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A Comparison Of The Prognostic Value Of Bnp Versus Nt-Probnp After Hospitalisation For Heart Failure, G. C. M. Linssen, T. Jaarsma, H. L. Hillege, A. A. Voors, D. J. Van Veldhuisen Jan 2018

A Comparison Of The Prognostic Value Of Bnp Versus Nt-Probnp After Hospitalisation For Heart Failure, G. C. M. Linssen, T. Jaarsma, H. L. Hillege, A. A. Voors, D. J. Van Veldhuisen

Faculty of Health Sciences Publications

Aims: Concentrations of circulating B type natriuretic peptides provide important prognostic information in heart failure (HF) patients. We directly compared the prognostic performance of brain natriuretic peptide (BNP) versus N terminal-proBNP (NT-proBNP) measurements in a large population of HF patients at hospital discharge after an admission for decompensated HF. Methods and results: BNP and NT-proBNP were measured in 563 stable HF patients before discharge. All patients were followed for a fixed period of 18 months. The primary endpoint was time to first major event (HF hospitalisation or death). Patients were in NYHA class II (47%) or III/IV (53%) at ...


Pro-Gastrin-Releasing Peptide And Outcome In Patients With Heart Failure And Anaemia: Results From The Red-Hf Study, Thor Ueland, Lars Gullestad, Lei Kou, Pål Aukrust, Inderjit S. Anand, Marianne Nordlund Broughton, John J. Mcmurray, Dirk J. Van Veldhuisen, David J. Warren, Nils Bolstad Jan 2018

Pro-Gastrin-Releasing Peptide And Outcome In Patients With Heart Failure And Anaemia: Results From The Red-Hf Study, Thor Ueland, Lars Gullestad, Lei Kou, Pål Aukrust, Inderjit S. Anand, Marianne Nordlund Broughton, John J. Mcmurray, Dirk J. Van Veldhuisen, David J. Warren, Nils Bolstad

Faculty of Health Sciences Publications

Aims: Neuroendocrine activation is associated with poor outcome in heart failure (HF). The neuropeptide gastrin‐releasing peptide (GRP), derived from the precursor proGRP1‐125 (proGRP), has recently been implicated in inflammation and wound repair. We investigated the predictive value of proGRP on clinical outcomes in HF patients with reduced ejection fraction. Methods and results: The association between plasma proGRP (time‐resolved immunofluorometric assay) and the primary endpoint of death from any cause or first hospitalization for worsening of HF was evaluated using multivariable Cox proportional hazard models in 1541 patients with systolic HF and mild to moderate anaemia, enrolled in ...


European Society Of Cardiology - Acute Cardiovascular Care Association Position Paper On Safe Discharge Of Acute Heart Failure Patients From The Emergency Department [Accepted Manuscript], Òscar Miró, Frank W. Peacock, John J. Mcmurray, Hector Bueno, Michael Christ, Alan S. Maisel, Louise Cullen, Martin R. Cowie, Salvatore Di Somma, Francisco J. Martin Sanchez, Elke Platz, Josep Masip, Uwe Zeymer, Christiaan Vrints, Susanna Price, Alexandre Mebazaa, Christian Mueller Jun 2017

European Society Of Cardiology - Acute Cardiovascular Care Association Position Paper On Safe Discharge Of Acute Heart Failure Patients From The Emergency Department [Accepted Manuscript], Òscar Miró, Frank W. Peacock, John J. Mcmurray, Hector Bueno, Michael Christ, Alan S. Maisel, Louise Cullen, Martin R. Cowie, Salvatore Di Somma, Francisco J. Martin Sanchez, Elke Platz, Josep Masip, Uwe Zeymer, Christiaan Vrints, Susanna Price, Alexandre Mebazaa, Christian Mueller

Faculty of Health Sciences Publications

Heart failure is a global public health challenge frequently presenting to the emergency department. After initial stabilization and management, one of the most important decisions is to determine which patients can be safely discharged and which require hospitalization. This is a complex decision that depends on numerous subjective factors, including both the severity of the patient's underlying condition and an estimate of the acuity of the presentation. An emergency department observation period may help select the correct option. Ideally, during an observation period, risk stratification should be carried out using parameters specifically designed for use in the emergency department ...


European Society Of Cardiology - Acute Cardiovascular Care Association Position Paper On Safe Discharge Of Acute Heart Failure Patients From The Emergency Department [Accepted Manuscript], Òscar Miró, F. Peacock, John Mcmurray, Héctor Bueno, M. Christ, Alan Maisel, Louise Cullen, Martin R. Cowie, Salvatore Di Somma, Francisco J. Martín-Sánchez, Elke Platz, J. Masip, Uwe Zeymer, Christiaan Vrints, Susanna Price, Alexandre Mebazaa, Christian Mueller Jan 2017

European Society Of Cardiology - Acute Cardiovascular Care Association Position Paper On Safe Discharge Of Acute Heart Failure Patients From The Emergency Department [Accepted Manuscript], Òscar Miró, F. Peacock, John Mcmurray, Héctor Bueno, M. Christ, Alan Maisel, Louise Cullen, Martin R. Cowie, Salvatore Di Somma, Francisco J. Martín-Sánchez, Elke Platz, J. Masip, Uwe Zeymer, Christiaan Vrints, Susanna Price, Alexandre Mebazaa, Christian Mueller

Faculty of Health Sciences Publications

Heart failure is a global public health challenge frequently presenting to the emergency department. After initial stabilization and management, one of the most important decisions is to determine which patients can be safely discharged and which require hospitalization. This is a complex decision that depends on numerous subjective factors, including both the severity of the patient’s underlying condition and an estimate of the acuity of the presentation. An emergency department observation period may help select the correct option. Ideally, during an observation period, risk stratification should be carried out using parameters specifically designed for use in the emergency department ...


Renin-Angiotensin System Inhibition, Worsening Renal Function, And Outcome In Heart Failure Patients With Reduced And Preserved Ejection Fraction: A Meta-Analysis Of Published Study Data, Iris E. Beldhuis, Koen W. Streng, Jozine M.T. Maaten, Adriaan A. Voors, Peter Van Der Meer, Patrick Rossignol, John Mcmurray, Kevin Damman Jan 2017

Renin-Angiotensin System Inhibition, Worsening Renal Function, And Outcome In Heart Failure Patients With Reduced And Preserved Ejection Fraction: A Meta-Analysis Of Published Study Data, Iris E. Beldhuis, Koen W. Streng, Jozine M.T. Maaten, Adriaan A. Voors, Peter Van Der Meer, Patrick Rossignol, John Mcmurray, Kevin Damman

Faculty of Health Sciences Publications

Background—Renin–angiotensin aldosterone system (RAAS) inhibitors significantly improve outcome in heart failure (HF) patients with reduced ejection fraction (HFREF), irrespective of the occurrence of worsening renal function (WRF). However, in HF patients with preserved ejection fraction (HFPEF), RAAS inhibitors have not been shown to improve outcome but are still frequently prescribed. Methods and Results—Random effect meta-analysis was performed to investigate the relationship between RAAS inhibitor therapy, WRF in both HF phenotypes, and mortality. Studies were selected based on literature search in MEDLNE and included randomized, placebo controlled trials of RAAS inhibitors in chronic HF. The primary outcome consisted ...


Return To The Workforce After First Hospitalization For Heart Failure: A Danish Nationwide Cohort Study, Rasmus Rørth, Chih Wong, Kristian Kragholm, Emil L. Fosbøl, Ulrik M. Mogensen, Morten Lamberts, Mark C. Petrie, Pardeep Jhund, Thomas A. Gerds, Christian Torp-Pedersen, Gunnar H. Gislason, John Mcmurray, Lars Kober, Søren L. Kristensen Jan 2016

Return To The Workforce After First Hospitalization For Heart Failure: A Danish Nationwide Cohort Study, Rasmus Rørth, Chih Wong, Kristian Kragholm, Emil L. Fosbøl, Ulrik M. Mogensen, Morten Lamberts, Mark C. Petrie, Pardeep Jhund, Thomas A. Gerds, Christian Torp-Pedersen, Gunnar H. Gislason, John Mcmurray, Lars Kober, Søren L. Kristensen

Faculty of Health Sciences Publications

Return to work is important financially, as a marker of functional status and for self-esteem in patients developing chronic illness. We examined return to work after first heart failure (HF) hospitalization.


Risk Related To Pre-Diabetes Mellitus And Diabetes Mellitus In Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure Trial, Søren L. Kristensen, David Preiss, Pardeep Jhund, Iain Squire, Jose Silva Cardoso, Bela Merkely, Felipe Martinez, Randall C. Starling, Akshay S. Desai, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, S. D. Solomon, Karl Swedberg, Michael R. Zile, John Mcmurray, Milton Packer Jan 2016

Risk Related To Pre-Diabetes Mellitus And Diabetes Mellitus In Heart Failure With Reduced Ejection Fraction: Insights From Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure Trial, Søren L. Kristensen, David Preiss, Pardeep Jhund, Iain Squire, Jose Silva Cardoso, Bela Merkely, Felipe Martinez, Randall C. Starling, Akshay S. Desai, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, S. D. Solomon, Karl Swedberg, Michael R. Zile, John Mcmurray, Milton Packer

Faculty of Health Sciences Publications

The prevalence of pre–diabetes mellitus and its consequences in patients with heart failure and reduced ejection fraction are not known. We investigated these in the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial.


Geographic Variations In The Paradigm-Hf Heart Failure Trial, Søren L. Kristensen, Felipe Martinez, Pardeep S. Jhund, Juan Luis Arango, Jan Bĕlohlávek, Sergey Boytsov, Walter Cabrera, Efrain Gomez, Albert Alain Hagege, Jun Huang, Songsak Kiatchoosakun, Kee-Sik Kim, Iván Mendoza, Michele Senni, Iain B. Squire, Dragos Vinereanu, Raymond Chiew-Chiew Wong, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Milton Packer, John J. V. Mcmurray Jan 2016

Geographic Variations In The Paradigm-Hf Heart Failure Trial, Søren L. Kristensen, Felipe Martinez, Pardeep S. Jhund, Juan Luis Arango, Jan Bĕlohlávek, Sergey Boytsov, Walter Cabrera, Efrain Gomez, Albert Alain Hagege, Jun Huang, Songsak Kiatchoosakun, Kee-Sik Kim, Iván Mendoza, Michele Senni, Iain B. Squire, Dragos Vinereanu, Raymond Chiew-Chiew Wong, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Milton Packer, John J. V. Mcmurray

Faculty of Health Sciences Publications

Aims: The globalization of clinical trials has highlighted geographic variations in patient characteristics, event rates, and treatment effects. We investigated these further in PARADIGM-HF, the largest and most globally representative trial in heart failure (HF) to date. Methods and results: We looked at five regions: North America (NA) 602 (8%), Western Europe (WE) 1680 (20%), Central/Eastern Europe/Russia (CEER) 2762 (33%), Latin America (LA) 1433 (17%), and Asia-Pacific (AP) 1487 (18%). Notable differences included: WE patients (mean age 68 years) and NA (65 years) were older than AP (58 years) and LA (63 years) and had more coronary disease ...


Prognostic Value Of Baseline And Changes In Circulating Soluble St2 Levels And The Effects Of Nesiritide In Acute Decompensated Heart Failure, W. H. Wilson Tang, Yuping Wu, Justin L. Grodin, Amy P. Hsu, Adrian F. Hernandez, Javed Butler, Marco Metra, Adriaan A. Voors, G. Michael Felker, Richard W. Troughton, Roger M. Mills, John J. Mcmurray, Paul W. Armstrong, Christopher M. O'Connor, Randall C. Starling Jan 2016

Prognostic Value Of Baseline And Changes In Circulating Soluble St2 Levels And The Effects Of Nesiritide In Acute Decompensated Heart Failure, W. H. Wilson Tang, Yuping Wu, Justin L. Grodin, Amy P. Hsu, Adrian F. Hernandez, Javed Butler, Marco Metra, Adriaan A. Voors, G. Michael Felker, Richard W. Troughton, Roger M. Mills, John J. Mcmurray, Paul W. Armstrong, Christopher M. O'Connor, Randall C. Starling

Faculty of Health Sciences Publications

Objectives The study sought to investigate the association between soluble growth stimulation expressed gene 2 (sST2) level and adverse outcomes in acute heart failure (HF). Background Several studies have demonstrated the prognostic utility of sST2 levels in HF. Methods sST2 levels were measured in sequential baseline and follow-up (48 to 72 h and 30 days) plasma samples from 858 acute HF subjects enrolled in the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) trial biomarker substudy and were related to in-hospital and post-discharge clinical outcomes. Results Higher sST2 levels were associated with increased death risk at ...


Combined Free Light Chains Are Novel Predictors Of Prognosis In Heart Failure, Colette E. Jackson, Caroline Haig, Paul Welsh, Jonathan R. Dalzell, Ioannis K. Tsorlalis, Alex Mcconnachie, David Preiss, Iain B. Mcinnes, Naveed Sattar, Mark C. Petrie, Roy S. Gardner, John Mcmurray Jan 2015

Combined Free Light Chains Are Novel Predictors Of Prognosis In Heart Failure, Colette E. Jackson, Caroline Haig, Paul Welsh, Jonathan R. Dalzell, Ioannis K. Tsorlalis, Alex Mcconnachie, David Preiss, Iain B. Mcinnes, Naveed Sattar, Mark C. Petrie, Roy S. Gardner, John Mcmurray

Faculty of Health Sciences Publications

Objectives This study investigated the prevalence and potential incremental prognostic value of combined free light chains (cFLCs) in patients recently hospitalized with decompensated heart failure (HF). Background Inflammatory pathways are recognized in the pathogenesis and progression of HF. Free light chain (FLC) elevation is conventionally associated with monoclonal gammopathies, including multiple myeloma. Polyclonal increases in both kappa and lambda FLCs occur in autoimmune and other chronic inflammatory conditions. Recently, a novel assay for measuring kappa and lambda immunoglobulin FLCs together, known as combined free light chain (cFLC) has been developed. Methods Six hundred twenty-eight patients recently hospitalized with decompensated HF ...


The Hospitalization Burden And Post-Hospitalization Mortality Risk In Heart Failure With Preserved Ejection Fraction: Results From The I-Preserve Trial (Irbesartan In Heart Failure And Preserved Ejection Fraction), Peter E. Carson, Inder S. Anand, Sithu Win, Thomas S. Rector, Markus Haass, Jose Lopez-Sendon, Alan Miller, John R. Teerlink, Michel White, Robert S. Mckelvie, Michel Komajda, Michael R. Zile, John J. Mcmurray, Barry Massie Jan 2015

The Hospitalization Burden And Post-Hospitalization Mortality Risk In Heart Failure With Preserved Ejection Fraction: Results From The I-Preserve Trial (Irbesartan In Heart Failure And Preserved Ejection Fraction), Peter E. Carson, Inder S. Anand, Sithu Win, Thomas S. Rector, Markus Haass, Jose Lopez-Sendon, Alan Miller, John R. Teerlink, Michel White, Robert S. Mckelvie, Michel Komajda, Michael R. Zile, John J. Mcmurray, Barry Massie

Faculty of Health Sciences Publications

Objectives The aim of this study was to investigate prognosis in patients with heart failure (HF) with preserved ejection fraction and the causes of hospitalization and post-hospitalization mortality. Background Although hospitalizations in patients with HF with preserved ejection fraction are common, there are limited data from clinical trials on the causes of admission and the influence of hospitalizations on subsequent mortality risk. Methods Patients (n = 4,128) with New York Heart Association functional class II to IV HF and left ventricular ejection fractions > 45% were enrolled in I-PRESERVE (Irbesartan in Heart Failure and Preserved Ejection Fraction). A blinded events committee ...


History Of Atrial Fibrillation As A Risk Factor In Patients With Heart Failure And Preserved Ejection Fraction, Oludamilola W. Oluleye, Thomas S. Rector, Sithu Win, John Mcmurray, Michael R. Zile, Michel Komajda, Robert Mckelvie, Barry Massie, Peter E. Carson, Inder S. Anand Jan 2014

History Of Atrial Fibrillation As A Risk Factor In Patients With Heart Failure And Preserved Ejection Fraction, Oludamilola W. Oluleye, Thomas S. Rector, Sithu Win, John Mcmurray, Michael R. Zile, Michel Komajda, Robert Mckelvie, Barry Massie, Peter E. Carson, Inder S. Anand

Faculty of Health Sciences Publications

Atrial fibrillation (AFib) is common in heart failure (HF) with preserved ejection fraction (HFpEF). Current AFib stroke risk prediction models include the presence of HF but do not specifically include HFpEF as a risk factor. Whether a history of AFib should be used to identify patients with HFpEF who are at risk has not been established.


Incidence, Determinants, And Prognostic Significance Of Hyperkalemia And Worsening Renal Function In Patients With Heart Failure Receiving The Mineralocorticoid Receptor Antagonist Eplerenone Or Placebo In Addition To Optimal Medical Therapy: Results From The Eplerenone In Mild Patients Hospitalization And Survival Study In Heart Failure (Emphasis-Hf), Patrick Rossignol, Daniela Dobre, John Mcmurray, Karl Swedberg, Henry Krum, Dirk J. Van Veldhuisen, Harry Shi, Michael Messig, John Vincent, Nicolas Girerd, G. Bakris, Bertram Pitt, Faiez Zannad Jan 2014

Incidence, Determinants, And Prognostic Significance Of Hyperkalemia And Worsening Renal Function In Patients With Heart Failure Receiving The Mineralocorticoid Receptor Antagonist Eplerenone Or Placebo In Addition To Optimal Medical Therapy: Results From The Eplerenone In Mild Patients Hospitalization And Survival Study In Heart Failure (Emphasis-Hf), Patrick Rossignol, Daniela Dobre, John Mcmurray, Karl Swedberg, Henry Krum, Dirk J. Van Veldhuisen, Harry Shi, Michael Messig, John Vincent, Nicolas Girerd, G. Bakris, Bertram Pitt, Faiez Zannad

Faculty of Health Sciences Publications

Mineralocorticoid receptor antagonists improve outcomes in patients with systolic heart failure but may induce worsening of renal function (WRF) and hyperkalemia (HK). We assessed the risk factors for mineralocorticoid receptor antagonist–related WRF and for HK, as well as the association between HK and WRF with clinical outcomes in the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF).


Worsening Renal Function And Outcome In Heart Failure Patients With Preserved Ejection Fraction And The Impact Of Angiotensin Receptor Blocker Treatment, Kevin Damman, Ana C. Perez, Inder S. Anand, Michel Komajda, Robert S. Mckelvie, Michael R. Zile, Barrie Massie, Peter E. Carson, John J.V. Mcmurray Jan 2014

Worsening Renal Function And Outcome In Heart Failure Patients With Preserved Ejection Fraction And The Impact Of Angiotensin Receptor Blocker Treatment, Kevin Damman, Ana C. Perez, Inder S. Anand, Michel Komajda, Robert S. Mckelvie, Michael R. Zile, Barrie Massie, Peter E. Carson, John J.V. Mcmurray

Faculty of Health Sciences Publications

BACKGROUND Worsening renal function (WRF) associated with renin-angiotensin-aldosterone system (RAAS) inhibition does not confer excess risk in heart failure patients with reduced ejection fraction (HFrEF).

OBJECTIVES The goal of this study was to investigate the relationship between WRF and outcomes in heart failure patients with preserved ejection fraction (HFpEF) and the interaction with RAAS blockade.

METHODS In 3,595 patients included in the I-PRESERVE (Irbesartan in Heart Failure With Preserved Ejection Fraction) trial, change in estimated glomerular filtration rate (eGFR) and development of WRF after initiation of irbesartan or placebo were examined. We examined the association between WRF and the ...


Developing Therapies For Heart Failure With Preserved Ejection Fraction: Current State And Future Directions, Javed Butler, Gregg C. Fonarow, Michael R. Zile, Carolyn S. Lam, Lothar Roessig, Erik B. Schelbert, Sanjiv J. Shah, Ali Ahmed, Robert O. Bonow, John G. F. Cleland, Robert J. Cody, Ovidiu Chioncel, Sean P. Collins, Preston M. Dunnmon, Gerasimos S. Filippatos, Martin P. Lefkowitz, Catherine N. Marti, John J. Mcmurray, Frank Misselwitz, Savina Nodari, Christopher M. O'Connor, Marc A. Pfeffer, Burkert Pieske, Bertram Pitt, Giuseppe Rosano, Hani N. Sabbah, Michele Senni, Scott D. Solomon, Norman L. Stockbridge, John R. Teerlink, Vasiliki V. Georgiopoulou, Mihai Gheorghiade Jan 2014

Developing Therapies For Heart Failure With Preserved Ejection Fraction: Current State And Future Directions, Javed Butler, Gregg C. Fonarow, Michael R. Zile, Carolyn S. Lam, Lothar Roessig, Erik B. Schelbert, Sanjiv J. Shah, Ali Ahmed, Robert O. Bonow, John G. F. Cleland, Robert J. Cody, Ovidiu Chioncel, Sean P. Collins, Preston M. Dunnmon, Gerasimos S. Filippatos, Martin P. Lefkowitz, Catherine N. Marti, John J. Mcmurray, Frank Misselwitz, Savina Nodari, Christopher M. O'Connor, Marc A. Pfeffer, Burkert Pieske, Bertram Pitt, Giuseppe Rosano, Hani N. Sabbah, Michele Senni, Scott D. Solomon, Norman L. Stockbridge, John R. Teerlink, Vasiliki V. Georgiopoulou, Mihai Gheorghiade

Faculty of Health Sciences Publications

The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is projected to worsen. To date, there are no approved therapies available for reducing mortality or hospitalizations for these patients. The pathophysiology of HFpEF is complex and includes alterations in cardiac structure and function, systemic and pulmonary vascular abnormalities, end-organ involvement, and comorbidities. There remain major gaps in our understanding of HFpEF pathophysiology. To facilitate a discussion of how to proceed effectively in future with development of therapies for HFpEF, a meeting was facilitated by the Food and Drug Administration and included representatives from academia, industry, and ...


Prognostic Effect Of High-Sensitive Troponin T Assessment In Elderly Patients With Chronic Heart Failure : Results From The Corona Trial, Jørgen Gravning, Erik Tandberg Askevold, Ståle Nymo, Thor Ueland, John Wikstrand, John Mcmurray, Pål Aukrust, Lars Gullestad, John Kjekshus Jan 2014

Prognostic Effect Of High-Sensitive Troponin T Assessment In Elderly Patients With Chronic Heart Failure : Results From The Corona Trial, Jørgen Gravning, Erik Tandberg Askevold, Ståle Nymo, Thor Ueland, John Wikstrand, John Mcmurray, Pål Aukrust, Lars Gullestad, John Kjekshus

Faculty of Health Sciences Publications

The incremental prognostic value of high-sensitive troponin T (hs-cTnT) in heart failure (HF) beyond that of high-sensitivity C-reactive protein and amino-terminal probrain natriuretic peptide is debated. We examined the prognostic value of hs-cTnT in a subgroup of patients from the Controlled Rosuvastatin Multinational Trial in HF (CORONA) study.


Models Containing Age And Nihss Predict Recovery Of Ambulation And Upper Limb Function Six Months After Stroke : An Observational Study, Li Khim Kwah, Lisa A. Harvey, Joanna Diong, Robert D. Herbert Jan 2013

Models Containing Age And Nihss Predict Recovery Of Ambulation And Upper Limb Function Six Months After Stroke : An Observational Study, Li Khim Kwah, Lisa A. Harvey, Joanna Diong, Robert D. Herbert

Faculty of Health Sciences Publications

Questions

What is the incidence of recovery of ambulation and upper limb function six months after stroke? Can measures such as age and the National Institutes of Health Stroke Scale (NIHSS) be used to develop models to predict the recovery of ambulation and upper limb function?

Design

Prospective cohort study.

Participants

Consecutive sample of 200 people with stroke admitted to a Sydney Hospital.

Outcome measures

Ambulation was measured with item 5 of the Motor Assessment Scale (MAS); patients scoring ≥ 3 could ambulate independently. Upper limb function was measured with items 7 and 8 of the MAS; patients scoring ≥ 5 could ...


Association Of Heart Rate And Outcomes In A Broad Spectrum Of Patients With Chronic Heart Failure: Results From The Charm (Candesartan In Heart Failure: Assessment Of Reduction In Mortality And Morbidity) Program, Davide Castagno, Hicham Skali, Madoka Takeuchi, Karl Sweberg, Salim Yusuf, Christopher B. Granger, Eric L. Michelson, Marc A. Pfeffer, John J.V. Mcmurray, Scott D. Solomon Jan 2012

Association Of Heart Rate And Outcomes In A Broad Spectrum Of Patients With Chronic Heart Failure: Results From The Charm (Candesartan In Heart Failure: Assessment Of Reduction In Mortality And Morbidity) Program, Davide Castagno, Hicham Skali, Madoka Takeuchi, Karl Sweberg, Salim Yusuf, Christopher B. Granger, Eric L. Michelson, Marc A. Pfeffer, John J.V. Mcmurray, Scott D. Solomon

Faculty of Health Sciences Publications

No abstract provided.


Sex Differences In Clinical Characteristics And Outcomes In Elderly Patients With Heart Failure And Preserved Ejection Fraction: The Irbesartan In Heart Failure With Preserved Ejection Fraction (I-Preserve) Trial, Carolyn S. P. Lam, Peter E. Carson, Inder S. Anand, Thomas S. Rector, Michael Kuskowski, Michel Komajda, Robert Mckelvie, John Mcmurray, Michael R. Zile, Barry M. Massie, Dalane W. Kitzman Jan 2012

Sex Differences In Clinical Characteristics And Outcomes In Elderly Patients With Heart Failure And Preserved Ejection Fraction: The Irbesartan In Heart Failure With Preserved Ejection Fraction (I-Preserve) Trial, Carolyn S. P. Lam, Peter E. Carson, Inder S. Anand, Thomas S. Rector, Michael Kuskowski, Michel Komajda, Robert Mckelvie, John Mcmurray, Michael R. Zile, Barry M. Massie, Dalane W. Kitzman

Faculty of Health Sciences Publications

There are few sex-specific outcome data in heart failure with preserved ejection fraction.


Prognostic Value Of Baseline Plasma Amino-Terminal Pro-Brain Natriuretic Peptide And Its Interactions With Irbesartan Treatment Effects In Patients With Heart Failure And Preserved Ejection Fraction : Findings From The I-Preserve Trial, Inder S. Anand, Thomas S. Rector, John Gf Cleland, Michael Kuskowski, Robert Mckelvie, Hans Persson, John Mcmurray, Michael R. Zile, Michel Komajda, Barry M. Massie, Peter E. Carson Jan 2011

Prognostic Value Of Baseline Plasma Amino-Terminal Pro-Brain Natriuretic Peptide And Its Interactions With Irbesartan Treatment Effects In Patients With Heart Failure And Preserved Ejection Fraction : Findings From The I-Preserve Trial, Inder S. Anand, Thomas S. Rector, John Gf Cleland, Michael Kuskowski, Robert Mckelvie, Hans Persson, John Mcmurray, Michael R. Zile, Michel Komajda, Barry M. Massie, Peter E. Carson

Faculty of Health Sciences Publications

Plasma concentrations of natriuretic peptides (NPs) are associated with morbidity and mortality in patients with systolic heart failure (HF). However, the role of NP as a prognostic marker in patients with HF and preserved ejection fraction (HFpEF) has not been studied in a large cohort of well-characterized patients. Moreover, it is unclear whether treatments have a differential effect on morbidity and mortality across the spectrum of NP levels.