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Full-Text Articles in Medicine and Health Sciences

Patients With Prostate Cancer And Androgen Deprivation Therapy Have Increased Risk Of Fractures—A Study From The Fractures And Fall Injuries In The Elderly Cohort (Frailco), M. Wallander, K. F. Axelsson, D. Lundh, Mattias Lorentzon Jan 2019

Patients With Prostate Cancer And Androgen Deprivation Therapy Have Increased Risk Of Fractures—A Study From The Fractures And Fall Injuries In The Elderly Cohort (Frailco), M. Wallander, K. F. Axelsson, D. Lundh, Mattias Lorentzon

Faculty of Health Sciences Publications

Summary Osteoporosis is a common complication of androgen deprivation therapy (ADT). In this large Swedish cohort study consisting of a total of nearly 180,000 older men, we found that those with prostate cancer and ADT have a significantly increased risk of future osteoporotic fractures. Introduction: Androgen deprivation therapy (ADT) in patients with prostate cancer is associated to increased risk of fractures. In this study, we investigated the relationship between ADT in patients with prostate cancer and the risk of incident fractures and non-skeletal fall injuries both compared to those without ADT and compared to patients without prostate cancer. Methods ...


Import Of Extracellular Atp In Yeast And Man Modulates Ampk And Torc1 Signalling, Gabriella M. Forte, Elizabeth Davie, Shervi Lie, Mirita Franz-Wachtel, Ashley J. Ovens, Tingting Wang, Jonathan S. Oakhill, Boris MačEk, Iain M. Hagan, Janni Petersen Jan 2019

Import Of Extracellular Atp In Yeast And Man Modulates Ampk And Torc1 Signalling, Gabriella M. Forte, Elizabeth Davie, Shervi Lie, Mirita Franz-Wachtel, Ashley J. Ovens, Tingting Wang, Jonathan S. Oakhill, Boris MačEk, Iain M. Hagan, Janni Petersen

Faculty of Health Sciences Publications

AMP-activated kinase (AMPK) and target of rapamycin (TOR) signalling coordinate cell growth, proliferation, metabolism and cell survival with the nutrient environment of cells. The poor vasculature and nutritional stress experienced by cells in solid tumours raises the question: how do they assimilate sufficient nutrients to survive? Here, we show that human and fission yeast cells import ATP and AMP from their external environment to regulate AMPK and TOR signalling. Exposure of fission yeast (Schizosaccharomyces pombe) and human cells to external AMP impeded cell growth; however, in yeast this restraining impact required AMPK. In contrast, external ATP rescued the growth defect ...


Tumour-Specific And Organ-Specific Protein Synthesis Rates In Patients With Pancreatic Cancer, David P.J. Van Dijk, Astrid M. H. Horstman, Joey S. J. Smeets, Marcel Den Dulk, Heike I. Grabsch, Cornelis H. C. Dejong, Sander S. Rensen, Steven W. M. Olde Damink, Luc J. C. Van Loon Jan 2019

Tumour-Specific And Organ-Specific Protein Synthesis Rates In Patients With Pancreatic Cancer, David P.J. Van Dijk, Astrid M. H. Horstman, Joey S. J. Smeets, Marcel Den Dulk, Heike I. Grabsch, Cornelis H. C. Dejong, Sander S. Rensen, Steven W. M. Olde Damink, Luc J. C. Van Loon

Faculty of Health Sciences Publications

Background: Living tissues maintain a fine balance between protein synthesis and protein breakdown rates. Animal studies indicate that protein synthesis rates are higher in organs when compared with skeletal muscle tissue. As such, organ and tumour protein synthesis could have major effects on whole‐body protein metabolism in wasting disorders such as cancer cachexia. We aimed to assess protein synthesis rates in pancreatic tumour tissue and healthy pancreas, liver, and skeletal muscle tissue in vivo in humans. Methods: In eight patients with pancreatic cancer undergoing pancreaticoduodenectomy, primed continuous infusions with L‐[ring‐13C6]phenylalanine and L‐[3,5‐2H2]tyrosine ...


Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care [Accepted Manuscript], Prue Cormie, Morgan Atkinson, Lucy Bucci, Anne Cust, Elizabeth Eakin, Sandra Hayes, Alexandra Mccarthy, Andrew Murnane, Sharni Patchell, Diana Adams May 2018

Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care [Accepted Manuscript], Prue Cormie, Morgan Atkinson, Lucy Bucci, Anne Cust, Elizabeth Eakin, Sandra Hayes, Alexandra Mccarthy, Andrew Murnane, Sharni Patchell, Diana Adams

Faculty of Health Sciences Publications

Introduction: Clinical research has established exercise as a safe and effective intervention to counteract the adverse physical and psychological effects of cancer and its treatment. This article summarises the position of the Clinical Oncology Society of Australia (COSA) on the role of exercise in cancer care, taking into account the strengths and limitations of the evidence base. It provides guidance for all health professionals involved in the care of people with cancer about integrating exercise into routine cancer care.

Main recommendations: COSA calls for:

  • exercise to be embedded as part of standard practice in cancer care and to be viewed ...


Depression And Prostate Cancer: Examining Comorbidity And Male-Specific Symptoms, Simon M. Rice, John L. Oliffe, Mary T. Kelly, Prue Cormie, Suzanne Chambers, John S. Ogrodniczuk, David Kealy Jan 2018

Depression And Prostate Cancer: Examining Comorbidity And Male-Specific Symptoms, Simon M. Rice, John L. Oliffe, Mary T. Kelly, Prue Cormie, Suzanne Chambers, John S. Ogrodniczuk, David Kealy

Faculty of Health Sciences Publications

Depression in men with prostate cancer is a significant and complex issue that can challenge clinicians’ diagnostic efforts. The objective of the current study was to evaluate prototypic and male-specific depression symptoms and suicidal ideation in men with a diagnosis of prostate cancer relative to those with and without comorbidity. The Patient Health Questionnaire-9 (PHQ-9) and Male Depression Risk Scale-22 (MDRS-22) were completed online along with demographic and background variables by 100 men with a diagnosis of prostate cancer (n = 54 prostatectomy, n = 33 receiving active treatment). Hierarchical logistic regression was used to examine recent (past 2 weeks) suicide ideation ...


Capturing Ultraviolet Radiation Exposure And Physical Activity: Feasibility Study And Comparison Between Self-Reports, Mobile Apps, Dosimeters, And Accelerometers, Elke Hacker, Caitlin Horsham, Martin Allen, Andrea Nathan, John Lowe, Monika Janda Jan 2018

Capturing Ultraviolet Radiation Exposure And Physical Activity: Feasibility Study And Comparison Between Self-Reports, Mobile Apps, Dosimeters, And Accelerometers, Elke Hacker, Caitlin Horsham, Martin Allen, Andrea Nathan, John Lowe, Monika Janda

Faculty of Health Sciences Publications

Background: Skin cancer is the most prevalent cancer in Australia. Skin cancer prevention programs aim to reduce sun exposure and increase sun protection behaviors. Effectiveness is usually assessed through self-report. Objective: It was the aim of this study to test the acceptance and validity of a newly developed ultraviolet radiation (UVR) exposure app, designed to reduce the data collection burden to research participants. Physical activity data was collected because a strong focus on sun avoidance may result in unhealthy reductions in physical activity. This paper provides lessons learned from collecting data from participants using paper diaries, a mobile app, dosimeters ...


Feasibility And Preliminary Efficacy Of A 10-Week Resistance And Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment In Rectal Cancer Patients, Favil Singh, Daniel A. Galvão, Robert U. Newton, Nigel A. Spry, Michael K. Baker, Dennis R. Taaffe Jan 2018

Feasibility And Preliminary Efficacy Of A 10-Week Resistance And Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment In Rectal Cancer Patients, Favil Singh, Daniel A. Galvão, Robert U. Newton, Nigel A. Spry, Michael K. Baker, Dennis R. Taaffe

Faculty of Health Sciences Publications

Background: Neoadjuvant chemoradiation treatment (CRT) in rectal cancer patients is associated with a reduction in physical capacity, lean mass and increased fatigue. As a countermeasure to these treatment-related adverse effects, we examined the feasibility and preliminary efficacy of a 10-week exercise program during CRT. Methods: Ten rectal cancer patients (7 men, aged 27-70 years, body mass index = 26.4 ± 3.8 kg/m2) receiving CRT undertook supervised resistance and aerobic exercise twice weekly. Assessments were undertaken pre- and post-intervention for upper and lower body muscle strength by 1-RM, muscle endurance, physical performance tests, body composition by dual X-ray absorptiometry, quality ...


The Prevention Of Fragility Fractures In Patients With Non-Metastatic Prostate Cancer: A Position Statement By The International Osteoporosis Foundation, Luisella Cianferotti, Francesco Bertoldo, Marco Carini, John A. Kanis, Alberto Lapini, Nicola Longo, Giuseppe Martorana, Vincenzo Mirone, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi Jan 2017

The Prevention Of Fragility Fractures In Patients With Non-Metastatic Prostate Cancer: A Position Statement By The International Osteoporosis Foundation, Luisella Cianferotti, Francesco Bertoldo, Marco Carini, John A. Kanis, Alberto Lapini, Nicola Longo, Giuseppe Martorana, Vincenzo Mirone, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi

Faculty of Health Sciences Publications

Androgen deprivation therapy is commonly employed for the treatment of non-metastatic prostate cancer as primary or adjuvant treatment. The skeleton is greatly compromised in men with prostate cancer during androgen deprivation therapy because of the lack of androgens and estrogens, which are trophic factors for bone. Men receiving androgen deprivation therapy sustain variable degrees of bone loss with an increased risk of fragility fractures. Several bone antiresorptive agents have been tested in randomized controlled trials in these patients. Oral bisphosphonates, such as alendronate and risedronate, and intravenous bisphosphonates, such as pamidronate and zoledronic acid, have been shown to increase bone ...


Knowing, Being, And Doing: Aboriginal And Non-Aboriginal Collaboration In Cancer Services, Joanna Zubrzycki, Rick Shipp, Victoria Jones Jan 2017

Knowing, Being, And Doing: Aboriginal And Non-Aboriginal Collaboration In Cancer Services, Joanna Zubrzycki, Rick Shipp, Victoria Jones

Faculty of Health Sciences Publications

This qualitative inquiry explored the processes and practices of collaboration as experienced by a group of Australian multidisciplinary Aboriginal and non-Aboriginal health workers. Each worker had participated, for a period of 2 to 5 years, in an Australian Government–funded project in which a range of health initiatives led to improved access to cancer services by Aboriginal communities in a rural region of South Eastern Australia. Initiatives which addressed high rates of mortality from cancer, poor access to cancer screening, and engagement with cancer treatment were developed through the formation of close working relationships between Aboriginal and non-Aboriginal health workers ...


Implementing Exercise In Cancer Care: Study Protocol To Evaluate A Community-Based Exercise Program For People With Cancer, Prue Cormie, Stephanie Lamb, Robert U. Newton, Lani Valentine, Sandy Mckiernan, Nigel Spry, David Joseph, Dennis R. Taaffe, Christopher M. Doran, Daniel A. Galvão Jan 2017

Implementing Exercise In Cancer Care: Study Protocol To Evaluate A Community-Based Exercise Program For People With Cancer, Prue Cormie, Stephanie Lamb, Robert U. Newton, Lani Valentine, Sandy Mckiernan, Nigel Spry, David Joseph, Dennis R. Taaffe, Christopher M. Doran, Daniel A. Galvão

Faculty of Health Sciences Publications

Background: Clinical research has established the efficacy of exercise in reducing treatment-related side-effects and increasing wellbeing in people with cancer. Major oncology organisations have identified the importance of incorporating exercise in comprehensive cancer care but information regarding effective approaches to translating evidence into practice is lacking. This paper describes the implementation of a community-based exercise program for people with cancer and the protocol for program evaluation. Methods/Design: The Life Now Exercise program is a community-based exercise intervention designed to mitigate and rehabilitate the adverse effects of cancer and its treatment and improve physical and psychosocial wellbeing in people with ...


The Feasibility Of A Pragmatic Distance-Based Intervention To Increase Physical Activity In Lung Cancer Survivors, C. J. Peddle-Mcintye, Michael Baker, Y. C.G. Lee, Daniel A. Galvao, Assoc P. Cormie, V. Graham, Robert U. Newton Jan 2017

The Feasibility Of A Pragmatic Distance-Based Intervention To Increase Physical Activity In Lung Cancer Survivors, C. J. Peddle-Mcintye, Michael Baker, Y. C.G. Lee, Daniel A. Galvao, Assoc P. Cormie, V. Graham, Robert U. Newton

Faculty of Health Sciences Publications

The purpose of this study was to investigate the feasibility and preliminary efficacy of a pragmatic distance-based intervention designed to increase physical activity (PA) participation in lung cancer survivors. Fourteen lung cancer survivors were recruited via invitation from the State Cancer Registry to join a 12-week PA intervention of print materials paired with brief telephone follow-up. Outcome measures of feasibility, PA participation and quality of life (QoL) were assessed at baseline, post-intervention and follow-up via telephone interview. Eligibility, recruitment and attrition rates were 16%, 58% and 29% respectively. No adverse events were reported; however, pain scores worsened following the intervention ...


Urine Cytology Screening Of French Workers Exposed To Occupational Urinary Tract Carcinogens: A Prospective Cohort Study Over A 20-Year Period, Frederic Dutheil, Lucile Rouanet, Aurélien Mulliez, Geraldine Naughton, Luc Fontana, Michel Druet-Cabanac, Farès Moustafa, Alain Chamoux Jan 2017

Urine Cytology Screening Of French Workers Exposed To Occupational Urinary Tract Carcinogens: A Prospective Cohort Study Over A 20-Year Period, Frederic Dutheil, Lucile Rouanet, Aurélien Mulliez, Geraldine Naughton, Luc Fontana, Michel Druet-Cabanac, Farès Moustafa, Alain Chamoux

Faculty of Health Sciences Publications

Objectives To demonstrate that urine cytology screening can provide relevant epidemiological data for earlier detection of urothelial cancer caused by occupational exposure. Design Prospective cohort study. Setting Industries using urothelial carcinogens in France. Urine samples were collected on site, after a work week and were analysed at the University Hospital of Clermont-Ferrand, France. Participants Participants were workers exposed to urothelial carcinogens. Women and current smokers at time of study recruitment were exclusion criteria. Outcomes Urine cells atypia were ranged into three classes: negative/normal, atypical/suspicious/ dysplasia or positive/malignant. Results We included 2020 workers over a period of 20 ...


Ampk ß1 Reduces Tumor Progression And Improves Survival In P53 Null Mice, Vanessa P. Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A. Hammill, Jonathan L. Bramson, Robert A. Foster, Theodoros Tsakiridis, Bruce Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R. Steinberg Jan 2017

Ampk ß1 Reduces Tumor Progression And Improves Survival In P53 Null Mice, Vanessa P. Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A. Hammill, Jonathan L. Bramson, Robert A. Foster, Theodoros Tsakiridis, Bruce Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R. Steinberg

Faculty of Health Sciences Publications

The AMP‐activated protein kinase (AMPK) is a heterotrimeric protein complex that is an important sensor of cellular energy status. Reduced expression of the AMPK β1 isoform has been linked to reduced survival in different cancers, but whether this accelerates tumor progression and the potential mechanism mediating these effects are not known. Furthermore, it is unknown whether AMPK β1 is implicated in tumorigenesis, and if so, what tissues may be most sensitive. In the current study, we find that in the absence of the tumor suppressor p53, germline genetic deletion of AMPK β1 accelerates the appearance of a T‐cell ...


Colorectal Cancer And Long-Term Exposure To Trihalomethanes In Drinking Water: A Multicenter Case-Control Study In Spain And Italy, Cristina M. Villanueva, Esther Gracia-Lavedan, Cristina Bosetti, Elena Righi, Antonio J. Molina, Vicente Martín, Elena Boldo, Nuria Aragonés, Beatriz Perez-Gomez, Marina Pollan, Ines G. Acebo, Jone M. Altzibar, Ana J. Zabala, Eva Ardanaz, Rosana Peiró, Adonina Tardón, Maria D. Chirlaque, Alessandra Tavani, Jerry Polesel, Diego Serraino, Federica Pisa, Gemma Castaño-Vinyals, Ana Espinosa, Ciber Epidemiologia Y Salud Publicauniversitat Pompeu Fabra Nadia, Margarita, Victor, Carlo, Gabriella, Mark, Manolis Jan 2017

Colorectal Cancer And Long-Term Exposure To Trihalomethanes In Drinking Water: A Multicenter Case-Control Study In Spain And Italy, Cristina M. Villanueva, Esther Gracia-Lavedan, Cristina Bosetti, Elena Righi, Antonio J. Molina, Vicente Martín, Elena Boldo, Nuria Aragonés, Beatriz Perez-Gomez, Marina Pollan, Ines G. Acebo, Jone M. Altzibar, Ana J. Zabala, Eva Ardanaz, Rosana Peiró, Adonina Tardón, Maria D. Chirlaque, Alessandra Tavani, Jerry Polesel, Diego Serraino, Federica Pisa, Gemma Castaño-Vinyals, Ana Espinosa, Ciber Epidemiologia Y Salud Publicauniversitat Pompeu Fabra Nadia, Margarita, Victor, Carlo, Gabriella, Mark, Manolis

Faculty of Health Sciences Publications

Background: Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. Objectives: We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. Methods: A multicenter case–control study was conducted in Spain and Italy in 2008–2013. Hospital-based incident cases and population-based (Spain) and hospital-based (Italy) controls were interviewed to ascertain residential histories, type of water consumed in each residence, frequency and duration of showering/bathing, and major recognized risk factors for colorectal cancer. We estimated adjusted odds ratios (OR) for colorectal ...


Feasibility Of Presurgical Exercise In Men With Prostate Cancer Undergoing Prostatectomy, Favil Singh, Robert U. Newton, Michael K. Baker, Nigel A. Spry, Dennis R. Taaffe, Jeffery Thavaseelan, Daniel A. Galvão Jan 2017

Feasibility Of Presurgical Exercise In Men With Prostate Cancer Undergoing Prostatectomy, Favil Singh, Robert U. Newton, Michael K. Baker, Nigel A. Spry, Dennis R. Taaffe, Jeffery Thavaseelan, Daniel A. Galvão

Faculty of Health Sciences Publications

Background: Prostatectomy is associated with short- and long-term morbidity, which includes attenuation of muscle function and deterioration of lean body mass. Physical function is a known predictor of morbidity and mortality, with initial evidence indicating that presurgical exercise is associated with fewer postsurgical complications and shorter hospitalization. The aim was to determine the feasibility of a supervised presurgical exercise program for prostate cancer (PCa) patients scheduled for prostatectomy. Methods: Ten men (68+6.4 years old) with localized PCa undertook a 6-week resistance and aerobic exercise program prior surgery. Training was undertaken twice weekly and patients were assessed at baseline ...


Impact Of Genetic Variation On Human Camkk2 Regulation By Ca2+ -Calmodulin And Multisite Phosphorylation, Matthew O'Brien, Jonathan S. Oakhill, Naomi Ling, Christopher G. Langendorf, Ashfaqul Hoque, Toby A. Dite, Anthony R. Means, Bruce Kemp, John W. Scott Jan 2017

Impact Of Genetic Variation On Human Camkk2 Regulation By Ca2+ -Calmodulin And Multisite Phosphorylation, Matthew O'Brien, Jonathan S. Oakhill, Naomi Ling, Christopher G. Langendorf, Ashfaqul Hoque, Toby A. Dite, Anthony R. Means, Bruce Kemp, John W. Scott

Faculty of Health Sciences Publications

The Ca2+-calmodulin dependent protein kinase kinase-2 (CaMKK2) is a key regulator of neuronal function and whole-body energy metabolism. Elevated CaMKK2 activity is strongly associated with prostate and hepatic cancers, whereas reduced CaMKK2 activity has been linked to schizophrenia and bipolar disease in humans. Here we report the functional effects of nine rare-variant point mutations that were detected in large-scale human genetic studies and cancer tissues, all of which occur close to two regulatory phosphorylation sites and the catalytic site on human CaMKK2. Four mutations (G87R, R139W, R142W and E268K) cause a marked decrease in Ca2+-independent autonomous activity, however ...


Management Of Aromatase Inhibitor-Associated Bone Loss (Aibl) In Postmenopausal Women With Hormone Sensitive Breast Cancer: Joint Position Statement Of The Iof, Cabs, Ects, Ieg, Esceo Ims, And Siog, P. Hadji, Matti S. Aapro, Jean J. Body, Michael Gnant, Maria L. Brandi, Jean Y. Reginster, M. C. Zillikens, C. C. Glüer, T. De Villiers, Rod Baber, G. David Roodman, Cyrus Cooper, Bente Lomholt Langdahl, Santiago Palacios, John Kanis, Nasser M. Al-Daghri, Xavier Nogues, Erik F. Eriksen, Andreas Kurth, Rene Rizzoli, Robert E. Coleman Jan 2017

Management Of Aromatase Inhibitor-Associated Bone Loss (Aibl) In Postmenopausal Women With Hormone Sensitive Breast Cancer: Joint Position Statement Of The Iof, Cabs, Ects, Ieg, Esceo Ims, And Siog, P. Hadji, Matti S. Aapro, Jean J. Body, Michael Gnant, Maria L. Brandi, Jean Y. Reginster, M. C. Zillikens, C. C. Glüer, T. De Villiers, Rod Baber, G. David Roodman, Cyrus Cooper, Bente Lomholt Langdahl, Santiago Palacios, John Kanis, Nasser M. Al-Daghri, Xavier Nogues, Erik F. Eriksen, Andreas Kurth, Rene Rizzoli, Robert E. Coleman

Faculty of Health Sciences Publications

Background Several guidelines have been reported for bone-directed treatment in women with early breast cancer (EBC) for averting fractures, particularly during aromatase inhibitor (AI) therapy. Recently, a number of studies on additional fracture related risk factors, new treatment options as well as real world studies demonstrating a much higher fracture rate than suggested by randomized clinical controlled trials (RCTs). Therefore, this updated algorithm was developed to better assess fracture risk and direct treatment as a position statement of several interdisciplinary cancer and bone societies involved in the management of AI-associated bone loss (AIBL). Patients and methods A systematic literature review ...


Prognostic Limitations Of Donor T Cell Chimerism After Myeloablative Allogeneic Stem Cell Transplantation For Acute Myeloid Leukemia And Myelodysplastic Syndromes, Eric Wong, Kate Mason, Jenny Collins, Barbara Hockridge, Janis Boyd, Alexandra Gorelik, Jeffrey Szer, David S. Ritchie Jan 2017

Prognostic Limitations Of Donor T Cell Chimerism After Myeloablative Allogeneic Stem Cell Transplantation For Acute Myeloid Leukemia And Myelodysplastic Syndromes, Eric Wong, Kate Mason, Jenny Collins, Barbara Hockridge, Janis Boyd, Alexandra Gorelik, Jeffrey Szer, David S. Ritchie

Faculty of Health Sciences Publications

Donor T cell chimerism is associated with relapse outcomes after allogeneic stem cell transplantation (alloSCT) for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). However, measures of statistical association do not adequately assess the performance of a prognostic biomarker, which is best characterized by its sensitivity and specificity for the chosen outcome. We analyzed donor T cell chimerism results at day 100 (D100chim) after myeloablative alloSCT for AML or MDS in 103 patients and determined its sensitivity and specificity for relapse-free survival at 6 months (RFS6) and 12 months (RFS12) post-alloSCT. The area under the receiver operating characteristic curve for ...


School-Based Brief Psycho-Educational Intervention To Raise Adolescent Cancer Awareness And Address Barriers To Medical Help-Seeking About Cancer: A Cluster Randomised Controlled Trial, Gill Hubbard, Iona Stoddart, Liz Forbat, Richard D. Neal, Ronan E. O'Carroll, Sally Haw, Petra Rauchhaus, Richard G. Kyle Jan 2016

School-Based Brief Psycho-Educational Intervention To Raise Adolescent Cancer Awareness And Address Barriers To Medical Help-Seeking About Cancer: A Cluster Randomised Controlled Trial, Gill Hubbard, Iona Stoddart, Liz Forbat, Richard D. Neal, Ronan E. O'Carroll, Sally Haw, Petra Rauchhaus, Richard G. Kyle

Faculty of Health Sciences Publications

Objectives: Raising cancer awareness and addressing barriers to help-seeking may improve early diagnosis. The aim was to assess whether a psycho-educational intervention increased adolescents' cancer awareness and addressed help-seeking barriers. Methods: This was a cluster randomised controlled trial involving 2173 adolescents in 20 schools. The intervention was a 50-min presentation delivered by a member of Teenage Cancer Trust's (UK charity) education team. Schools were stratified by deprivation and roll size and randomly allocated to intervention/control conditions within these strata. Outcome measures were the number of cancer warning signs and cancer risk factors recognised, help-seeking barriers endorsed and cancer ...


Acute Inflammatory Response To Low-, Moderate-, And High-Load Resistance Exercise In Women With Breast Cancer-Related Lymphedema, Prue Cormie, Benjamin Singh, Sandi Hayes, Jonathan M. Peake, Daniel A. Galvao, Dennis R. Taaffe, Nigel A. Spry, Kazunori Nosaka, Bruce Cornish, Kathryn H. Schmitz, Robert U. Newton Jan 2016

Acute Inflammatory Response To Low-, Moderate-, And High-Load Resistance Exercise In Women With Breast Cancer-Related Lymphedema, Prue Cormie, Benjamin Singh, Sandi Hayes, Jonathan M. Peake, Daniel A. Galvao, Dennis R. Taaffe, Nigel A. Spry, Kazunori Nosaka, Bruce Cornish, Kathryn H. Schmitz, Robert U. Newton

Faculty of Health Sciences Publications

Background. Resistance exercise is emerging as a potential adjunct therapy to aid in the management of breast cancer–related lymphedema (BCRL). However, the mechanisms underlying the relationships between the acute and long-term benefits of resistance exercise on BCRL are not well understood. Purpose. To examine the acute inflammatory response to upper-body resistance exercise in women with BCRL and to compare these effects between resistance exercises involving low, moderate, and high loads. The impact on lymphedema status and associated symptoms was also compared. Methods. A total of 21 women, 62 ± 10 years old, with BCRL participated in the study. Participants completed ...


Activation Of Pthrp-Camp-Creb1 Signaling Following P53 Loss Is Essential For Osteosarcoma Initiation And Maintenance, Mannu K. Walia, Patricia M. W. Ho, Scott Taylor, Alvin J. M. Ng, Ankita Gupte, Alistair M. Chalk, Andrew C. W. Zannettino, T. John Martin, Carl R. Walkley Jan 2016

Activation Of Pthrp-Camp-Creb1 Signaling Following P53 Loss Is Essential For Osteosarcoma Initiation And Maintenance, Mannu K. Walia, Patricia M. W. Ho, Scott Taylor, Alvin J. M. Ng, Ankita Gupte, Alistair M. Chalk, Andrew C. W. Zannettino, T. John Martin, Carl R. Walkley

Faculty of Health Sciences Publications

Mutations in the P53 pathway are a hallmark of human cancer. The identification of pathways upon which p53-deficient cells depend could reveal therapeutic targets that may spare normal cells with intact p53. In contrast to P53 point mutations in other cancer, complete loss of P53 is a frequent event in osteosarcoma (OS), the most common cancer of bone. The consequences of p53 loss for osteoblastic cells and OS development are poorly understood. Here we use murine OS models to demonstrate that elevated Pthlh (Pthrp), cAMP levels and signalling via CREB1 are characteristic of both p53-deficient osteoblasts and OS. Normal osteoblasts ...


The Transcription Factor Asciz And Its Target Dynll1 Are Essential For The Development And Expansion Of Myc-Driven B Cell Lymphoma, David M. Wong, Lingli Li, Sabine Jurado, Ashleigh King, Rebecca Bamford, Meaghan Wall, Mannu K. Walia, Gemma L. Kelly, Carl R. Walkley, David M. Tarlinton, Andreas Strasser, Jörg Heierhorst Jan 2016

The Transcription Factor Asciz And Its Target Dynll1 Are Essential For The Development And Expansion Of Myc-Driven B Cell Lymphoma, David M. Wong, Lingli Li, Sabine Jurado, Ashleigh King, Rebecca Bamford, Meaghan Wall, Mannu K. Walia, Gemma L. Kelly, Carl R. Walkley, David M. Tarlinton, Andreas Strasser, Jörg Heierhorst

Faculty of Health Sciences Publications

How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murine Eμ-Myc model of lymphoma. Deletion of Asciz or Dynll1 prevented the abnormal expansion of pre-B cells in pre-cancerous Eμ-Myc mice and potentiated the pro-apoptotic activity of MYC in pre-leukemic immature B cells. Constitutive loss of Asciz or Dynll1 delayed lymphoma development in Eμ-Myc mice, and induced deletion of Asciz in established lymphomas extended the survival of tumor-bearing mice. We propose ...


Iap Antagonists Sensitize Murine Osteosarcoma Cells To Killing By Tnfα, Tanmay M. Shekhar, Mark A. Miles, Ankita Gupte, Scott Taylor, Brianna Tascone, Carl R. Walkley, Christine J. Hawkins Jan 2016

Iap Antagonists Sensitize Murine Osteosarcoma Cells To Killing By Tnfα, Tanmay M. Shekhar, Mark A. Miles, Ankita Gupte, Scott Taylor, Brianna Tascone, Carl R. Walkley, Christine J. Hawkins

Faculty of Health Sciences Publications

Outcomes for patients diagnosed with the bone cancer osteosarcoma have not improved significantly in the last four decades. Only around 60% of patients and about a quarter of those with metastatic disease survive for more than five years. Although DNA-damaging chemotherapy drugs can be effective, they can provoke serious or fatal adverse effects including cardiotoxicity and therapy-related cancers. Better and safer treatments are therefore needed. We investigated the anti-osteosarcoma activity of IAP antagonists (also known as Smac mimetics) using cells from primary and metastatic osteosarcomas that arose spontaneously in mice engineered to lack p53 and Rb expression in osteoblast-derived cells ...


Exploring The Breast Care Nurse Role In Supporting Women With Breast Cancer, Tracey Ahern Nov 2015

Exploring The Breast Care Nurse Role In Supporting Women With Breast Cancer, Tracey Ahern

Theses

Breast cancer is the most common female cancer worldwide and the incidence is increasing. Due to advances in diagnosis and treatment, the number of women surviving breast cancer is also increasing. Those living with and beyond a breast cancer diagnosis need access to a wide variety of information and support which may vary depending on their circumstances. Breast care nurses (BCNs) are well recognised by Australian breast cancer patients for the information and support they provide. However, even though the BCN role has existed within the Australian healthcare system since the 1990’s very little national research has reported on ...


The Dna Helicase Recql4 Is Required For Normal Osteoblast Expansion And Osteosarcoma Formation, A. J. M. Ng, Mannu K. Walia, Monique F. Smeets, Anthony J. Mutsaers, Natalie A. Sims, L. E. Purton, Nicole C. Walsh, T. John Martin, Carl Walkley Jan 2015

The Dna Helicase Recql4 Is Required For Normal Osteoblast Expansion And Osteosarcoma Formation, A. J. M. Ng, Mannu K. Walia, Monique F. Smeets, Anthony J. Mutsaers, Natalie A. Sims, L. E. Purton, Nicole C. Walsh, T. John Martin, Carl Walkley

Faculty of Health Sciences Publications

RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS patients have a highly increased incidence of osteosarcoma (OS). The role of RECQL4 in normal adult bone development and homeostasis is largely uncharacterized and how mutation of RECQL4 contributes to OS susceptibility is not known. We hypothesised that Recql4 was required for normal skeletal development and both benign and malignant osteoblast function, which we have tested in the mouse. Recql4 deletion in vivo at the osteoblastic progenitor stage of ...


Palliative Care Needs In Patients Hospitalized With Heart Failure (Pchf) Study: Rationale And Design, Ross T. Campbell, Colette E. Jackson, Ann Wright, Roy S. Gardner, Ian Ford, Patricia M. Davidson, Martin A. Denvir, Karen J. Hogg, Miriam J. Johnson, Mark C. Petrie, John J. V. Mcmurray Jan 2015

Palliative Care Needs In Patients Hospitalized With Heart Failure (Pchf) Study: Rationale And Design, Ross T. Campbell, Colette E. Jackson, Ann Wright, Roy S. Gardner, Ian Ford, Patricia M. Davidson, Martin A. Denvir, Karen J. Hogg, Miriam J. Johnson, Mark C. Petrie, John J. V. Mcmurray

Faculty of Health Sciences Publications

Aims: The primary aim of this study is to provide data to inform the design of a randomized controlled clinical trial (RCT) of a palliative care (PC) intervention in heart failure (HF). We will identify an appropriate study population with a high prevalence of PC needs defined using quantifiable measures. We will also identify which components a specific and targeted PC intervention in HF should include and attempt to define the most relevant trial outcomes. Methods: An unselected, prospective, near‐consecutive, cohort of patients admitted to hospital with acute decompensated HF will be enrolled over a 2‐year period. All ...


The Ski Proto-Oncogene Enhances The In Vivo Repopulation Of Hematopoietic Stem Cells And Causes Myeloproliferative Disease, Sofie Singbrant, Meaghan Wall, Jennifer Moody, Göran Karlsson, Alistair M. Chalk, Brian J. Liddicoat, Megan R. Russell, Carl R. Walkley, Stefan Karlsson Jan 2014

The Ski Proto-Oncogene Enhances The In Vivo Repopulation Of Hematopoietic Stem Cells And Causes Myeloproliferative Disease, Sofie Singbrant, Meaghan Wall, Jennifer Moody, Göran Karlsson, Alistair M. Chalk, Brian J. Liddicoat, Megan R. Russell, Carl R. Walkley, Stefan Karlsson

Faculty of Health Sciences Publications

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compartments, and a marked enhancement of myeloid differentiation at the expense of other lineages. Accordingly, enforced expression of SKI induced a gene signature associated with hematopoietic stem cells and myeloid differentiation, as well as hepatocyte growth factor signaling. Here we demonstrate that, in ...


Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies, Prue Cormie, Suzanne K. Chambers, Robert U. Newton, Robert Alexander Gardiner, Nigel A. Spry, Dennis R. Taaffe, David Joseph, M. Akhil Hamid, Peter Chong, David Hughes, Kyra Hamilton, Daniel A. Galvao Jan 2014

Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies, Prue Cormie, Suzanne K. Chambers, Robert U. Newton, Robert Alexander Gardiner, Nigel A. Spry, Dennis R. Taaffe, David Joseph, M. Akhil Hamid, Peter Chong, David Hughes, Kyra Hamilton, Daniel A. Galvao

Faculty of Health Sciences Publications

Background: Despite being a critical survivorship care issue, there is a clear gap in current knowledge of the optimal treatment of sexual dysfunction in men with prostate cancer. There is sound theoretical rationale and emerging evidence that exercise may be an innovative therapy to counteract sexual dysfunction in men with prostate cancer. Furthermore, despite the multidimensional aetiology of sexual dysfunction, there is a paucity of research investigating the efficacy of integrated treatment models. Therefore, the purpose of this study is to: 1) examine the efficacy of exercise as a therapy to aid in the management of sexual dysfunction in men ...


Pthrp, Its Receptor, And Protein Kinase A Activation In Osteosarcoma, Carl Walkley, Mannu K. Walia, P.W.M. Ho, T. J. Martin Jan 2014

Pthrp, Its Receptor, And Protein Kinase A Activation In Osteosarcoma, Carl Walkley, Mannu K. Walia, P.W.M. Ho, T. J. Martin

Faculty of Health Sciences Publications

In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.


Toad Glandular Secretions And Skin Extractions As Anti-Inflammatory And Anticancer Agents, Ji Qi, Ck Tan, Saeed Hashimi, Abu Hasanat Zulfiker, David Good, Ming Wei Jan 2014

Toad Glandular Secretions And Skin Extractions As Anti-Inflammatory And Anticancer Agents, Ji Qi, Ck Tan, Saeed Hashimi, Abu Hasanat Zulfiker, David Good, Ming Wei

Faculty of Health Sciences Publications

No abstract provided.