Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 22 of 22

Full-Text Articles in Medicine and Health Sciences

Rsv-Encoded Ns2 Promotes Epithelial Cell Shedding And Distal Airway Obstruction, R. M. Liesman, U. J. Buchholz, C. L. Luongo, A. D. Proia, J. P. Divicenzo, P. L. Collins, R. J. Pickles Apr 2019

Rsv-Encoded Ns2 Promotes Epithelial Cell Shedding And Distal Airway Obstruction, R. M. Liesman, U. J. Buchholz, C. L. Luongo, A. D. Proia, J. P. Divicenzo, P. L. Collins, R. J. Pickles

Osteopathic Medicine, Jerry M. Wallace School of

Respiratory syncytial virus (RSV) infection is the major cause of bronchiolitis in young children. The factors that contribute to the increased propensity of RSV-induced distal airway disease compared with other commonly encountered respiratory viruses remain unclear. Here, we identified the RSV-encoded nonstructural 2 (NS2) protein as a viral genetic determinant for initiating RSV-induced distal airway obstruction. Infection of human cartilaginous airway epithelium (HAE) and a hamster model of disease with recombinant respiratory viruses revealed that NS2 promotes shedding of infected epithelial cells, resulting in two consequences of virus infection. First, epithelial cell shedding accelerated the reduction of virus titers, presumably …


Response Of The Axial Skeleton To Bipedal Loading Behaviors In An Experimental Animal Model, G. A. Russo, D. Marsh, A. D. Foster Oct 2018

Response Of The Axial Skeleton To Bipedal Loading Behaviors In An Experimental Animal Model, G. A. Russo, D. Marsh, A. D. Foster

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Formation Of Macular Inner Nuclear Layer Cysts In Optic Atrophy, K. Jiramongkolchai, M. T. Bhatti, A. D. Proia, S. F. Freedman, M. El-Dairi Mar 2016

Formation Of Macular Inner Nuclear Layer Cysts In Optic Atrophy, K. Jiramongkolchai, M. T. Bhatti, A. D. Proia, S. F. Freedman, M. El-Dairi

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Extrauterine Listeriosis In The Gravid Mouse Influences Embryonic Growth And Development, M. M. Suyemoto, T. S. Hamrick, P. A. Spears, J. R. Horton, I. M. Washington, E. A. Havell, L. B. Borst, P. E. Orndorff Aug 2013

Extrauterine Listeriosis In The Gravid Mouse Influences Embryonic Growth And Development, M. M. Suyemoto, T. S. Hamrick, P. A. Spears, J. R. Horton, I. M. Washington, E. A. Havell, L. B. Borst, P. E. Orndorff

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Current Thoughts On Maternal Nutrition And Fetal Programming Of The Metabolic Syndrome, B. Brenseke, M. R. Prater, J. Bahamonde, J. C. Gutierrez Jan 2013

Current Thoughts On Maternal Nutrition And Fetal Programming Of The Metabolic Syndrome, B. Brenseke, M. R. Prater, J. Bahamonde, J. C. Gutierrez

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Keratouveitis From Euphorbia Cyparissias Exposure Is A Temporal Phenomenon, D. Fleischman, J. J. Meyer, W. C. Fowler Jan 2012

Keratouveitis From Euphorbia Cyparissias Exposure Is A Temporal Phenomenon, D. Fleischman, J. J. Meyer, W. C. Fowler

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


A Regional Model Of Interprofessional Education, M. Olenick, E. Foote, P. Vanston, J. Szarek, Z. Vaskalis, M. J. Dimattio, R. A. Smego Jan 2011

A Regional Model Of Interprofessional Education, M. Olenick, E. Foote, P. Vanston, J. Szarek, Z. Vaskalis, M. J. Dimattio, R. A. Smego

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Factors Associated With The Acquisition And Severity Of Gestational Listeriosis, M. M. Suyemoto, P. A. Spears, T. S. Hamrick, J. A. Barnes, E. A. Havell, P. E. Orndorff Sep 2010

Factors Associated With The Acquisition And Severity Of Gestational Listeriosis, M. M. Suyemoto, P. A. Spears, T. S. Hamrick, J. A. Barnes, E. A. Havell, P. E. Orndorff

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Interferon Γ–Inducible Protein-10 (Ip-10) And Eotaxin As Biomarkers In Age-Related Macular Degeneration, F. M. Mo, A. D. Proia, W. H. Johnson, D. Cyr, K. Lashkari Aug 2010

Interferon Γ–Inducible Protein-10 (Ip-10) And Eotaxin As Biomarkers In Age-Related Macular Degeneration, F. M. Mo, A. D. Proia, W. H. Johnson, D. Cyr, K. Lashkari

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Antibacterial Efficacy Of Core-Shell Nanostructures Encapsulating Gentamicin Against An In Vivo Intracellular Salmonella Model, A. Ranjan, N. Pothayee, M. N. Seleem, R. D. Tyler, B. Brenseke, N. Sriranganathan, J. S. Riffle, R. Kasimanickam Jan 2009

Antibacterial Efficacy Of Core-Shell Nanostructures Encapsulating Gentamicin Against An In Vivo Intracellular Salmonella Model, A. Ranjan, N. Pothayee, M. N. Seleem, R. D. Tyler, B. Brenseke, N. Sriranganathan, J. S. Riffle, R. Kasimanickam

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


In Situ Real-Time Chemiluminescence Imaging Of Reactive Oxygen Species Formation From Cardiomyocytes, Y. Li, H. Shen, H. Zhu, M. A. Trush, M. Jiang, G. Wang Jan 2008

In Situ Real-Time Chemiluminescence Imaging Of Reactive Oxygen Species Formation From Cardiomyocytes, Y. Li, H. Shen, H. Zhu, M. A. Trush, M. Jiang, G. Wang

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Alternative Models For Academic Family Practices, J. L. Michener, T. Ostbye, V. S. Kaprielian, K. M. Krause, K. S. H. Yarnall, S. D. Yaggy, M. Gradison Mar 2006

Alternative Models For Academic Family Practices, J. L. Michener, T. Ostbye, V. S. Kaprielian, K. M. Krause, K. S. H. Yarnall, S. D. Yaggy, M. Gradison

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Amyloid Directly Inhibits Human Alpha4beta2-Nicotinic Acetylcholine Receptors Heterologously Expressed In Human Sh-Ep1 Cells, J. Wu, Y-P Kuo, L. Xu, J. B. Eaton, L. Zhao, J. Wu, R. J. Lukas Sep 2004

Amyloid Directly Inhibits Human Alpha4beta2-Nicotinic Acetylcholine Receptors Heterologously Expressed In Human Sh-Ep1 Cells, J. Wu, Y-P Kuo, L. Xu, J. B. Eaton, L. Zhao, J. Wu, R. J. Lukas

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Multilamellar Bodies As Potential Scattering Particles In Human Age-Related Nuclear Cataracts, K. O. Gilliland, C. D. Freel, C. W. Lane, W. C. Fowler, M. J. Costello Jun 2001

Multilamellar Bodies As Potential Scattering Particles In Human Age-Related Nuclear Cataracts, K. O. Gilliland, C. D. Freel, C. W. Lane, W. C. Fowler, M. J. Costello

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Analysis Of Target Cell Susceptibility As A Basis For The Development Of A Chemoprotective Strategy Against Benzene-Induced Hematotoxicities, M. A. Trush, L. E. Twerdok, S. J. Rembish, H. Zhu, Y. Li Jan 1996

Analysis Of Target Cell Susceptibility As A Basis For The Development Of A Chemoprotective Strategy Against Benzene-Induced Hematotoxicities, M. A. Trush, L. E. Twerdok, S. J. Rembish, H. Zhu, Y. Li

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Reactive Oxygen-Dependent Dna Damage Resulting From The Oxidation Of Phenolic Compounds By A Copper-Redox Cycle Mechanism, Y. Li, M. A. Trush Jan 1994

Reactive Oxygen-Dependent Dna Damage Resulting From The Oxidation Of Phenolic Compounds By A Copper-Redox Cycle Mechanism, Y. Li, M. A. Trush

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Effect Of Protein Kinase C Inhibitors And Activators On Corneal Re-Epithelialization In The Rat, A. Hirakata, A. G. Gupta, A. D. Proia Jan 1993

Effect Of Protein Kinase C Inhibitors And Activators On Corneal Re-Epithelialization In The Rat, A. Hirakata, A. G. Gupta, A. D. Proia

Osteopathic Medicine, Jerry M. Wallace School of

PURPOSE: To examine the ability of protein kinase C (PKC) inhibitors and activators to influence the rate of corneal re-epithelialization in the rat. METHOD: Rat corneas with 3 mm diameter central epithelial abrasions were organ-cultured in control medium or in medium with inhibitors or activators of PKC. RESULTS: In control corneas, the defect was completely re-epithelialized by 25 hr. In the presence of the PKC inhibitors staurosporine (100 nM), sphinganine (50 mumol/l), or H-7 (100 mumol/l) there were significantly larger epithelial defects than in controls after 5-25 hr of incubation. Re-epithelialization rates were similar to control corneas when the incubation …


The Effect Of Total-Body Irradiation On Corneal Neovascularization In The Fischer 344 Rat After Chemical Cauterization, M. W. Scroggs, A. D. Proia, C. F. Smith, E. C. Halperin, G. K. Klintworth Jun 1991

The Effect Of Total-Body Irradiation On Corneal Neovascularization In The Fischer 344 Rat After Chemical Cauterization, M. W. Scroggs, A. D. Proia, C. F. Smith, E. C. Halperin, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


The Effect Of Oxygen On Corneal Neovascularization, M. A. Culton, D. B. Chandler, A. D. Proia, D. W. Hickingbotham, G. K. Klintworth Jul 1990

The Effect Of Oxygen On Corneal Neovascularization, M. A. Culton, D. B. Chandler, A. D. Proia, D. W. Hickingbotham, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

Since tissue oxygen levels are believed to play a pivotal role in new vessel growth in several situations, we studied the effect of several oxygen concentrations (0, 10, 21, 50, 75, or 100%) on corneal vascularization induced in the rat by chemical cautery. We achieved this by perfusing known concentrations of oxygen through goggles fitted over both eyes of the rat after corneal cauterization. Neovascularization was measured in flat corneal preparations with India ink-filled vessels 4 days postcautery using computerized image analysis. The angiogenic response of rats whose eyes were continuously exposed to 0-75% oxygen were not significantly different from …


The Effect Of Oxygen On Corneal Neovascularization, M. Culton, D. B. Chandler, A. D. Proia, D. Hickingbotham, G. K. Klintworth Jul 1990

The Effect Of Oxygen On Corneal Neovascularization, M. Culton, D. B. Chandler, A. D. Proia, D. Hickingbotham, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Effect Of Inhibitors Of Arachidonic Acid Metabolism On Corneal Neovascularization In The Rat, W. L. Haynes, A. D. Proia, G. K. Klintworth Jul 1989

Effect Of Inhibitors Of Arachidonic Acid Metabolism On Corneal Neovascularization In The Rat, W. L. Haynes, A. D. Proia, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.


Cholinergic Stimulation Of Phosphatidic Acid Formation By Rat Cornea In Vitro, A. D. Proia, S. M. Chung, G. K. Klintworth, E. G. Lapetina Jun 1986

Cholinergic Stimulation Of Phosphatidic Acid Formation By Rat Cornea In Vitro, A. D. Proia, S. M. Chung, G. K. Klintworth, E. G. Lapetina

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.