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Epidemiology Of Hip Fractures In Bulgaria: Development Of A Country-Specific Frax Model, E. Kirilova, H. Johansson, N. Kirilov, S. Vladeva, T. Petranova, Z. Kolarov, E. Liu, M. Lorentzon, L. Vandenput, N. C. Harvey, E. Mccloskey, John A. Kanis Jan 2020

Epidemiology Of Hip Fractures In Bulgaria: Development Of A Country-Specific Frax Model, E. Kirilova, H. Johansson, N. Kirilov, S. Vladeva, T. Petranova, Z. Kolarov, E. Liu, M. Lorentzon, L. Vandenput, N. C. Harvey, E. Mccloskey, John A. Kanis

Faculty of Health Sciences Publications

Summary: A retrospective population-based survey was undertaken in a region of Bulgaria to determine the incidence of hip fracture. The estimated number of hip fractures nationwide for 2015 was 9322 and is predicted to increase to 11,398 in 2050. The hip fracture rates were used to create a FRAX model. Objective: To describe the epidemiology of hip fractures in Bulgaria, which was then used to develop the country-specific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in Stara Zagora, Bulgaria, representing approximately 4.6% of the country’s population. We identified hip fractures occurring in ...


Bmd-Related Genetic Risk Scores Predict Site-Specific Fractures As Well As Trabecular And Cortical Bone Microstructure, Maria Nethander, Ulrika Pettersson-Kymmer, Liesbeth Vandenput, Mattias Lorentzon, Magnus Karlsson, Dan Mellström, Claes Ohlsson Jan 2020

Bmd-Related Genetic Risk Scores Predict Site-Specific Fractures As Well As Trabecular And Cortical Bone Microstructure, Maria Nethander, Ulrika Pettersson-Kymmer, Liesbeth Vandenput, Mattias Lorentzon, Magnus Karlsson, Dan Mellström, Claes Ohlsson

Faculty of Health Sciences Publications

Context: It is important to identify patients at highest risk of fractures. Objective: To compare the separate and combined performances of bone-related genetic risk scores (GRSs) for prediction of forearm, hip and vertebral fractures separately, as well as of trabecular and cortical bone microstructure parameters separately. Design, Setting, and Participants: Using 1103 single nucleotide polymorphisms (SNPs) independently associated with estimated bone mineral density of the heel (eBMD), we developed a weighted GRS for eBMD and determined its contribution to fracture prediction beyond 2 previously developed GRSs for femur neck BMD (49 SNPs) and lumbar spine BMD (48 SNPs). Associations between ...


Patients With Prostate Cancer And Androgen Deprivation Therapy Have Increased Risk Of Fractures—A Study From The Fractures And Fall Injuries In The Elderly Cohort (Frailco), M. Wallander, K. F. Axelsson, D. Lundh, Mattias Lorentzon Jan 2019

Patients With Prostate Cancer And Androgen Deprivation Therapy Have Increased Risk Of Fractures—A Study From The Fractures And Fall Injuries In The Elderly Cohort (Frailco), M. Wallander, K. F. Axelsson, D. Lundh, Mattias Lorentzon

Faculty of Health Sciences Publications

Summary Osteoporosis is a common complication of androgen deprivation therapy (ADT). In this large Swedish cohort study consisting of a total of nearly 180,000 older men, we found that those with prostate cancer and ADT have a significantly increased risk of future osteoporotic fractures. Introduction: Androgen deprivation therapy (ADT) in patients with prostate cancer is associated to increased risk of fractures. In this study, we investigated the relationship between ADT in patients with prostate cancer and the risk of incident fractures and non-skeletal fall injuries both compared to those without ADT and compared to patients without prostate cancer. Methods ...


Increased Autophagy In Ephrinb2-Deficient Osteocytes Is Associated With Elevated Secondary Mineralization And Brittle Bone, Christina Vrahnas, Martha Blank, Toby A. Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Huynh Nguyen, Mark R. Forwood, Yifang Hu, Mike Ikegame, Keith R. Bambery, Cyril Petibois, Eleanor J. Mackie, Mark J. Tobin, Gordon K. Smyth, Jonathan S. Oakhill, T. John Martin, Natalie A. Sims Jan 2019

Increased Autophagy In Ephrinb2-Deficient Osteocytes Is Associated With Elevated Secondary Mineralization And Brittle Bone, Christina Vrahnas, Martha Blank, Toby A. Dite, Liliana Tatarczuch, Niloufar Ansari, Blessing Crimeen-Irwin, Huynh Nguyen, Mark R. Forwood, Yifang Hu, Mike Ikegame, Keith R. Bambery, Cyril Petibois, Eleanor J. Mackie, Mark J. Tobin, Gordon K. Smyth, Jonathan S. Oakhill, T. John Martin, Natalie A. Sims

Faculty of Health Sciences Publications

Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly (secondary mineralization) until bone is remodeled. The interconnected osteocyte network within the bone matrix differentiates from bone-forming osteoblasts; although osteoblast differentiation requires EphrinB2, osteocytes retain its expression. Here we report brittle bones in mice with osteocyte-targeted EphrinB2 deletion. This is not caused by low bone mass, but by defective bone material. While osteoid mineralization is initiated at normal rate, mineral accrual is accelerated, indicating that EphrinB2 in osteocytes limits mineral accumulation. No known regulators of mineralization are modified in the brittle cortical ...


Pubertal Timing And Adult Fracture Risk In Men: A Population-Based Cohort Study, Liesbeth Vandenput, Jenny M. Kindblom, Maria Bygdell, Maria Nethander, Claes Ohlsson Jan 2019

Pubertal Timing And Adult Fracture Risk In Men: A Population-Based Cohort Study, Liesbeth Vandenput, Jenny M. Kindblom, Maria Bygdell, Maria Nethander, Claes Ohlsson

Faculty of Health Sciences Publications

Background: Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak height velocity (PHV), an objective measure of pubertal timing, and fracture risk in adult men. Methods and findings: In the BMI Epidemiology Study Gothenburg, 31,971 Swedish men born between January 1, 1945, and December 31, 1961, with detailed growth data (height and weight) available from centrally ...


Extensive Undertreatment Of Osteoporosis In Older Swedish Women, Mattias Lorentzon, A. G. Nilsson, Helena Johansson, John A. Kanis, Dan Mellström, D. Sundh Jan 2019

Extensive Undertreatment Of Osteoporosis In Older Swedish Women, Mattias Lorentzon, A. G. Nilsson, Helena Johansson, John A. Kanis, Dan Mellström, D. Sundh

Faculty of Health Sciences Publications

Summary In a population-based study of older Swedish women, we investigated the proportion of women treated with osteoporosis medication in relation to the proportion of women eligible for treatment according to national guidelines. We found that only a minority (22%) of those eligible for treatment were prescribed osteoporosis medication. Introduction Fracture rates increase markedly in old age and the incidence of hip fracture in Swedish women is among the highest in the world. Although effective pharmacological treatment is available, treatment rates remain low. Limited data are available regarding treatment rates in relation to fracture risk in a population-based setting in ...


Effect Of Abaloparatide On Vertebral,Nonvertebral, Major Osteoporotic And Clinical Fractures In A Subset Of Postmenopausal Women At Increased Risk Of Fracture By Frax Probability, Eugene V. Mccloskey, Lorraine Fitzpatrick, M.-Y. Hu, G. Williams, John A. Kanis Jan 2019

Effect Of Abaloparatide On Vertebral,Nonvertebral, Major Osteoporotic And Clinical Fractures In A Subset Of Postmenopausal Women At Increased Risk Of Fracture By Frax Probability, Eugene V. Mccloskey, Lorraine Fitzpatrick, M.-Y. Hu, G. Williams, John A. Kanis

Faculty of Health Sciences Publications

Summary We evaluated the efficacy of abaloparatide in women who were at increased risk for fracture, based on CHMP recommended risk thresholds, at the Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) study baseline. Among patients at high risk based on FRAX probabilities, 18 months of abaloparatide significantly decreased risk for all fracture endpoints compared with placebo. Purpose Abaloparatide, a novel anabolic agent for the treatment of postmenopausal osteoporosis, significantly reduced the risk of vertebral and nonvertebral fractures in the ACTIVE study compared with placebo. In this post hoc analysis, we evaluated abaloparatide’s efficacy in a subset of women in ...


High Versus Low Dietary Protein Intake And Bone Health In Older Adults: A Systematic Review And Meta-Analysis, Inge Groenendijk, Laura Den Boeft, J. C. Van Loon, Lisette C. P. G. M. De Groot Jan 2019

High Versus Low Dietary Protein Intake And Bone Health In Older Adults: A Systematic Review And Meta-Analysis, Inge Groenendijk, Laura Den Boeft, J. C. Van Loon, Lisette C. P. G. M. De Groot

Faculty of Health Sciences Publications

Protein may play a beneficial role in the prevention of bone loss and in slowing down osteoporosis. The effect of dietary protein may be different in older adults compared to younger adults, since this population has a greater need for protein. The aim of this systematic review and meta-analysis was to investigate the impact of a dietary protein intake above the Recommended Dietary Allowance (RDA) of 0.8 g/kg body weight/day from any source on Bone Mineral Density (BMD)/Bone Mineral Content (BMC), bone turnover markers, and fracture risk in older adults compared to a lower dietary protein ...


Increased Cortical Porosity And Reduced Trabecular Density Are Not Necessarily Synonymous With Bone Loss And Microstructural Deterioration, Roger M. Zebaze, Elizabeth J. Atkinson, Yu Peng, Minh Bui, Ali Ghasem-Zadeh, Sundeep Khosla, Ego Seeman Jan 2019

Increased Cortical Porosity And Reduced Trabecular Density Are Not Necessarily Synonymous With Bone Loss And Microstructural Deterioration, Roger M. Zebaze, Elizabeth J. Atkinson, Yu Peng, Minh Bui, Ali Ghasem-Zadeh, Sundeep Khosla, Ego Seeman

Faculty of Health Sciences Publications

Absolute values of cortical porosity and trabecular density are used to estimate fracture risk, but these values are the net result of their growth‐related assembly and age‐related deterioration. Because bone loss affects both cortical and trabecular bone, we hypothesized that a surrogate measure of bone fragility should capture the age‐related deterioration of both traits, and should do so independently of their peak values. Accordingly, we developed a structural fragility score (SFS), which quantifies the increment in distal radial cortical porosity and decrement in trabecular density relative to their premenopausal mean values in 99 postmenopausal women with forearm ...


Temporal Changes In Access To Frax In Thailand Between 2010 And 2018, Pojchong Chotiyarnwong, Nicholas C. Harvey, Helena Johansson, Enwu Liu, Mattias Lorentzon, John A. Kanis, Eugene V. Mccloskey Jan 2019

Temporal Changes In Access To Frax In Thailand Between 2010 And 2018, Pojchong Chotiyarnwong, Nicholas C. Harvey, Helena Johansson, Enwu Liu, Mattias Lorentzon, John A. Kanis, Eugene V. Mccloskey

Faculty of Health Sciences Publications

Summary The usage of FRAX® tool in Thailand and other countries was explored using Google Analytics data. Over the period 2010–2018, Thailand ranked 35th in the world for FRAX usage (the US is ranked first). Incorporation of FRAX into a national osteoporosis guideline in Thailand appears to have increased its usage. Purpose To document access to the web-based FRAX® tool and specifically its access in Thailand between 2010 and 2018. Methods A descriptive retrospective study using data from Google Analytics that provides numerical and geographical information on internet access to the FRAX tool website worldwide. Result In Thailand, Bangkok ...


Normal Bone Microstructure And Density But Worse Physical Function In Older Women Treated With Selective Serotonin Reuptake Inhibitors, A Cross-Sectional Population-Based Study, Berit A. M. Larsson, Dan Mellström, Lisa Johansson, Anna G. Nilsson, Mattias Lorentzon, Daniel Sundh Jan 2018

Normal Bone Microstructure And Density But Worse Physical Function In Older Women Treated With Selective Serotonin Reuptake Inhibitors, A Cross-Sectional Population-Based Study, Berit A. M. Larsson, Dan Mellström, Lisa Johansson, Anna G. Nilsson, Mattias Lorentzon, Daniel Sundh

Faculty of Health Sciences Publications

Depression in the elderly is today often treated with selective serotonin reuptake inhibitors (SSRIs) because of their favorable adverse effect profile. However, treatment with SSRIs is associated with increased risk of fractures. Whether this increased risk depends on reduced bone strength or increased fall risk due to reduced physical function is not certain. The aim was therefore to investigate if treatment with SSRIs is associated with impaired bone microstructure, bone density, or physical function in older women. From an ongoing population-based study, 1057 women (77.7 ± 1.5 years) were included. Validated questionnaires were used to assess information regarding medical ...


Vertebral Fractures And Their Association With Health-Related Quality Of Life, Back Pain And Physical Function In Older Women, Lisa Johansson, Daniel Sundh, Dan Nilsson, Dan Mellström, Mattias Lorentzon Jan 2018

Vertebral Fractures And Their Association With Health-Related Quality Of Life, Back Pain And Physical Function In Older Women, Lisa Johansson, Daniel Sundh, Dan Nilsson, Dan Mellström, Mattias Lorentzon

Faculty of Health Sciences Publications

Summary Studies investigating prevalent vertebral fracture (VF) diagnosed using densitometry-based VF assessment (VFA) and associations with physical function, assessed by performance-based measures, are lacking. In this population-based study of 1027 older women, we found that prevalent VF, identified by VFA, was associated with inferior physical health, back pain and inferior physical function. Purpose: Several studies have investigated the associations between health-related quality of life (HRQL) and back pain with prevalent VF, detected by spine radiographs, but just a few have been population-based and have used vertebral fracture assessment (VFA) for diagnosing VF. The aims of this study were to investigate ...


Does Nutrition Play A Role In The Prevention And Management Of Sarcopenia?, S. M. Robinson, J. Y. Reginster, R. Rizzoli, S. C. Shaw, J. A. Kanis, I. Bautmans, H. Bischoff-Ferrari, O. Bruyère, M. Cesari, B. Dawson-Hughes, R. A. Fielding, J. M. Kaufman, F. Landi, Vincenzo Malafarina, Y. Rolland, L. J. Van Loon, B. Vellas, M. Visser, C. Cooper Jan 2018

Does Nutrition Play A Role In The Prevention And Management Of Sarcopenia?, S. M. Robinson, J. Y. Reginster, R. Rizzoli, S. C. Shaw, J. A. Kanis, I. Bautmans, H. Bischoff-Ferrari, O. Bruyère, M. Cesari, B. Dawson-Hughes, R. A. Fielding, J. M. Kaufman, F. Landi, Vincenzo Malafarina, Y. Rolland, L. J. Van Loon, B. Vellas, M. Visser, C. Cooper

Faculty of Health Sciences Publications

There is a growing body of evidence that links nutrition to muscle mass, strength and function in older adults, suggesting that it has an important role to play both in the prevention and management of sarcopenia. This review summarises the discussions of a working group [ESCEO working group meeting 8th September 2016] that met to review current evidence and to consider its implications for preventive and treatment strategies. The review points to the importance of ‘healthier’ dietary patterns that are adequate in quality in older age, to ensure sufficient intakes of protein, vitamin D, antioxidant nutrients and long-chain polyunsaturated fatty ...


Implementation Of A Patient Blood Management Program In An Australian Private Hospital Orthopedic Unit, Paul N. Morgan, Patrick L. Coleman, Cintia Mayel Martinez-Garduno, Anoja Gunaratne, Elizabeth Mcinnes, Sandy Middleton Jan 2018

Implementation Of A Patient Blood Management Program In An Australian Private Hospital Orthopedic Unit, Paul N. Morgan, Patrick L. Coleman, Cintia Mayel Martinez-Garduno, Anoja Gunaratne, Elizabeth Mcinnes, Sandy Middleton

Faculty of Health Sciences Publications

Background: Preoperative anemia in surgical patients has been linked to increased rates of allogeneic blood transfusion (ABT) and associated adverse patient outcomes such as prolonged ventilation in intensive care, increased length of hospital stay, and infections. We conducted a multifaceted implementation for orthopedic surgeons to improve preoperative patient assessment of anemia and iron deficiency to reduce perioperative blood transfusions. Materials and methods: Using a before-and-after study design of independent samples, we recruited a convenience sample of surgeons who performed primary total hip arthroplasty at 1 Australian private hospital. Our implementation intervention consisted of: executive support, interactive education, and peer-to-peer support ...


Clinically Relevant Doses Of Vitamin A Decrease Cortical Bone Mass In Mice, Vikte Lionikaite, Karin L. Gustafsson, Anna Westerlund, Sara H. Windahl, Antti Koskela, Juha Tuukkanen, Helena Johansson, Claes Ohlsson, H. Herschel Conaway, Petra Henning, Ulf H. Lerner Jan 2018

Clinically Relevant Doses Of Vitamin A Decrease Cortical Bone Mass In Mice, Vikte Lionikaite, Karin L. Gustafsson, Anna Westerlund, Sara H. Windahl, Antti Koskela, Juha Tuukkanen, Helena Johansson, Claes Ohlsson, H. Herschel Conaway, Petra Henning, Ulf H. Lerner

Faculty of Health Sciences Publications

Excess vitamin A has been associated with decreased cortical bone thickness and increased fracture risk. While most studies in rodents have employed high dosages of vitamin A for short periods of time, we investigated the bone phenotype in mice after longer exposure to more clinically relevant doses. For 1, 4 and 10 weeks, mice were fed a control diet (4.5 µg retinyl acetate/g chow), a diet modeled from the human upper tolerable limit (UTL; 20 µg retinyl acetate/g chow) and a diet three times UTL (supplemented; 60 µg retinyl acetate/g chow). Time-dependent decreases in periosteal circumference ...


Genetic Determinants Of Circulating Estrogen Levels And Evidence Of A Causal Effect Of Estradiol On Bone Density In Men, Anna L. Eriksson, John R. B. Perry, Andreas D. Coviello, Graciela E. Delgado, Luigi Ferrucci, Andrew R. Hoffman, Ilpo T. Huhtaniemi, M. Arfan Ikram, Magnus K. Karlsson, Marcus E. Kleber, Gail A. Laughlin, Yongmei Liu, Mattias Lorentzon, Kathryn L. Lunetta, Dan Mellström, Joanne M. Murabito, Anna Murray, Maria Nethander, Carrie M. Nielson, Inga Prokopenko, Stephen R. Pye, Leslie J. Raffel, Fernando Rivadeneira, Priya Srikanth, Lisette Stolk, Alexander Teumer, Thomas G. Travison, André G. Uitterlinden, Dhananjay Vaidya, Dirk Vanderschueren, Joseph M. Zmuda, Winfried März, Eric S. Orwoll, Pamela Ouyang, Liesbeth Vandenput, Frederick C. W. Wu, Frank H. De Jong, Shalender Bhasin, Douglas P. Kiel, Claes Ohlsson Jan 2018

Genetic Determinants Of Circulating Estrogen Levels And Evidence Of A Causal Effect Of Estradiol On Bone Density In Men, Anna L. Eriksson, John R. B. Perry, Andreas D. Coviello, Graciela E. Delgado, Luigi Ferrucci, Andrew R. Hoffman, Ilpo T. Huhtaniemi, M. Arfan Ikram, Magnus K. Karlsson, Marcus E. Kleber, Gail A. Laughlin, Yongmei Liu, Mattias Lorentzon, Kathryn L. Lunetta, Dan Mellström, Joanne M. Murabito, Anna Murray, Maria Nethander, Carrie M. Nielson, Inga Prokopenko, Stephen R. Pye, Leslie J. Raffel, Fernando Rivadeneira, Priya Srikanth, Lisette Stolk, Alexander Teumer, Thomas G. Travison, André G. Uitterlinden, Dhananjay Vaidya, Dirk Vanderschueren, Joseph M. Zmuda, Winfried März, Eric S. Orwoll, Pamela Ouyang, Liesbeth Vandenput, Frederick C. W. Wu, Frank H. De Jong, Shalender Bhasin, Douglas P. Kiel, Claes Ohlsson

Faculty of Health Sciences Publications

Context Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. Objective To investigate the genetic regulation of serum E2 and E1 in men. Design, Setting, and Participants Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts. Main Outcome Measures Genetic determinants of serum E2 and E1 levels. Results Variants in/near CYP19A1 demonstrated the strongest evidence for association with E2, resolving to three independent signals. Two additional independent signals were found on the X chromosome; FAMily with sequence similarity 9, member B (FAM9B), rs5934505 (P = 3.4 × 10−8) and Xq27.3, rs5951794 (P ...


High-Impact Mechanical Loading Increases Bone Material Strength In Postmenopausal Women—A 3-Month Intervention Study, Daniel Sundh, Martin Nilsson, Michail Zoulakis, Courtney Pasco, Melis Yilmaz, Galateia J. Kazakia, Martin Hellgren, Mattias Lorentzon Jan 2018

High-Impact Mechanical Loading Increases Bone Material Strength In Postmenopausal Women—A 3-Month Intervention Study, Daniel Sundh, Martin Nilsson, Michail Zoulakis, Courtney Pasco, Melis Yilmaz, Galateia J. Kazakia, Martin Hellgren, Mattias Lorentzon

Faculty of Health Sciences Publications

Bone adapts to loading in several ways, including redistributing bone mass and altered geometry and microarchitecture. Because of previous methodological limitations, it is not known how the bone material strength is affected by mechanical loading in humans. The aim of this study was to investigate the effect of a 3‐month unilateral high‐impact exercise program on bone material properties and microarchitecture in healthy postmenopausal women. A total of 20 healthy and inactive postmenopausal women (aged 55.6 ± 2.3 years [mean ± SD]) were included and asked to perform an exercise program of daily one‐legged jumps (with incremental number ...


Lactobacillus Reuteri Reduces Bone Loss In Older Women With Low Bone Mineral Density: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial, A. G. Nilsson, D. Sundh, F. Bäckhed, Mattias Lorentzon Jan 2018

Lactobacillus Reuteri Reduces Bone Loss In Older Women With Low Bone Mineral Density: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial, A. G. Nilsson, D. Sundh, F. Bäckhed, Mattias Lorentzon

Faculty of Health Sciences Publications

Background: The importance of the gut microbiome for bone metabolism in mice has recently been demonstrated, but no studies are available in humans. Lactobacillus reuteri ATCCPTA 6475 (L. reuteri 6475) has been reported to increase bone mineral density (BMD) in mice but its effect on the human skeleton is unknown. The objective of this trial was to investigate if L. reuteri 6475 affects bone loss in older women with low BMD. Methods: In this double‐blind, placebo‐controlled study, women from the population who were 75 to 80 years old and had low BMD were randomized to orally receive 1010 ...


Low Testosterone, But Not Estradiol, Is Associated With Incident Falls In Older Men: The International Mros Study, Liesbeth Vandenput, Dan Mellström, Gail A. Laughlin, Peggy M. Cawthon, Jane A. Cauley, Andrew R. Hoffman, Magnus K. Karlsson, Björn E. Rosengren, Östen Ljunggren, Maria Nethander, Anna L. Eriksson, Mattias Lorentzon, Jason Leung, Timothy Kwok, Eric S. Orwoll, Claes Ohlsson Jan 2017

Low Testosterone, But Not Estradiol, Is Associated With Incident Falls In Older Men: The International Mros Study, Liesbeth Vandenput, Dan Mellström, Gail A. Laughlin, Peggy M. Cawthon, Jane A. Cauley, Andrew R. Hoffman, Magnus K. Karlsson, Björn E. Rosengren, Östen Ljunggren, Maria Nethander, Anna L. Eriksson, Mattias Lorentzon, Jason Leung, Timothy Kwok, Eric S. Orwoll, Claes Ohlsson

Faculty of Health Sciences Publications

Fracture risk is determined by bone strength and the risk of falls. The relationship between serum sex steroids and bone strength parameters in men is well known, whereas the predictive value of sex steroids for falls is less studied. The aim of this study was to assess the associations between serum testosterone (T) and estradiol (E2) and the likelihood of falls. Older men (aged ≥65 years) from the United States (n = 1919), Sweden (n = 2495), and Hong Kong (n = 1469) participating in the Osteoporotic Fractures in Men Study had baseline T and E2 analyzed by mass spectrometry. Bioavailable (Bio) levels ...


Which Measuring Site In Ankylosing Spondylitis Is Best To Detect Bone Loss And What Predicts The Decline: Results From A 5-Year Prospective Study, Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. Jacobsson, Helena Forsblad-D'Elia Jan 2017

Which Measuring Site In Ankylosing Spondylitis Is Best To Detect Bone Loss And What Predicts The Decline: Results From A 5-Year Prospective Study, Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. Jacobsson, Helena Forsblad-D'Elia

Faculty of Health Sciences Publications

Background: Studies have shown increased prevalence of osteoporosis and increased risk for vertebral fractures in patients with ankylosing spondylitis (AS). Measurements of bone mineral density (BMD) in the lumbar spine anterior-posterior (AP) projection may be difficult to interpret due to the ligamentous calcifications, and the lateral projection might be a better measuring site. Our objectives were to investigate BMD changes after 5 years at different measuring sites in patients with AS and to evaluate disease-related variables and medications as predictors for BMD changes. Methods: In a longitudinal study, BMD in Swedish AS patients, 50 ± 13 years old, was measured with ...


Gait Outcomes Of Older Adults Receiving Subacute Hospital Rehabilitation Following Orthopaedic Trauma: A Longitudinal Cohort Study, Saira A. Mathew, Paul N. Varghese, Suzanne S. Kuys, Kristiann C. Heesch, Steven M. Mcphail Jan 2017

Gait Outcomes Of Older Adults Receiving Subacute Hospital Rehabilitation Following Orthopaedic Trauma: A Longitudinal Cohort Study, Saira A. Mathew, Paul N. Varghese, Suzanne S. Kuys, Kristiann C. Heesch, Steven M. Mcphail

Faculty of Health Sciences Publications

Objectives: This study aimed to describe gait speed at admission and discharge from inpatient hospital rehabilitation among older adults recovering from orthopaedic trauma and factors associated with gait speed performance and discharge destination. Design: A longitudinal cohort study was conducted. Setting: Australian tertiary hospital subacute rehabilitation wards. Participants: Patients aged ≥60 years recovering from orthopaedic trauma (n=746, 71% female) were eligible for inclusion. Interventions: Usual care (multidisciplinary inpatient hospital rehabilitation). Primary and secondary outcome measures: Gait speed was assessed using the timed 10 m walk test. The proportion of patients exceeding a minimum gait speed threshold indicator (a priori ...


The Prevention Of Fragility Fractures In Patients With Non-Metastatic Prostate Cancer: A Position Statement By The International Osteoporosis Foundation, Luisella Cianferotti, Francesco Bertoldo, Marco Carini, John A. Kanis, Alberto Lapini, Nicola Longo, Giuseppe Martorana, Vincenzo Mirone, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi Jan 2017

The Prevention Of Fragility Fractures In Patients With Non-Metastatic Prostate Cancer: A Position Statement By The International Osteoporosis Foundation, Luisella Cianferotti, Francesco Bertoldo, Marco Carini, John A. Kanis, Alberto Lapini, Nicola Longo, Giuseppe Martorana, Vincenzo Mirone, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi

Faculty of Health Sciences Publications

Androgen deprivation therapy is commonly employed for the treatment of non-metastatic prostate cancer as primary or adjuvant treatment. The skeleton is greatly compromised in men with prostate cancer during androgen deprivation therapy because of the lack of androgens and estrogens, which are trophic factors for bone. Men receiving androgen deprivation therapy sustain variable degrees of bone loss with an increased risk of fragility fractures. Several bone antiresorptive agents have been tested in randomized controlled trials in these patients. Oral bisphosphonates, such as alendronate and risedronate, and intravenous bisphosphonates, such as pamidronate and zoledronic acid, have been shown to increase bone ...


Vitamin D Supplementation In The Prevention And Management Of Major Chronic Diseases Not Related To Mineral Homeostasis In Adults: Research For Evidence And A Scientific Statement From The European Society For Clinical And Economic Aspects Of Osteopo, Luisella Cianferotti, Francesco Bertoldo, Heike A. Bischoff-Ferrari, O. Bruyere, Cyrus Cooper, Maurizio Cutolo, John A. Kanis, Jean-Marc Kaufman, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi Jan 2017

Vitamin D Supplementation In The Prevention And Management Of Major Chronic Diseases Not Related To Mineral Homeostasis In Adults: Research For Evidence And A Scientific Statement From The European Society For Clinical And Economic Aspects Of Osteopo, Luisella Cianferotti, Francesco Bertoldo, Heike A. Bischoff-Ferrari, O. Bruyere, Cyrus Cooper, Maurizio Cutolo, John A. Kanis, Jean-Marc Kaufman, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi

Faculty of Health Sciences Publications

Introduction: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. Purpose and Methods: Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field. Results and conclusions: Robust mechanistic evidence is available from ...


Evidence Of Compensatory Joint Kinetics During Stair Ascent And Descent In Parkinson's Disease [Accepted Manuscript], Zachary J. Conway, Peter A. Silburn, Tim Blackmore, Michael H. Cole Jan 2017

Evidence Of Compensatory Joint Kinetics During Stair Ascent And Descent In Parkinson's Disease [Accepted Manuscript], Zachary J. Conway, Peter A. Silburn, Tim Blackmore, Michael H. Cole

Faculty of Health Sciences Publications

Background: Stair ambulation is a challenging activity of daily life that requires larger joint moments than walking. Stabilisation of the body and prevention of lower limb collapse during this task depends upon adequately-sized hip, knee and ankle extensor moments. However, people with Parkinson’s disease (PD) often present with strength deficits that may impair their capacity to control the lower limbs and ultimately increase their falls risk. Objective: To investigate hip, knee and ankle joint moments during stair ascent and descent and determine the contribution of these joints to the body’s support in people with PD. Methods: Twelve PD ...


Prevalence Of Arthritis According To Age, Sex And Socioeconomic Status In Six Low And Middle Income Countries: Analysis Of Data From The World Health Organization Study On Global Ageing And Adult Health (Sage) Wave 1, S. L. Brennan-Olsen, S. Cook, M. T. Leech, S. J. Bowe, P. Kowal, N. Naidoo, I. N. Ackerman, R. S. Page, S. M. Hosking, J. A. Pasco, M. Mohebbi Jan 2017

Prevalence Of Arthritis According To Age, Sex And Socioeconomic Status In Six Low And Middle Income Countries: Analysis Of Data From The World Health Organization Study On Global Ageing And Adult Health (Sage) Wave 1, S. L. Brennan-Olsen, S. Cook, M. T. Leech, S. J. Bowe, P. Kowal, N. Naidoo, I. N. Ackerman, R. S. Page, S. M. Hosking, J. A. Pasco, M. Mohebbi

Faculty of Health Sciences Publications

Background: In higher income countries, social disadvantage is associated with higher arthritis prevalence; however, less is known about arthritis prevalence or determinants in low to middle income countries (LMICs). We assessed arthritis prevalence by age and sex, and marital status and occupation, as two key parameters of socioeconomic position (SEP), using data from the World Health Organization Study on global AGEing and adult health (SAGE). Methods: SAGE Wave 1 (2007–10) includes nationally-representative samples of older adults (≥50 yrs), plus smaller samples of adults aged 18-49 yrs., from China, Ghana, India, Mexico, Russia and South Africa (n = 44,747). Arthritis ...


The Association Of Time And Medications With Changes In Bone Mineral Density In The 2 Years After Critical Illness, Neil R. Orford, Michael Bailey, Rinaldo Bellomo, Julie A. Pasco, Claire Cattigan, Tania Elderkin, Sharon L. Brennan-Olsen, David J. Cooper, Mark A. Kotowicz Jan 2017

The Association Of Time And Medications With Changes In Bone Mineral Density In The 2 Years After Critical Illness, Neil R. Orford, Michael Bailey, Rinaldo Bellomo, Julie A. Pasco, Claire Cattigan, Tania Elderkin, Sharon L. Brennan-Olsen, David J. Cooper, Mark A. Kotowicz

Faculty of Health Sciences Publications

Background: Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and time remain unexplored. The objective of this study was to describe the association of time after ICU admission, and post-ICU administration of bone anti-fracture therapy or glucocorticoids after critical illness, with change in BMD. Methods: In this prospective observational study, conducted in a tertiary hospital ICU, we studied adult patients requiring mechanical ventilation for at least 24 hours and measured BMD annually for 2 years after ICU discharge. We performed ...


Overview Of Fracture Prediction Tools [Accepted Manuscript], John A. Kanis John.Kanis@Acu.Edu.Au, Nicholas C. Harvey, Helena Johansson, Anders Odén, Eugene V. Mccloskey, William D. Leslie Jan 2017

Overview Of Fracture Prediction Tools [Accepted Manuscript], John A. Kanis John.Kanis@Acu.Edu.Au, Nicholas C. Harvey, Helena Johansson, Anders Odén, Eugene V. Mccloskey, William D. Leslie

Faculty of Health Sciences Publications

The characterization of risk factors for fracture that contribute significantly to fracture risk, over and above that provided by the bone mineral density, has stimulated the development of risk assessment tools. The more adequately evaluated tools, all available online, include the FRAX® tool, the Garvan fracture risk calculator and, in the United Kingdom only, QFracture®. Differences in the input variables, output, and model construct give rise to marked differences in the computed risks from each calculator. Reasons for the differences include the derivation of fracture probability (FRAX) rather than incidence (Garvan and QFracture), limited calibration (Garvan), and inappropriate source information ...


Increased Cortical Porosity In Women With Hip Fracture, Daniel Sundh, A. G. Nilsson, Martin Nilsson, L. Johansson, Dan Mellström, Mattias Lorentzon Jan 2017

Increased Cortical Porosity In Women With Hip Fracture, Daniel Sundh, A. G. Nilsson, Martin Nilsson, L. Johansson, Dan Mellström, Mattias Lorentzon

Faculty of Health Sciences Publications

Background: Hip fractures cause increased mortality and disability and consume enormous healthcare resources. Only 46% of hip fracture patients have osteoporosis at the total hip according to dual‐energy X‐ray absorptiometry (DXA) measurement. Cortical porosity increases with ageing and is believed to be important for bone strength. Objective: To investigate whether older women with hip fracture have higher cortical porosity than controls, and if so whether this difference is independent of clinical risk factors and areal bone mineral density (aBMD). Methods: From an ongoing population‐based study, we identified 46 women with a prevalent X‐ray‐verified hip fracture ...


Low Serum Dheas Predicts Increased Fracture Risk In Older Men: The Mros Sweden Study, Claes Ohlsson, Maria Nethander, Andreas Kindmark, Östen Ljunggren, Mattias Lorentzon, Björn E. Rosengren, Magnus K. Karlsson, Dan Mellström, Liesbeth Vandenput Jan 2017

Low Serum Dheas Predicts Increased Fracture Risk In Older Men: The Mros Sweden Study, Claes Ohlsson, Maria Nethander, Andreas Kindmark, Östen Ljunggren, Mattias Lorentzon, Björn E. Rosengren, Magnus K. Karlsson, Dan Mellström, Liesbeth Vandenput

Faculty of Health Sciences Publications

The adrenal‐derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age. DHEAS is considered an inactive precursor, which is converted into androgens and estrogens via local metabolism in peripheral target tissues. The predictive value of serum DHEAS for fracture risk is unknown. The aim of this study was, therefore, to assess the associations between baseline DHEAS levels and incident fractures in a large cohort of older men. Serum DHEAS levels were analyzed with mass spectrometry in the population‐based Osteoporotic Fractures in Men study in Sweden (n = 2568 ...


Type 2 Diabetes And Risk Of Hip Fractures And Non-Skeletal Fall Injuries In The Elderly: A Study From The Fractures And Fall Injuries In The Elderly Cohort (Frailco), Märit Wallander, Kristian F. Axelsson, Anna G. Nilsson, Dan Lundh, Mattias Lorentzon Jan 2017

Type 2 Diabetes And Risk Of Hip Fractures And Non-Skeletal Fall Injuries In The Elderly: A Study From The Fractures And Fall Injuries In The Elderly Cohort (Frailco), Märit Wallander, Kristian F. Axelsson, Anna G. Nilsson, Dan Lundh, Mattias Lorentzon

Faculty of Health Sciences Publications

Questions remain about whether the increased risk of fractures in patients with type 2 diabetes (T2DM) is related mainly to increased risk of falling or to bone‐specific properties. The primary aim of this study was to investigate the risk of hip fractures and non‐skeletal fall injuries in older men and women with and without T2DM. We included 429,313 individuals (aged 80.8 ± 8.2 years [mean ± SD], 58% women) from the Swedish registry “Senior Alert” and linked the data to several nationwide registers. We identified 79,159 individuals with T2DM (45% with insulin [T2DM‐I], 41% with ...