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Full-Text Articles in Medicine and Health Sciences

Higher Low-Density Lipoprotein Cholesterol Levels Are Associated With Decreased Mortality In Patients With Intracerebral Hemorrhage [Accepted Manuscript], Jason J. Chang, Aristeidis Katsanos, Yasser Khorchid, Kira Dillard, Ali Kerro, Lucia Goodwin Burgess, Nitin Goyal, Anne W. Alexandrov, Andrei V. Alexandrov, Georgios Tsivgoulis Feb 2018

Higher Low-Density Lipoprotein Cholesterol Levels Are Associated With Decreased Mortality In Patients With Intracerebral Hemorrhage [Accepted Manuscript], Jason J. Chang, Aristeidis Katsanos, Yasser Khorchid, Kira Dillard, Ali Kerro, Lucia Goodwin Burgess, Nitin Goyal, Anne W. Alexandrov, Andrei V. Alexandrov, Georgios Tsivgoulis

Faculty of Health Sciences Publications

Background and aims: The relationship between lipoprotein levels, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and clinical outcome after intracerebral hemorrhage (ICH) remains controversial. We sought to evaluate the association of lipoprotein cholesterol levels and statin dosage with clinical and neuroimaging outcomes in patients with ICH. Methods: Data on consecutive patients hospitalized with spontaneous acute ICH was prospectively collected over a 5-year period and retrospectively analyzed. Demographic characteristics, clinical severity documented by NIHSS-score and ICH-score, neuroimaging parameters, pre-hospital statin use and doses, and LDL-C and HDL-C levels were recorded. Outcome events characterized were hematoma volume, hematoma expansion, in-hospital functional ...


Impact Of Chronic Inflammation, Assessed By Hs-Crp, On The Association Between Red Cell Distribution Width And Arterial Cardiovascular Disease: The Tromso Study, Jostein Lappegard, Trygve S. Ellingsen, Kristian Hindberg, Ellisiv Bøgeberg Mathiesen, Inger Njolstad, Tom Wilsgaard, Maja-Lisa Loechen, Sigrid Kufaas Braekkan, John-Bjarne Hansen Jan 2018

Impact Of Chronic Inflammation, Assessed By Hs-Crp, On The Association Between Red Cell Distribution Width And Arterial Cardiovascular Disease: The Tromso Study, Jostein Lappegard, Trygve S. Ellingsen, Kristian Hindberg, Ellisiv Bøgeberg Mathiesen, Inger Njolstad, Tom Wilsgaard, Maja-Lisa Loechen, Sigrid Kufaas Braekkan, John-Bjarne Hansen

Faculty of Health Sciences Publications

Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between inflammation and arterial CVD. Baseline characteristics, including RDW and hs-CRP, were obtained from 5,765 individuals attending a population-based cohort study. We followed up participants from inclusion in the fourth survey of the Tromsø Study (1994/1995) until December 31, 2012 ...


Hospital Arrival Times And Post-Imaging Delays In Stroke Thrombolysis Implementation, Hiroyuki Kawano, Andrew Bivard, Mark W. Parsons, Christine L. Paul, Martin Krause, Catherine D'Este, Christopher F. Bladin, Richard I. Lindley, John R. Attia, Frans Henskens, Mark Longworth, Sandy Middleton, Annika Ryan, Erin Kerr, Robert W. Sanson-Fisher, Christopher R. Levi, Thrombolysis Implementation In Stroke (Tips) Study Group Jan 2017

Hospital Arrival Times And Post-Imaging Delays In Stroke Thrombolysis Implementation, Hiroyuki Kawano, Andrew Bivard, Mark W. Parsons, Christine L. Paul, Martin Krause, Catherine D'Este, Christopher F. Bladin, Richard I. Lindley, John R. Attia, Frans Henskens, Mark Longworth, Sandy Middleton, Annika Ryan, Erin Kerr, Robert W. Sanson-Fisher, Christopher R. Levi, Thrombolysis Implementation In Stroke (Tips) Study Group

Faculty of Health Sciences Publications

Background: Rapid alteplase delivery for ischemic stroke patients has been shown to increase the likelihood of disability-free life. Identification of barriers to rapid alteplase delivery and streamlining processes around imaging assessments are important. Our aim was to examine the relationships between hospital arrival time and postimaging processes in stroke thrombolysis. Methods: De-identified data of patients who underwent intravenous alteplase therapy at 20 hospitals in Australia were entered into the Thrombolysis ImPlementation in Stroke (TIPS) audit tool. During the pre-intervention phase, 601 patients who received alteplase ≤ 270 minutes of stroke onset were analysed. Onset-to-door (OTD), door-to-needle (DTN), door-to-imaging (DTI), and imaging-to-needle ...


Oral Flora In Acute Stroke Patients: A Prospective Exploratory Observational Study, Elizabeth Boaden, Mary Lyons, Sim K. Singhrao, Hazel Dickinson, Michael J. Leathley, Catherine E. Lightbody, Alison Mcloughlin, Zarine Khan, Stjohn Crean, Craig Smith, Susan Higham, Caroline Watkins Jan 2017

Oral Flora In Acute Stroke Patients: A Prospective Exploratory Observational Study, Elizabeth Boaden, Mary Lyons, Sim K. Singhrao, Hazel Dickinson, Michael J. Leathley, Catherine E. Lightbody, Alison Mcloughlin, Zarine Khan, Stjohn Crean, Craig Smith, Susan Higham, Caroline Watkins

Faculty of Health Sciences Publications

Objective: To describe the bacterial profile of the oral flora during the first 2 weeks following a stroke, examining changes in the condition of the oral cavity and infections. Background: Dysphagia is common after a stroke and can lead to aspiration pneumonia. Oral flora changes associated with stroke have been implicated as a possible source of bacteria that can cause systemic infections. Materials and methods: Seventy‐seven participants were recruited over a period of 9 months. Fifty participants had a complete set of swabs from four different oral sites and a saliva sample taken at three time points over a ...


Towards Best Practice In Acute Stroke Care In Ghana: A Survey Of Hospital Services, Leonard Baatiema, Michael Otim, George Mnatzaganian, Ama De-Graft Aikins, Judith Coombes, Shawn Somerset Jan 2017

Towards Best Practice In Acute Stroke Care In Ghana: A Survey Of Hospital Services, Leonard Baatiema, Michael Otim, George Mnatzaganian, Ama De-Graft Aikins, Judith Coombes, Shawn Somerset

Faculty of Health Sciences Publications

Background: Stroke and other non-communicable diseases are important emerging public health concerns in sub-Saharan Africa where stroke-related mortality and morbidity are higher compared to other parts of the world. Despite the availability of evidence-based acute stroke interventions globally, uptake in low-middle income countries (LMIC) such as Ghana is uncertain. This study aimed to identify and evaluate available acute stroke services in Ghana and the extent to which these services align with global best practice. Methods: A multi-site, hospital-based survey was conducted in 11 major referral hospitals (regional and tertiary - teaching hospitals) in Ghana from November 2015 to April 2016. Respondents ...


Increasing The Amount Of Usual Rehabilitation Improves Activity After Stroke: A Systematic Review, Emma J. Schneider, Natasha A. Lannin, Louise Ada, Julia Schmidt Jan 2016

Increasing The Amount Of Usual Rehabilitation Improves Activity After Stroke: A Systematic Review, Emma J. Schneider, Natasha A. Lannin, Louise Ada, Julia Schmidt

Faculty of Health Sciences Publications

Questions: In people receiving rehabilitation aimed at reducing activity limitations of the lower and/or upper limb after stroke, does adding extra rehabilitation (of the same content as the usual rehabilitation) improve activity? What is the amount of extra rehabilitation that needs to be provided to achieve a beneficial effect? Design: Systematic review with meta-analysis of randomised trials. Participants: Adults aged 18 years or older that had a diagnosis of stroke. Intervention: Extra rehabilitation with the same content as usual rehabilitation aimed at reducing activity limitations of the lower and/or upper limb. Outcome measures: Activity measured as lower or ...


Implementing A Complex Rehabilitation Intervention In A Stroke Trial: A Qualitative Process Evaluation Of Avert, Julie A. Luker, Louise E. Craig, Leanne Bennett, Fiona Ellery, Peter Langhorne, Olivia Wu, Julie Bernhardt Jan 2016

Implementing A Complex Rehabilitation Intervention In A Stroke Trial: A Qualitative Process Evaluation Of Avert, Julie A. Luker, Louise E. Craig, Leanne Bennett, Fiona Ellery, Peter Langhorne, Olivia Wu, Julie Bernhardt

Faculty of Health Sciences Publications

Background: The implementation of multidisciplinary stroke rehabilitation interventions is challenging, even when the intervention is evidence-based. Very little is known about the implementation of complex interventions in rehabilitation clinical trials. The aim of study was to better understand how the implementation of a rehabilitation intervention in a clinical trial within acute stroke units is experienced by the staff involved. This qualitative process evaluation was part of a large Phase III stroke rehabilitation trial (AVERT). Methods: A descriptive qualitative approach was used. We purposively sampled 53 allied health and nursing staff from 19 acute stroke units in Australia, New Zealand and ...


Triage, Treatment And Transfer Of Patients With Stroke In Emergency Department Trial (The T3 Trial): A Cluster Randomised Trial Protocol, Sandy Middleton, Chris Levi, Simeon Dale, N. Chung, Elizabeth Mcinnes, Julie Considine, Catherine D'Este, Dominique Cadilhac, Jeremy Grimshaw, Richard Gerraty, Louise Craig, Verena Schadewaldt, Patrick Mcelduff, Mark Fitzgerald, Clare Quinn, Greg Cadigan, Sonia Denisenko, Mark Longworth, Janette Ward Jan 2016

Triage, Treatment And Transfer Of Patients With Stroke In Emergency Department Trial (The T3 Trial): A Cluster Randomised Trial Protocol, Sandy Middleton, Chris Levi, Simeon Dale, N. Chung, Elizabeth Mcinnes, Julie Considine, Catherine D'Este, Dominique Cadilhac, Jeremy Grimshaw, Richard Gerraty, Louise Craig, Verena Schadewaldt, Patrick Mcelduff, Mark Fitzgerald, Clare Quinn, Greg Cadigan, Sonia Denisenko, Mark Longworth, Janette Ward

Faculty of Health Sciences Publications

Background Internationally recognised evidence-based guidelines recommend appropriate triage of patients with stroke in emergency departments (EDs), administration of tissue plasminogen activator (tPA), and proactive management of fever, hyperglycaemia and swallowing before prompt transfer to a stroke unit to maximise outcomes. We aim to evaluate the effectiveness in EDs of a theory-informed, nurse-initiated, intervention to improve multidisciplinary triage, treatment and transfer (T3) of patients with acute stroke to improve 90-day death and dependency. Organisational and contextual factors associated with intervention uptake also will be evaluated. Methods This prospective, multicentre, parallel group, cluster randomised trial with blinded outcome assessment will be conducted ...


Risk Of Stroke In Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis Of The Controlled Rosuvastatin In Multinational Trial Heart Failure (Corona) And The Gruppo Italiano Per Lo Studio Della Sopravvivenza Nell'insufficienza Cardiaca-Heart Failure (Gissi-Hf) Trials, Azmil H. Abdul-Rahim, Ana Cristina Perez, Rachael L. Fulton, Pardeep Jhund, Roberto Latini, Gianni Tognoni, John Wikstrand, John Kjekshus, Gregory Y. H. Lip, Aldo Pietro Maggioni, Luigi Tavazzi, Kennedy R. Lees, John Mcmurray Jan 2015

Risk Of Stroke In Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis Of The Controlled Rosuvastatin In Multinational Trial Heart Failure (Corona) And The Gruppo Italiano Per Lo Studio Della Sopravvivenza Nell'insufficienza Cardiaca-Heart Failure (Gissi-Hf) Trials, Azmil H. Abdul-Rahim, Ana Cristina Perez, Rachael L. Fulton, Pardeep Jhund, Roberto Latini, Gianni Tognoni, John Wikstrand, John Kjekshus, Gregory Y. H. Lip, Aldo Pietro Maggioni, Luigi Tavazzi, Kennedy R. Lees, John Mcmurray

Faculty of Health Sciences Publications

Our aim was to describe the incidence and predictors of stroke in patients who have heart failure without atrial fibrillation (AF).


History Of Atrial Fibrillation As A Risk Factor In Patients With Heart Failure And Preserved Ejection Fraction, Oludamilola W. Oluleye, Thomas S. Rector, Sithu Win, John Mcmurray, Michael R. Zile, Michel Komajda, Robert Mckelvie, Barry Massie, Peter E. Carson, Inder S. Anand Jan 2014

History Of Atrial Fibrillation As A Risk Factor In Patients With Heart Failure And Preserved Ejection Fraction, Oludamilola W. Oluleye, Thomas S. Rector, Sithu Win, John Mcmurray, Michael R. Zile, Michel Komajda, Robert Mckelvie, Barry Massie, Peter E. Carson, Inder S. Anand

Faculty of Health Sciences Publications

Atrial fibrillation (AFib) is common in heart failure (HF) with preserved ejection fraction (HFpEF). Current AFib stroke risk prediction models include the presence of HF but do not specifically include HFpEF as a risk factor. Whether a history of AFib should be used to identify patients with HFpEF who are at risk has not been established.


Identifying Continence Options After Stroke (Icons): A Cluster Randomised Controlled Feasibility Trial, Lois H. Thomas, Caroline Leigh Watkins, Christopher J. Sutton, Denise Forshaw, Michael J. Leathley, Beverley French, Christopher R. Burton, Francine Cheater, Brenda Roe, David Britt, Jo Booth, Elaine Mccoll, Bernadette Carter, Helen Rodgers, Katie Brittain, Andrew Walker, James Barrett, Gemma Whiteley, Pat Brand, May Griffiths, Philip Helvin, Brian James, Gill Pearl, Jane Whitewood, Jacqui Vella, Audrey Childs, Richard Childs, Sean Crosby, Steve Hall, Anj Lewin, Liz Royle, Carole Scott, Jean Wright Jan 2014

Identifying Continence Options After Stroke (Icons): A Cluster Randomised Controlled Feasibility Trial, Lois H. Thomas, Caroline Leigh Watkins, Christopher J. Sutton, Denise Forshaw, Michael J. Leathley, Beverley French, Christopher R. Burton, Francine Cheater, Brenda Roe, David Britt, Jo Booth, Elaine Mccoll, Bernadette Carter, Helen Rodgers, Katie Brittain, Andrew Walker, James Barrett, Gemma Whiteley, Pat Brand, May Griffiths, Philip Helvin, Brian James, Gill Pearl, Jane Whitewood, Jacqui Vella, Audrey Childs, Richard Childs, Sean Crosby, Steve Hall, Anj Lewin, Liz Royle, Carole Scott, Jean Wright

Faculty of Health Sciences Publications

Background: Urinary incontinence ( UI ) affects half of patients hospitalised after stroke and is often poorly managed. Cochrane systematic reviews have shown some positive impact of conservative interventions ( such as bladder training ) in reducing UI, but their effectiveness has not been demonstrated with stroke patients. Methods: We conducted a cluster randomised controlled feasibility trial of a systematic voiding programme ( SVP ) for the management of UI after stroke. Stroke services were randomised to receive SVP ( n = 4 ), SVP plus supported implementation ( SVP+, n = 4 ), or usual care ( UC, n = 4 ). Feasibility outcomes were participant recruitment and retention. The main effectiveness outcome was ...


Fish Oil Diet Associated With Acute Reperfusion Related Hemorrhage, And With Reduced Stroke-Related Sickness Behaviors And Motor Impairment, Michaela Celeste Pascoe, David W. Howells, David P. Crewther, Nicki Constantinou, Leeanne M. Carey, Sarah S. Rewell, Giovanni M. Turchini, Gunveen Kaur, Sheila G. Crewther Jan 2014

Fish Oil Diet Associated With Acute Reperfusion Related Hemorrhage, And With Reduced Stroke-Related Sickness Behaviors And Motor Impairment, Michaela Celeste Pascoe, David W. Howells, David P. Crewther, Nicki Constantinou, Leeanne M. Carey, Sarah S. Rewell, Giovanni M. Turchini, Gunveen Kaur, Sheila G. Crewther

Faculty of Health Sciences Publications

Ischemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids ( PUFAs ). However, the potential protective effects of PUFA supplementation on affective behaviors after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioral effects of PUFA supplementation over a 6-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was ...


Efficacy And Safety Of Apixaban Compared With Warfarin At Different Levels Of Predicted International Normalized Ratio Control For Stroke Prevention In Atrial Fibrillation, Lars Wallentin, Renato D. Lopes, Michael Hanna, Laine Thomas, Anne Hellkamp, Sunil Nepal, Elaine Hylek, Sana M. Al-Khatib, John H. Alexander, Marco Alings, John Amerena, Jack Ansell, Philip Aylward, Jozef Bartunek, Patrick Commerford, Raffaele De Caterina, Çetin Erol, Veli-Pekka Harjola, Claes Held, John Horowitz, Kurt Huber, Steen Husted, Matyas Keltai, Fernando Lanas, Liu Lisheng, John Mcmurray, Byung Hee Oh, Mårten Rosenqvist, Witold Ruzyllo, Philippe Gabriel Steg, Dragos Vinereanu, Denis Xavier, Christopher B. Granger Jan 2013

Efficacy And Safety Of Apixaban Compared With Warfarin At Different Levels Of Predicted International Normalized Ratio Control For Stroke Prevention In Atrial Fibrillation, Lars Wallentin, Renato D. Lopes, Michael Hanna, Laine Thomas, Anne Hellkamp, Sunil Nepal, Elaine Hylek, Sana M. Al-Khatib, John H. Alexander, Marco Alings, John Amerena, Jack Ansell, Philip Aylward, Jozef Bartunek, Patrick Commerford, Raffaele De Caterina, Çetin Erol, Veli-Pekka Harjola, Claes Held, John Horowitz, Kurt Huber, Steen Husted, Matyas Keltai, Fernando Lanas, Liu Lisheng, John Mcmurray, Byung Hee Oh, Mårten Rosenqvist, Witold Ruzyllo, Philippe Gabriel Steg, Dragos Vinereanu, Denis Xavier, Christopher B. Granger

Faculty of Health Sciences Publications

In the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial, apixaban compared with warfarin reduced stroke and systemic embolism, major bleeding, and mortality. We evaluated treatment effects in relation to 2 predictions of time in therapeutic range (TTR).


Models Containing Age And Nihss Predict Recovery Of Ambulation And Upper Limb Function Six Months After Stroke : An Observational Study, Li Khim Kwah, Lisa A. Harvey, Joanna Diong, Robert D. Herbert Jan 2013

Models Containing Age And Nihss Predict Recovery Of Ambulation And Upper Limb Function Six Months After Stroke : An Observational Study, Li Khim Kwah, Lisa A. Harvey, Joanna Diong, Robert D. Herbert

Faculty of Health Sciences Publications

Questions

What is the incidence of recovery of ambulation and upper limb function six months after stroke? Can measures such as age and the National Institutes of Health Stroke Scale (NIHSS) be used to develop models to predict the recovery of ambulation and upper limb function?

Design

Prospective cohort study.

Participants

Consecutive sample of 200 people with stroke admitted to a Sydney Hospital.

Outcome measures

Ambulation was measured with item 5 of the Motor Assessment Scale (MAS); patients scoring ≥ 3 could ambulate independently. Upper limb function was measured with items 7 and 8 of the MAS; patients scoring ≥ 5 could ...


Predictors Of Stroke In Patients With Impaired Glucose Tolerance: Results From The Nateglinide And Valsartan In Impaired Glucose Tolerance Outcomes Research Trial, David Preiss, Thomas D. Giles, Laine E. Thomas, Jie-Lena Sun, Steven M. Haffner, Rury R. Holman, Eberhard Standl, Theodore Mazzone, Guy E. H. M. Rutten, Gianni Tognoni, Fu-Tien Chiang, John J. V. Mcmurray, Robert M. Califf Jan 2013

Predictors Of Stroke In Patients With Impaired Glucose Tolerance: Results From The Nateglinide And Valsartan In Impaired Glucose Tolerance Outcomes Research Trial, David Preiss, Thomas D. Giles, Laine E. Thomas, Jie-Lena Sun, Steven M. Haffner, Rury R. Holman, Eberhard Standl, Theodore Mazzone, Guy E. H. M. Rutten, Gianni Tognoni, Fu-Tien Chiang, John J. V. Mcmurray, Robert M. Califf

Faculty of Health Sciences Publications

Background and Purpose: Risk factors for stroke are well-established in general populations but sparsely studied in individuals with impaired glucose tolerance. Methods: We identified predictors of stroke among participants with impaired glucose tolerance in the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research ( NAVIGATOR ) trial. Cox proportional-hazard regression models were constructed using baseline variables, including the 2 medications studied, valsartan and nateglinide. Results: Among 9306 participants, 237 experienced a stroke over 6.4 years. Predictors of stroke included classical risk factors such as existing cerebrovascular and coronary heart disease, higher pulse pressure, higher low-density lipoprotein cholesterol, older age, and ...


Left Ventricular Systolic Dysfunction, Heart Failure, And The Risk Of Stroke And Systemic Embolism In Patients With Atrial Fibrillation : Insights From The Aristotle Trial, John Mcmurray, Justin A. Ezekowitz, Basil S. Lewis, Bernard J. Gersh, Sean Van Diepen, John Amerena, Jozef Bartunek, Patrick Commerford, Byung Hee Oh, Veli-Pekka Harjola, Sana M. Al-Khatib, Michael Hanna, John H. Alexander, Renato D. Lopes, Daniel M. Wojdyla, Lars Wallentin, Christopher B. Granger Jan 2013

Left Ventricular Systolic Dysfunction, Heart Failure, And The Risk Of Stroke And Systemic Embolism In Patients With Atrial Fibrillation : Insights From The Aristotle Trial, John Mcmurray, Justin A. Ezekowitz, Basil S. Lewis, Bernard J. Gersh, Sean Van Diepen, John Amerena, Jozef Bartunek, Patrick Commerford, Byung Hee Oh, Veli-Pekka Harjola, Sana M. Al-Khatib, Michael Hanna, John H. Alexander, Renato D. Lopes, Daniel M. Wojdyla, Lars Wallentin, Christopher B. Granger

Faculty of Health Sciences Publications

We examined the risk of stroke or systemic embolism (SSE) conferred by heart failure (HF) and left ventricular systolic dysfunction (LVSD) in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation Trial (ARISTOTLE), as well as the effect of apixaban versus warfarin.


Stroke In Patients With Type 2 Diabetes Mellitus, Chronic Kidney Disease, And Anemia Treated With Darbepoetin Alfa: The Trial To Reduce Cardiovascular Events With Aranesp Therapy (Treat) Experience, Hicham Skali, Hans Henrik Parving, Patrick Parfrey, Emmanuel A. Burdmann, E. F. Lewis, Peter Ivanovich, Sai Ram Keithi-Reddy, Janet B. Mcgill, John Mcmurray, Ajay K. Singh, Scott Solomon, Hajime Uno, Marc A. Pfeffer Jan 2011

Stroke In Patients With Type 2 Diabetes Mellitus, Chronic Kidney Disease, And Anemia Treated With Darbepoetin Alfa: The Trial To Reduce Cardiovascular Events With Aranesp Therapy (Treat) Experience, Hicham Skali, Hans Henrik Parving, Patrick Parfrey, Emmanuel A. Burdmann, E. F. Lewis, Peter Ivanovich, Sai Ram Keithi-Reddy, Janet B. Mcgill, John Mcmurray, Ajay K. Singh, Scott Solomon, Hajime Uno, Marc A. Pfeffer

Faculty of Health Sciences Publications

More strokes were observed in the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) among patients assigned to darbepoetin alfa. We sought to identify baseline characteristics and postrandomization factors that might explain this association.