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Full-Text Articles in Medicine and Health Sciences

The Epidemiology Of Hip Fractures Across Western Victoria, Australia [Accepted Manuscript], Kara L. Holloway, Muhammad A. Sajjad, Mohammadreza Mohebbi, Mark A. Kotowicz, Patricia M. Livingston, Mustafa Khasraw, Sharon Hakkennes, Trisha L. Dunning, Susan Brumby, Richard S. Page, Daryl Pedler, Alasdair Sutherland, Svetha Venkatesh, Sharon L. Brennan Mar 2018

The Epidemiology Of Hip Fractures Across Western Victoria, Australia [Accepted Manuscript], Kara L. Holloway, Muhammad A. Sajjad, Mohammadreza Mohebbi, Mark A. Kotowicz, Patricia M. Livingston, Mustafa Khasraw, Sharon Hakkennes, Trisha L. Dunning, Susan Brumby, Richard S. Page, Daryl Pedler, Alasdair Sutherland, Svetha Venkatesh, Sharon L. Brennan

Faculty of Health Sciences Publications

Background Hip fractures are associated with considerable morbidity and mortality. Hip fracture incidence varies across different levels of accessibility/remoteness and socioeconomic status (SES). As part of the Ageing, Chronic Disease and Injury Study, we aimed to map the pattern of hip fractures across the western region of the Australian state of Victoria, which contains a range of remoteness levels and SES. Methods Data on hip fractures resulting in hospital admission were extracted from the Victorian Admitted Episodes Dataset (VAED) for men and women aged 40 + years during 2010–2013 inclusive. An age-adjusted incidence rate (per 10,000 population/year ...


Higher Low-Density Lipoprotein Cholesterol Levels Are Associated With Decreased Mortality In Patients With Intracerebral Hemorrhage [Accepted Manuscript], Jason J. Chang, Aristeidis Katsanos, Yasser Khorchid, Kira Dillard, Ali Kerro, Lucia Goodwin Burgess, Nitin Goyal, Anne W. Alexandrov, Andrei V. Alexandrov, Georgios Tsivgoulis Feb 2018

Higher Low-Density Lipoprotein Cholesterol Levels Are Associated With Decreased Mortality In Patients With Intracerebral Hemorrhage [Accepted Manuscript], Jason J. Chang, Aristeidis Katsanos, Yasser Khorchid, Kira Dillard, Ali Kerro, Lucia Goodwin Burgess, Nitin Goyal, Anne W. Alexandrov, Andrei V. Alexandrov, Georgios Tsivgoulis

Faculty of Health Sciences Publications

Background and aims: The relationship between lipoprotein levels, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and clinical outcome after intracerebral hemorrhage (ICH) remains controversial. We sought to evaluate the association of lipoprotein cholesterol levels and statin dosage with clinical and neuroimaging outcomes in patients with ICH. Methods: Data on consecutive patients hospitalized with spontaneous acute ICH was prospectively collected over a 5-year period and retrospectively analyzed. Demographic characteristics, clinical severity documented by NIHSS-score and ICH-score, neuroimaging parameters, pre-hospital statin use and doses, and LDL-C and HDL-C levels were recorded. Outcome events characterized were hematoma volume, hematoma expansion, in-hospital functional ...


Pulmonary Hypertension As Seen In A Rural Area In Sub-Saharan Africa: High Prevalence, Late Clinical Presentation And A High Short-Term Mortality Rate During Follow Up, Anastase Dzudie, Bonaventure Suiru Dzekem, Cabral Tantchou Tchoumi, Leopold Ndemnge Aminde, Ana O. Mocumbi, Martin Abanda, Friedrich Thienemann, Andre Pascal Kengne, Karen Sliwa Karen.Sliwahahnle@Acu.Edu.Au Jan 2018

Pulmonary Hypertension As Seen In A Rural Area In Sub-Saharan Africa: High Prevalence, Late Clinical Presentation And A High Short-Term Mortality Rate During Follow Up, Anastase Dzudie, Bonaventure Suiru Dzekem, Cabral Tantchou Tchoumi, Leopold Ndemnge Aminde, Ana O. Mocumbi, Martin Abanda, Friedrich Thienemann, Andre Pascal Kengne, Karen Sliwa Karen.Sliwahahnle@Acu.Edu.Au

Faculty of Health Sciences Publications

Introduction: The epidemiology of pulmonary hypertension (PH) in low- to middle-income countries is poorly characterised. We assessed the prevalence, baseline characteristics and mortality rate in patients with echocardiographically diagnosed PH at a rural cardiac centre in Cameroon. Methods: We conducted a prospective cohort study in a subsample of 150 participants, aged 18 years and older, diagnosed with PH [defined as right ventricular systolic pressure (RVSP) ≥ 35 mmHg in the absence of pulmonary stenosis and right heart failure]. PH was classified as mild (RVSP: 35–50 mmHg), moderate (RVSP: 51–60 mmHg) and severe (RVSP: > 60 mmHg). Results: Of 2 194 ...


Air Pollution, Noise, Blue Space, And Green Space And Premature Mortality In Barcelona: A Mega Cohort, Mark J. Nieuwenhuijsen, Mireia Gascon, David Martinez, Anna Ponjoan, Jordi Blanch, Maria Del Mar Garcia-Gil, Rafael Ramos, Maria Foraster, Natalie Mueller, Ana Espinosa, Marta Cirach, Haneen Khreis, Payam Dadvand, Xavier Basagaña Jan 2018

Air Pollution, Noise, Blue Space, And Green Space And Premature Mortality In Barcelona: A Mega Cohort, Mark J. Nieuwenhuijsen, Mireia Gascon, David Martinez, Anna Ponjoan, Jordi Blanch, Maria Del Mar Garcia-Gil, Rafael Ramos, Maria Foraster, Natalie Mueller, Ana Espinosa, Marta Cirach, Haneen Khreis, Payam Dadvand, Xavier Basagaña

Faculty of Health Sciences Publications

Introduction: Cities often experience high air pollution and noise levels and lack of natural outdoor environments, which may be detrimental to health. The aim of this study was to evaluate the effects of air pollution, noise, and blue and green space on premature all-cause mortality in Barcelona using a mega cohort approach. Methods: Both men and women of 18 years and above registered on 1 January 2010 by the Sistema d’Informació pel Desenvolupament de la Investigació en Atenció Primària (SIDIAP) and living in the city of Barcelona were included in the cohort and followed up until 31 December 2014 ...


Mild Cognitive Impairment Impacts Health Outcomes Of Patients With Atrial Fibrillation Undergoing A Disease Management Intervention, Jocasta Ball, Maja-Lisa Loechen, Melinda Carrington, Joshua Wiley, S. Stewart Jan 2018

Mild Cognitive Impairment Impacts Health Outcomes Of Patients With Atrial Fibrillation Undergoing A Disease Management Intervention, Jocasta Ball, Maja-Lisa Loechen, Melinda Carrington, Joshua Wiley, S. Stewart

Faculty of Health Sciences Publications

Objective: Mild cognitive impairment (MCI) is prevalent in atrial fibrillation (AF) and has the potential to contribute to poor outcomes. We investigated the influence of MCI on survival and rehospitalisation in patients with chronic forms of AF undergoing a home-based, AF-specific disease management intervention (home-based intervention (HBI)) or standard management(SM). Methods The Montreal Cognitive Assessment tool was administered at baseline (a score of < 26/30 indicated MCI) in patients with AF randomised to HBI versus SM. Post hoc analyses of mortality and rehospitalisations during a minimum 24-month follow-up were conducted in the overall cohort and in each study group separately. Results Of 260 patients (mean age 72±11, 47% female), 65% demonstrated MCI on screening (34% in SM; 31% in HBI). Overall, the number of days spent alive and outof- hospital during follow-up (P=0.012) and all-cause rehospitalisation were influenced by MCI during follow-up (OR 3.16 (95% CI 1.46 to 6.84)) but MCI did not influence any outcomes in the SM group. However, survival was negatively influenced by MCI in the HBI group (P=0.036); those with MCI in this group were 5.6 times more likely to die during follow-up (OR 5.57 (95% CI 1.10 to 28.1)). Those with MCI in the HBI group also spent less days alive and out-of-hospital than those with no MCI (P=0.022). MCI was also identified as a significant independent correlate of shortest duration of event-free survival (OR 3.48 (95% CI 1.06 to 11.4)), allcause rehospitalisation (OR 3.30 (95% CI 1.25 to 8.69)) and cardiovascular disease (CVD)-related rehospitalisation (OR 2.35 (95% CI 1.12 to 4.91)) in this group. Conclusions The effectiveness of home-based, disease management for patients with chronic forms of AF is negatively affected by comorbid MCI. The benefit of adjunctive support for patients with MCI on CVD-related health outcomes requires further investigation.


Incidence Of Hospitalisation For Heart Failure And Case-Fatality Among 3.25 Million People With And Without Diabetes [Accepted Manuscript], David A. Mcallister, Stephanie H. Read, Jan Kerssens, Shona Livingstone, Stuart Mcgurnaghan, Pardeep Jhund, John Petrie, Naveed Sattar, Colin Fischbacher, Soren Lund Kristensen, John Mcmurray, Helen M. Colhoun, Sarah H. Wild Jan 2018

Incidence Of Hospitalisation For Heart Failure And Case-Fatality Among 3.25 Million People With And Without Diabetes [Accepted Manuscript], David A. Mcallister, Stephanie H. Read, Jan Kerssens, Shona Livingstone, Stuart Mcgurnaghan, Pardeep Jhund, John Petrie, Naveed Sattar, Colin Fischbacher, Soren Lund Kristensen, John Mcmurray, Helen M. Colhoun, Sarah H. Wild

Faculty of Health Sciences Publications

Background:
Recent clinical trials of new glucose-lowering treatments have drawn attention to the importance of hospitalization for heart failure as a complication of diabetes mellitus. However, the epidemiology is not well described, particularly for type 1 diabetes mellitus. We examined the incidence and case-fatality of heart failure hospitalizations in the entire population aged ≥30 years resident in Scotland during 2004 to 2013.
Methods:
Date and type of diabetes mellitus diagnosis were linked to heart failure hospitalizations and deaths using the national Scottish registers. Incidence rates and case-fatality were estimated in regression models (quasi-Poisson and logistic regression respectively). All estimates are ...


Vitamin D Supplementation In The Prevention And Management Of Major Chronic Diseases Not Related To Mineral Homeostasis In Adults: Research For Evidence And A Scientific Statement From The European Society For Clinical And Economic Aspects Of Osteopo, Luisella Cianferotti, Francesco Bertoldo, Heike A. Bischoff-Ferrari, O. Bruyere, Cyrus Cooper, Maurizio Cutolo, John A. Kanis, Jean-Marc Kaufman, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi Jan 2017

Vitamin D Supplementation In The Prevention And Management Of Major Chronic Diseases Not Related To Mineral Homeostasis In Adults: Research For Evidence And A Scientific Statement From The European Society For Clinical And Economic Aspects Of Osteopo, Luisella Cianferotti, Francesco Bertoldo, Heike A. Bischoff-Ferrari, O. Bruyere, Cyrus Cooper, Maurizio Cutolo, John A. Kanis, Jean-Marc Kaufman, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi

Faculty of Health Sciences Publications

Introduction: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. Purpose and Methods: Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field. Results and conclusions: Robust mechanistic evidence is available from ...


Uric Acid Predicts Mortality And Ischaemic Stroke In Subjects With Diastolic Dysfunction: The Tromsø Study1994-2013, Jon V. Norvik, Henrik Schirmer, Kirsti Ytrehus, Hilde Storhaug, Trond Jenssen, B. O. Eriksen, Ellisiv B. Mathiesen, Maja-Lisa Loechen, Tom Wilsgaard, Marit Solbu Jan 2017

Uric Acid Predicts Mortality And Ischaemic Stroke In Subjects With Diastolic Dysfunction: The Tromsø Study1994-2013, Jon V. Norvik, Henrik Schirmer, Kirsti Ytrehus, Hilde Storhaug, Trond Jenssen, B. O. Eriksen, Ellisiv B. Mathiesen, Maja-Lisa Loechen, Tom Wilsgaard, Marit Solbu

Faculty of Health Sciences Publications

Aims: To investigate whether serum uric acid predicts adverse outcomes in persons with indices of diastolic dysfunction in a general population. Methods and results: We performed a prospective cohort study among 1460 women and 1480 men from 1994 to 2013. Endpoints were all-cause mortality, incident myocardial infarction, and incident ischaemic stroke. We stratified the analyses by echocardiographic markers of diastolic dysfunction, and uric acid was the independent variable of interest. Hazard ratios (HR) were estimated per 59 μmol/L increase in baseline uric acid. Multivariable adjusted Cox proportional hazards models showed that uric acid predicted all-cause mortality in subjects with ...


Thirty Years Of Evidence On The Efficacy Of Drug Treatments For Chronic Heart Failure With Reduced Ejection Fraction: A Network Meta-Analysis, Heather Burnett, Amy Earley, Adriaan A. Voors, Michele Senni, John Mcmurray, Celine Deschaseaux, Shannon Cope Jan 2017

Thirty Years Of Evidence On The Efficacy Of Drug Treatments For Chronic Heart Failure With Reduced Ejection Fraction: A Network Meta-Analysis, Heather Burnett, Amy Earley, Adriaan A. Voors, Michele Senni, John Mcmurray, Celine Deschaseaux, Shannon Cope

Faculty of Health Sciences Publications

Treatments that reduce mortality and morbidity in patients with heart failure with reduced ejection fraction, including angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), β-blockers (BB), mineralocorticoid receptor antagonists (MRA), and angiotensin receptor–neprilysin inhibitors (ARNI), have not been studied in a head-to-head fashion. This network meta-analysis aimed to compare the efficacy of these drugs and their combinations regarding all-cause mortality in patients with heart failure with reduced ejection fraction.


Importance Of Clinical Worsening Of Heart Failure Treated In The Outpatient Setting: Evidence From The Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure Trial (Paradigm-Hf), Naoki Okumura, Pardeep Jhund, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott Solomon, Milton Packer, John Mcmurray Jan 2016

Importance Of Clinical Worsening Of Heart Failure Treated In The Outpatient Setting: Evidence From The Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure Trial (Paradigm-Hf), Naoki Okumura, Pardeep Jhund, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott Solomon, Milton Packer, John Mcmurray

Faculty of Health Sciences Publications

Many episodes of worsening of heart failure (HF) are treated by increasing oral therapy or temporary intravenous treatment in the community or emergency department (ED), without hospital admission. We studied the frequency and prognostic importance of these episodes of worsening in the Prospective Comparison of ARNI (angiotensin-receptor-neprilysin inhibitor) with ACEI (angiotensin-converting enzyme inhibitor) to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial (PARADIGM-HF).


Impact Of Nurse-Led, Multidisciplinary Home-Based Intervention On Event-Free Survival Across The Spectrum Of Chronic Heart Disease: Composite Analysis Of Health Outcomes In 1226 Patients From 3 Randomized Trials, Simon Stewart, Joshua F. Wiley, Jocasta Clare Ball, Yih-Kai Chan, Yasmin Ahamed, David Robert Thompson, Melinda Jane Carrington Jan 2016

Impact Of Nurse-Led, Multidisciplinary Home-Based Intervention On Event-Free Survival Across The Spectrum Of Chronic Heart Disease: Composite Analysis Of Health Outcomes In 1226 Patients From 3 Randomized Trials, Simon Stewart, Joshua F. Wiley, Jocasta Clare Ball, Yih-Kai Chan, Yasmin Ahamed, David Robert Thompson, Melinda Jane Carrington

Faculty of Health Sciences Publications

Background: We sought to determine the overall impact of a nurse: led, multidisciplinary home: based intervention ( HBI ) adapted to hospitalized patients with chronic forms of heart disease of varying types. Methods and Results: Prospectively planned, combined, secondary analysis of 3 randomized trials ( 1226 patients ) of HBI were compared with standard management. Hospitalized patients presenting with heart disease but not heart failure, atrial fibrillation but not heart failure, and heart failure, as well, were recruited. Overall, 612 and 614 patients, respectively, were allocated to a home visit 7 to 14 days postdischarge by a cardiac nurse with follow: up and multidisciplinary ...


Can Air Pollution Negate The Health Benefits Of Cycling And Walking?, Marko Tainio, Audrey J. De Nazelle, Thomas Götschi, Sonja Kahlmeier, David Rojas-Rueda, Mark J. Nieuwenhuijsen, Thiago Hérick De Sá, Paul Kelly, James Woodcock Jan 2016

Can Air Pollution Negate The Health Benefits Of Cycling And Walking?, Marko Tainio, Audrey J. De Nazelle, Thomas Götschi, Sonja Kahlmeier, David Rojas-Rueda, Mark J. Nieuwenhuijsen, Thiago Hérick De Sá, Paul Kelly, James Woodcock

Faculty of Health Sciences Publications

Active travel (cycling, walking) is beneficial for the health due to increased physical activity (PA). However, active travel may increase the intake of air pollution, leading to negative health consequences. We examined the risk–benefit balance between active travel related PA and exposure to air pollution across a range of air pollution and PA scenarios. The health effects of active travel and air pollution were estimated through changes in all-cause mortality for different levels of active travel and air pollution. Air pollution exposure was estimated through changes in background concentrations of fine particulate matter (PM2.5), ranging from 5 to ...


Global, Regional, And National Life Expectancy, All-Cause Mortality, And Cause-Specific Mortality For 249 Causes Of Death, 1980-2015: A Systematic Analysis For The Global Burden Of Disease Study 2015, Haidong Wang, Mohsen Naghavi, Christine Allen, Ryan M. Barber, Zulfiqar A. Bhutta, Austin Carter, Daniel C. Casey, Fiona J. Charlson, Alan Zian Chen, Matthew M. Coates, Megan Coggeshall, Lalit Dandona, Daniel J. Dicker, Holly E. Erskine, Alize J. Ferrari, Christina Fitzmaurice, Kyle Foreman, Mohammad H. Forouzanfar, Maya S. Fraser, Nancy Fullman, Peter W. Gething, Ellen M. Goldberg, Nicholas Graetz, Juanita A. Haagsma, Simon I. Hay, Chantal Huynh, Catherine O. Johnson, Nicholas J. Kassebaum, Yohannes Kinfu, Xie Rachel Kulikoff, Michael Kutz, Hmwe H. Kyu, Heidi J. Larson, Janni Leung, Xiaofeng Liang, Stephen S. Lim, Margaret Lind, Rafael Lozano, Neal Marquez, George A. Mensah, Joe Mikesell, Ali H. Mokdad, Meghan D. Mooney, Grant Nguyen, Elaine Nsoesie, David M. Pigott, Christine Pinho, Gregory A. Roth, Joshua A. Salomon, Logan Sandar, Naris Silpakit, Amber Sligar, Reed J. D. Sorensen, Jeffrey Stanaway, Caitlyn Steiner, Stephanie Teeple, Bernadette A. Thomas, Christopher Troeger, Amelia Vanderzanden, Stein Emil Vollset, Valentine Wanga, Harvey A. Whiteford, Timothy Wolock, Leo Zoeckler, Cassandra E. I. Szoeke, Gbd 2015 Mortality And Causes Of Death Collaborators Jan 2016

Global, Regional, And National Life Expectancy, All-Cause Mortality, And Cause-Specific Mortality For 249 Causes Of Death, 1980-2015: A Systematic Analysis For The Global Burden Of Disease Study 2015, Haidong Wang, Mohsen Naghavi, Christine Allen, Ryan M. Barber, Zulfiqar A. Bhutta, Austin Carter, Daniel C. Casey, Fiona J. Charlson, Alan Zian Chen, Matthew M. Coates, Megan Coggeshall, Lalit Dandona, Daniel J. Dicker, Holly E. Erskine, Alize J. Ferrari, Christina Fitzmaurice, Kyle Foreman, Mohammad H. Forouzanfar, Maya S. Fraser, Nancy Fullman, Peter W. Gething, Ellen M. Goldberg, Nicholas Graetz, Juanita A. Haagsma, Simon I. Hay, Chantal Huynh, Catherine O. Johnson, Nicholas J. Kassebaum, Yohannes Kinfu, Xie Rachel Kulikoff, Michael Kutz, Hmwe H. Kyu, Heidi J. Larson, Janni Leung, Xiaofeng Liang, Stephen S. Lim, Margaret Lind, Rafael Lozano, Neal Marquez, George A. Mensah, Joe Mikesell, Ali H. Mokdad, Meghan D. Mooney, Grant Nguyen, Elaine Nsoesie, David M. Pigott, Christine Pinho, Gregory A. Roth, Joshua A. Salomon, Logan Sandar, Naris Silpakit, Amber Sligar, Reed J. D. Sorensen, Jeffrey Stanaway, Caitlyn Steiner, Stephanie Teeple, Bernadette A. Thomas, Christopher Troeger, Amelia Vanderzanden, Stein Emil Vollset, Valentine Wanga, Harvey A. Whiteford, Timothy Wolock, Leo Zoeckler, Cassandra E. I. Szoeke, Gbd 2015 Mortality And Causes Of Death Collaborators

Faculty of Health Sciences Publications

Background: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures.

Methods: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child ...


Trends In Modifiable Risk Factors Are Associated With Declining Incidence Of Hospitalized And Nonhospitalized Acute Coronary Heart Disease In A Population, Jan Mannsverk, Tom Wilsgaard, Ellisiv Bøgeberg Mathiesen, Maja-Lisa Løchen, Knut Rasmussen, Dag S. Thelle, Inger Njølstad, Laila Arnesdatter Hopstock, Kaare Harald Bønaa Jan 2016

Trends In Modifiable Risk Factors Are Associated With Declining Incidence Of Hospitalized And Nonhospitalized Acute Coronary Heart Disease In A Population, Jan Mannsverk, Tom Wilsgaard, Ellisiv Bøgeberg Mathiesen, Maja-Lisa Løchen, Knut Rasmussen, Dag S. Thelle, Inger Njølstad, Laila Arnesdatter Hopstock, Kaare Harald Bønaa

Faculty of Health Sciences Publications

Background: Few studies have used individual person data to study whether contemporary trends in the incidence of coronary heart disease are associated with changes in modifiable coronary risk factors. Methods and Results: We identified 29 582 healthy men and women ≥25 years of age who participated in 3 population surveys conducted between 1994 and 2008 in Tromsø, Norway. Age- and sex-adjusted incidence rates were calculated for coronary heart disease overall, out-of-hospital sudden death, and hospitalized ST-segment–elevation and non–ST-segment–elevation myocardial infarction. We measured coronary risk factors at each survey and estimated the relationship between changes in risk factors ...


Prognostic Value Of Basal High-Sensitive Cardiac Troponin Levels On Mortality In The General Population, Noreen Van Der Linden, Lieke J. J. Klinkenberg, Otto Bekers, Luc Van Loon, Marja P. Van Dieijen-Visser, Maurice P. Zeegers, Steven J. R. Meex Jan 2016

Prognostic Value Of Basal High-Sensitive Cardiac Troponin Levels On Mortality In The General Population, Noreen Van Der Linden, Lieke J. J. Klinkenberg, Otto Bekers, Luc Van Loon, Marja P. Van Dieijen-Visser, Maurice P. Zeegers, Steven J. R. Meex

Faculty of Health Sciences Publications

Interest in the use of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) has expanded from diagnosis of acute myocardial infarction to risk assessment for morbidity and mortality. Although cTnT and cTnI were shown to have equivalent diagnostic performance in the setting of suspected acute myocardial infarction, potential prognostic differences are largely unexplored. The aim of this study is to quantify and compare the relationship between cTnT and cTnI, and cardiovascular and all-cause mortality in the general population. Medline, Embase, and the Cochrane Library (from inception through October 2016) were searched for prospective observational cohort studies reporting on the ...


International Geographic Variation In Event Rates In Trials Of Heart Failure With Preserved And Reduced Ejection Fraction, Søren L. Kristensen, Lars Kober, Pardeep Jhund, Scott Solomon, John Kjekshus, Robert Mckelvie, Michael R. Zile, Christopher B. Granger, John Wikstrand, Michel Komajda, Peter E. Carson, Marc A. Pfeffer, Karl Swedberg, Hans Wedel, Salim Yusuf, John Mcmurray Jan 2015

International Geographic Variation In Event Rates In Trials Of Heart Failure With Preserved And Reduced Ejection Fraction, Søren L. Kristensen, Lars Kober, Pardeep Jhund, Scott Solomon, John Kjekshus, Robert Mckelvie, Michael R. Zile, Christopher B. Granger, John Wikstrand, Michel Komajda, Peter E. Carson, Marc A. Pfeffer, Karl Swedberg, Hans Wedel, Salim Yusuf, John Mcmurray

Faculty of Health Sciences Publications

International geographic differences in outcomes may exist for clinical trials of heart failure and reduced ejection fraction (HF-REF), but there are few data for those with preserved ejection fraction )HF-PEF)


Influence Of Hospitalization For Cardiovascular Versus Noncardiovascular Reasons On Subsequent Mortality In Patients With Chronic Heart Failure Across The Spectrum Of Ejection Fraction, Akshay S. Desai, Brian L. Claggett, Marc A. Pfeffer, Natalie Bello, Peter Finn, Christopher B. Granger, John Mcmurray, Stuart J. Pocock, Karl Swedberg, Salim Yusuf, Scott Solomon Jan 2014

Influence Of Hospitalization For Cardiovascular Versus Noncardiovascular Reasons On Subsequent Mortality In Patients With Chronic Heart Failure Across The Spectrum Of Ejection Fraction, Akshay S. Desai, Brian L. Claggett, Marc A. Pfeffer, Natalie Bello, Peter Finn, Christopher B. Granger, John Mcmurray, Stuart J. Pocock, Karl Swedberg, Salim Yusuf, Scott Solomon

Faculty of Health Sciences Publications

Noncardiovascular (non-CV) comorbidities may contribute to hospitalizations in patients with heart failure (HF). We examined the incidence of mortality following hospitalization for cardiovascular (CV) versus non-CV reasons in the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program.


Soluble Glycoprotein 130 Predicts Fatal Outcomes In Chronic Heart Failure : Analysis From The Controlled Rosuvastatin Multinational Trial In Heart Failure (Corona), Erik Tandberg Askevold, Ståle Nymo, Thor Ueland, Jørgen Gravning, Ragnhild Wergeland, John Kjekshus, Arne Yndestad, John G. F. Cleland, John Mcmurray, Pål Aukrust, Lars Gullestad Jan 2013

Soluble Glycoprotein 130 Predicts Fatal Outcomes In Chronic Heart Failure : Analysis From The Controlled Rosuvastatin Multinational Trial In Heart Failure (Corona), Erik Tandberg Askevold, Ståle Nymo, Thor Ueland, Jørgen Gravning, Ragnhild Wergeland, John Kjekshus, Arne Yndestad, John G. F. Cleland, John Mcmurray, Pål Aukrust, Lars Gullestad

Faculty of Health Sciences Publications

Glycoprotein 130 (gp130) is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family, which may be involved in the progression of heart failure (HF). We hypothesized that soluble gp130 would provide prognostic information beyond that of IL-6 in a population with HF from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).


How Small Is Too Small? A Systematic Review Of Center Volume And Outcome After Cardiac Transplantation, Stephen J. Pettit, Pardeep Jhund, Nathaniel M. Hawkins, Roy S. Gardner, Saleem Haj-Yahia, John Mcmurray, Mark C. Petrie Jan 2012

How Small Is Too Small? A Systematic Review Of Center Volume And Outcome After Cardiac Transplantation, Stephen J. Pettit, Pardeep Jhund, Nathaniel M. Hawkins, Roy S. Gardner, Saleem Haj-Yahia, John Mcmurray, Mark C. Petrie

Faculty of Health Sciences Publications

The aim of this study was to assess the relationship between the volume of cardiac transplantation procedures performed in a center and the outcome after cardiac transplantation.