older Adults: Exploration Of Genetic Moderators, Swathi Gujral, Marcia Burns, Kirk I. Erickson, Dana Rofey, Jeremiah J. Peiffer, Simon M. Laws, Belinda Brown
Research outputs 2022 to 2026
Background/Objective: (1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms. Method: This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE 4 carrier status were …
Clinical-Grade Human Skin-Derived Abcb5+ Mesenchymal Stromal Cells Exert Anti-Apoptotic And Anti-Inflammatory Effects In Vitro And Modulate Mrna Expression In A Cisplatin-Induced Kidney Injury Murine Model, Erika Rendra, Adriana T. Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback
Clinical-Grade Human Skin-Derived Abcb5+ Mesenchymal Stromal Cells Exert Anti-Apoptotic And Anti-Inflammatory Effects In Vitro And Modulate Mrna Expression In A Cisplatin-Induced Kidney Injury Murine Model, Erika Rendra, Adriana T. Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback
Research outputs 2022 to 2026
Acute kidney injury (AKI) is characterized by a rapid reduction in renal function and glomerular filtration rate (GFR). The broadly used anti-cancer chemotherapeutic agent cisplatin often induces AKI as an adverse drug side effect. Therapies targeted at the reversal of AKI and its potential progression to chronic kidney disease or end-stage renal disease are currently insufficiently effective. Mesenchymal stromal cells (MSCs) possess diverse immunomodulatory properties that confer upon them significant therapeutic potential for the treatment of diverse inflammatory disorders. Human dermal MSCs expressing ATP-Binding Cassette member B5 (ABCB5) have shown therapeutic efficacy in clinical trials in chronic skin wounds or …
Co-Designing An Online Treatment Decision Aid For Men With Low-Risk Prostate Cancer: Navigate, Penelope Schofield, Amelia Hyatt, Alan White, Fiona White, Mark Frydenberg, Suzanne Chambers, Robert Gardiner, Declan G. Murphy, Lawrence Cavedon, Jeremy Millar, Natalie Richards, Barbara Murphy, Ilona Juraskova
Co-Designing An Online Treatment Decision Aid For Men With Low-Risk Prostate Cancer: Navigate, Penelope Schofield, Amelia Hyatt, Alan White, Fiona White, Mark Frydenberg, Suzanne Chambers, Robert Gardiner, Declan G. Murphy, Lawrence Cavedon, Jeremy Millar, Natalie Richards, Barbara Murphy, Ilona Juraskova
Research outputs 2022 to 2026
Objectives: To develop an online treatment decision aid (OTDA) to assist patients with low-risk prostate cancer (LRPC) and their partners in making treatment decisions. Patients and methods: Navigate, an OTDA for LRPC, was rigorously co-designed by patients with a confirmed diagnosis or at risk of LRPC and their partners, clinicians, researchers and website designers/developers. A theoretical model guided the development process. A mixed methods approach was used incorporating (1) evidence for essential design elements for OTDAs; (2) evidence for treatment options for LRPC; (3) an iterative co-design process involving stakeholder workshops and prototype review; and (4) expert rating using the …