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Australian Catholic University

2016

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Full-Text Articles in Medicine and Health Sciences

Exploring The Journey Towards Successful Ageing In The Philippines: A Mixed Method Study, Nicamil Sanchez Dec 2016

Exploring The Journey Towards Successful Ageing In The Philippines: A Mixed Method Study, Nicamil Sanchez

Theses

Currently, there are no universally accepted definitions, dimensions or scales for measuring successful ageing. Rowe and Kahn’s (1977) three dimensions of successful ageing, namely, wellbeing, physical functioning, and social engagement, have been adopted by most studies in the literature to measure successful ageing. A review of the extant literature on successful ageing revealed that the majority of the studies on successful ageing have been conducted in developed western countries, despite the fact that the majority of older persons live in developing countries like the Philippines. Additionally, studies on successful ageing have been limited in their consideration of the sociocultural ...


Effects Of Creatine Availability On Skeletal Muscle Metabolism, Kristyen Andre Tomcik Dec 2016

Effects Of Creatine Availability On Skeletal Muscle Metabolism, Kristyen Andre Tomcik

Theses

Nutritional strategies which increase energy substrate availability enhance exercise capacity and affect cell signalling and muscle morphology. The co-ingestion of carbohydrate with creatine has been shown to enhance both intramuscular creatine as well as glycogen storage, with the former being thoroughly investigated with respect to resistance-based exercise. Despite evidence of synergy, the direct performance benefits of this co-supplementation strategy on endurance-based exercise and its metabolic effect(s) on cellular signalling remained to be investigated. The work comprising this thesis represents a series of independent yet related studies that determined the effects of manipulating creatine along with carbohydrate (glucose) and/or ...


Patient And Parent Perspectives Of Adolescent Laparoscopic Adjustable Gastric Banding (Lagb) [Accepted Manuscript], Kim Yvonne Willcox, Narelle Warren, Paul O'Brien, Wendy Brown, Peter Nottle, Jason Winnett, Ahmad Aly, Leah Brennan Nov 2016

Patient And Parent Perspectives Of Adolescent Laparoscopic Adjustable Gastric Banding (Lagb) [Accepted Manuscript], Kim Yvonne Willcox, Narelle Warren, Paul O'Brien, Wendy Brown, Peter Nottle, Jason Winnett, Ahmad Aly, Leah Brennan

Faculty of Health Sciences Publications

Introduction Adolescent obesity is a significant global health challenge and severely obese adolescents commonly experience serious medical and psychosocial challenges. Consequently, severe adolescent obesity is increasingly being treated surgically. The limited available research examining the effectiveness of adolescent bariatric surgery focuses primarily on bio-medical outcomes. There is a need for a more comprehensive understanding of the behavioural, emotional and social factors which affect adolescents’ and parents’ experience of weight-loss surgery. Materials/Methods Patient and parents’ perspectives of adolescent LAGB were examined using a qualitative research methodology. Individual, semi-structured interviews were conducted with eight adolescent patients and five parents. Thematic analysis ...


Cricket Fast Bowler Monitoring And Workload Management, Dean Mcnamara Oct 2016

Cricket Fast Bowler Monitoring And Workload Management, Dean Mcnamara

Theses

The sport of cricket is challenged by three formats of the game; each with varying workload demands. The most recent format is T20 cricket, first played internationally in 2005. Further to this, elite performers are often required to play for upwards of four different professional teams across the year; increasing the complexities in player workload management and other sports science-related support. Fast bowlers have greater overall match-play demands than other playing positions in cricket. Wearable microtechnology for tracking external load in athletes is common practice. Despite microtechnology enabling meaningful analyses of workload beyond routinely reported metrics, little application has occurred ...


Residential Proximity To Urban Centres, Local-Area Walkability And Change In Waist Circumference Among Australian Adults, Takemi Sugiyama, Theo Niyonsenga, Natasha J. Howard, Neil T. Coffee, Catherine Paquet, Anne W. Taylor Sep 2016

Residential Proximity To Urban Centres, Local-Area Walkability And Change In Waist Circumference Among Australian Adults, Takemi Sugiyama, Theo Niyonsenga, Natasha J. Howard, Neil T. Coffee, Catherine Paquet, Anne W. Taylor

Faculty of Health Sciences Publications

Consistent associations have been observed between macro-level urban sprawl and overweight/obesity, but whether residential proximity to urban centres predicts adiposity change over time has not been established. Further, studies of local-area walkability and overweight/obesity have generated mixed results. This study examined 4-year change in adults’ waist circumference in relation to proximity to city centre, proximity to closest suburban centre, and local-area walkability. Data were from adult participants (n=2080) of a cohort study on chronic conditions and health risk factors in Adelaide, Australia. Baseline data were collected in 2000-03 with a follow-up in 2005-06. Multilevel regression models examined ...


Quantifying The Functional Role Of Discrete Movement Variability: Links To Adaptation And Learning, Paul Geoffrey Taylor Sep 2016

Quantifying The Functional Role Of Discrete Movement Variability: Links To Adaptation And Learning, Paul Geoffrey Taylor

Theses

Introduction: Movement variability can be defined as the variance in human movement from one trial or cycle to the next, often when attempting to maintain dynamic equilibrium (in the case of continuous skills) or achieve consistent movement outcome (for discrete skills). Some theoretical perspectives of motor control consider movement variability to be deleterious. However, the dynamical systems perspective proposes beneficial and functional roles for movement variability. Within this view variability has developed as an independent theme of research that has gained momentum over the past 25 years, attracting focus from various sub-disciplines within the field with a major contribution from ...


The Reliability Of Shoulder Range Of Motion Measures In Competitive Swimmers, Helen Walker, Tania Pizzari, Henry Wajswelner, Peter Blanch, Laura Schwab, Kim Bennell, Belinda Gabbe Sep 2016

The Reliability Of Shoulder Range Of Motion Measures In Competitive Swimmers, Helen Walker, Tania Pizzari, Henry Wajswelner, Peter Blanch, Laura Schwab, Kim Bennell, Belinda Gabbe

Faculty of Health Sciences Publications

Objectives: Investigate reliability of shoulder internal and external rotation (IR, ER), abduction in internal rotation (ABIR) and combined elevation (CE) range of motion tests in competitive swimmers.

Design: Within participants, inter- and intra-examiner reliability.

Setting: Physiotherapy Department, University of Melbourne, Australia.

Participants: 17 competitive swimmers (aged 12-24 years) who participate in at least 5 weekly swimming sessions and two physiotherapy examiners.

Main outcome measures: Inter- and intra-examiner reliability of IR, ER, ABIR and CE.

Results: Good to excellent intra-examiner reliability across tests (ICCs: 0.85-0.96) with standard error of measurement (SEM)and minimal detectable change at 90% confidence interval ...


Trial Of A Family-Based Education Program For Patients With Heart Failure And Their Carers In Rural Thailand, Nittaya Srisuk Sep 2016

Trial Of A Family-Based Education Program For Patients With Heart Failure And Their Carers In Rural Thailand, Nittaya Srisuk

Theses

Introduction: Heart failure is a major public health problem, affecting over 26 million people worldwide. It is associated with a high rate of mortality, symptom burden and diminished quality of life. Best practice guidelines for the management of chronic heart failure recommend that patients and carers/family members are educated about heart failure self-care. Effective heart failure self-care has the potential to improve health outcomes. Studies conducted in Thailand addressing heart failure self-care are limited and none have investigated the potential benefits of education programs on the health outcomes of both parties within the dyad: the patient with heart failure ...


Facilitating Change And Evaluating Impact During A Neonatal Intensive Care Redevelopment: A Participatory Action Research Project, Margaret Broom Sep 2016

Facilitating Change And Evaluating Impact During A Neonatal Intensive Care Redevelopment: A Participatory Action Research Project, Margaret Broom

Theses

There have been many reports indicating that if the design of Neonatal Intensive Care Units provides neonates with a more developmentally appropriate environment during the period of their admission, there would be significant neurodevelopmental benefits. To create such an environment, Neonatal Intensive Care floor plans have been modified from open plan to a single family room or larger rooms where 2-6 neonates are accommodated. Single family room design enables staff to adapt the physical environment (e.g. light, noise) to meet each neonate’s gestational age and sleep/wake cycle requirements. However, previous researchers have suggested that changing room design ...


Monitoring Athlete Preparedness In Professional Australian Football: Load, Self-Report Measures And Performance, Tania Fiorina Gallo Aug 2016

Monitoring Athlete Preparedness In Professional Australian Football: Load, Self-Report Measures And Performance, Tania Fiorina Gallo

Theses

Monitoring athlete preparedness, including quantifying training and competition load and determining fatigue/training status, is used to complement training and recovery prescription in professional sport (Kenttä & Hassmén, 2002). The overall objective of this research was to investigate contemporary athlete monitoring practices in professional Australian football (AF). The aim of study 1 was to identify the relationship between external training load and session rating of perceived exertion (s-RPE) training load and the impact that playing experience, playing position and 2-km time-trial performance had on that relationship. Microtechnology devices provided external training load (distance, mean speed, high-speed running distance, Player loadTM (PL ...


Calcium And Vitamin-D Supplementation On Bone Structural Properties In Young Male Jockeys: A Randomised Controlled Trial, Leslie Silk Mar 2016

Calcium And Vitamin-D Supplementation On Bone Structural Properties In Young Male Jockeys: A Randomised Controlled Trial, Leslie Silk

Theses

Introduction: Young male jockeys compromise bone health by engaging in caloric restriction and high volumes of physical activity during periods of musculoskeletal growth and development. Failure to attain peak bone mass (PBM) during growth can have adverse short and long term musculoskeletal effects, with numerous studies demonstrating inferior bone health in jockey populations. However, no study to date has addressed counteracting the deleterious effects that participation in this sport has on bone health. The purpose of this six-month double-blind randomised placebo controlled trial was to examine the efficacy of 800mg calcium and 400 IU vitamin D daily supplementation on improving ...


Psychometric Evaluation Of Disordered Eating Measures In Bariatric Surgery Candidates [Accepted Manuscript], Katrina Parker, Sarah Mitchell, Paul O'Brien, Leah Brennan Mar 2016

Psychometric Evaluation Of Disordered Eating Measures In Bariatric Surgery Candidates [Accepted Manuscript], Katrina Parker, Sarah Mitchell, Paul O'Brien, Leah Brennan

Faculty of Health Sciences Publications

Introduction: Assessment of disordered eating is common in bariatric surgery candidates, yet psychometric properties of disordered eating measures in this population are largely unknown. Methods: Measures were completed by 405 adult bariatric surgery candidates at pre-surgical consultation. Fit of the original scale structures was tested using confirmatory factor analysis (CFA) and alternative factor solutions were generated using exploratory factor analysis (EFA). Reliability (internal consistency), construct validity (convergent and divergent) and criterion validity (with the EDE as criterion) were assessed. Materials: The measures prioritised for evaluation are the following: Eating Disorder Examination Questionnaire (EDE-Q; n = 405), Three-Factor EatingQuestionnaire (TFEQ; n = 405 ...


Quality Of Life Outcomes Of Bariatric Surgery: A Systematic Review [Accepted Manuscript], Aleeya Hachem, Leah Brennan Feb 2016

Quality Of Life Outcomes Of Bariatric Surgery: A Systematic Review [Accepted Manuscript], Aleeya Hachem, Leah Brennan

Faculty of Health Sciences Publications

Bariatric surgery is often pursued to improve quality of life (QOL). This paper systematically reviews the literature examining QOL following bariatric surgery. Fifteen controlled trials examined changes in QOL in obese (BMI > 30) adults (18–65 years) following bariatric surgery; seven compared bariatric surgery to non-surgical interventions and six compared different types of bariatric surgery. Bariatric surgery resulted in greater improvements in QOL than other obesity treatments. Significant differences in QOL improvements were found between different types of bariatric surgery. QOL improvements were more likely to occur within the first 2 years following surgery, with greater improvements in physical QOL ...


Early Origins Of Mental Disorder: Risk Factors In The Perinatal And Infant Period, Louise Newman, Fiona Judd, Craig A. Olsson, David J. Castle, Chad Bousman, Penelope Sheehan, Christos Pantelis, Jeffrey M. Craig, Angela Komiti, Ian P. Everall Jan 2016

Early Origins Of Mental Disorder: Risk Factors In The Perinatal And Infant Period, Louise Newman, Fiona Judd, Craig A. Olsson, David J. Castle, Chad Bousman, Penelope Sheehan, Christos Pantelis, Jeffrey M. Craig, Angela Komiti, Ian P. Everall

Faculty of Health Sciences Publications

Background: There is increasing understanding of the significance of early neurodevelopment in establishing risk for the range of mental disorders. Models of the early aetiology of mental disorders are complex with a range of potential factors from genetic and epigenetic to environmental influencing neurological and psychological development. Whilst the mechanisms are not fully understood, this paper provides an overview of potential biological and neurobiological factors that might be involved. Method: An aetiological model is presented and discussed. The discussion includes a range of risk factors for mental disorder. Maternal anxiety disorder is presented and reviewed as an example of the ...


Triage, Treatment And Transfer Of Patients With Stroke In Emergency Department Trial (The T3 Trial): A Cluster Randomised Trial Protocol, Sandy Middleton, Chris Levi, Simeon Dale, N. Chung, Elizabeth Mcinnes, Julie Considine, Catherine D'Este, Dominique Cadilhac, Jeremy Grimshaw, Richard Gerraty, Louise Craig, Verena Schadewaldt, Patrick Mcelduff, Mark Fitzgerald, Clare Quinn, Greg Cadigan, Sonia Denisenko, Mark Longworth, Janette Ward Jan 2016

Triage, Treatment And Transfer Of Patients With Stroke In Emergency Department Trial (The T3 Trial): A Cluster Randomised Trial Protocol, Sandy Middleton, Chris Levi, Simeon Dale, N. Chung, Elizabeth Mcinnes, Julie Considine, Catherine D'Este, Dominique Cadilhac, Jeremy Grimshaw, Richard Gerraty, Louise Craig, Verena Schadewaldt, Patrick Mcelduff, Mark Fitzgerald, Clare Quinn, Greg Cadigan, Sonia Denisenko, Mark Longworth, Janette Ward

Faculty of Health Sciences Publications

Background Internationally recognised evidence-based guidelines recommend appropriate triage of patients with stroke in emergency departments (EDs), administration of tissue plasminogen activator (tPA), and proactive management of fever, hyperglycaemia and swallowing before prompt transfer to a stroke unit to maximise outcomes. We aim to evaluate the effectiveness in EDs of a theory-informed, nurse-initiated, intervention to improve multidisciplinary triage, treatment and transfer (T3) of patients with acute stroke to improve 90-day death and dependency. Organisational and contextual factors associated with intervention uptake also will be evaluated. Methods This prospective, multicentre, parallel group, cluster randomised trial with blinded outcome assessment will be conducted ...


A New Diagnosis Of Asthma Or Copd Is Linked To Smoking Cessation - The Tromsø Study, Signe Elise Danielsen, Maja-Lisa Løchen, Astri Medbø, Monica Linea Vold, Hasse Melbye Jan 2016

A New Diagnosis Of Asthma Or Copd Is Linked To Smoking Cessation - The Tromsø Study, Signe Elise Danielsen, Maja-Lisa Løchen, Astri Medbø, Monica Linea Vold, Hasse Melbye

Faculty of Health Sciences Publications

No abstract provided.


Guided Internet-Delivered Cognitive Behavioural Therapy In Patients With Non-Cardiac Chest Pain - A Pilot Randomized Controlled Study, Ghassan Mourad, Anna Stromberg, Egil Jonsbu, Mikael Gustafsson, Peter Johansson, Tiny Jaarsma Jan 2016

Guided Internet-Delivered Cognitive Behavioural Therapy In Patients With Non-Cardiac Chest Pain - A Pilot Randomized Controlled Study, Ghassan Mourad, Anna Stromberg, Egil Jonsbu, Mikael Gustafsson, Peter Johansson, Tiny Jaarsma

Faculty of Health Sciences Publications

More than 50 % of patients seeking hospital care because of chest pain are diagnosed as having “non-cardiac” symptoms [1, 2]. Many patients are discharged without knowing the cause of their chest pain [3, 4]. Patients with noncardiac chest pain experience psychological distress [5, 6] and use healthcare resources to a great extent, leading to high healthcare costs [7–11]. Despite reassurance [12], many patients think they have an undetected cardiac disease and avoid activities that they believe might be harmful to the heart [13, 14]. Cardiac anxiety is common in patients with recurrent non-cardiac chest pain [6], leading to a ...


Air Pollution Exposure During Pregnancy And Childhood Autistic Traits In Four European Population-Based Cohort Studies: The Escape Project, Mònica Guxens, Akhgar Ghassabian, Tong Gong, Raquel Garcia-Esteban, Daniela Porta, Lise Giorgis-Allemand, Catarina Almqvist, Aritz Aranbarri, Rob Beelen, Chiara Badaloni, Giulia Cesaroni, Audrey De Nazelle, Marisa Estarlich, Francesco Forastiere, Joan Forns, Ulrike Gehring, Jesús Ibarluzea, Vincent W. V. Jaddoe, Michal Korek, Paul Lichtenstein, Mark J. Nieuwenhuijsen, Marisa Rebagliato, Rémy Slama, Henning Tiemeier, Frank C. Verhulst, Heather E. Volk, Göran Pershagen, Bert Brunekreef, Jordi Sunyer Jan 2016

Air Pollution Exposure During Pregnancy And Childhood Autistic Traits In Four European Population-Based Cohort Studies: The Escape Project, Mònica Guxens, Akhgar Ghassabian, Tong Gong, Raquel Garcia-Esteban, Daniela Porta, Lise Giorgis-Allemand, Catarina Almqvist, Aritz Aranbarri, Rob Beelen, Chiara Badaloni, Giulia Cesaroni, Audrey De Nazelle, Marisa Estarlich, Francesco Forastiere, Joan Forns, Ulrike Gehring, Jesús Ibarluzea, Vincent W. V. Jaddoe, Michal Korek, Paul Lichtenstein, Mark J. Nieuwenhuijsen, Marisa Rebagliato, Rémy Slama, Henning Tiemeier, Frank C. Verhulst, Heather E. Volk, Göran Pershagen, Bert Brunekreef, Jordi Sunyer

Faculty of Health Sciences Publications

Background Prenatal exposure to air pollutants has been suggested as a possible etiologic factor for the occurrence of autism spectrum disorder. Objectives: We aimed to assess whether prenatal air pollution exposure is associated with childhood autistic traits in the general population. Methods: Ours was a collaborative study of four European population-based birth/child cohorts—CATSS (Sweden), Generation R (the Netherlands), GASPII (Italy), and INMA (Spain). Nitrogen oxides (NO2, NOx) and particulate matter (PM) with diameters of ≤ 2.5 μm (PM2.5), ≤ 10 μm (PM10), and between 2.5 and 10 μm (PMcoarse), and PM2.5 absorbance were estimated for birth ...


From Social Exclusion To Supported Inclusion: Adults With Intellectual Disability Discuss Their Lived Experiences Of A Sructured Social Group, Nathan J. Wilson, Hayden Jaques, Amanda Johnson, Michelle Brotherton Jan 2016

From Social Exclusion To Supported Inclusion: Adults With Intellectual Disability Discuss Their Lived Experiences Of A Sructured Social Group, Nathan J. Wilson, Hayden Jaques, Amanda Johnson, Michelle Brotherton

Faculty of Health Sciences Publications

Background People with intellectual disability often have few friends and experience social exclusion. Recognising this gap, supported social groups with the aim of inclusion and interdependence were created by a supported employment provider. Methods Interviews were undertaken with 10 adults with intellectual disability exploring their lived experiences of a supported social group. Data were analysed using descriptive phenomenology. Results Two themes emerged (i) supported engagement fosters wellbeing, and (ii) developing social belonging and connectedness. Participants not only acknowledged the support that they needed to participate, but also that the social group had changed their lives in many ways. Conclusions Adults ...


The Effectiveness Of Clinical Networks In Improving Quality Of Care And Patient Outcomes: A Systematic Review Of Quantitative And Qualitative Studies, Bernadette B. Brown, Cyra Patel, Elizabeth C. Mcinnes, Nicholas Mays, Jane Young, Mary Haines Jan 2016

The Effectiveness Of Clinical Networks In Improving Quality Of Care And Patient Outcomes: A Systematic Review Of Quantitative And Qualitative Studies, Bernadette B. Brown, Cyra Patel, Elizabeth C. Mcinnes, Nicholas Mays, Jane Young, Mary Haines

Faculty of Health Sciences Publications

Background: Reorganisation of healthcare services into networks of clinical experts is increasing as a strategy to promote the uptake of evidence based practice and to improve patient care. This is reflected in significant financial investment in clinical networks. However, there is still some question as to whether clinical networks are effective vehicles for quality improvement. The aim of this systematic review was to ascertain the effectiveness of clinical networks and identify how successful networks improve quality of care and patient outcomes. Methods: A systematic search was undertaken in accordance with the PRISMA approach in Medline, Embase, CINAHL and PubMed for ...


Ingestion Of Wheat Protein Increases In Vivo Muscle Protein Synthesis Rates In Healthy Older Men In A Randomized Trial, Stefan H. M. Gorissen, Astrid M. H. Horstman, Rinske Franssen, Julie J. R. Crombag, Henning Langer, Jörgen Bierau, Frederique Respondek, Luc J.C. Van Loon Jan 2016

Ingestion Of Wheat Protein Increases In Vivo Muscle Protein Synthesis Rates In Healthy Older Men In A Randomized Trial, Stefan H. M. Gorissen, Astrid M. H. Horstman, Rinske Franssen, Julie J. R. Crombag, Henning Langer, Jörgen Bierau, Frederique Respondek, Luc J.C. Van Loon

Faculty of Health Sciences Publications

Background: Muscle mass maintenance is largely regulated by basal muscle protein synthesis and the capacity to stimulate muscle protein synthesis after food intake. The postprandial muscle protein synthetic response is modulated by the amount, source, and type of protein consumed. It has been suggested that plant-based proteins are less potent in stimulating postprandial muscle protein synthesis than animal-derived proteins. However, few data support this contention. Objective: We aimed to assess postprandial plasma amino acid concentrations and muscle protein synthesis rates after the ingestion of a substantial 35-g bolus of wheat protein hydrolysate compared with casein and whey protein. Methods: Sixty ...


Effects Of Sacubitril/Valsartan In The Paradigm-Hf Trial (Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure) According To Background Therapy, Naoki Okumura, Pardeep Jhund, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott Solomon, Milton Packer, John Mcmurray Jan 2016

Effects Of Sacubitril/Valsartan In The Paradigm-Hf Trial (Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure) According To Background Therapy, Naoki Okumura, Pardeep Jhund, Jianjian Gong, Martin P. Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor C. Shi, Karl Swedberg, Michael R. Zile, Scott Solomon, Milton Packer, John Mcmurray

Faculty of Health Sciences Publications

In the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the angiotensin-converting enzyme inhibitor enalapril in patients with heart failure and reduced ejection fraction. We examined whether this benefit was consistent irrespective of background therapy.


Influence Of Ejection Fraction On Outcomes And Efficacy Of Sacubitril/Valsartan (Lcz696) In Heart Failure With Reduced Ejection Fraction: The Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure (Paradigm-Hf) Trial, Scott Solomon, Brian L. Claggett, Akshay S. Desai, Milton Packer, Michael R. Zile, Karl Swedberg, Jean L. Rouleau, Victor C. Shi, Randall C. Starling, Ömer Kozan, Andrej Dukat, Martin P. Lefkowitz, John Mcmurray Jan 2016

Influence Of Ejection Fraction On Outcomes And Efficacy Of Sacubitril/Valsartan (Lcz696) In Heart Failure With Reduced Ejection Fraction: The Prospective Comparison Of Arni With Acei To Determine Impact On Global Mortality And Morbidity In Heart Failure (Paradigm-Hf) Trial, Scott Solomon, Brian L. Claggett, Akshay S. Desai, Milton Packer, Michael R. Zile, Karl Swedberg, Jean L. Rouleau, Victor C. Shi, Randall C. Starling, Ömer Kozan, Andrej Dukat, Martin P. Lefkowitz, John Mcmurray

Faculty of Health Sciences Publications

The angiotensin receptor neprilysin inhibitor sacubitril/valsartan (LCZ696) reduced cardiovascular morbidity and mortality compared with enalapril in patients with heart failure (HF) and reduced ejection fraction (EF) in the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial. We evaluated the influence of EF on clinical outcomes and on the effectiveness of sacubitril/valsartan compared with enalapril.


Architectural Changes Of The Biceps Femoris Long Head After Concentric Or Eccentric Training [Accepted Manuscript], Ryan G. Timmins, Joshua D. Ruddy, Joel Presland, Nirav Maniar, Morgan Williams Jan 2016

Architectural Changes Of The Biceps Femoris Long Head After Concentric Or Eccentric Training [Accepted Manuscript], Ryan G. Timmins, Joshua D. Ruddy, Joel Presland, Nirav Maniar, Morgan Williams

Faculty of Health Sciences Publications

Purpose: To determine i) the architectural adaptations of the biceps femoris long head (BFlf) following concentric or eccentric strength training interventions; ii) the time course of adaptation during training and detraining.

Methods: Participants in this randomized controlled trial (control [n=28], concentric training group [n=14], eccentric training group [n=14], males) completed a 4-week control period, followed by 6 weeks of either concentric- or eccentric-only knee flexor training on an isokinetic dynamometer and finished with 28 days of detraining. Architectural characteristics of BFlf were assessed at rest and during graded isometric contractions utilizing two-dimensional ultrasonography at 28 days pre-baseline ...


Participation: Both A Means And An End. A Conceptual Analysis Of Processes And Outcomes In Childhood Disability [Accepted Manuscript], Christine Imms, Mats Granlund, Peter Wilson, Bert Steenbergen, Peter Rosenbaum, Andrew M. Gordon Jan 2016

Participation: Both A Means And An End. A Conceptual Analysis Of Processes And Outcomes In Childhood Disability [Accepted Manuscript], Christine Imms, Mats Granlund, Peter Wilson, Bert Steenbergen, Peter Rosenbaum, Andrew M. Gordon

Faculty of Health Sciences Publications

This paper outlines a conceptual approach that we believe should be used to inform research and practice aimed at supporting children whose lives are complicated by impairment and/or chronic medical conditions, and their families. We promote the idea that ‘participation’ in meaningful life activities should be an essential intervention goal, to meet the challenges of healthy growth and development, and to provide opportunities that will help ensure that young people with impairments reach their full potential across the lifespan. We also argue that both intervention activities and research can focus on participation as either an independent or dependent variable ...


Sarcopenia In Daily Practice: Assessment And Management, Charlotte Beaudart, Eugene Mccloskey, Olivier Bruyère, Matteo Cesari, Yves Rolland, Rene Rizzoli, Islène Araujo De Carvalho, Jotheeswaran Amuthavalli Thiyagarajan, Ivan Bautmans, Marie-Claude Bertière, Maria Luisa Brandi, Nasser M. Al-Daghri, Nansa Burlet, Etienne Cavalier, Francesca Cerreta, Antonio Cherubini, Roger Fielding, Evelien Gielen, Francesco Landi, Jean Petermans, Jean-Yves Reginster, Marjolein Visser, John Kanis, Cyrus Cooper Jan 2016

Sarcopenia In Daily Practice: Assessment And Management, Charlotte Beaudart, Eugene Mccloskey, Olivier Bruyère, Matteo Cesari, Yves Rolland, Rene Rizzoli, Islène Araujo De Carvalho, Jotheeswaran Amuthavalli Thiyagarajan, Ivan Bautmans, Marie-Claude Bertière, Maria Luisa Brandi, Nasser M. Al-Daghri, Nansa Burlet, Etienne Cavalier, Francesca Cerreta, Antonio Cherubini, Roger Fielding, Evelien Gielen, Francesco Landi, Jean Petermans, Jean-Yves Reginster, Marjolein Visser, John Kanis, Cyrus Cooper

Faculty of Health Sciences Publications

Background: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools have been recommended to assess muscle mass, muscle strength and physical performance in clinical trials. Whilst these tools have proven to be accurate and reliable in investigational settings, many are not easily applied to daily practice.


An Australian Longitudinal Pilot Study Examining Health Determinants Of Cardiac Outcomes 12 Months Post Percutaneous Coronary Intervention, Karen-Leigh Edward, John Stephenson, Jo-Ann M. Giandinoto, Andrew Wilson, Robert Whitbourn, Jack Gutman, Andrew Newcomb Jan 2016

An Australian Longitudinal Pilot Study Examining Health Determinants Of Cardiac Outcomes 12 Months Post Percutaneous Coronary Intervention, Karen-Leigh Edward, John Stephenson, Jo-Ann M. Giandinoto, Andrew Wilson, Robert Whitbourn, Jack Gutman, Andrew Newcomb

Faculty of Health Sciences Publications

Background: Percutaneous coronary intervention (PCI) is a very common revascularisation procedure for coronary artery disease (CAD). The purpose of this study was to evaluate cardiac outcomes, health related quality of life (HRQoL), resilience and adherence behaviours in patients who have undergone a PCI at two time points (6 and 12 months) following their procedure. Methods: A longitudinal pilot study was conducted to observe the cardiac outcomes across a cohort of patients who had undergone a percutaneous coronary intervention (PCI). Participants who had undergone PCI 6 months prior were invited. Those participants who met the inclusion criteria and provided consent then ...


Social Dancing And Incidence Of Falls In Older Adults: A Cluster Randomised Controlled Trial, Dafna Merom, Erin Mathieu, Ester Cerin, Rachael L. Morton, Judy M. Simpson, Chris Rissel, Kaarin J. Anstey, Catherine Sherrington, Stephen R. Lord, Robert G. Cumming Jan 2016

Social Dancing And Incidence Of Falls In Older Adults: A Cluster Randomised Controlled Trial, Dafna Merom, Erin Mathieu, Ester Cerin, Rachael L. Morton, Judy M. Simpson, Chris Rissel, Kaarin J. Anstey, Catherine Sherrington, Stephen R. Lord, Robert G. Cumming

Faculty of Health Sciences Publications

Background: The prevention of falls among older people is a major public health challenge. Exercises that challenge balance are recognized as an efficacious fall prevention strategy. Given that small-scale trials have indicated that diverse dance styles can improve balance and gait of older adults, two of the strongest risk factors for falls in older people, this study aimed to determine whether social dance is effective in i) reducing the number of falls and ii) improving physical and cognitive fall-related risk factors. Methods and Findings: A parallel two-arm cluster randomized controlled trial was undertaken in 23 self-care retirement villages (clusters) around ...


Acute Inflammatory Response To Low-, Moderate-, And High-Load Resistance Exercise In Women With Breast Cancer-Related Lymphedema, Prue Cormie, Benjamin Singh, Sandi Hayes, Jonathan M. Peake, Daniel A. Galvao, Dennis R. Taaffe, Nigel A. Spry, Kazunori Nosaka, Bruce Cornish, Kathryn H. Schmitz, Robert U. Newton Jan 2016

Acute Inflammatory Response To Low-, Moderate-, And High-Load Resistance Exercise In Women With Breast Cancer-Related Lymphedema, Prue Cormie, Benjamin Singh, Sandi Hayes, Jonathan M. Peake, Daniel A. Galvao, Dennis R. Taaffe, Nigel A. Spry, Kazunori Nosaka, Bruce Cornish, Kathryn H. Schmitz, Robert U. Newton

Faculty of Health Sciences Publications

Background. Resistance exercise is emerging as a potential adjunct therapy to aid in the management of breast cancer–related lymphedema (BCRL). However, the mechanisms underlying the relationships between the acute and long-term benefits of resistance exercise on BCRL are not well understood. Purpose. To examine the acute inflammatory response to upper-body resistance exercise in women with BCRL and to compare these effects between resistance exercises involving low, moderate, and high loads. The impact on lymphedema status and associated symptoms was also compared. Methods. A total of 21 women, 62 ± 10 years old, with BCRL participated in the study. Participants completed ...


Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation For Tissue Engineering Applications, Elsa C. Chan, Shyh-Ming Kuo, Anne M. Kong, Wayne A. Morrison, Gregory J. Dusting, Geraldine M. Mitchell, Shiang Y. Lim, Guei-Sheung Liu Jan 2016

Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation For Tissue Engineering Applications, Elsa C. Chan, Shyh-Ming Kuo, Anne M. Kong, Wayne A. Morrison, Gregory J. Dusting, Geraldine M. Mitchell, Shiang Y. Lim, Guei-Sheung Liu

Faculty of Health Sciences Publications

Here, we describe a porous 3-dimensional collagen scaffold material that supports capillary formation in vitro, and promotes vascularization when implanted in vivo. Collagen scaffolds were synthesized from type I bovine collagen and have a uniform pore size of 80 μm. In vitro, scaffolds seeded with primary human microvascular endothelial cells suspended in human fibrin gel formed CD31 positive capillary-like structures with clear lumens. In vivo, after subcutaneous implantation in mice, cell-free collagen scaffolds were vascularized by host neovessels, whilst a gradual degradation of the scaffold material occurred over 8 weeks. Collagen scaffolds, impregnated with human fibrinogen gel, were implanted subcutaneously ...