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Variation In The Vitamin D Receptor Gene Is Associated With Multiple Sclerosis In An Austrlaian Population, Lotti Tajouri, Micky Ovcaric, Rob Curtain, Matthew Johnson, Lyn Griffiths, Peter Csurhes, Michael Pender, Rod Lea
Variation In The Vitamin D Receptor Gene Is Associated With Multiple Sclerosis In An Austrlaian Population, Lotti Tajouri, Micky Ovcaric, Rob Curtain, Matthew Johnson, Lyn Griffiths, Peter Csurhes, Michael Pender, Rod Lea
Lotti Tajouri
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, Tag I and Fok I) in an Australian MS case-control population. One hundred and four Australian MS patients were studied with patients classified clinically as Relapsing Remitting MS (RR-MS), Secondary Progressive MS (SP-MS) or Primary Progressive MS (PP-MS). Also, 104 age-, sex-, and ethnicity-matched controls were investigated as a comparative group. Our results show a significant difference of …