Medicine and Health Sciences Commons^™

Reduction Of Antipsychotic Use In Patients With Dementia Residing In Nursing Homes, Marysarah Frank

DNP Scholarly Projects

Abstract

Residents of nursing homes diagnosed with dementia have long been treated with psychotropic drugs for the symptoms of behavioral disturbances that are frequently associated with major neurocognitive disease. Specifically, the antipsychotic drugs have been widely used in this population. Despite a lack of evidence, antipsychotic rates have shown up to 25% of dementia patients in nursing homes (NH) are prescribed these drugs. This off-label use is not FDA approved for behavioral symptoms of dementia and the drugs have been given a black box warning related to the risk of serious and potentially irreversible side effects and even an increased …

Understanding The Physical Properties That Control Protein Crystallization By Analysis Of Largescale Experimental Data, W. Nicholson Price Ii, Yang Chen, Samuel K. Handelman, Helen Neely, Philip Manor, Richard Karlin, Rajesh Nair, Jinfeng Liu, Michael Baran, John Everett, Saichiu N. Tong, Farhad Forouhar, Swarup S. Swaminathan, Thomas Acton, Rong Xiao, Joseph R. Luft, Angela Lauricella, George T. Detitta, Burkhard Rost, Gaetano T. Montelione, John T. Hunt

Law Faculty Scholarship

Crystallization is the most serious bottleneck in high-throughput protein-structure determination by diffraction methods. We have used data mining of the large-scale experimental results of the Northeast Structural Genomics Consortium and experimental folding studies to characterize the biophysical properties that control protein crystallization. This analysis leads to the conclusion that crystallization propensity depends primarily on the prevalence of well-ordered surface epitopes capable of mediating interprotein interactions and is not strongly influenced by overall thermodynamic stability. We identify specific sequence features that correlate with crystallization propensity and that can be used to estimate the crystallization probability of a given construct. Analyses of …