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Health Care Professionals’ Perceptions Of Home Telemonitoring In Heart Failure Care: Cross-Sectional Survey, Ina Thon Aamodt, Edita Lycholip, Jelena Celutkiene, Anna Strömberg, Dan Atar, Ragnhild Sørum Falk, Thomas G. Von Lueder, Ragnhild Hellesø, Tiny Jaarsma, Irene Lie Jan 2019

Health Care Professionals’ Perceptions Of Home Telemonitoring In Heart Failure Care: Cross-Sectional Survey, Ina Thon Aamodt, Edita Lycholip, Jelena Celutkiene, Anna Strömberg, Dan Atar, Ragnhild Sørum Falk, Thomas G. Von Lueder, Ragnhild Hellesø, Tiny Jaarsma, Irene Lie

Faculty of Health Sciences Publications

Background: Noninvasive telemonitoring (TM) can be used in heart failure (HF) patients to perform early detection of decompensation at home, prevent unnecessary health care utilization, and decrease health care costs. However, the evidence is not sufficient to be part of HF guidelines for follow-up care, and we have no knowledge of how TM is used in the Nordic Baltic region. Objective: The aim of this study was to describe health care professionals’ (HCPs) perception of and presumed experience with noninvasive TM in daily HF patient care, perspectives of the relevance of and reasons for applying noninvasive TM, and barriers to ...


A Trial To Evaluate The Effect Of The Sodium-Glucose Co-Transporter 2 Inhibitor Dapagliflozin On Morbidity And Mortality In Patients With Heart Failure And Reduced Left Ventricular Ejection Fraction (Dapa-Hf), John J. V. Mcmurray, David L. Demets, Silvio E. Inzucchini, Lars Køber, Mikhail N. Kosiborod, Anna M. Langkilde, Felipe A. Martinez, Olof Bengtsson, Piotr P. Ponikowski, Marc S. Sabatine, Mikaela Sjöstrand, Scott D. Solomon Jan 2019

A Trial To Evaluate The Effect Of The Sodium-Glucose Co-Transporter 2 Inhibitor Dapagliflozin On Morbidity And Mortality In Patients With Heart Failure And Reduced Left Ventricular Ejection Fraction (Dapa-Hf), John J. V. Mcmurray, David L. Demets, Silvio E. Inzucchini, Lars Køber, Mikhail N. Kosiborod, Anna M. Langkilde, Felipe A. Martinez, Olof Bengtsson, Piotr P. Ponikowski, Marc S. Sabatine, Mikaela Sjöstrand, Scott D. Solomon

Faculty of Health Sciences Publications

Background Sodium–glucose co‐transporter 2 (SGLT2) inhibitors have been shown to reduce the risk of incident heart failure hospitalization in individuals with type 2 diabetes who have, or are at high risk of, cardiovascular disease. Most patients in these trials did not have heart failure at baseline and the effect of SGLT2 inhibitors on outcomes in individuals with established heart failure (with or without diabetes) is unknown. Design and methods The Dapagliflozin And Prevention of Adverse‐outcomes in Heart Failure trial (DAPA‐HF) is an international, multicentre, parallel group, randomized, double‐blind, study in patients with chronic heart failure ...


Sacubitril/Valsartan In Asian Patients With Heart Failure With Reduced Ejection Fraction, Pooja Dewan, Kieran F. Docherty, John J. V. Mcmurray Jan 2019

Sacubitril/Valsartan In Asian Patients With Heart Failure With Reduced Ejection Fraction, Pooja Dewan, Kieran F. Docherty, John J. V. Mcmurray

Faculty of Health Sciences Publications

The Prospective comparison of Angiotensin Receptor-neprilysin inhibitor (ARNI) with Angiotensin converting enzyme inhibitor (ACEI) to Determine Impact on Global Mortality and morbidity in Heart Failure (HF) trial (PARADIGM-HF) showed that adding a neprilysin inhibitor (sacubitril) to a renin-angiotensin system blocker (and other standard therapy) reduced morbidity and mortality in ambulatory patients with chronic HF with reduced ejection fraction (HFrEF). In PARADIGM-HF, valsartan combined with sacubitril (a so-called ARNI) was superior to the current gold standard of an ACEI, specifically enalapril, reducing the risk of the primary composite outcome of cardiovascular (CV) death or first HF hospitalization by 20% and all-cause ...


Winter Peaks In Heart Failure: An Inevitable Or Preventable Consequence Of Seasonal Vulnerability?, Simon Stewart, Trine T. Moholdt, Louise M. Burrell, Karen Sliwa, Ana O. Mocumbi, John J. V. Mcmurray, Ashley K. Keates, John A. Hawley Jan 2019

Winter Peaks In Heart Failure: An Inevitable Or Preventable Consequence Of Seasonal Vulnerability?, Simon Stewart, Trine T. Moholdt, Louise M. Burrell, Karen Sliwa, Ana O. Mocumbi, John J. V. Mcmurray, Ashley K. Keates, John A. Hawley

Faculty of Health Sciences Publications

Climate change is a major contributor to annual winter peaks in cardiovascular events across the globe. However, given the paradoxical observation that cardiovascular seasonality is observed in relatively mild as well as cold climates, global warming may not be as positive for the syndrome of heart failure (HF) as some predict. In this article, we present our Model of Seasonal Flexibility to explain the spectrum of individual responses to climatic conditions. We have identified distinctive phenotypes of resilience and vulnerability to explain why winter peaks in HF occur. Moreover, we identify how better identification of climatic vulnerability and the use ...


Outcomes And Effect Of Treatment According To Etiology In Hfref: An Analysis Of Paradigm-Hf, Craig Balmforth, Joanne Simpson, Li Shen, Pardeep S. Jhund, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Milton Packer, John J. V. Mcmurray Jan 2019

Outcomes And Effect Of Treatment According To Etiology In Hfref: An Analysis Of Paradigm-Hf, Craig Balmforth, Joanne Simpson, Li Shen, Pardeep S. Jhund, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Milton Packer, John J. V. Mcmurray

Faculty of Health Sciences Publications

Objectives The purpose of this study was to compare outcomes (and the effect of sacubitril/valsartan) according to etiology in the PARADIGM-HF (Prospective comparison of angiotensin-receptor-neprilysin inhibitor [ARNI] with angiotensin-converting-enzyme inhibitor [ACEI] to Determine Impact on Global Mortality and morbidity in Heart Failure) trial. Background Etiology of heart failure (HF) has changed over time in more developed countries and is also evolving in non-Western societies. Outcomes may vary according to etiology, as may the effects of therapy. Methods We examined outcomes and the effect of sacubtril/valsartan according to investigator-reported etiology in PARADIGM-HF. The outcomes analyzed were the primary composite ...


Statins In The Prevention And Treatment Of Heart Failure: A Review Of The Evidence, Matthew M. Y. Lee, Naveed Sattar, John J. V. Mcmurray, Chris J. Packard Jan 2019

Statins In The Prevention And Treatment Of Heart Failure: A Review Of The Evidence, Matthew M. Y. Lee, Naveed Sattar, John J. V. Mcmurray, Chris J. Packard

Faculty of Health Sciences Publications

Purpose of Review We summarize the best evidence for statins in the prevention and treatment of heart failure. Recent Findings In patients with cardiovascular risk factors or established atherosclerotic cardiovascular disease (but without heart failure), statins reduce the risk of incident heart failure—mainly by preventing myocardial infarction although an additional benefit from reducing myocardial ischemia cannot be excluded. However, in patients with established heart failure, statins do not reduce the risk of cardiovascular death, which is mainly caused by pump failure and ventricular arrhythmias. Retrospective analyses, however, suggest that statins may reduce the rate of heart failure hospitalization and ...


Heart Failure In Sub-Saharan Africa, Okechukwu Ogah, Adewole Adebiyi, Karen Sliwa-Hahnle Jan 2019

Heart Failure In Sub-Saharan Africa, Okechukwu Ogah, Adewole Adebiyi, Karen Sliwa-Hahnle

Faculty of Health Sciences Publications

Sub-Saharan Africa (SSA) is currently experiencing multiple burden of disease as a result of demographic and epidemiologic transition. This is occasioned rapid urbanization, unhealthy diets rich in fats and salt, western lifestyle and sedentary living. Heart failure (HF) has become a global public health issue. It is associated with high morbidity and mortality, frequent hospitalization and high economic cost. In SSA, HF is a disease of young and middle-aged adults with the attendant high disability-adjusted life years. This is unlike to the clinical profile and pattern of HF in high-income countries of North America, Western Europe and Japan where HF ...


Multimorbidity In Patients With Heart Failure From 11 Asian Regions: A Prospective Cohort Study Using The Asian-Hf Registry, Jasper Tromp, Wan Ting Tay, Wouter Ouwekerk, Tiew-Hwa Katherine Teng, Jonathan Yap, Michael R. Macdonald, Kirsten Leineweber, John Mcmurray, Michael R. Zile, Inder S. Anand, Carolyn S. P. Lam Jan 2018

Multimorbidity In Patients With Heart Failure From 11 Asian Regions: A Prospective Cohort Study Using The Asian-Hf Registry, Jasper Tromp, Wan Ting Tay, Wouter Ouwekerk, Tiew-Hwa Katherine Teng, Jonathan Yap, Michael R. Macdonald, Kirsten Leineweber, John Mcmurray, Michael R. Zile, Inder S. Anand, Carolyn S. P. Lam

Faculty of Health Sciences Publications

Background
Comorbidities are common in patients with heart failure (HF) and complicate treatment and outcomes. We identified patterns of multimorbidity in Asian patients with HF and their association with patients’ quality of life (QoL) and health outcomes.
Methods and findings
We used data on 6,480 patients with chronic HF (1,204 with preserved ejection fraction) enrolled between 1 October 2012 and 6 October 2016 in the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry. The ASIAN-HF registry is a prospective cohort study, with patients prospectively enrolled from in- and outpatient clinics from 11 Asian regions (Hong Kong, Taiwan ...


Prognostic Importance Of Emerging Cardiac, Inflammatory, And Renal Biomarkers In Chronic Heart Failure Patients With Reduced Ejection Fraction And Anaemia: Red-Hf Study, Paul Welsh, Lei Kou, Changhong Yu, Inder S. Anand, Dirk J. Van Veldhuisen, Aldo Pietro Maggioni, Akshay S. Desai, Scott Solomon, Marc A. Pfeffer, Sunfa Cheng, Lars Gullestad, Pål Aukrust, Thor Ueland, Karl Swedberg, James B. Young, Michael W. Kattan, Naveed Sattar, John Mcmurray Jan 2018

Prognostic Importance Of Emerging Cardiac, Inflammatory, And Renal Biomarkers In Chronic Heart Failure Patients With Reduced Ejection Fraction And Anaemia: Red-Hf Study, Paul Welsh, Lei Kou, Changhong Yu, Inder S. Anand, Dirk J. Van Veldhuisen, Aldo Pietro Maggioni, Akshay S. Desai, Scott Solomon, Marc A. Pfeffer, Sunfa Cheng, Lars Gullestad, Pål Aukrust, Thor Ueland, Karl Swedberg, James B. Young, Michael W. Kattan, Naveed Sattar, John Mcmurray

Faculty of Health Sciences Publications

Aims
To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED‐HF) trial.
Methods and results
Circulating cardiac [N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), and high‐sensitivity troponin T (hsTnT)], neurohumoral [mid‐regional pro‐adrenomedullin (MR‐proADM) and copeptin], renal (cystatin C), and inflammatory [high‐sensitivity C‐reactive protein (hsCRP)] biomarkers were measured at randomization in 1853 participants with complete data. The relationship between these biomarkers and the primary composite endpoint of heart failure hospitalization or cardiovascular death over 28 months of follow‐up (n = 834) was ...


Using Co-Design To Develop An Intervention To Improve Communication About The Heart Failure Trajectory And End-Of-Life Care, Lisa Hjelmfors, Anna Stromberg, Maria J. Friedrichsen, Anna Sandgren, Jan Martensson, Tiny Jaarsma Jan 2018

Using Co-Design To Develop An Intervention To Improve Communication About The Heart Failure Trajectory And End-Of-Life Care, Lisa Hjelmfors, Anna Stromberg, Maria J. Friedrichsen, Anna Sandgren, Jan Martensson, Tiny Jaarsma

Faculty of Health Sciences Publications

Background
The aim of this paper was to describe the development of an intervention that is developed to improve communication about the heart failure (HF) trajectory and end-of-life care. We also present data that provides a first insight in specific areas of feasibility of the intervention.
Methods
Co-design was used and patients, family members and health care professionals were constructive participants in the design process of the intervention. Feasibility of the intervention was tested in two areas; acceptability and limited efficacy.
Results
Two communication tools were designed and evaluated; 1) a Question Prompt List (QPL) for patients and family members ...


Which Patients With Heart Failure Should Receive Specialist Palliative Care?, Ross T. Campbell, Mark C. Petrie, Colette E. Jackson, Pardeep Jhund, Ann Wright, Roy S. Gardner, Piotr Sonecki, Andrea Pozzi, Paula Mcskimming, Alex Mcconnachie, Fiona Finlay, Patricia Davidson, Martin Denvir, Miriam J. Johnson, K. Hogg, John Mcmurray Jan 2018

Which Patients With Heart Failure Should Receive Specialist Palliative Care?, Ross T. Campbell, Mark C. Petrie, Colette E. Jackson, Pardeep Jhund, Ann Wright, Roy S. Gardner, Piotr Sonecki, Andrea Pozzi, Paula Mcskimming, Alex Mcconnachie, Fiona Finlay, Patricia Davidson, Martin Denvir, Miriam J. Johnson, K. Hogg, John Mcmurray

Faculty of Health Sciences Publications

Aims
We investigated which patients with heart failure (HF) should receive specialist palliative care (SPC) by first creating a definition of need for SPC in patients hospitalised with HF using patient‐reported outcome measures (PROMs) and then testing this definition using the outcome of days alive and out of hospital (DAOH). We also evaluated which baseline variables predicted need for SPC and whether those with this need received SPC.
Methods and results
PROMs assessing quality of life (QoL), symptoms, and mood were administered at baseline and every 4 months. SPC need was defined as persistently severe impairment of any PROM ...


Effect Of Sacubitril/Valsartan On Recurrent Events In The Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure Trial (Paradigm-Hf), Ulrik M. Mogensen, Jianjian Gong, Pardeep Jhund, Li Shen, Lars Kober, Akshay S. Desai, Martin P. Lefkowitz, Milton Packer, Jean L. Rouleau, Scott Solomon, Brian L. Claggett, Karl Sweberg, Michael R. Zile, Guenr Mueller-Velten, John Mcmurray Jan 2018

Effect Of Sacubitril/Valsartan On Recurrent Events In The Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure Trial (Paradigm-Hf), Ulrik M. Mogensen, Jianjian Gong, Pardeep Jhund, Li Shen, Lars Kober, Akshay S. Desai, Martin P. Lefkowitz, Milton Packer, Jean L. Rouleau, Scott Solomon, Brian L. Claggett, Karl Sweberg, Michael R. Zile, Guenr Mueller-Velten, John Mcmurray

Faculty of Health Sciences Publications

Aims
Recurrent hospitalizations are a major part of the disease burden in heart failure (HF), but conventional analyses consider only the first event. We compared the effect of sacubitril/valsartan vs. enalapril on recurrent events, incorporating all HF hospitalizations and cardiovascular (CV) deaths in PARADIGM‐HF, using a variety of statistical approaches advocated for this type of analysis.
Methods and results
In PARADIGM‐HF, a total of 8399 patients were randomized and followed for a median of 27 months. We applied various recurrent event analyses, including a negative binomial model, the Wei, Lin and Weissfeld (WLW), and Lin, Wei, Ying ...


Incidence Of Hospitalisation For Heart Failure And Case-Fatality Among 3.25 Million People With And Without Diabetes [Accepted Manuscript], David A. Mcallister, Stephanie H. Read, Jan Kerssens, Shona Livingstone, Stuart Mcgurnaghan, Pardeep Jhund, John Petrie, Naveed Sattar, Colin Fischbacher, Soren Lund Kristensen, John Mcmurray, Helen M. Colhoun, Sarah H. Wild Jan 2018

Incidence Of Hospitalisation For Heart Failure And Case-Fatality Among 3.25 Million People With And Without Diabetes [Accepted Manuscript], David A. Mcallister, Stephanie H. Read, Jan Kerssens, Shona Livingstone, Stuart Mcgurnaghan, Pardeep Jhund, John Petrie, Naveed Sattar, Colin Fischbacher, Soren Lund Kristensen, John Mcmurray, Helen M. Colhoun, Sarah H. Wild

Faculty of Health Sciences Publications

Background:
Recent clinical trials of new glucose-lowering treatments have drawn attention to the importance of hospitalization for heart failure as a complication of diabetes mellitus. However, the epidemiology is not well described, particularly for type 1 diabetes mellitus. We examined the incidence and case-fatality of heart failure hospitalizations in the entire population aged ≥30 years resident in Scotland during 2004 to 2013.
Methods:
Date and type of diabetes mellitus diagnosis were linked to heart failure hospitalizations and deaths using the national Scottish registers. Incidence rates and case-fatality were estimated in regression models (quasi-Poisson and logistic regression respectively). All estimates are ...


Initiation Of Domiciliary Care And Nursing Home Admission Following First Hospitalization Of Heart Failure Patients: A Nationwide Cohort Study, Rasmus Rørth, Emil L. Fosbøl, Kristian Kragholm, Ulrik M. Mogensen, Pardeep S. Jhund, Mark C. Petrie, Christian Torp-Pedersen, Gunnar H. Gislason, John J. V. Mcmurray, Lars Køber, Søren L. Kristensen Jan 2018

Initiation Of Domiciliary Care And Nursing Home Admission Following First Hospitalization Of Heart Failure Patients: A Nationwide Cohort Study, Rasmus Rørth, Emil L. Fosbøl, Kristian Kragholm, Ulrik M. Mogensen, Pardeep S. Jhund, Mark C. Petrie, Christian Torp-Pedersen, Gunnar H. Gislason, John J. V. Mcmurray, Lars Køber, Søren L. Kristensen

Faculty of Health Sciences Publications

Background: Heart failure (HF) has a major impact on a patient’s quality of life and functional status. This impact may be sufficiently profound to prevent independent living although how often this is the case is unknown. We examined the need for domiciliary assistance and admission to a nursing home following first HF hospitalization. Methods: In nationwide Danish registries, we identified a cohort of patients discharged alive after a first-time HF hospitalization in the period 2008–2014 who were matched 1:5 with comparison subjects based on age and sex and followed for 5 years. Results: We included 37,547 ...


Trajectory Of Thirst Intensity And Distress From Admission To 4-Weeks Follow Up At Home In Patients With Heart Failure, Nana Waldréus, Misook L. Chung, Martje H. L. Van Der Wal, Tiny Jaarsma Jan 2018

Trajectory Of Thirst Intensity And Distress From Admission To 4-Weeks Follow Up At Home In Patients With Heart Failure, Nana Waldréus, Misook L. Chung, Martje H. L. Van Der Wal, Tiny Jaarsma

Faculty of Health Sciences Publications

Background: Patients with heart failure (HF) can suffer from increased thirst intensity and distress. Trajectories of thirst intensity and distress from hospital to home are unclear. The aim of this study was to describe thirst intensity and distress trajectories in patients from the time of hospital admission to 4 weeks after discharge, and describe trajectories of thirst intensity and distress by patients’ characteristics (gender, age, body mass index [BMI], plasma urea, anxiety, and depression). Patients and methods: In this observational study, data were collected from patients with HF (n=30) at hospital admission, discharge, and at 2 and 4 weeks ...


Patient Experiences Of Web-Based Cognitive Behavioral Therapy For Heart Failure And Depression: Qualitative Study, Johan Lundgren, Peter Johansson, Tiny Jaarsma, Gerhard Andersson, Anita Kärner Köhler Jan 2018

Patient Experiences Of Web-Based Cognitive Behavioral Therapy For Heart Failure And Depression: Qualitative Study, Johan Lundgren, Peter Johansson, Tiny Jaarsma, Gerhard Andersson, Anita Kärner Köhler

Faculty of Health Sciences Publications

Background: Web-based cognitive behavioral therapy (wCBT) has been proposed as a possible treatment for patients with heart failure and depressive symptoms. Depressive symptoms are common in patients with heart failure and such symptoms are known to significantly worsen their health. Although there are promising results on the effect of wCBT, there is a knowledge gap regarding how persons with chronic heart failure and depressive symptoms experience wCBT. Objective: The aim of this study was to explore and describe the experiences of participating and receiving health care through a wCBT intervention among persons with heart failure and depressive symptoms. Methods: In ...


A Comparison Of The Prognostic Value Of Bnp Versus Nt-Probnp After Hospitalisation For Heart Failure, G. C. M. Linssen, T. Jaarsma, H. L. Hillege, A. A. Voors, D. J. Van Veldhuisen Jan 2018

A Comparison Of The Prognostic Value Of Bnp Versus Nt-Probnp After Hospitalisation For Heart Failure, G. C. M. Linssen, T. Jaarsma, H. L. Hillege, A. A. Voors, D. J. Van Veldhuisen

Faculty of Health Sciences Publications

Aims: Concentrations of circulating B type natriuretic peptides provide important prognostic information in heart failure (HF) patients. We directly compared the prognostic performance of brain natriuretic peptide (BNP) versus N terminal-proBNP (NT-proBNP) measurements in a large population of HF patients at hospital discharge after an admission for decompensated HF. Methods and results: BNP and NT-proBNP were measured in 563 stable HF patients before discharge. All patients were followed for a fixed period of 18 months. The primary endpoint was time to first major event (HF hospitalisation or death). Patients were in NYHA class II (47%) or III/IV (53%) at ...


Continuity And Utilization Of Health And Community Care In Elderly Patients With Heart Failure Before And After Hospitalization, Emma Säfström, Tiny Jaarsma, Anna Strömberg Jan 2018

Continuity And Utilization Of Health And Community Care In Elderly Patients With Heart Failure Before And After Hospitalization, Emma Säfström, Tiny Jaarsma, Anna Strömberg

Faculty of Health Sciences Publications

Background: The period after hospitalization due to deteriorated heart failure (HF) is characterized as a time of high generalized risk. The transition from hospital to home is often problematic due to insufficient coordination of care, leading to a fragmentation of care rather than a seamless continuum of care. The aim was to describe health and community care utilization prior to and 30 days after hospitalization, and the continuity of care in patients hospitalized due to de novo or deteriorated HF from the patients’ perspective and from a medical chart review. Methods: This was a cross-sectional study with consecutive inclusion of ...


Pro-Gastrin-Releasing Peptide And Outcome In Patients With Heart Failure And Anaemia: Results From The Red-Hf Study, Thor Ueland, Lars Gullestad, Lei Kou, Pål Aukrust, Inderjit S. Anand, Marianne Nordlund Broughton, John J. Mcmurray, Dirk J. Van Veldhuisen, David J. Warren, Nils Bolstad Jan 2018

Pro-Gastrin-Releasing Peptide And Outcome In Patients With Heart Failure And Anaemia: Results From The Red-Hf Study, Thor Ueland, Lars Gullestad, Lei Kou, Pål Aukrust, Inderjit S. Anand, Marianne Nordlund Broughton, John J. Mcmurray, Dirk J. Van Veldhuisen, David J. Warren, Nils Bolstad

Faculty of Health Sciences Publications

Aims: Neuroendocrine activation is associated with poor outcome in heart failure (HF). The neuropeptide gastrin‐releasing peptide (GRP), derived from the precursor proGRP1‐125 (proGRP), has recently been implicated in inflammation and wound repair. We investigated the predictive value of proGRP on clinical outcomes in HF patients with reduced ejection fraction. Methods and results: The association between plasma proGRP (time‐resolved immunofluorometric assay) and the primary endpoint of death from any cause or first hospitalization for worsening of HF was evaluated using multivariable Cox proportional hazard models in 1541 patients with systolic HF and mild to moderate anaemia, enrolled in ...


The Dynamics Of Self-Care In The Course Of Heart Failure Management: Data From The In Touch Study, Edita Lycholip, Ina Thon Aamodt, Irene Lie, Toma Šimbelytė, Roma Puronaitė, Hans Hillege, Arjen De Vries, Imke Kraai, Anna Stromberg, Tiny Jaarsma, Jelena Čelutkienė Jan 2018

The Dynamics Of Self-Care In The Course Of Heart Failure Management: Data From The In Touch Study, Edita Lycholip, Ina Thon Aamodt, Irene Lie, Toma Šimbelytė, Roma Puronaitė, Hans Hillege, Arjen De Vries, Imke Kraai, Anna Stromberg, Tiny Jaarsma, Jelena Čelutkienė

Faculty of Health Sciences Publications

Introduction: Self-care is an important patient-reported outcome (PRO) for heart failure (HF) patients, which might be affected by disease management and/or telemonitoring (TM). The number of studies reporting the influence of TM on self-care is limited. Aims: This study aimed: to assess whether TM, in addition to information-and-communication-technology (ICT)-guided disease management system (ICT-guided DMS), affects self-care behavior; to evaluate the dynamics of self-care during the study; to investigate factors contributing to self-care changes; and to identify a patient profile that predisposes the patient to improvement in self-care. Methods: In the INnovative ICT-guided-DMS combined with Telemonitoring in OUtpatient clinics ...


Thirty Years Of Evidence On The Efficacy Of Drug Treatments For Chronic Heart Failure With Reduced Ejection Fraction: A Network Meta-Analysis, Heather Burnett, Amy Earley, Adriaan A. Voors, Michele Senni, John Mcmurray, Celine Deschaseaux, Shannon Cope Jan 2017

Thirty Years Of Evidence On The Efficacy Of Drug Treatments For Chronic Heart Failure With Reduced Ejection Fraction: A Network Meta-Analysis, Heather Burnett, Amy Earley, Adriaan A. Voors, Michele Senni, John Mcmurray, Celine Deschaseaux, Shannon Cope

Faculty of Health Sciences Publications

Treatments that reduce mortality and morbidity in patients with heart failure with reduced ejection fraction, including angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), β-blockers (BB), mineralocorticoid receptor antagonists (MRA), and angiotensin receptor–neprilysin inhibitors (ARNI), have not been studied in a head-to-head fashion. This network meta-analysis aimed to compare the efficacy of these drugs and their combinations regarding all-cause mortality in patients with heart failure with reduced ejection fraction.


Exergaming Through The Eyes Of Patients With Heart Failure: A Qualitative Content Analysis Study., Leonie V. Klompstra, Tiny Jaarsma, Jan Martensson, Anna Stromberg Jan 2017

Exergaming Through The Eyes Of Patients With Heart Failure: A Qualitative Content Analysis Study., Leonie V. Klompstra, Tiny Jaarsma, Jan Martensson, Anna Stromberg

Faculty of Health Sciences Publications

Objective: Exergaming appears to be a promising tool to increase exercise capacity in patients with chronic heart failure (HF). Therefore, it is important to obtain more in-depth knowledge about preferences, attitudes, use, and abilities in regard to exergaming. The aim of this study was to describe the experiences of patients with HF when using an exergame platform at home. Materials and Methods: A qualitative descriptive study using content analysis was conducted on interviews with 14 patients with HF (6 women, ages ranging between 56 and 81 years). The patients were recruited from three centers in Sweden included in a randomized ...


Dementia-Related Adverse Events In Paradigm-Hf And Other Trials In Heart Failure With Reduced Ejection Fraction, Jane A. Cannon, Li Shen, Pardeep S. Jhund, Søren L. Kristensen, Lars Kober, Fabian Chen, Jianjian Gong, Martin P. Lefkowitz, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Milton Packer, John J. V. Mcmurray Jan 2017

Dementia-Related Adverse Events In Paradigm-Hf And Other Trials In Heart Failure With Reduced Ejection Fraction, Jane A. Cannon, Li Shen, Pardeep S. Jhund, Søren L. Kristensen, Lars Kober, Fabian Chen, Jianjian Gong, Martin P. Lefkowitz, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Milton Packer, John J. V. Mcmurray

Faculty of Health Sciences Publications

Aims: Inhibition of neprilysin, an enzyme degrading natriuretic and other vasoactive peptides, is beneficial in heart failure with reduced ejection fraction (HFrEF), as shown in PARADIGM-HF which compared the angiotensin receptor–neprilysin inhibitor (ARNI) sacubitril/valsartan with enalapril. As neprilysin is also one of many enzymes clearing amyloid-β peptides from the brain, there is a theoretical concern about the long-term effects of sacubitril/valsartan on cognition. Therefore, we have examined dementia-related adverse effects (AEs) in PARADIGM-HF and placed these findings in the context of other recently conducted HFrEF trials. Methods and results: In PARADIGM-HF, patients with symptomatic HFrEF were randomized ...


Limited Added Value Of Circulating Inflammatory Biomarkers In Chronic Heart Failure, Ståle H. Nymo, Pål Aukrust, John Kjekshus, John J.V. Mcmurray, John G. F. Cleland, John Wikstrand, Pieter Muntendam, Ursula Henrike Wienhues-Thelen, Roberto Latini, Erik Tandberg Askevold, Jørgen Gravning, Christen P. Dahl, Kaspar Broch, Arne Yndestad, Lars Gullestad, Thor Ueland Jan 2017

Limited Added Value Of Circulating Inflammatory Biomarkers In Chronic Heart Failure, Ståle H. Nymo, Pål Aukrust, John Kjekshus, John J.V. Mcmurray, John G. F. Cleland, John Wikstrand, Pieter Muntendam, Ursula Henrike Wienhues-Thelen, Roberto Latini, Erik Tandberg Askevold, Jørgen Gravning, Christen P. Dahl, Kaspar Broch, Arne Yndestad, Lars Gullestad, Thor Ueland

Faculty of Health Sciences Publications

Objectives This study sought to evaluate whether a panel of biomarkers improved prognostication in patients with heart failure (HF) and reduced ejection fraction of ischemic origin using a systematized approach according to suggested requirements for validation of new biomarkers. Background Modeling combinations of multiple circulating markers could potentially identify patients with HF at particularly high risk and aid in the selection of individualized therapy. Methods From a panel of 20 inflammatory and extracellular matrix biomarkers, 2 different biomarker panels were created and added to the Seattle HF score and the prognostic model from the CORONA (Controlled Rosuvastatin Multinational Trial in ...


Serum Chloride And Sodium Interplay In Patients With Acute Myocardial Infarction And Heart Failure With Reduced Ejection Fraction: An Analysis From The High-Risk Myocardial Infarction Database Initiative, João P. Ferreira, Nicolas Girerd, Kevin Duarte, Stefano Coiro, John Mcmurray, H. J. Dargie, Bertram Pitt, Kenneth Dickstein, Jeffrey M. Testani, Faiez Zannad, Patrick Rossignol Jan 2017

Serum Chloride And Sodium Interplay In Patients With Acute Myocardial Infarction And Heart Failure With Reduced Ejection Fraction: An Analysis From The High-Risk Myocardial Infarction Database Initiative, João P. Ferreira, Nicolas Girerd, Kevin Duarte, Stefano Coiro, John Mcmurray, H. J. Dargie, Bertram Pitt, Kenneth Dickstein, Jeffrey M. Testani, Faiez Zannad, Patrick Rossignol

Faculty of Health Sciences Publications

Background—Serum chloride levels were recently found to be independently associated with mortality in heart failure (HF). Methods and Results—We investigated the relationship between serum chloride and clinical outcomes in 7195 subjects with acute myocardial infarction complicated by reduced left ventricular function and HF. The studied outcomes were all-cause mortality, cardiovascular mortality, and hospitalization for HF. Both chloride and sodium had a nonlinear association with the studied outcomes (P<0.05 for linearity). Patients in the lowest chloride tertile (chloride ≤100) were older, had more comorbidities, and had lower sodium levels (P<0.05 for all). Serum chloride showed a significant interaction with sodium with regard to all studied outcomes (P for interaction < 0.05 for all). The lowest chloride tertile (≤100 mmol/L) was associated with increased mortality rates in the context of lower sodium (≤138 mmol/L; adjusted hazard ratio [95% confidence interval] for all-cause mortality=1.42 (1.14–1.77); P=0.002), whereas in the context of higher sodium levels ( > 141 mmol/L), the association with mortality was lost. Spline-transformed chloride and its interaction with sodium did not add significant prognostic information on top of other well-established prognostic variables (P ...


B-Type Natriuretic Peptides In Chronic Obstructive Pulmonary Disease: A Systematic Review, Nathaniel M. Hawkins, Amit Khosla, Sean A. Virani, John J.V. Mcmurray, J. Mark Fitzgerald Jan 2017

B-Type Natriuretic Peptides In Chronic Obstructive Pulmonary Disease: A Systematic Review, Nathaniel M. Hawkins, Amit Khosla, Sean A. Virani, John J.V. Mcmurray, J. Mark Fitzgerald

Faculty of Health Sciences Publications

Background: Patients with chronic obstructive pulmonary disease (COPD) have increased cardiovascular risk. Natriuretic peptides (NP) in other populations are useful in identifying cardiovascular disease, stratifying risk, and guiding therapy.


Clinical And Echocardiographic Characteristics And Cardiovascular Outcomes According To Diabetes Status In Patients With Heart Failure And Preserved Ejection Fraction: A Report From The I-Preserve Trial (Irbesartan In Heart Failure With Preserved Ejection Fraction), Søren L. Kristensen, Ulrik M. Mogensen, Pardeep Jhund, Mark C. Petrie, David Preiss, Sithu Win, Lars Kober, Robert Mckelvie, Michael R. Zile, Inder S. Anand, Michel Komajda, John S. Gottdiener, Peter E. Carson, John Mcmurray Jan 2017

Clinical And Echocardiographic Characteristics And Cardiovascular Outcomes According To Diabetes Status In Patients With Heart Failure And Preserved Ejection Fraction: A Report From The I-Preserve Trial (Irbesartan In Heart Failure With Preserved Ejection Fraction), Søren L. Kristensen, Ulrik M. Mogensen, Pardeep Jhund, Mark C. Petrie, David Preiss, Sithu Win, Lars Kober, Robert Mckelvie, Michael R. Zile, Inder S. Anand, Michel Komajda, John S. Gottdiener, Peter E. Carson, John Mcmurray

Faculty of Health Sciences Publications

In patients with heart failure and preserved ejection fraction, little is known about the characteristics of, and outcomes in, those with and without diabetes mellitus.


Renin-Angiotensin System Inhibition, Worsening Renal Function, And Outcome In Heart Failure Patients With Reduced And Preserved Ejection Fraction: A Meta-Analysis Of Published Study Data, Iris E. Beldhuis, Koen W. Streng, Jozine M.T. Maaten, Adriaan A. Voors, Peter Van Der Meer, Patrick Rossignol, John Mcmurray, Kevin Damman Jan 2017

Renin-Angiotensin System Inhibition, Worsening Renal Function, And Outcome In Heart Failure Patients With Reduced And Preserved Ejection Fraction: A Meta-Analysis Of Published Study Data, Iris E. Beldhuis, Koen W. Streng, Jozine M.T. Maaten, Adriaan A. Voors, Peter Van Der Meer, Patrick Rossignol, John Mcmurray, Kevin Damman

Faculty of Health Sciences Publications

Background—Renin–angiotensin aldosterone system (RAAS) inhibitors significantly improve outcome in heart failure (HF) patients with reduced ejection fraction (HFREF), irrespective of the occurrence of worsening renal function (WRF). However, in HF patients with preserved ejection fraction (HFPEF), RAAS inhibitors have not been shown to improve outcome but are still frequently prescribed. Methods and Results—Random effect meta-analysis was performed to investigate the relationship between RAAS inhibitor therapy, WRF in both HF phenotypes, and mortality. Studies were selected based on literature search in MEDLNE and included randomized, placebo controlled trials of RAAS inhibitors in chronic HF. The primary outcome consisted ...


Low Circulating Microrna Levels In Heart Failure Patients Are Associated With Atherosclerotic Disease And Cardiovascular-Related Rehospitalizations, Eline L. Vegter, Ekaterina S. Ovchinnikova, Dirk J. Van Veldhuisen, Tiny Jaarsma, Eugene Berezikov, Peter Van Der Meer, Adriaan A. Voors Jan 2017

Low Circulating Microrna Levels In Heart Failure Patients Are Associated With Atherosclerotic Disease And Cardiovascular-Related Rehospitalizations, Eline L. Vegter, Ekaterina S. Ovchinnikova, Dirk J. Van Veldhuisen, Tiny Jaarsma, Eugene Berezikov, Peter Van Der Meer, Adriaan A. Voors

Faculty of Health Sciences Publications

Objective: Circulating microRNAs (miRNAs) have been implicated in both heart failure and atherosclerotic disease. The aim of this study was to examine associations between heart failure specific circulating miRNAs, atherosclerotic disease and cardiovascular-related outcome in patients with heart failure. Methods: The levels of 11 heart failure-specific circulating miRNAs were compared in plasma of 114 heart failure patients with and without different manifestations of atherosclerotic disease. We then studied these miRNAs in relation to biomarkers associated to atherosclerosis and to cardiovascular-related rehospitalizations during 18 months of follow-up. Results: At least one manifestation of atherosclerotic disease was found in 70 (61%) of ...


Return To The Workforce After First Hospitalization For Heart Failure: A Danish Nationwide Cohort Study, Rasmus Rørth, Chih Wong, Kristian Kragholm, Emil L. Fosbøl, Ulrik M. Mogensen, Morten Lamberts, Mark C. Petrie, Pardeep Jhund, Thomas A. Gerds, Christian Torp-Pedersen, Gunnar H. Gislason, John Mcmurray, Lars Kober, Søren L. Kristensen Jan 2016

Return To The Workforce After First Hospitalization For Heart Failure: A Danish Nationwide Cohort Study, Rasmus Rørth, Chih Wong, Kristian Kragholm, Emil L. Fosbøl, Ulrik M. Mogensen, Morten Lamberts, Mark C. Petrie, Pardeep Jhund, Thomas A. Gerds, Christian Torp-Pedersen, Gunnar H. Gislason, John Mcmurray, Lars Kober, Søren L. Kristensen

Faculty of Health Sciences Publications

Return to work is important financially, as a marker of functional status and for self-esteem in patients developing chronic illness. We examined return to work after first heart failure (HF) hospitalization.