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Full-Text Articles in Medicine and Health Sciences

Epidemiology Of Hip Fractures In Bulgaria: Development Of A Country-Specific Frax Model, E. Kirilova, H. Johansson, N. Kirilov, S. Vladeva, T. Petranova, Z. Kolarov, E. Liu, M. Lorentzon, L. Vandenput, N. C. Harvey, E. Mccloskey, John A. Kanis Jan 2020

Epidemiology Of Hip Fractures In Bulgaria: Development Of A Country-Specific Frax Model, E. Kirilova, H. Johansson, N. Kirilov, S. Vladeva, T. Petranova, Z. Kolarov, E. Liu, M. Lorentzon, L. Vandenput, N. C. Harvey, E. Mccloskey, John A. Kanis

Faculty of Health Sciences Publications

Summary: A retrospective population-based survey was undertaken in a region of Bulgaria to determine the incidence of hip fracture. The estimated number of hip fractures nationwide for 2015 was 9322 and is predicted to increase to 11,398 in 2050. The hip fracture rates were used to create a FRAX model. Objective: To describe the epidemiology of hip fractures in Bulgaria, which was then used to develop the country-specific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in Stara Zagora, Bulgaria, representing approximately 4.6% of the country’s population. We identified hip fractures occurring in ...


Changes In Waist Circumference Independent Of Weight: Implications For Population Level Monitoring Of Obesity [Accepted Manuscript], Emma Gearon, Stephanie K. Tanamas, Christopher Stevenson, Venurs Hui Yee Loh, Anna Peters Jun 2018

Changes In Waist Circumference Independent Of Weight: Implications For Population Level Monitoring Of Obesity [Accepted Manuscript], Emma Gearon, Stephanie K. Tanamas, Christopher Stevenson, Venurs Hui Yee Loh, Anna Peters

Faculty of Health Sciences Publications

ing of obesity is most commonly conducted using body mass index (BMI). We test the hypothesis that because of increases in waist circumference (WC) independent of increases in weight, BMI alone detects an increasingly smaller proportion of the population with obesity. Methods: Australian adults with measured height, weight, and WC were selected from three nationally representative cross-sectional surveys (1989, 1999–2000, 2011–12; n = 8313, 5903 & 3904). Participants were defined as having obesity using classifications for an obese BMI (≥ 30 kg·m− 2) and substantially-increased-risk WC (≥ 88 cm [women], ≥ 102 cm [men]). Age-standardised prevalence of obesity according to BMI and ...


The Prevalence And Impact Of Low Back Pain In Pre-Professional And Professional Dancers: A Prospective Study [Accepted Manuscript], Christopher T. V. Swain, Elizabeth J. Bradshaw, Douglas G. Whyte, Christina L. Ekegren Mar 2018

The Prevalence And Impact Of Low Back Pain In Pre-Professional And Professional Dancers: A Prospective Study [Accepted Manuscript], Christopher T. V. Swain, Elizabeth J. Bradshaw, Douglas G. Whyte, Christina L. Ekegren

Faculty of Health Sciences Publications

Objectives To determine the prevalence of low back pain (LBP) in pre-professional and professional dancers and its impact on dance participation, care-seeking and medication use. Design Prospective cohort study. Setting One pre-professional ballet school, two pre-professional university dance programs, and a professional ballet company. Participants Male and female classical ballet and contemporary dancers. Main outcome measures An initial questionnaire collected demographic and LBP history data. The monthly prevalence of LBP (all episodes, activity limiting episodes and chronic LBP) and impact (activity limitation, care-seeking, and medication use) was collected over a nine-month period. Results 119 dancers participated, which represented 54% of ...


Initiation Of Domiciliary Care And Nursing Home Admission Following First Hospitalization Of Heart Failure Patients: A Nationwide Cohort Study, Rasmus Rørth, Emil L. Fosbøl, Kristian Kragholm, Ulrik M. Mogensen, Pardeep S. Jhund, Mark C. Petrie, Christian Torp-Pedersen, Gunnar H. Gislason, John J. V. Mcmurray, Lars Køber, Søren L. Kristensen Jan 2018

Initiation Of Domiciliary Care And Nursing Home Admission Following First Hospitalization Of Heart Failure Patients: A Nationwide Cohort Study, Rasmus Rørth, Emil L. Fosbøl, Kristian Kragholm, Ulrik M. Mogensen, Pardeep S. Jhund, Mark C. Petrie, Christian Torp-Pedersen, Gunnar H. Gislason, John J. V. Mcmurray, Lars Køber, Søren L. Kristensen

Faculty of Health Sciences Publications

Background: Heart failure (HF) has a major impact on a patient’s quality of life and functional status. This impact may be sufficiently profound to prevent independent living although how often this is the case is unknown. We examined the need for domiciliary assistance and admission to a nursing home following first HF hospitalization. Methods: In nationwide Danish registries, we identified a cohort of patients discharged alive after a first-time HF hospitalization in the period 2008–2014 who were matched 1:5 with comparison subjects based on age and sex and followed for 5 years. Results: We included 37,547 ...


Epidemiology Of Hip Fracture In Belarus: Development Of A Country-Specific Frax Model And Its Comparison To Neighboring Country Models, H. Ramanau, I. Chernyanin, E. Rudenka, Olga Lesnyak, A. Zakroyeva, John P. Bilezikian, Helena Johansson, Nicholas C. Harvey, Eugene Mccloskey, John A. Kanis Jan 2018

Epidemiology Of Hip Fracture In Belarus: Development Of A Country-Specific Frax Model And Its Comparison To Neighboring Country Models, H. Ramanau, I. Chernyanin, E. Rudenka, Olga Lesnyak, A. Zakroyeva, John P. Bilezikian, Helena Johansson, Nicholas C. Harvey, Eugene Mccloskey, John A. Kanis

Faculty of Health Sciences Publications

Summary Fracture probabilities resulting from the newly generated FRAX model for Belarus based on regional estimates of the hip fracture incidence were compared with FRAX models of neighboring countries. Differences between the country-specific FRAX patterns and the rank orders of fracture probabilities were modest. Objective This paper describes the epidemiology of hip fractures in Belarus that was used to develop the country-specific fracture prediction FRAX® tool and illustrates its features compared to models for the neighboring countries of Poland, Russia, and Lithuania. Methods We carried out a population-based study in a region of Belarus (the city of Mozyr) representing approximately ...


Measures Of Physical Performance And Muscle Strength As Predictors Of Fracture Risk Independent Of Frax, Falls, And Abmd: A Meta-Analysis Of The Osteoporotic Fractures In Men (Mros) Study, Nicholas C. Harvey, Anders Oden, E. Orwoll, Jodi Lapidus, T. Kwok, Magnus Karlsson, Björn E. Rosengren, Eva Ribom, Cyrus Cooper, Peggy M. Cawthon, John A. Kanis, Claes Ohlsson, Dan Mellström, Helena Johansson, Eugene Mccloskey Jan 2018

Measures Of Physical Performance And Muscle Strength As Predictors Of Fracture Risk Independent Of Frax, Falls, And Abmd: A Meta-Analysis Of The Osteoporotic Fractures In Men (Mros) Study, Nicholas C. Harvey, Anders Oden, E. Orwoll, Jodi Lapidus, T. Kwok, Magnus Karlsson, Björn E. Rosengren, Eva Ribom, Cyrus Cooper, Peggy M. Cawthon, John A. Kanis, Claes Ohlsson, Dan Mellström, Helena Johansson, Eugene Mccloskey

Faculty of Health Sciences Publications

Measures of muscle mass, strength, and function predict risk of incident fractures, but it is not known whether this risk information is additive to that from FRAX (fracture risk assessment tool) probability. In the Osteoporotic Fractures in Men (MrOS) Study cohorts (Sweden, Hong Kong, United States), we investigated whether measures of physical performance/appendicular lean mass (ALM) by DXA predicted incident fractures in older men, independently of FRAX probability. Baseline information included falls history, clinical risk factors for falls and fractures, femoral neck aBMD, and calculated FRAX probabilities. An extension of Poisson regression was used to investigate the relationship between ...


Incidence Of Hospitalisation For Heart Failure And Case-Fatality Among 3.25 Million People With And Without Diabetes [Accepted Manuscript], David A. Mcallister, Stephanie H. Read, Jan Kerssens, Shona Livingstone, Stuart Mcgurnaghan, Pardeep Jhund, John Petrie, Naveed Sattar, Colin Fischbacher, Soren Lund Kristensen, John Mcmurray, Helen M. Colhoun, Sarah H. Wild Jan 2018

Incidence Of Hospitalisation For Heart Failure And Case-Fatality Among 3.25 Million People With And Without Diabetes [Accepted Manuscript], David A. Mcallister, Stephanie H. Read, Jan Kerssens, Shona Livingstone, Stuart Mcgurnaghan, Pardeep Jhund, John Petrie, Naveed Sattar, Colin Fischbacher, Soren Lund Kristensen, John Mcmurray, Helen M. Colhoun, Sarah H. Wild

Faculty of Health Sciences Publications

Background:
Recent clinical trials of new glucose-lowering treatments have drawn attention to the importance of hospitalization for heart failure as a complication of diabetes mellitus. However, the epidemiology is not well described, particularly for type 1 diabetes mellitus. We examined the incidence and case-fatality of heart failure hospitalizations in the entire population aged ≥30 years resident in Scotland during 2004 to 2013.
Methods:
Date and type of diabetes mellitus diagnosis were linked to heart failure hospitalizations and deaths using the national Scottish registers. Incidence rates and case-fatality were estimated in regression models (quasi-Poisson and logistic regression respectively). All estimates are ...


Impact Of Chronic Inflammation, Assessed By Hs-Crp, On The Association Between Red Cell Distribution Width And Arterial Cardiovascular Disease: The Tromso Study, Jostein Lappegard, Trygve S. Ellingsen, Kristian Hindberg, Ellisiv Bøgeberg Mathiesen, Inger Njolstad, Tom Wilsgaard, Maja-Lisa Loechen, Sigrid Kufaas Braekkan, John-Bjarne Hansen Jan 2018

Impact Of Chronic Inflammation, Assessed By Hs-Crp, On The Association Between Red Cell Distribution Width And Arterial Cardiovascular Disease: The Tromso Study, Jostein Lappegard, Trygve S. Ellingsen, Kristian Hindberg, Ellisiv Bøgeberg Mathiesen, Inger Njolstad, Tom Wilsgaard, Maja-Lisa Loechen, Sigrid Kufaas Braekkan, John-Bjarne Hansen

Faculty of Health Sciences Publications

Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between inflammation and arterial CVD. Baseline characteristics, including RDW and hs-CRP, were obtained from 5,765 individuals attending a population-based cohort study. We followed up participants from inclusion in the fourth survey of the Tromsø Study (1994/1995) until December 31, 2012 ...


Epidemiology Of Peripartum Cardiomyopathy In Africa, Kamilu M. Karaye, Abdulrazaq G. Habib, Karen Sliwa Jan 2018

Epidemiology Of Peripartum Cardiomyopathy In Africa, Kamilu M. Karaye, Abdulrazaq G. Habib, Karen Sliwa

Faculty of Health Sciences Publications

Peripartum cardiomyopathy (PPCM) is a disease that predominantly affects Black African women. The history of peripartum cardiac failure in Africa dates to the 1960s, before the availability of echocardiography. With the availability of echocardiography in the late 1970s, studies on well-characterised PPCM began to be reported. To date, there is no population-based PPCM study in Africa. However, hospital-based studies have reported incidence rates as high as 1:100 deliveries in Nigeria and representing up to 52% of all cardiomyopathies. For reasons that are not yet very clear, there are obvious wide disparities in incidence and prevalence within and between African ...


Targeting Reductions In Sitting Time To Increase Physical Activity And Improve Health [Accepted Manuscript], Sarah K. Keadle, David E. Conroy, Matthew P. Buman, David Wayne Dunstan, Charles E. Matthews Aug 2017

Targeting Reductions In Sitting Time To Increase Physical Activity And Improve Health [Accepted Manuscript], Sarah K. Keadle, David E. Conroy, Matthew P. Buman, David Wayne Dunstan, Charles E. Matthews

Faculty of Health Sciences Publications

New evidence suggests that reductions in sedentary behavior may increase physical activity and improve health. These findings point to new behavioral targets for intervention and new ways to think about intervening to increase overall physical activity in the population. This report provides a knowledge update reflecting the rapid accumulation of new evidence related to sedentary behavior and health among adults. Recent observational studies suggest that leveraging the time-inverse relationship between sedentary and active behaviors by replacing sitting with standing, light- or moderate-intensity activity can have important health benefits, particularly among less active adults. Clinical studies are providing evidence of the ...


Prevalence Of Arthritis According To Age, Sex And Socioeconomic Status In Six Low And Middle Income Countries: Analysis Of Data From The World Health Organization Study On Global Ageing And Adult Health (Sage) Wave 1, S. L. Brennan-Olsen, S. Cook, M. T. Leech, S. J. Bowe, P. Kowal, N. Naidoo, I. N. Ackerman, R. S. Page, S. M. Hosking, J. A. Pasco, M. Mohebbi Jan 2017

Prevalence Of Arthritis According To Age, Sex And Socioeconomic Status In Six Low And Middle Income Countries: Analysis Of Data From The World Health Organization Study On Global Ageing And Adult Health (Sage) Wave 1, S. L. Brennan-Olsen, S. Cook, M. T. Leech, S. J. Bowe, P. Kowal, N. Naidoo, I. N. Ackerman, R. S. Page, S. M. Hosking, J. A. Pasco, M. Mohebbi

Faculty of Health Sciences Publications

Background: In higher income countries, social disadvantage is associated with higher arthritis prevalence; however, less is known about arthritis prevalence or determinants in low to middle income countries (LMICs). We assessed arthritis prevalence by age and sex, and marital status and occupation, as two key parameters of socioeconomic position (SEP), using data from the World Health Organization Study on global AGEing and adult health (SAGE). Methods: SAGE Wave 1 (2007–10) includes nationally-representative samples of older adults (≥50 yrs), plus smaller samples of adults aged 18-49 yrs., from China, Ghana, India, Mexico, Russia and South Africa (n = 44,747). Arthritis ...


Return To The Workforce After First Hospitalization For Heart Failure: A Danish Nationwide Cohort Study, Rasmus Rørth, Chih Wong, Kristian Kragholm, Emil L. Fosbøl, Ulrik M. Mogensen, Morten Lamberts, Mark C. Petrie, Pardeep Jhund, Thomas A. Gerds, Christian Torp-Pedersen, Gunnar H. Gislason, John Mcmurray, Lars Kober, Søren L. Kristensen Jan 2016

Return To The Workforce After First Hospitalization For Heart Failure: A Danish Nationwide Cohort Study, Rasmus Rørth, Chih Wong, Kristian Kragholm, Emil L. Fosbøl, Ulrik M. Mogensen, Morten Lamberts, Mark C. Petrie, Pardeep Jhund, Thomas A. Gerds, Christian Torp-Pedersen, Gunnar H. Gislason, John Mcmurray, Lars Kober, Søren L. Kristensen

Faculty of Health Sciences Publications

Return to work is important financially, as a marker of functional status and for self-esteem in patients developing chronic illness. We examined return to work after first heart failure (HF) hospitalization.


Biceps Femoris Long Head Architecture, Eccentric Knee Flexor Strength And Hamstring Injury Risk In Professional Football (Soccer): A Prospective Cohort Study [Accepted Manuscript], Ryan G. Timmins, Matthew N. Bourne, Anthony J. Shield, Morgan Williams, Christian Lorenzen, David A. Opar Jan 2016

Biceps Femoris Long Head Architecture, Eccentric Knee Flexor Strength And Hamstring Injury Risk In Professional Football (Soccer): A Prospective Cohort Study [Accepted Manuscript], Ryan G. Timmins, Matthew N. Bourne, Anthony J. Shield, Morgan Williams, Christian Lorenzen, David A. Opar

Faculty of Health Sciences Publications

Background/Aim: To investigate the role of eccentric knee flexor strength, between-limb imbalance and biceps femoris long head (BFlh) fascicle length on the risk of a future hamstring strain injury (HSI).

Methods: Elite soccer players (n=152) from eight different teams participated. Eccentric knee flexor strength during the Nordic hamstring exercise and BFlh fascicle length were assessed at the beginning of pre-season. The occurrences of a HSI following this were recorded by the team medical staff. Relative risk (RR) was determined for univariate data, and logistic regression was employed for multivariate data.

Results: Twenty-seven new HSIs were reported. Eccentric knee ...


Trends In Modifiable Risk Factors Are Associated With Declining Incidence Of Hospitalized And Nonhospitalized Acute Coronary Heart Disease In A Population, Jan Mannsverk, Tom Wilsgaard, Ellisiv Bøgeberg Mathiesen, Maja-Lisa Løchen, Knut Rasmussen, Dag S. Thelle, Inger Njølstad, Laila Arnesdatter Hopstock, Kaare Harald Bønaa Jan 2016

Trends In Modifiable Risk Factors Are Associated With Declining Incidence Of Hospitalized And Nonhospitalized Acute Coronary Heart Disease In A Population, Jan Mannsverk, Tom Wilsgaard, Ellisiv Bøgeberg Mathiesen, Maja-Lisa Løchen, Knut Rasmussen, Dag S. Thelle, Inger Njølstad, Laila Arnesdatter Hopstock, Kaare Harald Bønaa

Faculty of Health Sciences Publications

Background: Few studies have used individual person data to study whether contemporary trends in the incidence of coronary heart disease are associated with changes in modifiable coronary risk factors. Methods and Results: We identified 29 582 healthy men and women ≥25 years of age who participated in 3 population surveys conducted between 1994 and 2008 in Tromsø, Norway. Age- and sex-adjusted incidence rates were calculated for coronary heart disease overall, out-of-hospital sudden death, and hospitalized ST-segment–elevation and non–ST-segment–elevation myocardial infarction. We measured coronary risk factors at each survey and estimated the relationship between changes in risk factors ...


Impact Of Socioeconomic Status, Ethnicity, And Urbanization On Risk Factor Profiles Of Cardiovascular Disease In Africa, Karen Sliwa, Letitia Acquah, Bernard J. Gersh, Ana Olga Mocumbi Jan 2016

Impact Of Socioeconomic Status, Ethnicity, And Urbanization On Risk Factor Profiles Of Cardiovascular Disease In Africa, Karen Sliwa, Letitia Acquah, Bernard J. Gersh, Ana Olga Mocumbi

Faculty of Health Sciences Publications

Africa is a continent characterized by marked ethnic, sociodemographic, and economic diversity, with profound changes in many regions over the past 2 decades. This diversity has an impact on cardiovascular disease presentation and outcomes. Within Africa and within the individual countries, one can find regions having predominantly communicable diseases such as rheumatic heart disease, tuberculous pericarditis, or cardiomyopathy and others having a marked increase in noncommunicable disease such as hypertension and hypertensive heart disease. Ischemic heart disease remains rare in most countries. Difficulties in the planning and implementation of effective health care in most African countries are compounded by a ...


Ischemic Stroke And Risk Of Venous Thromboembolism In The General Population: The Tromsø Study, Ludvig B. Rinde, Birgit Småbrekke, Ellisiv B. Mathiesen, Maja-Lisa Løchen, Inger Njølstad, Erin M. Hald, Tom Wilsgaard, Sigrid K. Braekkan, John-Bjarne Hansen Jan 2016

Ischemic Stroke And Risk Of Venous Thromboembolism In The General Population: The Tromsø Study, Ludvig B. Rinde, Birgit Småbrekke, Ellisiv B. Mathiesen, Maja-Lisa Løchen, Inger Njølstad, Erin M. Hald, Tom Wilsgaard, Sigrid K. Braekkan, John-Bjarne Hansen

Faculty of Health Sciences Publications

Background: Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population‐based cohort. Methods and Results: Participants (n=30 002) were recruited from 3 surveys of the Tromsø study (conducted in 1994–1995, 2001, and 2007–2008) and followed through 2010. All incident events of ischemic stroke and VTE during follow‐up were recorded. Cox‐regression models with age as time scale and ischemic ...


Low-Level Cadmium Exposure Is Associated With Decreased Bone Mineral Density And Increased Risk Of Incident Fractures In Elderly Men: The Mros Sweden Study, Maria Wallin, Lars Barregard, Gerd Sallsten, Thomas Lundh, Magnus K. Karlsson, Mattias Lorentzon, Claes Ohlsson, Dan Mellström Jan 2016

Low-Level Cadmium Exposure Is Associated With Decreased Bone Mineral Density And Increased Risk Of Incident Fractures In Elderly Men: The Mros Sweden Study, Maria Wallin, Lars Barregard, Gerd Sallsten, Thomas Lundh, Magnus K. Karlsson, Mattias Lorentzon, Claes Ohlsson, Dan Mellström

Faculty of Health Sciences Publications

One risk factor for osteoporosis that has attracted increasing attention in recent years is exposure to cadmium. The aim of this study was to examine the associations between low‐level cadmium exposure, from diet and smoking, and bone mineral density (BMD) and incident fractures in elderly men. The study population consisted of 936 men from the Swedish cohort of the Osteoporotic Fractures in Men (MrOS) study, aged 70 to 81 years at inclusion (years 2002 to 2004), with reliable data on cadmium in urine (U‐Cd) analyzed using inductively coupled plasma mass spectrometry in baseline samples. The participants also answered ...


Within- And Between-City Contrasts In Nitrogen Dioxide And Mortality In 10 Canadian Cities: A Subset Of The Canadian Census Health And Environment Cohort (Canchec), Dan L. Crouse, Paul A. Peters, Paul J. Villeneuve, Marc-Olivier Proux, Hwashin H. Shin, Mark S. Goldberg, Markey Johnson, Amanda J. Wheeler, Ryan W. Allen, Dominic Odwa Atari, Michael Jerrett, Michael Brauer, Jeffrey R. Brook, Sabit Cakmak, Richard T. Burnett Jan 2015

Within- And Between-City Contrasts In Nitrogen Dioxide And Mortality In 10 Canadian Cities: A Subset Of The Canadian Census Health And Environment Cohort (Canchec), Dan L. Crouse, Paul A. Peters, Paul J. Villeneuve, Marc-Olivier Proux, Hwashin H. Shin, Mark S. Goldberg, Markey Johnson, Amanda J. Wheeler, Ryan W. Allen, Dominic Odwa Atari, Michael Jerrett, Michael Brauer, Jeffrey R. Brook, Sabit Cakmak, Richard T. Burnett

Faculty of Health Sciences Publications

The independent and joint effects of within- and between-city contrasts in air pollution on mortality have been investigated rarely. To examine the differential effects of between- versus within-city contrasts in pollution exposure, we used both ambient measurements and land use regression models to assess associations with mortality and exposure to nitrogen dioxide (NO2) among ~735,600 adults in 10 of the largest Canadian cities. We estimated exposure contrasts partitioned into within- and between-city contrasts, and the sum of these as overall exposures, for every year from 1984 to 2006. Residential histories allowed us to follow subjects annually during the study ...


Longitudinal And Secular Trends In Blood Pressure Among Women And Men In Birth Cohorts Born Between 1905 And 1977: The Tromso Study 1979 To 2008, Laila Arnesdatter Hopstock, Kaare Harald Bonaa, Anne Elise Eggen, Sameline Grimsgaard, Bjarne K. Jacobsen, Maja-Lisa Loechen, E. B. Mathiesen, I. Njolstad, Tom Wilsgaard Jan 2015

Longitudinal And Secular Trends In Blood Pressure Among Women And Men In Birth Cohorts Born Between 1905 And 1977: The Tromso Study 1979 To 2008, Laila Arnesdatter Hopstock, Kaare Harald Bonaa, Anne Elise Eggen, Sameline Grimsgaard, Bjarne K. Jacobsen, Maja-Lisa Loechen, E. B. Mathiesen, I. Njolstad, Tom Wilsgaard

Faculty of Health Sciences Publications

High blood pressure is a modifiable risk factor for cardiovascular disease. Previous studies showing a blood pressure decline in recent decades lack data to follow individuals born in different decades from early and middle adulthood to older age. We investigated changes in age-specific blood pressure by repeated measurements in 37973 women and men born 1905 to 1977 (aged 20–89 years) examined ≤ 5× between 1979 and 2008 in the population-based Tromsø Study. Mixed models were used to estimate time trends. Mean systolic and diastolic blood pressure decreased from 1979 to 2008 in both genders in the age groups 30 to ...


Eccentric Hamstring Strength And Hamstring Injury Risk In Australian Footballers [Accepted Manuscript], David A. Opar, Morgan D. Williams, Ryan G. Timmins, Steven Duhig, Anthony J. Shield Jan 2015

Eccentric Hamstring Strength And Hamstring Injury Risk In Australian Footballers [Accepted Manuscript], David A. Opar, Morgan D. Williams, Ryan G. Timmins, Steven Duhig, Anthony J. Shield

Faculty of Health Sciences Publications

Purpose: Are eccentric hamstring strength and between-limb imbalance in eccentric strength, measured during the Nordic hamstring exercise, risk factors for hamstring strain injury (HSI)?

Methods: Elite Australian footballers (n = 210) from five different teams participated. Eccentric hamstring strength during the Nordic exercise was obtained at the commencement and conclusion of preseason training and at the midpoint of the season. Injury history and demographic data were also collected. Reports on prospectively occurring HSI were completed by the team medical staff. Relative risk (RR) was determined for univariate data, and logistic regression was employed for multivariate data.

Results: Twenty-eight new HSI were ...


Clinically Significant Novel Biomarkers For Prediction Of First Ever Myocardial Infarction: The Tromsø Study, Tom Wilsgaard, Ellisiv Bøgeberg Mathiesen, Anil Patwardhan, Michael W. Rowe, Henrik Schirmer, Maja-Lisa Løchen, Julie Sudduth-Klinger, Sarah Hamren, Kaare Harald Bønaa, Inger Njølstad Jan 2015

Clinically Significant Novel Biomarkers For Prediction Of First Ever Myocardial Infarction: The Tromsø Study, Tom Wilsgaard, Ellisiv Bøgeberg Mathiesen, Anil Patwardhan, Michael W. Rowe, Henrik Schirmer, Maja-Lisa Løchen, Julie Sudduth-Klinger, Sarah Hamren, Kaare Harald Bønaa, Inger Njølstad

Faculty of Health Sciences Publications

Background: Identification of individuals with high risk for first-ever myocardial infarction ( MI ) can be improved. The objectives of the study were to survey multiple protein biomarkers for association with the 10-year risk of incident MI and identify a clinically significant risk model that adds information to current common risk models. Methods and Results: We used an immunoassay platform that uses a sensitive, sample-efficient molecular counting technology to measure 51 proteins in samples from the fourth survey ( 1994 ) in the Tromsø Study, a longitudinal study of men and women in Tromsø, Norway. A case control design was used with 419 first-ever ...


Acute Injuries In Track And Field Athletes: A 3-Year Observational Study At The Penn Relays Carnival With Epidemiology And Medical Coverage Implications [Accepted Manuscript], David Opar, Jonathan Drezner, Anthony Shield, David Webner, Brian Sennett, Rahul Kapur, Marc Cohen, James Ulager, Ana Cafengiu, Peter Cronholm Jan 2015

Acute Injuries In Track And Field Athletes: A 3-Year Observational Study At The Penn Relays Carnival With Epidemiology And Medical Coverage Implications [Accepted Manuscript], David Opar, Jonathan Drezner, Anthony Shield, David Webner, Brian Sennett, Rahul Kapur, Marc Cohen, James Ulager, Ana Cafengiu, Peter Cronholm

Faculty of Health Sciences Publications

Background: Few studies have examined acute injuries in track and field in both elite and subelite athletes.

Purpose: To observe the absolute number and relative rates of injury in track and field athletes across a wide range of competition levels and ages during 3 years of the Penn Relays Carnival to assist with future medical coverage planning and injury prevention strategies.

Study Design: Descriptive epidemiology study.

Methods: Over a 3-year period, all injuries treated by the medical staff were recorded on a standardized injury report form. Absolute number of injuries and relative injury rates (number of injuries per 1000 competing ...


Uric Acid Is Associated With Microalbuminuria And Decreased Glomerular Filtration Rate In The General Population During 7 And 13 Years Of Followup: The Tromsø Study, Hilde M. Storhaug, Ingrid Toft, Jon V. Norvik, Trond Jenssen, Bjørn O. Eriksen, Toralf Melsom, Maja-Lisa Løchen, Marit Dahl Solbu Jan 2015

Uric Acid Is Associated With Microalbuminuria And Decreased Glomerular Filtration Rate In The General Population During 7 And 13 Years Of Followup: The Tromsø Study, Hilde M. Storhaug, Ingrid Toft, Jon V. Norvik, Trond Jenssen, Bjørn O. Eriksen, Toralf Melsom, Maja-Lisa Løchen, Marit Dahl Solbu

Faculty of Health Sciences Publications

Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline SUA on the development of RD. Methods: In a prospective cohort study, we assessed the associations between change in SUA during follow-up, baseline SUA and RD (defined as albumin-creatinine-ratio (ACR) ≥1.13 mg albumin/mmol creatinine and ...


Venous Thromboembolism Increases The Risk Of Atrial Fibrillation: The Tromsø Study, Erin M. Hald, Kristin F. Enga, Maja-Lisa Løchen, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Sigrid K. Braekkan, John-Bjarne Hansen Jan 2014

Venous Thromboembolism Increases The Risk Of Atrial Fibrillation: The Tromsø Study, Erin M. Hald, Kristin F. Enga, Maja-Lisa Løchen, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Sigrid K. Braekkan, John-Bjarne Hansen

Faculty of Health Sciences Publications

Background: Pulmonary embolism (PE) may trigger atrial fibrillation through increased right atrial pressure and subsequent atrial strain, but the degree of evidence is low. In this study, we wanted to investigate the impact of incident venous thromboembolism (VTE) on future risk of atrial fibrillation in a prospective population-based study. Methods and Results: The study included 29 974 subjects recruited from the Tromsø study (1994–1995, 2001–2002, 2007–2008). Incident VTE and atrial fibrillation events were registered from date of enrolment to end of follow-up, December 31, 2010. Cox proportional hazard regression models using age as time-scale and VTE as ...


Comparing Multilevel And Bayesian Spatial Random Effects Survival Models To Assess Geographical Inequalities In Colorectal Cancer Survival: A Case Study, Paramita Dasgupta, Susanna M. Cramb, Joanne Aitken, Gavin Turrell, Peter D. Baade Jan 2014

Comparing Multilevel And Bayesian Spatial Random Effects Survival Models To Assess Geographical Inequalities In Colorectal Cancer Survival: A Case Study, Paramita Dasgupta, Susanna M. Cramb, Joanne Aitken, Gavin Turrell, Peter D. Baade

Faculty of Health Sciences Publications

Background Multilevel and spatial models are being increasingly used to obtain substantive information on area-level inequalities in cancer survival. Multilevel models assume independent geographical areas, whereas spatial models explicitly incorporate geographical correlation, often via a conditional autoregressive prior. However the relative merits of these methods for large population-based studies have not been explored. Using a case-study approach, we report on the implications of using multilevel and spatial survival models to study geographical inequalities in all-cause survival. Methods Multilevel discrete-time and Bayesian spatial survival models were used to study geographical inequalities in all-cause survival for a population-based colorectal cancer cohort of ...


Heart Failure: Preventing Disease And Death Worldwide, Piotr P. Ponikowski, Stefan D. Anker, Khalid F. Alhabib, Martin R. Cowie, Thomas L. Force, Shengshou Hu, Tiny Jaarsma, Henry Krum, Vishal Rastogi, Luis E. Rohde, Umesh C. Samal, Hiroaki Shimokawa, Bambang Budi Siswanto, Karen Sliwa, Gerasimos S. Filippatos Jan 2014

Heart Failure: Preventing Disease And Death Worldwide, Piotr P. Ponikowski, Stefan D. Anker, Khalid F. Alhabib, Martin R. Cowie, Thomas L. Force, Shengshou Hu, Tiny Jaarsma, Henry Krum, Vishal Rastogi, Luis E. Rohde, Umesh C. Samal, Hiroaki Shimokawa, Bambang Budi Siswanto, Karen Sliwa, Gerasimos S. Filippatos

Faculty of Health Sciences Publications

Heart failure is a life‐threatening disease and addressing it should be considered a global health priority. At present, approximately 26 million people worldwide are living with heart failure. The outlook for such patients is poor, with survival rates worse than those for bowel, breast or prostate cancer. Furthermore, heart failure places great stresses on patients, caregivers and healthcare systems. Demands on healthcare services, in particular, are predicted to increase dramatically over the next decade as patient numbers rise owing to ageing populations, detrimental lifestyle changes and improved survival of those who go on to develop heart failure as the ...


Developing Therapies For Heart Failure With Preserved Ejection Fraction: Current State And Future Directions, Javed Butler, Gregg C. Fonarow, Michael R. Zile, Carolyn S. Lam, Lothar Roessig, Erik B. Schelbert, Sanjiv J. Shah, Ali Ahmed, Robert O. Bonow, John G. F. Cleland, Robert J. Cody, Ovidiu Chioncel, Sean P. Collins, Preston M. Dunnmon, Gerasimos S. Filippatos, Martin P. Lefkowitz, Catherine N. Marti, John J. Mcmurray, Frank Misselwitz, Savina Nodari, Christopher M. O'Connor, Marc A. Pfeffer, Burkert Pieske, Bertram Pitt, Giuseppe Rosano, Hani N. Sabbah, Michele Senni, Scott D. Solomon, Norman L. Stockbridge, John R. Teerlink, Vasiliki V. Georgiopoulou, Mihai Gheorghiade Jan 2014

Developing Therapies For Heart Failure With Preserved Ejection Fraction: Current State And Future Directions, Javed Butler, Gregg C. Fonarow, Michael R. Zile, Carolyn S. Lam, Lothar Roessig, Erik B. Schelbert, Sanjiv J. Shah, Ali Ahmed, Robert O. Bonow, John G. F. Cleland, Robert J. Cody, Ovidiu Chioncel, Sean P. Collins, Preston M. Dunnmon, Gerasimos S. Filippatos, Martin P. Lefkowitz, Catherine N. Marti, John J. Mcmurray, Frank Misselwitz, Savina Nodari, Christopher M. O'Connor, Marc A. Pfeffer, Burkert Pieske, Bertram Pitt, Giuseppe Rosano, Hani N. Sabbah, Michele Senni, Scott D. Solomon, Norman L. Stockbridge, John R. Teerlink, Vasiliki V. Georgiopoulou, Mihai Gheorghiade

Faculty of Health Sciences Publications

The burden of heart failure with preserved ejection fraction (HFpEF) is considerable and is projected to worsen. To date, there are no approved therapies available for reducing mortality or hospitalizations for these patients. The pathophysiology of HFpEF is complex and includes alterations in cardiac structure and function, systemic and pulmonary vascular abnormalities, end-organ involvement, and comorbidities. There remain major gaps in our understanding of HFpEF pathophysiology. To facilitate a discussion of how to proceed effectively in future with development of therapies for HFpEF, a meeting was facilitated by the Food and Drug Administration and included representatives from academia, industry, and ...


Red Cell Distribution Width Is Associated With Incident Myocardial Infarction In A General Population: The Tromsø Study, Tove Skjelbakken, Jostein Lappegard, Trygve S. Ellingsen, Elizabeth Barret-Connor, Jan Brox, Maja-Lisa Løchen, Inger Njølstad, Tom Wilsgaard, Ellisiv B. Mathiesen, Sigrid K. Braekkan, John-Bjarne Hansen Jan 2014

Red Cell Distribution Width Is Associated With Incident Myocardial Infarction In A General Population: The Tromsø Study, Tove Skjelbakken, Jostein Lappegard, Trygve S. Ellingsen, Elizabeth Barret-Connor, Jan Brox, Maja-Lisa Løchen, Inger Njølstad, Tom Wilsgaard, Ellisiv B. Mathiesen, Sigrid K. Braekkan, John-Bjarne Hansen

Faculty of Health Sciences Publications

Background: Red cell distribution width (RDW), a measure of the variability in size of circulating erythrocytes, is associated with mortality and adverse outcome in selected populations with cardiovascular disease. It is scarcely known whether RDW is associated with incident myocardial infarction (MI). We aimed to investigate whether RDW was associated with risk of first-ever MI in a large cohort study with participants recruited from a general population. Methods and Results: Baseline characteristics, including RDW, were collected for 25 612 participants in the Tromsø Study in 1994–1995. Incident MI during follow-up was registered from inclusion through December 31, 2010. Cox ...


Osteoporosis In The European Union: A Compendium Of Country-Specific Reports, A. Svedbom, E. Hernlund, M. Ivergård, Juliet E. Compston, Cyrus Cooper, J. Stenmark, Eugene V. Mccloskey, Bengt Jönsson, John A. Kanis, The Eu Review Panel Of The Iof Jan 2013

Osteoporosis In The European Union: A Compendium Of Country-Specific Reports, A. Svedbom, E. Hernlund, M. Ivergård, Juliet E. Compston, Cyrus Cooper, J. Stenmark, Eugene V. Mccloskey, Bengt Jönsson, John A. Kanis, The Eu Review Panel Of The Iof

Faculty of Health Sciences Publications

Summary: This report describes epidemiology, burden, and treatment of osteoporosis in each of the 27 countries of the European Union (EU27). Introduction: In 2010, 22 million women and 5.5 million men were estimated to have osteoporosis in the EU; and 3.5 million new fragility fractures were sustained, comprising 620,000 hip fractures, 520,000 vertebral fractures, 560,000 forearm fractures and 1,800,000 other fractures. The economic burden of incident and prior fragility fractures was estimated at € 37 billion. Previous and incident fractures also accounted for 1,180,000 quality-adjusted life years lost during 2010. The costs ...


Dietary Selenium And Major Depression: A Nested Case-Control Study, Julie A. Pasco, Felice N. Jacka, Lana J. Willia, Melinda Evans-Cleverdon, Sharon L. Brennan, Mark A. Kotowicz, Geoffrey Charles Nicholson, Madeleine J. Ball, Michael Berk Jan 2012

Dietary Selenium And Major Depression: A Nested Case-Control Study, Julie A. Pasco, Felice N. Jacka, Lana J. Willia, Melinda Evans-Cleverdon, Sharon L. Brennan, Mark A. Kotowicz, Geoffrey Charles Nicholson, Madeleine J. Ball, Michael Berk

Faculty of Health Sciences Publications

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