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Skeletal muscle

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Muscle Atrophy Due To Nerve Damage Is Accompanied By Elevated Myofibrillar Protein Synthesis Rates, Henning Langer, Joan M. Senden, Annemie P. Gijsen, Stefan Kempa, Luc Van Loon, Simone Spuler Jan 2018

Muscle Atrophy Due To Nerve Damage Is Accompanied By Elevated Myofibrillar Protein Synthesis Rates, Henning Langer, Joan M. Senden, Annemie P. Gijsen, Stefan Kempa, Luc Van Loon, Simone Spuler

Faculty of Health Sciences Publications

Muscle loss is a severe complication of many medical conditions such as cancer, cardiac failure, muscular dystrophies, and nerve damage. The contribution of myofibrillar protein synthesis (MPS) to the loss of muscle mass after nerve damage is not clear. Using deuterium oxide (D2O) labeling, we demonstrate that MPS is significantly increased in rat m. tibialis anterior (TA) compared to control (3.23 ± 0.72 [damaged] to 2.09 ± 0.26%∗day−1 [control]) after 4 weeks of nerve constriction injury. This is the case despite substantial loss of mass of the TA (350 ± 96 mg [damaged] to 946 ± 361 mg ...