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Australian Catholic University

Skeletal muscle

2017

Faculty of Health Sciences Publications

Articles 1 - 2 of 2

Full-Text Articles in Medicine and Health Sciences

Striated Muscle Activator Of Rho Signalling (Stars) Is Reduced In Ageing Human Skeletal Muscle And Targeted By Mir-628-5p, Andrew Russell, M. A. Wallace, M. Kalanon, Evelyn Zacharewicz, P. A.D. Gatta, Andrew Garnham, Séverine Lamon Jan 2017

Striated Muscle Activator Of Rho Signalling (Stars) Is Reduced In Ageing Human Skeletal Muscle And Targeted By Mir-628-5p, Andrew Russell, M. A. Wallace, M. Kalanon, Evelyn Zacharewicz, P. A.D. Gatta, Andrew Garnham, Séverine Lamon

Faculty of Health Sciences Publications

Aim: The striated muscle activator of Rho signalling (STARS) is a muscle-specific actin-binding protein. The STARS signalling pathway is activated by resistance exercise and is anticipated to play a role in signal mechan-otransduction. Animal studies have reported a negative regulation of STARS signalling with age, but such regulation has not been investigated in humans. Methods: Ten young (18–30 years) and 10 older (60–75 years) subjects completed an acute bout of resistance exercise. Gene and protein expres-sion of members of the STARS signalling pathway and miRNA expression of a subset of miRNAs, predicted or known to target members of ...


Muscle Fiber Capillarization As Determining Factor On Indices Of Insulin Sensitivity In Humans, Tim Snijders, Joshua P. Nederveen, Lex B. Verdijk, Alfons J.H.M. Houben, Gijs H. Goossens, Gianna Parise, Luc Van Loon Jan 2017

Muscle Fiber Capillarization As Determining Factor On Indices Of Insulin Sensitivity In Humans, Tim Snijders, Joshua P. Nederveen, Lex B. Verdijk, Alfons J.H.M. Houben, Gijs H. Goossens, Gianna Parise, Luc Van Loon

Faculty of Health Sciences Publications

To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults. A skeletal muscle biopsy was taken from the m. vastus lateralis of 22 healthy (nondiabetic) male older adults. In addition, all participants underwent an Oral Glucose Tolerance Test (OGTT). Muscle fiber capillarization was assessed by immunohistochemistry. Participants were divided into a group with relatively low (LOW) or high (HIGH) muscle fiber capillarization (capillary-to-fiber perimeter exchange (CFPE) index), based on the median value for the entire group. All participants were healthy, nonobese, and had a normal glucose tolerance, according to the individual OGTT results ...