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Full-Text Articles in Medicine and Health Sciences

Residential Surrounding Greenness And Cognitive Decline: A 10-Year Follow-Up Of The Whitehall Ii Cohort, Carmen De Keijzer, C. Tonne, Xavier Basagaña, A. Valentín, Archana Singh-Manoux, Jordi Alonso, Josep M. Antó, Mark Nieuwenhuijsen, Jordi Sunyer, Payam Dadvand Jan 2018

Residential Surrounding Greenness And Cognitive Decline: A 10-Year Follow-Up Of The Whitehall Ii Cohort, Carmen De Keijzer, C. Tonne, Xavier Basagaña, A. Valentín, Archana Singh-Manoux, Jordi Alonso, Josep M. Antó, Mark Nieuwenhuijsen, Jordi Sunyer, Payam Dadvand

Faculty of Health Sciences Publications

Background:
Evidence on beneficial associations of green space with cognitive function in older adults is very scarce and mainly limited to cross-sectional studies.
Objectives:
We aimed to investigate the association between long-term residential surrounding greenness and cognitive decline.
Methods:
This longitudinal study was based on three waves of data from the Whitehall II cohort, providing a 10-y follow-up (1997–1999 to 2007–2009) of 6,506 participants (45–68 y old) from the United Kingdom. Residential surrounding greenness was obtained across buffers of 500 and 1,000m around the participants’ residential addresses at each follow-up using satellite images on greenness ...


Human Early Life Exposome (Helix) Study: A European Population-Based Exposome Cohort, Lea Maitre, Jeroen De Bont, Maribel Casas, Oliver Robinson, Gunn Marit Aasvang, Lydiane Agier, Sandra Andrusaityte, Ferran Ballester, Xavier Basagana, Eva Borras, Celine Brochot, Mariona Bustamante, Angel Carracedo, Montserrat De Castro, Audrius Dedele, David Donaire Gonzalez, Xavier Estivill, Jorunn Evandt, Serena Fossati, Lise Giorgis-Allemand, Juan R. Gonzalez, Berit Granum, Regina Grazuleviciene, Kristine B. Gutzkow, Line Smastuen Haug, Carles Hernandez-Ferrer, Barbara Heude, Jesus Ibarluzea, Jordi Julvez, Mrianna Karachaliou, Hector C. Keun, Norun Hjertager Krog, Chung-Ho E. Lau, Vasiliki Leventakou, Sarah Lyon-Caen, Cynthia Manzano, Dan Mason, R. R. C. Mceachan, Helle M. Meltzer, Inga Petraviciene, Joane Quentin, Theano Roumeliotaki, Eduard Sabido, Pierre-Jean Saulnier, Alexandros P. Siskos, Valerie Siroux, Jordi Sunyer, Ibon Tamayo, Jose Urquiza, Marina Vafeiadi, Diana Van Gent, Marta Vives-Usano, Dagmar Waiblinger, Charline Warembourg, Leda Chatzi, Muireann Coen, Peter Van Den Hazel, Mark Nieuwenhuijsen, Rémy Slama, Cathrine Thomsen, John Wright, Martine Vrijheid Jan 2018

Human Early Life Exposome (Helix) Study: A European Population-Based Exposome Cohort, Lea Maitre, Jeroen De Bont, Maribel Casas, Oliver Robinson, Gunn Marit Aasvang, Lydiane Agier, Sandra Andrusaityte, Ferran Ballester, Xavier Basagana, Eva Borras, Celine Brochot, Mariona Bustamante, Angel Carracedo, Montserrat De Castro, Audrius Dedele, David Donaire Gonzalez, Xavier Estivill, Jorunn Evandt, Serena Fossati, Lise Giorgis-Allemand, Juan R. Gonzalez, Berit Granum, Regina Grazuleviciene, Kristine B. Gutzkow, Line Smastuen Haug, Carles Hernandez-Ferrer, Barbara Heude, Jesus Ibarluzea, Jordi Julvez, Mrianna Karachaliou, Hector C. Keun, Norun Hjertager Krog, Chung-Ho E. Lau, Vasiliki Leventakou, Sarah Lyon-Caen, Cynthia Manzano, Dan Mason, R. R. C. Mceachan, Helle M. Meltzer, Inga Petraviciene, Joane Quentin, Theano Roumeliotaki, Eduard Sabido, Pierre-Jean Saulnier, Alexandros P. Siskos, Valerie Siroux, Jordi Sunyer, Ibon Tamayo, Jose Urquiza, Marina Vafeiadi, Diana Van Gent, Marta Vives-Usano, Dagmar Waiblinger, Charline Warembourg, Leda Chatzi, Muireann Coen, Peter Van Den Hazel, Mark Nieuwenhuijsen, Rémy Slama, Cathrine Thomsen, John Wright, Martine Vrijheid

Faculty of Health Sciences Publications

Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations.
Participants
The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania ...


Greenspace And Atopic Sensitization In Children And Adolescents: A Systematic Review, Katrina A. Lambert, Gayan Bowatte, Rachel Tham, Caroline J. Lodge, Luke A. Prendergast, Joachim Heinrich, Michael J. Abramson, Shyamali C. Dharmage, Bircan Erbas Jan 2018

Greenspace And Atopic Sensitization In Children And Adolescents: A Systematic Review, Katrina A. Lambert, Gayan Bowatte, Rachel Tham, Caroline J. Lodge, Luke A. Prendergast, Joachim Heinrich, Michael J. Abramson, Shyamali C. Dharmage, Bircan Erbas

Faculty of Health Sciences Publications

In the last decade, studies investigating greenspace have highlighted several benefits to human health. However, the effect of greenspace on allergies and atopic sensitization in children was not clear. While several studies have investigated this link, the evidence has not been systematically synthesized. We conducted a systematic search of eight databases. Study characteristics and findings were extracted from five articles covering 11 cohorts published between 2012 and 2016, and study quality assessments were performed. Due to significant heterogeneity, meta-analysis was not conducted. Findings were not consistent, possibly due to variations in exposure measurements, study populations and location, the specific allergens ...


The Urban Exposome During Pregnancy And Its Socioeconomic Determinants, Oliver Robinson, Ibon Tamayo, Montserrat De Castro, A. Valentín, Lise Giorgis-Allemand, Norun Hjertager Krog, Gunn Marit Aasvang, Albert Ambros, Ferran Ballester, Pippa Bird, Leda Chatzi, Marta Cirach, Audrius Dėdelė, David Donaire Gonzalez, Regina Gražuleviciene, Minas Iakovidis, Jesus Ibarluzea, Mariza Kampouri, Johanna Lepeule, Léa Maitre, R. R. C. Mceachan, Bente Oftedal, Valerie Siroux, Rémy Slama, Euripides Stephanou, Jordi Sunyer, Jose Urquiza, Kjell Vegard Weyde, John Wright, Martine Vrijheid, Mark Nieuwenhuijsen, Xavier Basagaña Jan 2018

The Urban Exposome During Pregnancy And Its Socioeconomic Determinants, Oliver Robinson, Ibon Tamayo, Montserrat De Castro, A. Valentín, Lise Giorgis-Allemand, Norun Hjertager Krog, Gunn Marit Aasvang, Albert Ambros, Ferran Ballester, Pippa Bird, Leda Chatzi, Marta Cirach, Audrius Dėdelė, David Donaire Gonzalez, Regina Gražuleviciene, Minas Iakovidis, Jesus Ibarluzea, Mariza Kampouri, Johanna Lepeule, Léa Maitre, R. R. C. Mceachan, Bente Oftedal, Valerie Siroux, Rémy Slama, Euripides Stephanou, Jordi Sunyer, Jose Urquiza, Kjell Vegard Weyde, John Wright, Martine Vrijheid, Mark Nieuwenhuijsen, Xavier Basagaña

Faculty of Health Sciences Publications

Background:
The urban exposome is the set of environmental factors that are experienced in the outdoor urban environment and that may influence child development.
Objective:
The authors’ goal was to describe the urban exposome among European pregnant women and understand its socioeconomic determinants.
Methods:
Using geographic information systems, remote sensing and spatio-temporal modeling we estimated exposure during pregnancy to 28 environmental indicators in almost 30,000 women from six population-based birth cohorts, in nine urban areas from across Europe. Exposures included meteorological factors, air pollutants, traffic noise, traffic indicators, natural space, the built environment, public transport, facilities, and walkability. Socioeconomic ...


Socioeconomic Inequalities In Urban And Transport Planning Related Exposures And Mortality: A Health Impact Assessment Study For Bradford, Uk, Natalie Mueller, David Rojas-Rueda, Haneen Khreis, Marta Cirach, Carles Mila, Ana Espinosa, Maria Foraster, R. R. C. Mceachan, Brian Kelly, John Wright, Mark Nieuwenhuijsen Jan 2018

Socioeconomic Inequalities In Urban And Transport Planning Related Exposures And Mortality: A Health Impact Assessment Study For Bradford, Uk, Natalie Mueller, David Rojas-Rueda, Haneen Khreis, Marta Cirach, Carles Mila, Ana Espinosa, Maria Foraster, R. R. C. Mceachan, Brian Kelly, John Wright, Mark Nieuwenhuijsen

Faculty of Health Sciences Publications

Background
Cities have unique geographic, environmental and sociocultural characteristics that influence the health status of their citizens. Identification and modification of these characteristics may help to promote healthier cities.
Objective
We estimated premature mortality impacts of breaching international exposure guidelines for physical activity (PA), air pollution, noise and access to green space for Bradford (UK) adult residents (n = 393,091).
Methods
We applied the Urban and TranspOrt Planning Health Impact Assessment (UTOPHIA) methodology and estimated mortality, life expectancy (LE) and economic impacts of non-compliance with recommended exposure levels. We also investigated the distribution of the mortality burden among the population ...


Association Between Air Pollution And Rhinitis Incidence In Two European Cohorts, Emilie Burte, Benedicte Leynaert, Roberto Bono, Bert Brunekreef, Jean Bousquet, Anne-Elie Carsin, Kees De Hoogh, Bertil Forsberg, Frederic Gormand, Joachim Heinrich, Jocelyne Just, Alessandro Marcon, Nino Kunzli, Mark Nieuwenhuijsen, Isabelle Pin, Morgane Stempfelet, Jordi Sunyer, Simona Villani, Valerie Siroux, Deborah Jarvis, Rachel Nadif, Benedicte Jacquemin Jan 2018

Association Between Air Pollution And Rhinitis Incidence In Two European Cohorts, Emilie Burte, Benedicte Leynaert, Roberto Bono, Bert Brunekreef, Jean Bousquet, Anne-Elie Carsin, Kees De Hoogh, Bertil Forsberg, Frederic Gormand, Joachim Heinrich, Jocelyne Just, Alessandro Marcon, Nino Kunzli, Mark Nieuwenhuijsen, Isabelle Pin, Morgane Stempfelet, Jordi Sunyer, Simona Villani, Valerie Siroux, Deborah Jarvis, Rachel Nadif, Benedicte Jacquemin

Faculty of Health Sciences Publications

Background
The association between air pollution and rhinitis is not well established.
Aim
The aim of this longitudinal analysis was to study the association between modeled air pollution at the subjects' home addresses and self-reported incidence of rhinitis.
Methods
We used data from 1533 adults from two multicentre cohorts' studies (EGEA and ECRHS). Rhinitis incidence was defined as reporting rhinitis at the second follow-up (2011 to 2013) but not at the first follow-up (2000 to 2007). Annual exposure to NO2, PM10 and PM2.5 at the participants' home addresses was estimated using land-use regression models developed by the ESCAPE project ...


Exhaust Ventilation In Attached Garages Improves Residential Indoor Air Quality, Gary Mallach, Melissa St-Jean, Morgan Macneill, Daniel G. Aubin, Lance Wallace, Tin Shin, Keith Van Ryswyk, Ryan H. Kulka, Hongyu You, Don W. Fugler, Eric Lavigne, Amanda Wheeler Jan 2017

Exhaust Ventilation In Attached Garages Improves Residential Indoor Air Quality, Gary Mallach, Melissa St-Jean, Morgan Macneill, Daniel G. Aubin, Lance Wallace, Tin Shin, Keith Van Ryswyk, Ryan H. Kulka, Hongyu You, Don W. Fugler, Eric Lavigne, Amanda Wheeler

Faculty of Health Sciences Publications

Previous research has shown that indoor benzene levels in homes with attached garages are higher than homes without attached garages. Exhaust ventilation in attached garages is one possible intervention to reduce these concentrations. To evaluate the effectiveness of this intervention, a randomized crossover study was conducted in 33 Ottawa homes in winter 2014. VOCs including benzene, toluene, ethylbenzene, and xylenes, nitrogen dioxide, carbon monoxide, and air exchange rates were measured over four 48‐hour periods when a garage exhaust fan was turned on or off. A blower door test conducted in each garage was used to determine the required exhaust ...


Bluehealth: A Study Programme Protocol For Mapping And Quantifying The Potential Benefits To Public Health And Well-Being From Europe's Blue Spaces, James Grellier, Mathew P. White, Maria Albin, Simon Bell, Lewis R. Elliott, Mireia Gascon, Silvio Gualdi, Laura Mancini, Mark Nieuwenhuijsen, Denis A. Sarigiannis, Matilda Van Den Bosch, Tanja Wolf, Susanne Wuijts, Lora E. Fleming Jan 2017

Bluehealth: A Study Programme Protocol For Mapping And Quantifying The Potential Benefits To Public Health And Well-Being From Europe's Blue Spaces, James Grellier, Mathew P. White, Maria Albin, Simon Bell, Lewis R. Elliott, Mireia Gascon, Silvio Gualdi, Laura Mancini, Mark Nieuwenhuijsen, Denis A. Sarigiannis, Matilda Van Den Bosch, Tanja Wolf, Susanne Wuijts, Lora E. Fleming

Faculty of Health Sciences Publications

Introduction
Proximity and access to water have long been central to human culture and accordingly deliver countless societal benefits. Over 200 million people live on Europe's coastline, and aquatic environments are the top recreational destination in the region. In terms of public health, interactions with ‘blue space’ (eg, coasts, rivers, lakes) are often considered solely in terms of risk (eg, drowning, microbial pollution). Exposure to blue space can, however, promote health and well-being and prevent disease, although underlying mechanisms are poorly understood.
Aims and methods
The BlueHealth project aims to understand the relationships between exposure to blue space and ...


Does The Health Impact Of Exposure To Neighbourhood Green Space Differ Between Population Groups? An Explorative Study In Four European Cities, Annemarie Ruijsbroek, Mariël Droomers, Hanneke Kruize, Elise Van Kempen, Christopher Gidlow, Gemma Hurst, Sandra Andrusaityte, Mark Nieuwenhuijsen, Jolanda Maas, Wim Hardyns, Karien Stronks, Peter P. Groenewegen Jan 2017

Does The Health Impact Of Exposure To Neighbourhood Green Space Differ Between Population Groups? An Explorative Study In Four European Cities, Annemarie Ruijsbroek, Mariël Droomers, Hanneke Kruize, Elise Van Kempen, Christopher Gidlow, Gemma Hurst, Sandra Andrusaityte, Mark Nieuwenhuijsen, Jolanda Maas, Wim Hardyns, Karien Stronks, Peter P. Groenewegen

Faculty of Health Sciences Publications

It has been suggested that certain residents, such as those with a low socioeconomic status, the elderly, and women, may benefit more from the presence of neighbourhood green space than others. We tested this hypothesis for age, gender, educational level, and employment status in four European cities. Data were collected in Barcelona (Spain; n = 1002), Kaunas (Lithuania; n = 989), Doetinchem (The Netherlands; n = 847), and Stoke-on-Trent (UK; n = 933) as part of the EU-funded PHENOTYPE project. Surveys were used to measure mental and general health, individual characteristics, and perceived neighbourhood green space. Additionally, we used audit data about neighbourhood green ...


Characterisation Of The Natural Environment: Quantitative Indicators Across Europe, Graham Smith, Marta Cirach, Wim Swart, Audrius Dėdelė, Christopher Gidlow, Elise Kempen, Hanneke Kruize, Regina Gražulevičiene, Mark Nieuwenhuijsen Jan 2017

Characterisation Of The Natural Environment: Quantitative Indicators Across Europe, Graham Smith, Marta Cirach, Wim Swart, Audrius Dėdelė, Christopher Gidlow, Elise Kempen, Hanneke Kruize, Regina Gražulevičiene, Mark Nieuwenhuijsen

Faculty of Health Sciences Publications

Background The World Health Organization recognises the importance of natural environments for human health. Evidence for natural environment-health associations comes largely from single countries or regions, with varied approaches to measuring natural environment exposure. We present a standardised approach to measuring neighbourhood natural environment exposure in cities in different regions of Europe. Methods The Positive Health Effects of the Natural Outdoor environment in TYPical populations of different regions in Europe (PHENOTYPE) study aimed to explore the mechanisms linking natural environment exposure and health in four European cities (Barcelona, Spain; Doetinchem, the Netherlands; Kaunas, Lithuania; and Stoke-on-Trent, UK). Common GIS protocols ...


The Effect Of Randomised Exposure To Different Types Of Natural Outdoor Environments Compared To Exposure To An Urban Environment On People With Indications Of Psychological Distress In Catalonia, Margarita Triguero-Mas, Christopher Gidlow, David Martínez, Jeroen De Bont, Glòria Carrasco-Turigas, Tania Martinez-Iñiguez, Gemma Hurst, Daniel Masterson, D. Donaire-Gonzalez, Edmund Seto, Marc V. Jones, Mark Nieuwenhuijsen Jan 2017

The Effect Of Randomised Exposure To Different Types Of Natural Outdoor Environments Compared To Exposure To An Urban Environment On People With Indications Of Psychological Distress In Catalonia, Margarita Triguero-Mas, Christopher Gidlow, David Martínez, Jeroen De Bont, Glòria Carrasco-Turigas, Tania Martinez-Iñiguez, Gemma Hurst, Daniel Masterson, D. Donaire-Gonzalez, Edmund Seto, Marc V. Jones, Mark Nieuwenhuijsen

Faculty of Health Sciences Publications

Introduction Experimental studies have reported associations between short-term exposure to natural outdoor environments (NOE) and health benefits. However, they lack insight into mechanisms, often have low external and ecological validity, and have rarely focused on people with some psycho-physiological affection. The aim of this study was to use a randomized, case-crossover design to investigate: (i) the effects of unconstrained exposure to real natural and urban environments on psycho-physiological indicators of people with indications of psychological distress, (ii) the possible differential effects of 30 and 30+180 minutes exposures, and (iii) the possible mechanisms explaining these effects. Material and methods People ...


Colorectal Cancer And Long-Term Exposure To Trihalomethanes In Drinking Water: A Multicenter Case-Control Study In Spain And Italy, Cristina M. Villanueva, Esther Gracia-Lavedan, Cristina Bosetti, Elena Righi, Antonio J. Molina, Vicente Martín, Elena Boldo, Nuria Aragonés, Beatriz Perez-Gomez, Marina Pollan, Ines G. Acebo, Jone M. Altzibar, Ana J. Zabala, Eva Ardanaz, Rosana Peiró, Adonina Tardón, Maria D. Chirlaque, Alessandra Tavani, Jerry Polesel, Diego Serraino, Federica Pisa, Gemma Castaño-Vinyals, Ana Espinosa, Ciber Epidemiologia Y Salud Publicauniversitat Pompeu Fabra Nadia, Margarita, Victor, Carlo, Gabriella, Mark, Manolis Jan 2017

Colorectal Cancer And Long-Term Exposure To Trihalomethanes In Drinking Water: A Multicenter Case-Control Study In Spain And Italy, Cristina M. Villanueva, Esther Gracia-Lavedan, Cristina Bosetti, Elena Righi, Antonio J. Molina, Vicente Martín, Elena Boldo, Nuria Aragonés, Beatriz Perez-Gomez, Marina Pollan, Ines G. Acebo, Jone M. Altzibar, Ana J. Zabala, Eva Ardanaz, Rosana Peiró, Adonina Tardón, Maria D. Chirlaque, Alessandra Tavani, Jerry Polesel, Diego Serraino, Federica Pisa, Gemma Castaño-Vinyals, Ana Espinosa, Ciber Epidemiologia Y Salud Publicauniversitat Pompeu Fabra Nadia, Margarita, Victor, Carlo, Gabriella, Mark, Manolis

Faculty of Health Sciences Publications

Background: Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. Objectives: We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. Methods: A multicenter case–control study was conducted in Spain and Italy in 2008–2013. Hospital-based incident cases and population-based (Spain) and hospital-based (Italy) controls were interviewed to ascertain residential histories, type of water consumed in each residence, frequency and duration of showering/bathing, and major recognized risk factors for colorectal cancer. We estimated adjusted odds ratios (OR) for colorectal ...


Road Traffic Noise And Children's Inattention, Kjell V. Weyde, Norun H. Krog, Bente Oftedal, Per Magnus, Simon Øverland, Stephen Stansfeld, Mark Nieuwenhuijsen, Martine Vrijheid, Montserrat D.C. Pascual, Gunn M. Aasvang Jan 2017

Road Traffic Noise And Children's Inattention, Kjell V. Weyde, Norun H. Krog, Bente Oftedal, Per Magnus, Simon Øverland, Stephen Stansfeld, Mark Nieuwenhuijsen, Martine Vrijheid, Montserrat D.C. Pascual, Gunn M. Aasvang

Faculty of Health Sciences Publications

Background An increasing number of children are exposed to road traffic noise levels that may lead to adverse effects on health and daily functioning. Childhood is a period of intense growth and brain maturation, and children may therefore be especially vulnerable to road traffic noise. The objective of the present study was to examine whether road traffic noise was associated with reported inattention symptoms in children, and whether this association was mediated by sleep duration. Methods This study was based on the Norwegian Mother and Child Cohort Study conducted by the Norwegian Institute of Public Health. Parental reports of children ...


A Systematic Comparison Of Statistical Methods To Detect Interactions In Exposome-Health Associations, J. Barrera-Gómez, Lydiane Agier, Lützen Portengen, Marc Chadeau-Hyam, Lise Giorgis-Allemand, Valérie Siroux, O. Robinson, Jelle Vlaanderen, Juan R. González, Mark Nieuwenhuijsen, Paolo Vineis, Martine Vrijheid, Roel Vermeulen, Rémy Slama, Xavier Basagaña Jan 2017

A Systematic Comparison Of Statistical Methods To Detect Interactions In Exposome-Health Associations, J. Barrera-Gómez, Lydiane Agier, Lützen Portengen, Marc Chadeau-Hyam, Lise Giorgis-Allemand, Valérie Siroux, O. Robinson, Jelle Vlaanderen, Juan R. González, Mark Nieuwenhuijsen, Paolo Vineis, Martine Vrijheid, Roel Vermeulen, Rémy Slama, Xavier Basagaña

Faculty of Health Sciences Publications

Background There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept (being defined as the totality of human environmental exposures from conception onwards). Uncovering such combined effects is challenging owing to the large number of exposures, several of them being highly correlated. We performed a simulation study in an exposome context to compare the performance of several statistical methods that have been proposed to detect statistical interactions. Methods Simulations were based on an exposome including 237 exposures with a realistic correlation structure. We ...


Wireless Distributed Environmental Sensor Networks For Air Pollution Measurement-The Promise And The Current Reality, David M. Broday, Alexander Arpaci, Alena Bartonova, Nuría Castell-Balaguer, Tom Cole-Hunter, Franck R. Dauge, Barak Fishbain, Rod L. Jones, Karen Galea, Milena Jovasevic-Stojanovic, David Kocman, Tania Martinez-Iñiguez, Mark Nieuwenhuijsen, Johanna Robinson, Vlasta Svecova, Phong Thai Jan 2017

Wireless Distributed Environmental Sensor Networks For Air Pollution Measurement-The Promise And The Current Reality, David M. Broday, Alexander Arpaci, Alena Bartonova, Nuría Castell-Balaguer, Tom Cole-Hunter, Franck R. Dauge, Barak Fishbain, Rod L. Jones, Karen Galea, Milena Jovasevic-Stojanovic, David Kocman, Tania Martinez-Iñiguez, Mark Nieuwenhuijsen, Johanna Robinson, Vlasta Svecova, Phong Thai

Faculty of Health Sciences Publications

The evaluation of the effects of air pollution on public health and human-wellbeing requires reliable data. Standard air quality monitoring stations provide accurate measurements of airborne pollutant levels, but, due to their sparse distribution, they cannot capture accurately the spatial variability of air pollutant concentrations within cities. Dedicated in-depth field campaigns have dense spatial coverage of the measurements but are held for relatively short time periods. Hence, their representativeness is limited. Moreover, the oftentimes integrated measurements represent time-averaged records. Recent advances in communication and sensor technologies enable the deployment of dense grids of Wireless Distributed Environmental Sensor Networks for air ...


Traffic-Related Air Pollution And Spectacles Use In Schoolchildren, Payam Dadvand, Mark Nieuwenhuijsen, Xavier Basagaña, Mar Alvarez-Pedrerol, Albert Dalmau-Bueno, Marta Cirach, Ioar Rivas, Bert Brunekreef, Xavier Querol, Ian G. Morgan, Jordi Sunyer Jan 2017

Traffic-Related Air Pollution And Spectacles Use In Schoolchildren, Payam Dadvand, Mark Nieuwenhuijsen, Xavier Basagaña, Mar Alvarez-Pedrerol, Albert Dalmau-Bueno, Marta Cirach, Ioar Rivas, Bert Brunekreef, Xavier Querol, Ian G. Morgan, Jordi Sunyer

Faculty of Health Sciences Publications

Purpose To investigate the association between exposure to traffic-related air pollution and use of spectacles (as a surrogate measure for myopia) in schoolchildren. Methods We analyzed the impact of exposure to NO2 and PM2.5 light absorbance at home (predicted by land-use regression models) and exposure to NO2 and black carbon (BC) at school (measured by monitoring campaigns) on the use of spectacles in a cohort of 2727 schoolchildren (7–10 years old) in Barcelona (2012–2015). We conducted cross-sectional analyses based on lifelong exposure to air pollution and prevalent cases of spectacles at baseline data collection campaign as well ...


Traffic-Related Air Pollution And Childhood Asthma: Recent Advances And Remaining Gaps In The Exposure Assessment Methods, Haneen Khreis, Mark Nieuwenhuijsen Jan 2017

Traffic-Related Air Pollution And Childhood Asthma: Recent Advances And Remaining Gaps In The Exposure Assessment Methods, Haneen Khreis, Mark Nieuwenhuijsen

Faculty of Health Sciences Publications

Background: Current levels of traffic-related air pollution (TRAP) are associated with the development of childhood asthma, although some inconsistencies and heterogeneity remain. An important part of the uncertainty in studies of TRAP-associated asthma originates from uncertainties in the TRAP exposure assessment and assignment methods. In this work, we aim to systematically review the exposure assessment methods used in the epidemiology of TRAP and childhood asthma, highlight recent advances, remaining research gaps and make suggestions for further research. Methods: We systematically reviewed epidemiological studies published up until 8 September 2016 and available in Embase, Ovid MEDLINE (R), and “Transport database”. We ...


Who Environmental Noise Guidelines For The European Region: A Systematic Review On Environmental Noise And Adverse Birth Outcomes, Mark Nieuwenhuijsen, Gordana Ristovska, Payam Dadvand Jan 2017

Who Environmental Noise Guidelines For The European Region: A Systematic Review On Environmental Noise And Adverse Birth Outcomes, Mark Nieuwenhuijsen, Gordana Ristovska, Payam Dadvand

Faculty of Health Sciences Publications

Introduction: Three recent systematic reviews suggested a relationship between noise exposure and adverse birth outcomes. The aim of this review was to evaluate the evidence for the World Health Organization (WHO) noise guidelines and conduct an updated systematic review of environmental noise, specifically aircraft and road traffic noise and birth outcomes, such as preterm birth, low birth weight, being small for gestational age and congenital malformations. Materials and methods: We reviewed again all the papers on environmental noise and birth outcomes included in the previous three systematic reviews and conducted a systematic search on noise and birth outcomes to update ...


Assessing The Exposome With External Measures: Commentary On The State Of The Science And Research Recommendations, Michelle C. Turner, Mark Nieuwenhuijsen, Kim Anderson, David Balshaw, Yuxia Cui, Genevieve Dunton, Jane A. Hoppin, Petros Koutrakis, Michael Jerrett Jan 2017

Assessing The Exposome With External Measures: Commentary On The State Of The Science And Research Recommendations, Michelle C. Turner, Mark Nieuwenhuijsen, Kim Anderson, David Balshaw, Yuxia Cui, Genevieve Dunton, Jane A. Hoppin, Petros Koutrakis, Michael Jerrett

Faculty of Health Sciences Publications

The exposome comprises all environmental exposures that a person experiences from conception throughout the life course. Here we review the state of the science for assessing external exposures within the exposome. This article reviews (a) categories of exposures that can be assessed externally, (b) the current state of the science in external exposure assessment, (c) current tools available for external exposure assessment, and (d) priority research needs. We describe major scientific and technological advances that inform external assessment of the exposome, including geographic information systems; remote sensing; global positioning system and geolocation technologies; portable and personal sensing, including smartphone-based sensors ...


The Exposome In Practice: Design Of The Exposomics Project, Paolo Vineis, Marc Chadeau-Hyam, H. Gmuender, John Gulliver, Z. Herceg, J. Kleinjans, Manolis Kogevinas, Soterios Kyrtopoulos, Mark Nieuwenhuijsen, David H. Phillips, Nicole Probst-Hensch, A. Scalbert, Roel Vermeulen, Christopher Wild Jan 2017

The Exposome In Practice: Design Of The Exposomics Project, Paolo Vineis, Marc Chadeau-Hyam, H. Gmuender, John Gulliver, Z. Herceg, J. Kleinjans, Manolis Kogevinas, Soterios Kyrtopoulos, Mark Nieuwenhuijsen, David H. Phillips, Nicole Probst-Hensch, A. Scalbert, Roel Vermeulen, Christopher Wild

Faculty of Health Sciences Publications

EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple “omic” technologies for the analysis of biological samples (internal markers of external ...


Occupational Exposure To Endocrine-Disrupting Chemicals And Birth Weight And Length Of Gestation: A European Meta-Analysis, Laura Birks, Maribel Casas, Ana M. Garcia, Jan Alexander, Henrique Barros, Anna Bergstrom, Jens Peter Bonde, Alex Burdorf, Nathalie Costet, Asta Danileviciute, Merete Eggesbø, Mariana F. Fernandez, M. Carmen Gonzalez-Galarzo, Regina Grazuleviciene, Wojciech Hanke, Vincent W. V. Jaddoe, Manolis Kogevinas, Inger Kull, Aitana Lertxundi, Vasiliki Melaki, Anne-Marie Nybo Andersen, Nicolas Olea, Kinga Polanska, Franca Rusconi, Loreto Santa-Marina, Ana Cristina Santos, Tanja Vrijkotte, Daniela Zugna, Mark Nieuwenhuijsen, Sylvaine Cordier, Martine Vrijheid Jan 2016

Occupational Exposure To Endocrine-Disrupting Chemicals And Birth Weight And Length Of Gestation: A European Meta-Analysis, Laura Birks, Maribel Casas, Ana M. Garcia, Jan Alexander, Henrique Barros, Anna Bergstrom, Jens Peter Bonde, Alex Burdorf, Nathalie Costet, Asta Danileviciute, Merete Eggesbø, Mariana F. Fernandez, M. Carmen Gonzalez-Galarzo, Regina Grazuleviciene, Wojciech Hanke, Vincent W. V. Jaddoe, Manolis Kogevinas, Inger Kull, Aitana Lertxundi, Vasiliki Melaki, Anne-Marie Nybo Andersen, Nicolas Olea, Kinga Polanska, Franca Rusconi, Loreto Santa-Marina, Ana Cristina Santos, Tanja Vrijkotte, Daniela Zugna, Mark Nieuwenhuijsen, Sylvaine Cordier, Martine Vrijheid

Faculty of Health Sciences Publications

Background:
Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth.
Objectives:
We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery.
Methods:
Using individual participant data from 133,957 mother–child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For ...


Trace Metal Exposure Is Associated With Increased Exhaled Nitric Oxide In Asthmatic Children, Krystal J. Godri Pollitt, Caitlin L. Maikawa, Amanda Wheeler, Scott Weichenthal, Nina A. Dobbin, Ling Liu, Mark S. Goldberg Jan 2016

Trace Metal Exposure Is Associated With Increased Exhaled Nitric Oxide In Asthmatic Children, Krystal J. Godri Pollitt, Caitlin L. Maikawa, Amanda Wheeler, Scott Weichenthal, Nina A. Dobbin, Ling Liu, Mark S. Goldberg

Faculty of Health Sciences Publications

Background
Children with asthma experience increased susceptibility to airborne pollutants. Exposure to traffic and industrial activity have been positively associated with exacerbation of symptoms as well as emergency room visits and hospitalisations. The effect of trace metals contained in fine particulate matter (aerodynamic diameter 2.5 μm and lower, PM2.5) on acute health effects amongst asthmatic children has not been well investigated. The objective of this panel study in asthmatic children was to determine the association between personal daily exposure to ambient trace metals and airway inflammation, as measured by fractional exhaled nitric oxide (FeNO).
Methods
Daily concentrations of ...


Benefits Of Mobile Phone Technology For Personal Environmental Monitoring, David Donaire Gonzalez, Antonia Valentin, Audrey De Nazelle, Albert Ambros, Gloria Carrasco-Turigas, Edmund Seto, Michael Jerrett, Mark Nieuwenhuijsen Jan 2016

Benefits Of Mobile Phone Technology For Personal Environmental Monitoring, David Donaire Gonzalez, Antonia Valentin, Audrey De Nazelle, Albert Ambros, Gloria Carrasco-Turigas, Edmund Seto, Michael Jerrett, Mark Nieuwenhuijsen

Faculty of Health Sciences Publications

Background: Tracking individuals in environmental epidemiological studies using novel mobile phone technologies can provide valuable information on geolocation and physical activity, which will improve our understanding of environmental exposures.
Objective: The objective of this study was to assess the performance of one of the least expensive mobile phones on the market to track people's travel-activity pattern.
Methods: Adults living and working in Barcelona (72/162 bicycle commuters) carried simultaneously a mobile phone and a Global Positioning System (GPS) tracker and filled in a travel-activity diary (TAD) for 1 week (N=162). The CalFit app for mobile phones was used ...


Can Changing The Timing Of Outdoor Air Intake Reduce Indoor Concentrations Of Traffic-Related Pollutants In Schools?, Morgan Macneill, N. Dobbin, Melissa St-Jean, Lance Wallace, L. Marro, Tin Shin, Hongyu You, Ryan H. Kulka, R. W. Allen, Amanda Wheeler Jan 2016

Can Changing The Timing Of Outdoor Air Intake Reduce Indoor Concentrations Of Traffic-Related Pollutants In Schools?, Morgan Macneill, N. Dobbin, Melissa St-Jean, Lance Wallace, L. Marro, Tin Shin, Hongyu You, Ryan H. Kulka, R. W. Allen, Amanda Wheeler

Faculty of Health Sciences Publications

Traffic emissions have been associated with a wide range of adverse health effects. Many schools are situated close to major roads, and as children spend much of their day in school, methods to reduce traffic‐related air pollutant concentrations in the school environment are warranted. One promising method to reduce pollutant concentrations in schools is to alter the timing of the ventilation so that high ventilation time periods do not correspond to rush hour traffic. Health Canada, in collaboration with the Ottawa‐Carleton District School Board, tested the effect of this action by collecting traffic‐related air pollution data from ...


Particulate Oxidative Burden As A Predictor Of Exhaled Nitric Oxide In Children With Asthma, Caitlin L. Maikawa, Scott Weichenthal, Amanda Wheeler, Nina A. Dobbin, Audrey Smargiassi, Greg Evans, Ling Liu, Mark S. Goldberg, Krystal J. Godri Pollitt Jan 2016

Particulate Oxidative Burden As A Predictor Of Exhaled Nitric Oxide In Children With Asthma, Caitlin L. Maikawa, Scott Weichenthal, Amanda Wheeler, Nina A. Dobbin, Audrey Smargiassi, Greg Evans, Ling Liu, Mark S. Goldberg, Krystal J. Godri Pollitt

Faculty of Health Sciences Publications

Background:
Epidemiological studies have provided strong evidence that fine particulate matter (PM2.5; aerodynamic diameter ≤ 2.5 μm) can exacerbate asthmatic symptoms in children. Pro-oxidant components of PM2.5 are capable of directly generating reactive oxygen species. Oxidative burden is used to describe the capacity of PM2.5 to generate reactive oxygen species in the lung.
Objective:
In this study we investigated the association between airway inflammation in asthmatic children and oxidative burden of PM2.5 personal exposure.
Methods:
Daily PM2.5 personal exposure samples (n = 249) of 62 asthmatic school-aged children in Montreal were collected over 10 consecutive days ...


Effects Of Ambient Coarse, Fine, And Ultrafine Particles And Their Biological Constituents On Systematic Biomarkers: A Controlled Human Exposure Study, Ling Liu, Bruce Urch, Raymond Poon, Mieczyslaw Szyszkowicz, Mary Speck, Diane R. Gold, Amanda J. Wheeler, James A. Scott, Jeffrey R. Brook, Peter S. Thorne, Frances S. Silverman Jan 2015

Effects Of Ambient Coarse, Fine, And Ultrafine Particles And Their Biological Constituents On Systematic Biomarkers: A Controlled Human Exposure Study, Ling Liu, Bruce Urch, Raymond Poon, Mieczyslaw Szyszkowicz, Mary Speck, Diane R. Gold, Amanda J. Wheeler, James A. Scott, Jeffrey R. Brook, Peter S. Thorne, Frances S. Silverman

Faculty of Health Sciences Publications

Background: Ambient coarse, fine, and ultrafine particles have been associated with mortality and morbidity. Few studies have compared how various particle size fractions affect systemic biomarkers. Objectives: We examined changes of blood and urinary biomarkers following exposures to three particle sizes. Methods: Fifty healthy nonsmoking volunteers, mean age of 28 years, were exposed to coarse (2.5–10 μm; mean, 213 μg/m3) and fine (0.15–2.5 μm; mean, 238 μg/m3) concentrated ambient particles (CAPs), and filtered ambient and/or medical air. Twenty-five participants were exposed to ultrafine CAP ( < 0.3 μm; mean, 136 μg/m3) and filtered medical air. Exposures lasted 130 min, separated by ≥ 2 weeks. Blood/urine samples were collected preexposure and 1 hr and 21 hr postexposure to determine blood interleukin-6 and C-reactive protein (inflammation), endothelin-1 and vascular endothelial growth factor (VEGF; vascular mediators), and malondialdehyde (lipid peroxidation); as well as urinary VEGF, 8-hydroxy-deoxy-guanosine (DNA oxidation), and malondialdehyde. Mixed-model regressions assessed pre- and postexposure differences. Results: One hour postexposure, for every 100-μg/m3 increase, coarse CAP was associated with increased blood VEGF (2.41 pg/mL; 95% CI: 0.41, 4.40) in models adjusted for O3, fine CAP with increased urinary malondialdehyde in single- (0.31 nmol/mg creatinine; 95% CI: 0.02, 0.60) and two-pollutant models, and ultrafine CAP with increased urinary 8-hydroxydeoxyguanosine in single- (0.69 ng/mg creatinine; 95% CI: 0.09, 1.29) and two-pollutant models, lasting < 21 hr. Endotoxin was significantly associated with biomarker changes similar to those found with CAPs. Conclusions: Ambient particles with various sizes/constituents may influence systemic biomarkers differently. Endotoxin in ambient particles may contribute to vascular mediator changes and oxidative stress.


Estimation Of Bias With The Single-Zone Assumption In Measurement Of Residential Air Exchange Using The Perfluorocardon Tracer Gas Method, K. Van Ryswyk, L. Wallace, D. Fugler, M. Macneill, M. È. Héroux, M. D. Gibson, J. R. Guernsey, W. Kindzierski, A. J. Wheeler Jan 2015

Estimation Of Bias With The Single-Zone Assumption In Measurement Of Residential Air Exchange Using The Perfluorocardon Tracer Gas Method, K. Van Ryswyk, L. Wallace, D. Fugler, M. Macneill, M. È. Héroux, M. D. Gibson, J. R. Guernsey, W. Kindzierski, A. J. Wheeler

Faculty of Health Sciences Publications

Residential air exchange rates (AERs) are vital in understanding the temporal and spatial drivers of indoor air quality (IAQ). Several methods to quantify AERs have been used in IAQ research, often with the assumption that the home is a single, well‐mixed air zone. Since 2005, Health Canada has conducted IAQ studies across Canada in which AERs were measured using the perfluorocarbon tracer (PFT) gas method. Emitters and detectors of a single PFT gas were placed on the main floor to estimate a single‐zone AER (AER1z). In three of these studies, a second set of emitters and detectors were ...


Within- And Between-City Contrasts In Nitrogen Dioxide And Mortality In 10 Canadian Cities: A Subset Of The Canadian Census Health And Environment Cohort (Canchec), Dan L. Crouse, Paul A. Peters, Paul J. Villeneuve, Marc-Olivier Proux, Hwashin H. Shin, Mark S. Goldberg, Markey Johnson, Amanda J. Wheeler, Ryan W. Allen, Dominic Odwa Atari, Michael Jerrett, Michael Brauer, Jeffrey R. Brook, Sabit Cakmak, Richard T. Burnett Jan 2015

Within- And Between-City Contrasts In Nitrogen Dioxide And Mortality In 10 Canadian Cities: A Subset Of The Canadian Census Health And Environment Cohort (Canchec), Dan L. Crouse, Paul A. Peters, Paul J. Villeneuve, Marc-Olivier Proux, Hwashin H. Shin, Mark S. Goldberg, Markey Johnson, Amanda J. Wheeler, Ryan W. Allen, Dominic Odwa Atari, Michael Jerrett, Michael Brauer, Jeffrey R. Brook, Sabit Cakmak, Richard T. Burnett

Faculty of Health Sciences Publications

The independent and joint effects of within- and between-city contrasts in air pollution on mortality have been investigated rarely. To examine the differential effects of between- versus within-city contrasts in pollution exposure, we used both ambient measurements and land use regression models to assess associations with mortality and exposure to nitrogen dioxide (NO2) among ~735,600 adults in 10 of the largest Canadian cities. We estimated exposure contrasts partitioned into within- and between-city contrasts, and the sum of these as overall exposures, for every year from 1984 to 2006. Residential histories allowed us to follow subjects annually during the study ...


Natural-Cause Mortality And Long-Term Exposure To Particle Components: An Analysis Of 19 European Cohorts Within The Multi-Center Escape Project, Rob Beelen, Gerard Hoek, Ole Raaschou-Nielsen, Massimo Stafoggia, Zorana Jovanovic Andersen, Gudrum Weinmayr, Barbara Hoffman, Kathrin Wolf, Evangelia Samoli, Paul H. Fischer, Mark Nieuwenhuijsen, Wei W. Xun, Klea Katsouyanni, Konstantina Dimakopoulou, Alessandro Marcon, E. Vartiainen, Timo Lanki, Tarja Yli-Tuomi, Bente Oftedal, Per E. Schwarze, Per Nafstad, Ulf De Faire, Nancy L. Pedersen, Claes-Goran Ostenson, Laura Fratiglioni, Johanna Penell, Michal Korek, Goran Pershagen, Kirsten Thorup Eriksen, Kim Overvad, Mette Sorensen, Marloes Eeftens, Petra H. Peeters, Kees Meliefste, Meng Wang, H. Bas Bueno-De-Mesquita, Dorothea Sugiri, Ursula Kramer, Joachim Heinrich, Kees De Hoogh, Timothy Key, Annette Peters, Regina Hampel, Hans Concin, Gabriel Nagel, Andrea Jaensch, Alex Ineichen, Ming-Yi Tsai, Emmanuel Schaffner, Nicole M. Probst-Hensch, Christian Schindler, Martina Ragettli, Alice Vilier, Francoise Clavel-Chapelon, Christophe Declercq, Fulvio Ricceri, Carlotta Sacerdote Jan 2015

Natural-Cause Mortality And Long-Term Exposure To Particle Components: An Analysis Of 19 European Cohorts Within The Multi-Center Escape Project, Rob Beelen, Gerard Hoek, Ole Raaschou-Nielsen, Massimo Stafoggia, Zorana Jovanovic Andersen, Gudrum Weinmayr, Barbara Hoffman, Kathrin Wolf, Evangelia Samoli, Paul H. Fischer, Mark Nieuwenhuijsen, Wei W. Xun, Klea Katsouyanni, Konstantina Dimakopoulou, Alessandro Marcon, E. Vartiainen, Timo Lanki, Tarja Yli-Tuomi, Bente Oftedal, Per E. Schwarze, Per Nafstad, Ulf De Faire, Nancy L. Pedersen, Claes-Goran Ostenson, Laura Fratiglioni, Johanna Penell, Michal Korek, Goran Pershagen, Kirsten Thorup Eriksen, Kim Overvad, Mette Sorensen, Marloes Eeftens, Petra H. Peeters, Kees Meliefste, Meng Wang, H. Bas Bueno-De-Mesquita, Dorothea Sugiri, Ursula Kramer, Joachim Heinrich, Kees De Hoogh, Timothy Key, Annette Peters, Regina Hampel, Hans Concin, Gabriel Nagel, Andrea Jaensch, Alex Ineichen, Ming-Yi Tsai, Emmanuel Schaffner, Nicole M. Probst-Hensch, Christian Schindler, Martina Ragettli, Alice Vilier, Francoise Clavel-Chapelon, Christophe Declercq, Fulvio Ricceri, Carlotta Sacerdote

Faculty of Health Sciences Publications

Background
Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality.
Objectives
Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter.
Methods
Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2 ...


Assessing The Human Health Impacts Of Exposure To Disinfection By-Products - A Critical Review Of Concepts And Methods, James Grellier, Lesley Rushton, David J. Briggs, Mark Nieuwenhuijsen Jan 2015

Assessing The Human Health Impacts Of Exposure To Disinfection By-Products - A Critical Review Of Concepts And Methods, James Grellier, Lesley Rushton, David J. Briggs, Mark Nieuwenhuijsen

Faculty of Health Sciences Publications

Understanding the public health implications of chemical contamination of drinking water is important for societies and their decision-makers. The possible population health impacts associated with exposure to disinfection by-products (DBPs) are of particular interest due to their potential carcinogenicity and their widespread occurrence as a result of treatments employed to control waterborne infectious disease.
We searched the literature for studies that have attempted quantitatively to assess population health impacts and health risks associated with exposure to DBPs in drinking water. We summarised and evaluated these assessments in terms of their objectives, methods, treatment of uncertainties, and interpretation and communication of ...