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Full-Text Articles in Medicine and Health Sciences

The Adibox Study: Adiposity And Bone Metabolism: Effects Of Exercise-Induced Weight Loss In Adolescents With Obesity, Elodie Chaplais Aug 2017

The Adibox Study: Adiposity And Bone Metabolism: Effects Of Exercise-Induced Weight Loss In Adolescents With Obesity, Elodie Chaplais

Theses

Introduction: This program of research targeted the impact of an 8-month weight loss intervention induced by physical activity and nutrition on bone health in adolescents with obesity. The overall aim of this thesis was to examine the impact of a lifestyle weight loss intervention on the bone parameters in adolescents with obesity.

Method: Sixty-five adolescents were recruited: 31 (6 males) adolescents with obesity in the weight loss intervention (age: 13.61 (1.27)), 23 normal weight (NW) adolescents (age: 15.90 (0.43)) and 11 (4 males) adolescents with obesity in another control group (14.02 (1.39)). Primary outcomes ...


Skeletal Muscle Ampk Is Essential For The Maintenance Of Fndc5 Expression, James S. V. Lally, Rebecca J. Ford, Jasper Johar, Justin D. Crane, Bruce Ernest Kemp, Gregory R. Steinberg Jan 2015

Skeletal Muscle Ampk Is Essential For The Maintenance Of Fndc5 Expression, James S. V. Lally, Rebecca J. Ford, Jasper Johar, Justin D. Crane, Bruce Ernest Kemp, Gregory R. Steinberg

Faculty of Health Sciences Publications

Fibronectin type III domain‐containing protein 5 (FNDC5) expression is controlled by the transcriptional co‐activator, peroxisome proliferator‐activated receptor gamma, coactivator 1 alpha (PGC1α). FNDC5 expression has been shown to be increased in muscle in response to endurance exercise in some but not all studies, therefore a greater understanding of the mechanisms controlling this process are needed. The AMP‐activated protein kinase (AMPK) is activated by exercise in an intensity dependent manner and is an important regulator of PGC1α activity; therefore, we explored the role of AMPK in the regulation of FNDC5 using AMPK β1β2 double muscle‐null mice ...


Skeletal Muscle Acc2 S212 Phosphorylation Is Not Required For The Control Of Fatty Acid Oxidation During Exercise, Hayley M. O'Neill, James S. Lally, Sandra Galic, Thomas Pulinilkunnil, Rebecca J. Ford, Jason R. B. Dyck, Bryce J, Van Denderen, Bruce Ernest Kemp, Gregory R. Steinberg Jan 2015

Skeletal Muscle Acc2 S212 Phosphorylation Is Not Required For The Control Of Fatty Acid Oxidation During Exercise, Hayley M. O'Neill, James S. Lally, Sandra Galic, Thomas Pulinilkunnil, Rebecca J. Ford, Jason R. B. Dyck, Bryce J, Van Denderen, Bruce Ernest Kemp, Gregory R. Steinberg

Faculty of Health Sciences Publications

During submaximal exercise fatty acids are a predominant energy source for muscle contractions. An important regulator of fatty acid oxidation is acetyl‐CoA carboxylase (ACC), which exists as two isoforms (ACC1 and ACC2) with ACC2 predominating in skeletal muscle. Both ACC isoforms regulate malonyl‐CoA production, an allosteric inhibitor of carnitine palmitoyltransferase 1 (CPT‐1); the primary enzyme controlling fatty acyl‐CoA flux into mitochondria for oxidation. AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that is activated during exercise or by pharmacological agents such as metformin and AICAR. In resting muscle the activation of AMPK ...


Erk1/2 In The Brain Mediates The Effects Of Central Resistin On Reducing Thermogenesis In Brown Adipose Tissue, Samin Kosari, Donny Michael Camera, John Alan Hawley, Martin Stebbing, Emilio Badoer Jan 2013

Erk1/2 In The Brain Mediates The Effects Of Central Resistin On Reducing Thermogenesis In Brown Adipose Tissue, Samin Kosari, Donny Michael Camera, John Alan Hawley, Martin Stebbing, Emilio Badoer

Faculty of Health Sciences Publications

We investigated the role of ERK1/2 in the brain on the effects of centrally administered resistin on thermogenesis. Resistin (7 µg) into anaesthetized rats significantly decreased brown adipose tissue temperature by 1.0 ± 0.4 °C (P < 0.005). This response was significantly attenuated by over 60% when ERK1/2 was inhibited by U0126 (7 µg) (P < 0.05). Resistin reduced uncoupling protein-1 mRNA expression (0.11 ± 0.01 vs 1.24 ± 0.85 resistin vs control respectively) and the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α, but the effects were not statistically significant. The results suggest that ERK1/2 in the brain contributes to resistin’s effects on thermogenesis.