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Australian Catholic University

Skeletal muscle

Physiology

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Full-Text Articles in Medicine and Health Sciences

A Novel In Vitro Model For The Assessment Of Postnatal Myonuclear Accretion, Anita Kneppers, Lex B. Verdijk, Chiel De Theije, Mark Corten, Ellis Gielen, Luc Van Loon, Annemie Schols, Ramon Langen Jan 2018

A Novel In Vitro Model For The Assessment Of Postnatal Myonuclear Accretion, Anita Kneppers, Lex B. Verdijk, Chiel De Theije, Mark Corten, Ellis Gielen, Luc Van Loon, Annemie Schols, Ramon Langen

Faculty of Health Sciences Publications

Background: Due to the post-mitotic nature of myonuclei, postnatal myogenesis is essential for skeletal muscle growth, repair, and regeneration. This process is facilitated by satellite cells through proliferation, differentiation, and subsequent fusion with a pre-existing muscle fiber (i.e., myonuclear accretion). Current knowledge of myogenesis is primarily based on the in vitro formation of syncytia from myoblasts, which represents aspects of developmental myogenesis, but may incompletely portray postnatal myogenesis. Therefore, we aimed to develop an in vitro model that better reflects postnatal myogenesis, to study the cell intrinsic and extrinsic processes and signaling involved in the regulation of postnatal myogenesis ...