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Australian Catholic University

Faculty of Health Sciences Publications

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Bmd-Related Genetic Risk Scores Predict Site-Specific Fractures As Well As Trabecular And Cortical Bone Microstructure, Maria Nethander, Ulrika Pettersson-Kymmer, Liesbeth Vandenput, Mattias Lorentzon, Magnus Karlsson, Dan Mellström, Claes Ohlsson Jan 2020

Bmd-Related Genetic Risk Scores Predict Site-Specific Fractures As Well As Trabecular And Cortical Bone Microstructure, Maria Nethander, Ulrika Pettersson-Kymmer, Liesbeth Vandenput, Mattias Lorentzon, Magnus Karlsson, Dan Mellström, Claes Ohlsson

Faculty of Health Sciences Publications

Context: It is important to identify patients at highest risk of fractures. Objective: To compare the separate and combined performances of bone-related genetic risk scores (GRSs) for prediction of forearm, hip and vertebral fractures separately, as well as of trabecular and cortical bone microstructure parameters separately. Design, Setting, and Participants: Using 1103 single nucleotide polymorphisms (SNPs) independently associated with estimated bone mineral density of the heel (eBMD), we developed a weighted GRS for eBMD and determined its contribution to fracture prediction beyond 2 previously developed GRSs for femur neck BMD (49 SNPs) and lumbar spine BMD (48 SNPs). Associations between ...


Epidemiology Of Hip Fractures In Bulgaria: Development Of A Country-Specific Frax Model, E. Kirilova, H. Johansson, N. Kirilov, S. Vladeva, T. Petranova, Z. Kolarov, E. Liu, M. Lorentzon, L. Vandenput, N. C. Harvey, E. Mccloskey, John A. Kanis Jan 2020

Epidemiology Of Hip Fractures In Bulgaria: Development Of A Country-Specific Frax Model, E. Kirilova, H. Johansson, N. Kirilov, S. Vladeva, T. Petranova, Z. Kolarov, E. Liu, M. Lorentzon, L. Vandenput, N. C. Harvey, E. Mccloskey, John A. Kanis

Faculty of Health Sciences Publications

Summary: A retrospective population-based survey was undertaken in a region of Bulgaria to determine the incidence of hip fracture. The estimated number of hip fractures nationwide for 2015 was 9322 and is predicted to increase to 11,398 in 2050. The hip fracture rates were used to create a FRAX model. Objective: To describe the epidemiology of hip fractures in Bulgaria, which was then used to develop the country-specific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in Stara Zagora, Bulgaria, representing approximately 4.6% of the country’s population. We identified hip fractures occurring in ...


Higher Body Mass Index In Adolescence Predicts Cardiomyopathy Risk In Midlife: Long-Term Follow-Up Among Swedish Men, Josefina Robertson, Maria Schaufelberger, Martin Lindgren, Martin Adiels, Linus Schiöler, Kjell Torén, John J. V. Mcmurray, Naveed Sattar, Maria Åberg, Annika Rosengren Jan 2019

Higher Body Mass Index In Adolescence Predicts Cardiomyopathy Risk In Midlife: Long-Term Follow-Up Among Swedish Men, Josefina Robertson, Maria Schaufelberger, Martin Lindgren, Martin Adiels, Linus Schiöler, Kjell Torén, John J. V. Mcmurray, Naveed Sattar, Maria Åberg, Annika Rosengren

Faculty of Health Sciences Publications

Background: Modifiable lifestyle factors in relation to risk for cardiomyopathy, a common and increasing cause of heart failure in the young, have not been widely studied. We sought to investigate a potential link between obesity, a recognized predictor of early heart failure, in adolescence and being diagnosed with cardiomyopathy in adulthood. Methods: This was a nationwide register-based prospective cohort study of 1 668 893 adolescent men (mean age, 18.3 years; SD, 0.7 years) who enlisted for compulsory military service from 1969 to 2005. At baseline, body mass index (BMI), blood pressure, and medical disorders were registered, along with ...


Diagnostic Tests, Drug Prescriptions, And Follow-Up Patterns After Incident Heart Failure: A Cohort Study Of 93,000 Uk Patients, Nathalie Conrad, Andrew Judge, Dexter Canoy, Jenny Tran, Johanna O'Donnell, Milad Nazarzadeh, Gholamreza Salimi-Khorshidi, Richard Hobbs, John G. Cleland, John J. V. Mcmurray, Kazem Rahimi Jan 2019

Diagnostic Tests, Drug Prescriptions, And Follow-Up Patterns After Incident Heart Failure: A Cohort Study Of 93,000 Uk Patients, Nathalie Conrad, Andrew Judge, Dexter Canoy, Jenny Tran, Johanna O'Donnell, Milad Nazarzadeh, Gholamreza Salimi-Khorshidi, Richard Hobbs, John G. Cleland, John J. V. Mcmurray, Kazem Rahimi

Faculty of Health Sciences Publications

Background Effective management of heart failure is complex, and ensuring evidence-based practice presents a major challenge to health services worldwide. Over the past decade, the United Kingdom introduced a series of national initiatives to improve evidence-based heart failure management, including a landmark pay-for-performance scheme in primary care and a national audit in secondary care started in 2004 and 2007, respectively. Quality improvement efforts have been evaluated within individual clinical settings, but patterns of care across its continuum, although a critical component of chronic disease management, have not been studied. We have designed this study to investigate patients’ trajectories of care ...


Health Care Professionals’ Perceptions Of Home Telemonitoring In Heart Failure Care: Cross-Sectional Survey, Ina Thon Aamodt, Edita Lycholip, Jelena Celutkiene, Anna Strömberg, Dan Atar, Ragnhild Sørum Falk, Thomas G. Von Lueder, Ragnhild Hellesø, Tiny Jaarsma, Irene Lie Jan 2019

Health Care Professionals’ Perceptions Of Home Telemonitoring In Heart Failure Care: Cross-Sectional Survey, Ina Thon Aamodt, Edita Lycholip, Jelena Celutkiene, Anna Strömberg, Dan Atar, Ragnhild Sørum Falk, Thomas G. Von Lueder, Ragnhild Hellesø, Tiny Jaarsma, Irene Lie

Faculty of Health Sciences Publications

Background: Noninvasive telemonitoring (TM) can be used in heart failure (HF) patients to perform early detection of decompensation at home, prevent unnecessary health care utilization, and decrease health care costs. However, the evidence is not sufficient to be part of HF guidelines for follow-up care, and we have no knowledge of how TM is used in the Nordic Baltic region. Objective: The aim of this study was to describe health care professionals’ (HCPs) perception of and presumed experience with noninvasive TM in daily HF patient care, perspectives of the relevance of and reasons for applying noninvasive TM, and barriers to ...


Income Inequality And Outcomes In Heart Failure, Pooja Dewan, Rasmus Rørth, Pardeep S. Jhund, Joao Pedro Ferreira, Faiez Zannad, Li Shen, Lars Køber, William T. Abraham, Akshay S. Desai, Kenneth Dickstein, Milton Packer, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Michael R. Zile, John J. V. Mcmurray Jan 2019

Income Inequality And Outcomes In Heart Failure, Pooja Dewan, Rasmus Rørth, Pardeep S. Jhund, Joao Pedro Ferreira, Faiez Zannad, Li Shen, Lars Køber, William T. Abraham, Akshay S. Desai, Kenneth Dickstein, Milton Packer, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Michael R. Zile, John J. V. Mcmurray

Faculty of Health Sciences Publications

Objectives This study examined the relationship between income inequality and heart failure outcomes. Background The income inequality hypothesis postulates that population health is influenced by income distribution within a society, with greater inequality associated with worse outcomes. Methods This study analyzed heart failure outcomes in 2 large trials conducted in 54 countries. Countries were divided by tertiles of Gini coefficients (where 0% represented absolute income equality and 100% represented absolute income inequality), and heart failure outcomes were adjusted for standard prognostic variables, country per capita income, education index, hospital bed density, and health worker density. Results Of the 15,126 ...


Diseases, Injuries, And Risk Factors In Child And Adolescent Health, 1990 To 2017: Findings From The Global Burden Of Diseases, Injuries, And Risk Factors 2017 Study, Robert C. Reiner, Helen Elizabeth Olsen, Chad Thomas Ikeda, Michelle M. Echko, Katherine E. Ballestreros, Helen Manguerra, Ira Martopullo, Anoushka Millear, Chloe Shields, Alison Smith, Bryan Strub, Molla Abebe, Zegeye Abebe, Beyene Meressa Adhena, Tara Ballav Adhikari, Mohammed Akibu, Rajaa M. Al-Raddadi, Nelson Alvis-Guzman, Carl Abelardo T. Antonio, Olatunde Aremu, Solomon Weldegebreal Asgedom, Netsanet Abera Asseffa, Leticia Avila-Burgos, Aleksandra Barac, Till W. Bärnighausen, Quique Bassat, Isabela M. Bensenor, Zulfiqar A. Bhutta, Ali Bijani, Karen Sliwa Jan 2019

Diseases, Injuries, And Risk Factors In Child And Adolescent Health, 1990 To 2017: Findings From The Global Burden Of Diseases, Injuries, And Risk Factors 2017 Study, Robert C. Reiner, Helen Elizabeth Olsen, Chad Thomas Ikeda, Michelle M. Echko, Katherine E. Ballestreros, Helen Manguerra, Ira Martopullo, Anoushka Millear, Chloe Shields, Alison Smith, Bryan Strub, Molla Abebe, Zegeye Abebe, Beyene Meressa Adhena, Tara Ballav Adhikari, Mohammed Akibu, Rajaa M. Al-Raddadi, Nelson Alvis-Guzman, Carl Abelardo T. Antonio, Olatunde Aremu, Solomon Weldegebreal Asgedom, Netsanet Abera Asseffa, Leticia Avila-Burgos, Aleksandra Barac, Till W. Bärnighausen, Quique Bassat, Isabela M. Bensenor, Zulfiqar A. Bhutta, Ali Bijani, Karen Sliwa

Faculty of Health Sciences Publications

Importance: Understanding causes and correlates of health loss among children and adolescents can identify areas of success, stagnation, and emerging threats and thereby facilitate effective improvement strategies. Objective: To estimate mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories. Design, Setting, and Participants: This study examined levels, trends, and spatiotemporal patterns of cause-specific mortality and nonfatal health outcomes using standardized approaches to data processing and statistical analysis. It also describes epidemiologic transitions by evaluating historical associations between disease indicators and the Socio-Demographic Index (SDI), a composite indicator of income ...


Extensive Undertreatment Of Osteoporosis In Older Swedish Women, Mattias Lorentzon, A. G. Nilsson, Helena Johansson, John A. Kanis, Dan Mellström, D. Sundh Jan 2019

Extensive Undertreatment Of Osteoporosis In Older Swedish Women, Mattias Lorentzon, A. G. Nilsson, Helena Johansson, John A. Kanis, Dan Mellström, D. Sundh

Faculty of Health Sciences Publications

Summary In a population-based study of older Swedish women, we investigated the proportion of women treated with osteoporosis medication in relation to the proportion of women eligible for treatment according to national guidelines. We found that only a minority (22%) of those eligible for treatment were prescribed osteoporosis medication. Introduction Fracture rates increase markedly in old age and the incidence of hip fracture in Swedish women is among the highest in the world. Although effective pharmacological treatment is available, treatment rates remain low. Limited data are available regarding treatment rates in relation to fracture risk in a population-based setting in ...


Patients With Prostate Cancer And Androgen Deprivation Therapy Have Increased Risk Of Fractures—A Study From The Fractures And Fall Injuries In The Elderly Cohort (Frailco), M. Wallander, K. F. Axelsson, D. Lundh, Mattias Lorentzon Jan 2019

Patients With Prostate Cancer And Androgen Deprivation Therapy Have Increased Risk Of Fractures—A Study From The Fractures And Fall Injuries In The Elderly Cohort (Frailco), M. Wallander, K. F. Axelsson, D. Lundh, Mattias Lorentzon

Faculty of Health Sciences Publications

Summary Osteoporosis is a common complication of androgen deprivation therapy (ADT). In this large Swedish cohort study consisting of a total of nearly 180,000 older men, we found that those with prostate cancer and ADT have a significantly increased risk of future osteoporotic fractures. Introduction: Androgen deprivation therapy (ADT) in patients with prostate cancer is associated to increased risk of fractures. In this study, we investigated the relationship between ADT in patients with prostate cancer and the risk of incident fractures and non-skeletal fall injuries both compared to those without ADT and compared to patients without prostate cancer. Methods ...


Prognostic Implications Of Changes In Amino-Terminal Pro–B-Type Natriuretic Peptide In Acute Decompensated Heart Failure: Insights From Ascend-Hf [Accepted Manuscript], Justin L. Grodin, Max J. Liebo, Javed Butler, Marco Metra, G. Michael Felker, Adrian F. Hernandez, Adriaan A. Voors, John J. V. Mcmurray, Paul W. Armstrong, Christopher M. O'Connor, Randall C. Starling, Richard W. Troughton, W. H. Wilson Tang Jan 2019

Prognostic Implications Of Changes In Amino-Terminal Pro–B-Type Natriuretic Peptide In Acute Decompensated Heart Failure: Insights From Ascend-Hf [Accepted Manuscript], Justin L. Grodin, Max J. Liebo, Javed Butler, Marco Metra, G. Michael Felker, Adrian F. Hernandez, Adriaan A. Voors, John J. V. Mcmurray, Paul W. Armstrong, Christopher M. O'Connor, Randall C. Starling, Richard W. Troughton, W. H. Wilson Tang

Faculty of Health Sciences Publications

Background: Amino-terminal pro–B-type natriuretic peptide (NTproBNP) is closely associated with prognosis in acute decompensated heart failure (ADHF). As a result, there has been great interest measuring it during the course of treatment. The prognostic implications in both short-term and follow-up changes in NTproBNP need further clarification. Methods: Baseline, 48–72 hour, and 30-day NTproBNP levels were measured in 795 subjects in the ASCEND-HF trial. Multivariable logistic and Cox-proportional hazards models were used to test the association between static, relative, and absolute changes in NTproBNP with outcomes during and after ADHF. Results: The median NTproBNP at baseline was 5773 (2981 ...


The Effect Of Minimally Invasive Surgical Aortic Valve Replacement On Postoperative Pulmonary And Skeletal Muscle Function [Accepted Manuscript], Hajar Boujemaa, Alaaddin Yilmaz, Boris Robic, Katrien Koppo, Guido Claessen, Ines Frederix, Paul Dendale, Heinz Völler, Luc J. C. Van Loon, Dominique Hansen Jan 2019

The Effect Of Minimally Invasive Surgical Aortic Valve Replacement On Postoperative Pulmonary And Skeletal Muscle Function [Accepted Manuscript], Hajar Boujemaa, Alaaddin Yilmaz, Boris Robic, Katrien Koppo, Guido Claessen, Ines Frederix, Paul Dendale, Heinz Völler, Luc J. C. Van Loon, Dominique Hansen

Faculty of Health Sciences Publications

Suboptimal post‐operative improvements in functional capacity are often observed after minimally invasive aortic valve replacement (mini‐AVR). It remains to be studied how AVR affects the cardiopulmonary and skeletal muscle function during exercise to explain these clinical observations and to provide a basis for improved/tailored post‐operative rehabilitation. Twenty‐two patients with severe aortic stenosis (AS) (aortic valve area (AVA) <1.0 cm²) were pre‐operatively compared to 22 healthy controls during submaximal constant‐workload endurance‐type exercise for oxygen uptake (urn:x-wiley:09580670:media:eph12495:eph12495-math-0001), carbon dioxide output (urn:x-wiley:09580670:media:eph12495:eph12495-math-0002), respiratory gas exchange ratio, expiratory volume (urn:x-wiley:09580670:media:eph12495:eph12495-math-0003), ventilatory equivalents for O2 (urn:x-wiley:09580670:media:eph12495:eph12495-math-0004/urn:x-wiley:09580670:media:eph12495:eph12495-math-0005) and CO2 (urn:x-wiley:09580670:media:eph12495:eph12495-math-0006/urn:x-wiley:09580670:media:eph12495:eph12495-math-0007), respiratory rate (RR), tidal volume (Vt), heart rate (HR), oxygen pulse (urn:x-wiley:09580670:media:eph12495:eph12495-math-0008/HR), blood lactate, Borg ratings of perceived exertion (RPE) and exercise‐onset urn:x-wiley:09580670:media:eph12495:eph12495-math-0009 kinetics. These exercise tests were repeated at 5 and 21 days after AVR surgery (n = 14), along with echocardiographic examinations. Respiratory exchange ratio and ventilatory equivalents (urn:x-wiley:09580670:media:eph12495:eph12495-math-0010/urn:x-wiley:09580670:media:eph12495:eph12495-math-0011 and urn:x-wiley:09580670:media:eph12495:eph12495-math-0012/urn:x-wiley:09580670:media:eph12495:eph12495-math-0013) were significantly elevated, urn:x-wiley:09580670:media:eph12495:eph12495-math-0014 and urn:x-wiley:09580670:media:eph12495:eph12495-math-0015/HR were significantly lowered, and exercise‐onset urn:x-wiley:09580670:media:eph12495:eph12495-math-0016 kinetics were significantly slower in AS patients vs. healthy controls (P < 0.05). Although the AVA was restored by mini‐AVR in AS patients, urn:x-wiley:09580670:media:eph12495:eph12495-math-0017/urn:x-wiley:09580670:media:eph12495:eph12495-math-0018 and urn:x-wiley:09580670:media:eph12495:eph12495-math-0019/urn:x-wiley:09580670:media:eph12495:eph12495-math-0020 further worsened significantly within 5 days after surgery, accompanied by elevations in Borg RPE, urn:x-wiley:09580670:media:eph12495:eph12495-math-0021 and RR, and lowered Vt. At 21 days after mini‐AVR, exercise‐onset urn:x-wiley:09580670:media:eph12495:eph12495-math-0022 kinetics further slowed significantly (P < 0.05). A decline in pulmonary function was observed early after mini‐AVR surgery, which was followed by a decline in skeletal muscle function in the subsequent weeks of recovery. Therefore, a tailored rehabilitation programme should include training modalities for the respiratory and peripheral muscular system.


A Novel Device To Assess Hip Strength: Concurrent Validity And Normative Values In Male Athletes [Accepted Manuscript], Michael O'Brien, Matthew N. Bourne, Joshua Heerey, Ryan Gregory Timmins, Tania Pizzari Jan 2019

A Novel Device To Assess Hip Strength: Concurrent Validity And Normative Values In Male Athletes [Accepted Manuscript], Michael O'Brien, Matthew N. Bourne, Joshua Heerey, Ryan Gregory Timmins, Tania Pizzari

Faculty of Health Sciences Publications

Objectives

To assess concurrent validity of the new, novel externally-fixed dynamometer (GroinBar) with hand-held dynamometry (HHD); to provide normative GroinBar scores for elite Australian rules football (AFL) and football (Soccer) players; and to evaluate preliminary predictive validity of the GroinBar and HHD in this population by comparing strength results with patient-reported outcome scores.

Design

Cross-sectional and reliability study

Participants

Total of 67 athletes, 36 AFL players and 31 football (Soccer) players

Setting

Elite AFL and football (Soccer) teams

Main Outcome Measures The GroinBar system, HHD, The Copenhagen Hip and Groin Outcome Score (HAGOS) Questionnaire.

Results

Moderate to good correlations were ...


A Trial To Evaluate The Effect Of The Sodium-Glucose Co-Transporter 2 Inhibitor Dapagliflozin On Morbidity And Mortality In Patients With Heart Failure And Reduced Left Ventricular Ejection Fraction (Dapa-Hf), John J. V. Mcmurray, David L. Demets, Silvio E. Inzucchini, Lars Køber, Mikhail N. Kosiborod, Anna M. Langkilde, Felipe A. Martinez, Olof Bengtsson, Piotr P. Ponikowski, Marc S. Sabatine, Mikaela Sjöstrand, Scott D. Solomon Jan 2019

A Trial To Evaluate The Effect Of The Sodium-Glucose Co-Transporter 2 Inhibitor Dapagliflozin On Morbidity And Mortality In Patients With Heart Failure And Reduced Left Ventricular Ejection Fraction (Dapa-Hf), John J. V. Mcmurray, David L. Demets, Silvio E. Inzucchini, Lars Køber, Mikhail N. Kosiborod, Anna M. Langkilde, Felipe A. Martinez, Olof Bengtsson, Piotr P. Ponikowski, Marc S. Sabatine, Mikaela Sjöstrand, Scott D. Solomon

Faculty of Health Sciences Publications

Background Sodium–glucose co‐transporter 2 (SGLT2) inhibitors have been shown to reduce the risk of incident heart failure hospitalization in individuals with type 2 diabetes who have, or are at high risk of, cardiovascular disease. Most patients in these trials did not have heart failure at baseline and the effect of SGLT2 inhibitors on outcomes in individuals with established heart failure (with or without diabetes) is unknown. Design and methods The Dapagliflozin And Prevention of Adverse‐outcomes in Heart Failure trial (DAPA‐HF) is an international, multicentre, parallel group, randomized, double‐blind, study in patients with chronic heart failure ...


Associations Of Neighborhood Walkability With Sedentary Time In Nigerian Older Adults, Adewale L. Oyeyemi, Sanda M. Kolo, Adamu A. Rufai, Adetoyeje Y. Oyeyemi, Babatunji A. Omotara, James F. Sallis Jan 2019

Associations Of Neighborhood Walkability With Sedentary Time In Nigerian Older Adults, Adewale L. Oyeyemi, Sanda M. Kolo, Adamu A. Rufai, Adetoyeje Y. Oyeyemi, Babatunji A. Omotara, James F. Sallis

Faculty of Health Sciences Publications

Previous studies have investigated the potential role of neighborhood walkability in reducing sedentary behavior. However, the majority of this research has been conducted in adults and Western developed countries. The purpose of the present study was to examine associations of neighborhood environmental attributes with sedentary time among older adults in Nigeria. Data from 353 randomly-selected community-dwelling older adults (60 years and above) in Maiduguri, Nigeria were analyzed. Perceived attributes of neighborhood environments and self-reported sedentary time were assessed using Nigerian-validated and reliable measures. Outcomes were weekly minutes of total sedentary time, minutes of sitting on a typical weekday, and minutes ...


Energy Availability In Athletics: Health, Performance, And Physique, Anna K. Melin, Ida A. Heikura, Adam S. Tenforde, Margo Mountjoy Jan 2019

Energy Availability In Athletics: Health, Performance, And Physique, Anna K. Melin, Ida A. Heikura, Adam S. Tenforde, Margo Mountjoy

Faculty of Health Sciences Publications

The reported prevalence of low energy availability (LEA) in female and male track and field athletes is between 18% and 58% with the highest prevalence among athletes in endurance and jump events. In male athletes, LEA may result in reduced testosterone levels and libido along with impaired training capacity. In female track and field athletes, functional hypothalamic amenorrhea as consequence of LEA has been reported among 60% of elite middle- and long-distance athletes and 23% among elite sprinters. Health concerns with functional hypothalamic amenorrhea include impaired bone health, elevated risk for bone stress injury, and cardiovascular disease. Furthermore, LEA negatively ...


Expanding The Map Of Intrinsic And Extrinsic Aspirations Using Network Analysis And Multidimensional Scaling: Examining Four New Aspirations, Frank Martela, Emma L. Bradshaw, Richard M. Ryan Jan 2019

Expanding The Map Of Intrinsic And Extrinsic Aspirations Using Network Analysis And Multidimensional Scaling: Examining Four New Aspirations, Frank Martela, Emma L. Bradshaw, Richard M. Ryan

Faculty of Health Sciences Publications

Life goals or aspirations can be distinguished as intrinsic or extrinsic, with different implications for well-being. In this study we used network analysis to reexamine this intrinsic-extrinsic distinction, illustrating how novel candidate aspirations can be mapped along this dimension using innovative methods. We identify four previously unexamined life aspirations, predicting that aspiring for power and social adherence would group with extrinsic goals, whereas aspiring for self-expression and mastery would group with intrinsic goals. In two samples (n = 196; n = 346) we analyze both the original life-goal variables and these novel aspirations using factor analysis, multidimensional scaling, circumplex modeling, and a ...


Expoapp: An Integrated System To Assess Multiple Personal Environmental Exposures, David Donaire-Gonzalez, Antònia Valentín, Erik Van Nunen, Ariadna Curto, Albert Rodriguez, Mario Fernandez-Nieto, Alessio Naccarati, Sonia Tarallo, Ming-Yi Tsai, Nicole M. Probst-Hensch, Roel Vermeulen, Gerard Hoek, Paolo Vineis, John Gulliver, Mark J. Nieuwenhuijsen Jan 2019

Expoapp: An Integrated System To Assess Multiple Personal Environmental Exposures, David Donaire-Gonzalez, Antònia Valentín, Erik Van Nunen, Ariadna Curto, Albert Rodriguez, Mario Fernandez-Nieto, Alessio Naccarati, Sonia Tarallo, Ming-Yi Tsai, Nicole M. Probst-Hensch, Roel Vermeulen, Gerard Hoek, Paolo Vineis, John Gulliver, Mark J. Nieuwenhuijsen

Faculty of Health Sciences Publications

To assess environmental exposures at the individual level, new assessment methods and tools are required. We developed an exposure assessment system (ExpoApp) for smartphones. ExpoApp integrates: (i) geo-location and accelerometry measurements from a waist attached smartphone, (ii) data from portable monitors, (iii) geographic information systems, and (iv) individual's information. ExpoApp calculates time spent in microenvironments, physical activity level, inhalation rate, and environmental exposures and doses (e.g., green spaces, inhaled ultrafine particles- UFP). We deployed ExpoApp in a panel study of 158 adults from five cities (Amsterdam and Utrecht- the Netherlands, Basel- Switzerland, Norwich- UK, and Torino- Italy) with ...


Hemopoietic Cell Kinase Amplification With Protein Tyrosine Phosphatase Receptor T Depletion Leads To Polycythemia, Aberrant Marrow Erythoid Maturation, And Splenomegaly, Matthew Ku, Ruth N. Mackinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J. Campbell, Louise E. Purton, Harshal Nandurkar Jan 2019

Hemopoietic Cell Kinase Amplification With Protein Tyrosine Phosphatase Receptor T Depletion Leads To Polycythemia, Aberrant Marrow Erythoid Maturation, And Splenomegaly, Matthew Ku, Ruth N. Mackinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J. Campbell, Louise E. Purton, Harshal Nandurkar

Faculty of Health Sciences Publications

Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological malignancies. It is detected in 10% of myeloproliferative neoplasms, 4–5% of myelodysplastic syndromes, and 1–2% of acute myeloid leukaemia. Recurrent, non-random occurrence of del(20q) indicates that it is a pathogenic driver in myeloid malignancies. Genetic mapping of patient samples has identified two regions of interest on 20q – the “Common Deleted Region” (CDR) and “Common Retained Region” (CRR), which was often amplified. We proposed that the CDR contained tumor suppressor gene(s) (TSG) and the CRR harbored oncogene(s ...


Influence Of The Urban Exposome On Birth Weight, Mark J. Nieuwenhuijsen, Lydiane Agier, Xavier Basagaña, Jose Urquiza, Ibon Tamayo-Uria, Lise Giorgis-Allemand, Oliver Robinson, Valérie Siroux, Léa Maitre, Montserrat De Castro, Antonia Valentin, David Donaire, Payam Dadvand, Gunn Marit Aasvang, Norun Hjertager Krog, Per E. Schwarze, Leda Chatzi, Regina Grazuleviciene, Sandra Andrusaityte, Audrius Dedele, Rosie Mceachan, John Wright, Jane West, Jesús Ibarluzea, Ferran Ballester, Martine Vrijheid, Remy Slama Jan 2019

Influence Of The Urban Exposome On Birth Weight, Mark J. Nieuwenhuijsen, Lydiane Agier, Xavier Basagaña, Jose Urquiza, Ibon Tamayo-Uria, Lise Giorgis-Allemand, Oliver Robinson, Valérie Siroux, Léa Maitre, Montserrat De Castro, Antonia Valentin, David Donaire, Payam Dadvand, Gunn Marit Aasvang, Norun Hjertager Krog, Per E. Schwarze, Leda Chatzi, Regina Grazuleviciene, Sandra Andrusaityte, Audrius Dedele, Rosie Mceachan, John Wright, Jane West, Jesús Ibarluzea, Ferran Ballester, Martine Vrijheid, Remy Slama

Faculty of Health Sciences Publications

Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life. Objective: We evaluated the association of the urban exposome with birth weight. Methods: We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either ...


Long-Term Impacts Of Prenatal And Infant Exposure To Fine Particulate Matter On Wheezing And Asthma, Jingyi Shao, Amanda J. Wheeler, Graeme R. Zosky, Fay H. Johnston Jan 2019

Long-Term Impacts Of Prenatal And Infant Exposure To Fine Particulate Matter On Wheezing And Asthma, Jingyi Shao, Amanda J. Wheeler, Graeme R. Zosky, Fay H. Johnston

Faculty of Health Sciences Publications

Background: This systematic review aimed to summarize epidemiologic evidence regarding long-term effects of prenatal and infant particulate matter with an aerodynamic diameter less than 2.5 [micro]m (PM2.5) exposure on wheezing and asthma. Methods: Epidemiologic data investigating the associations between ambient PM2.5 exposures during prenatal or the first 2 years of life and wheezing or asthma throughout life were extracted from five databases. All included studies were assessed according to the Critical Appraisal Skills Programme checklists. We performed meta-analyses if >=2 studies estimated the effects of continuous PM2.5. Results: Nine of 18 eligible studies were suitable ...


Physical Activity Is Associated With Attenuated Disease Progression In Chronic Obstructive Disease [Accepted Manuscript], Heleen Demeyer, David Donaire-Gonzalez, Elena Gimeno-Santos, Maria A. Ramon, Jordie De Battle, Marta Benet, Ignasi Serra, Stefano Guerra, Eva Farrero, Esther Rodriguez, Jaume Ferrer, Jaume Sauleda, Eduard Monso, Joaquim Gea, Robert Rodriguez-Roisin, Alvar Agusti, Josep M. Antó, Judith Garcia-Aymerich Jan 2019

Physical Activity Is Associated With Attenuated Disease Progression In Chronic Obstructive Disease [Accepted Manuscript], Heleen Demeyer, David Donaire-Gonzalez, Elena Gimeno-Santos, Maria A. Ramon, Jordie De Battle, Marta Benet, Ignasi Serra, Stefano Guerra, Eva Farrero, Esther Rodriguez, Jaume Ferrer, Jaume Sauleda, Eduard Monso, Joaquim Gea, Robert Rodriguez-Roisin, Alvar Agusti, Josep M. Antó, Judith Garcia-Aymerich

Faculty of Health Sciences Publications

Introduction: Chronic obstructive pulmonary disease (COPD) progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength, and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression. Methods: We studied 114 COPD patients from the PAC-COPD cohort (94% male, mean [SD], 70 yr [8 yr] of age, 54 [16] forced expiratory volume in 1 s % predicted) at baseline and 2.6 yr (0.6 yr) later. Baseline PA was assessed by accelerometry. Multivariable general ...


Sacubitril/Valsartan In Asian Patients With Heart Failure With Reduced Ejection Fraction, Pooja Dewan, Kieran F. Docherty, John J. V. Mcmurray Jan 2019

Sacubitril/Valsartan In Asian Patients With Heart Failure With Reduced Ejection Fraction, Pooja Dewan, Kieran F. Docherty, John J. V. Mcmurray

Faculty of Health Sciences Publications

The Prospective comparison of Angiotensin Receptor-neprilysin inhibitor (ARNI) with Angiotensin converting enzyme inhibitor (ACEI) to Determine Impact on Global Mortality and morbidity in Heart Failure (HF) trial (PARADIGM-HF) showed that adding a neprilysin inhibitor (sacubitril) to a renin-angiotensin system blocker (and other standard therapy) reduced morbidity and mortality in ambulatory patients with chronic HF with reduced ejection fraction (HFrEF). In PARADIGM-HF, valsartan combined with sacubitril (a so-called ARNI) was superior to the current gold standard of an ACEI, specifically enalapril, reducing the risk of the primary composite outcome of cardiovascular (CV) death or first HF hospitalization by 20% and all-cause ...


Single-Dose Prednisolone Alters Endocrine And Haematologic Responses And Exercise Performance In Men, Alexander Tacey, Lewan Parker, Bu B. Yeap, John Joseph, Ee Mun Lim, Andrew Garnham, David L. Hare, Tara C. Brennan-Speranza, Itamar Levinger Jan 2019

Single-Dose Prednisolone Alters Endocrine And Haematologic Responses And Exercise Performance In Men, Alexander Tacey, Lewan Parker, Bu B. Yeap, John Joseph, Ee Mun Lim, Andrew Garnham, David L. Hare, Tara C. Brennan-Speranza, Itamar Levinger

Faculty of Health Sciences Publications

The aim of this study was to investigate the effect of a single dose of prednisolone on (A) high-intensity interval cycling performance and (B) post-exercise metabolic, hormonal and haematological responses. Nine young men participated in this double-blind, randomised, cross-over study. The participants completed exercise sessions (4 × 4 min cycling bouts at 90–95% of peak heart rate), 12 h after ingesting prednisolone (20 mg) or placebo. Work load was adjusted to maintain the same relative heart rate between the sessions. Exercise performance was measured as total work performed. Blood samples were taken at rest, immediately post exercise and up to ...


Special Environments: Altitude And Heat, Philo U. Saunders, Laura A. Garvican-Lewis, Robert F. Chapman, Julien D. Périard Jan 2019

Special Environments: Altitude And Heat, Philo U. Saunders, Laura A. Garvican-Lewis, Robert F. Chapman, Julien D. Périard

Faculty of Health Sciences Publications

High-level athletes are always looking at ways to maximize training adaptations for competition performance, and using altered environmental conditions to achieve this outcome has become increasingly popular by elite athletes. Furthermore, a series of potential nutrition and hydration interventions may also optimize the adaptation to altered environments. Altitude training was first used to prepare for competition at altitude, and it still is today; however, more often now, elite athletes embark on a series of altitude training camps to try to improve sea-level performance. Similarly, the use of heat acclimation/acclimatization to optimize performance in hot/humid environmental conditions is a ...


Systematic Literature Review Of Health Impact Assessments In Low And Middle-Income Countries, Meelan Thondoo, David Rojas-Rueda, Joyeeta Gupta, Daniel H. De Vries, Mark J. Nieuwenhuijsen Jan 2019

Systematic Literature Review Of Health Impact Assessments In Low And Middle-Income Countries, Meelan Thondoo, David Rojas-Rueda, Joyeeta Gupta, Daniel H. De Vries, Mark J. Nieuwenhuijsen

Faculty of Health Sciences Publications

Health Impact Assessments (HIAs) motivate effective measures for safeguarding public health. There is consensus that HIAs in low and middle-income countries (LMICs) are lacking, but no study systematically focuses on those that have been successfully conducted across all regions of the world, nor do they highlight factors that may enable or hinder their implementation. Our objectives are to (1) systematically review, geographically map, and characterize HIA activity in LMICs; and (2) apply a process evaluation method to identify factors which are important to improve HIA implementation in LMICs. A systematic review of peer-reviewed HIAs in 156 LMICs was performed in ...


The Longitudinal Association Between Natural Outdoor Environments And Mortality In 9218 Older Men From Perth, Western Australia, Wilma L. Zijlema, Ania Stasinska, David Blake, Mila Dirgawati, Leon Flicker, Bu B. Yeap, Jonathan Golledge, Graeme J. Hankey, Mark Nieuwenhuijsen, Jane S. Heyworth Jan 2019

The Longitudinal Association Between Natural Outdoor Environments And Mortality In 9218 Older Men From Perth, Western Australia, Wilma L. Zijlema, Ania Stasinska, David Blake, Mila Dirgawati, Leon Flicker, Bu B. Yeap, Jonathan Golledge, Graeme J. Hankey, Mark Nieuwenhuijsen, Jane S. Heyworth

Faculty of Health Sciences Publications

Background/Aim Natural outdoor environments may mitigate harmful environmental factors associated with city living. We studied the longitudinal relationship between natural (‘green and blue’) outdoor environments and mortality in a cohort of older men residing in Perth, Western Australia. Methods We studied a cohort of 9218 men aged 65 years and older from the Health In Men Study. Participants were recruited in 1996–99 and followed until 2014, during which 5889 deaths were observed. Time-varying residential surrounding greenness based on the Normalized Difference Vegetation Index, and the number and size of parks, natural space and waterbodies were defined to characterize ...


Trial Feasibility And Process Evaluation Of A Motivationally-Embellished Group Peer Led Walking Intervention In Retirement Villages Using The Re-Aim Framework: The Residents In Action Trial (Riat), Cecilie Thøgersen-Ntoumani, Eleanor Quested, Stuart J. H. Biddle, Marlene Kritz, Jenny Olson, Elissa Burton, Ester Cerin, Keith D. Hill, Joanne A. Mcveigh, Nikos Ntoumanis Jan 2019

Trial Feasibility And Process Evaluation Of A Motivationally-Embellished Group Peer Led Walking Intervention In Retirement Villages Using The Re-Aim Framework: The Residents In Action Trial (Riat), Cecilie Thøgersen-Ntoumani, Eleanor Quested, Stuart J. H. Biddle, Marlene Kritz, Jenny Olson, Elissa Burton, Ester Cerin, Keith D. Hill, Joanne A. Mcveigh, Nikos Ntoumanis

Faculty of Health Sciences Publications

Objective: The Residents in Action Trial (RiAT; ACTRN12616001177448) was a 16-week motivationally-embellished peer-led walking intervention designed to increase walking, reduce sitting, and improve mental health and well-being in insufficiently active residents in retirement villages. In this paper we report on 1) trial feasibility and acceptability, and 2) evaluate the processes involved in the implementation of the intervention using the RE-AIM framework. Method: A mixed methods design was employed, consisting of data from accelerometers, surveys, (individual, pair-based and focus group) interviews, and participant logbooks. Participants included 116 walkers (M(SD) age = 78.37(8.30); 92% female), 8 peer leaders (i ...


Winter Peaks In Heart Failure: An Inevitable Or Preventable Consequence Of Seasonal Vulnerability?, Simon Stewart, Trine T. Moholdt, Louise M. Burrell, Karen Sliwa, Ana O. Mocumbi, John J. V. Mcmurray, Ashley K. Keates, John A. Hawley Jan 2019

Winter Peaks In Heart Failure: An Inevitable Or Preventable Consequence Of Seasonal Vulnerability?, Simon Stewart, Trine T. Moholdt, Louise M. Burrell, Karen Sliwa, Ana O. Mocumbi, John J. V. Mcmurray, Ashley K. Keates, John A. Hawley

Faculty of Health Sciences Publications

Climate change is a major contributor to annual winter peaks in cardiovascular events across the globe. However, given the paradoxical observation that cardiovascular seasonality is observed in relatively mild as well as cold climates, global warming may not be as positive for the syndrome of heart failure (HF) as some predict. In this article, we present our Model of Seasonal Flexibility to explain the spectrum of individual responses to climatic conditions. We have identified distinctive phenotypes of resilience and vulnerability to explain why winter peaks in HF occur. Moreover, we identify how better identification of climatic vulnerability and the use ...


Australian Nurses' Knowledge Of Pressure Injury Prevention And Management: A Cross-Sectional Survey, Paul Fulbrook, Petra Lawrence, Sandra Miles Jan 2019

Australian Nurses' Knowledge Of Pressure Injury Prevention And Management: A Cross-Sectional Survey, Paul Fulbrook, Petra Lawrence, Sandra Miles

Faculty of Health Sciences Publications

Purpose: The aim of this study was to assess nurses' knowledge of pressure injuries in order to gather benchmark data, identify knowledge gaps, and based on results, implement educational strategies to improve practice. Design: Cross-sectional survey. Subjects and setting: The study setting was a large Australian tertiary general hospital employing approximately 2500 nurses in both full-time and part-time roles. A proportional sample (25%) stratified by experience, preparation, and facility-generated categories (nursing grade) was generated. The sample included nursing students and nursing assistants. Three hundred six participants completing the survey. Instrument: The Pieper-Zulkowski Pressure Ulcer Knowledge Test (PZPUKT) version 2, comprising ...


Effects Of A Short Residential Thermal Spa Program To Prevent Work-Related Stress/Burnout On Stress Biomarkers: The Thermstress Proof Of Concept Study, Frederic Dutheil, Elodie Chaplais, Audrey Vilmant, Denise Lanoir, Daniel Courteix, Pascale Duche, Armand Abergel, Daniela M. Pfabigan, Shihui Han, Laurie Mondillon, Guillaume Vallet, Martial Mermillod, Gil Boudet, Phillippe Obert, Omar Izem, Yves Boirie, Bruno Pereira, Francois-Xavier Lesage Jan 2019

Effects Of A Short Residential Thermal Spa Program To Prevent Work-Related Stress/Burnout On Stress Biomarkers: The Thermstress Proof Of Concept Study, Frederic Dutheil, Elodie Chaplais, Audrey Vilmant, Denise Lanoir, Daniel Courteix, Pascale Duche, Armand Abergel, Daniela M. Pfabigan, Shihui Han, Laurie Mondillon, Guillaume Vallet, Martial Mermillod, Gil Boudet, Phillippe Obert, Omar Izem, Yves Boirie, Bruno Pereira, Francois-Xavier Lesage

Faculty of Health Sciences Publications

Objective Work-related stress is a public health issue. Stress has multiple physical and psychological consequences, the most serious of which are increased mortality and cardiovascular morbidity. The ThermStress protocol was designed to offer a short residential thermal spa program for work-related stress prevention that is compatible with a professional context. Methods Participants will be 56 male and female workers aged 18 years or above. All participants will undergo a 6-day residential spa program comprising psychological intervention, physical activity, thermal spa treatment, health education, eating disorder therapy and a follow-up. On six occasions, participants’ heart rate variability, cardiac remodelling and function ...