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Veterinary Medicine

Purdue University

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Full-Text Articles in Medicine and Health Sciences

Making The Case: Adding A Social Work Perspective To A Case Study In A Veterinary Practice, Paula Gerstenblatt, Diane Rhodes, Dorothea Ivey Sep 2022

Making The Case: Adding A Social Work Perspective To A Case Study In A Veterinary Practice, Paula Gerstenblatt, Diane Rhodes, Dorothea Ivey

People and Animals: The International Journal of Research and Practice

This article describes a case study exploration of a veterinary practice from the perspective of social work. Recognizing the stressful work of veterinary providers, including compassion fatigue and high suicide rates, the current study identified both a need for and the potential role of social workers in veterinary practice. Professionals were interviewed in an emergency/specialty practice. Using the interview data, the authors built a demonstrative case that underlines the vulnerability of veterinary professionals and the potential of social work to improve the quality of their work experiences and longevity.


Identity, Gender, And Tracking: The Reality Of Boundaries For Veterinary Students, Jenny R. Vermilya Jan 2022

Identity, Gender, And Tracking: The Reality Of Boundaries For Veterinary Students, Jenny R. Vermilya

New Directions in the Human-Animal Bond

Using in-depth interviews with veterinary students, Identity, Gender, and Tracking: The Reality of Boundaries for Veterinary Students explores the experience of enrollment in an educational program that tracks students based on the species of animals that they wish to treat. The identity of a veterinarian is one characterized by care; thus, students have to construct different definitions of care, creating a system of power and inequality. Tracking produces multiple boundaries for veterinary students, which has consequences not just for the veterinarian, but also for the treatment of animals. Written for administrators and students alike, Identity, Gender, and Tracking sheds light …


Momentary Energy Levels In Healthcare Professionals Working With Facility Dogs, Shania Sinha, Clare Jensen, Marguerite O'Haire Jan 2022

Momentary Energy Levels In Healthcare Professionals Working With Facility Dogs, Shania Sinha, Clare Jensen, Marguerite O'Haire

Discovery Undergraduate Interdisciplinary Research Internship

Past research has shown that pediatric healthcare professionals working with full-time therapy dogs (facility dogs) reported less work-related burnout and better mental health overall. However, specific in-the-moment effects of facility dogs on healthcare professionals have yet to be examined. The purpose of this study was to use Ecological Momentary Assessment (EMA) to assess the effects of facility dog presence on momentary energy levels of pediatric healthcare professionals. EMA data for the present study were collected from 122 healthcare professionals working in pediatric hospitals. Within the sample, participants working with a facility dog (handlers; n=61) were …


Quantitative Proteomics And Phosphoproteomics Reveal Tnf-Α-Mediated Protein Functions In Hepatocytes, Rodrigo Mohallem, Uma K. Aryal Sep 2021

Quantitative Proteomics And Phosphoproteomics Reveal Tnf-Α-Mediated Protein Functions In Hepatocytes, Rodrigo Mohallem, Uma K. Aryal

Department of Veterinary Clinical Sciences Faculty Publications

Increased secretion of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNFα), is often associated with adipose tissue dysregulation, which often accompanies obesity. High levels of TNFα have been linked to the development of insulin resistance in several tissues and organs, including skeletal muscle and the liver. In this study, we examined the complex regulatory roles of TNFα in murine hepatocytes utilizing a combination of global proteomic and phosphoproteomic analyses. Our results show that TNFα promotes extensive changes not only of protein levels, but also the dynamics of their downstream phosphorylation signaling. We provide evidence that TNFα induces DNA replication and …


The Canine-Campus Connection, Mary Renck Jalongo May 2021

The Canine-Campus Connection, Mary Renck Jalongo

New Directions in the Human-Animal Bond

A primary mission of universities is promoting student success and well-being. Many college and university personnel have implemented initiatives that offer students the documented benefits of positive human-animal interaction (HAI). Accumulating evidence suggests that assistance dogs, therapy dogs, and shelter dogs can support student wellness and learning. The best programs balance the welfare of humans and canines while assessing students’ needs and complying with all laws and regulations. Contributors to this edited volume have drawn upon research across many disciplines as well as their extensive practical experiences to produce a timely and valuable resource—for administrators and students. Whether readers are …


Pioneer Science And The Great Plagues: How Microbes, War, And Public Health Shaped Animal Health, Norman F. Cheville, Purdue University Press Mar 2021

Pioneer Science And The Great Plagues: How Microbes, War, And Public Health Shaped Animal Health, Norman F. Cheville, Purdue University Press

Purdue University Press Books

Pioneer Science and the Great Plagues covers the century when infectious plagues—anthrax, tuberculosis, tetanus, plague, smallpox, and polio—were conquered, and details the important role that veterinary scientists played. The narrative is driven by astonishing events that centered on animal disease: the influenza pandemic of 1872, discovery of the causes of anthrax and tuberculosis in the 1880s, conquest of Texas cattle fever and then yellow fever, German anthrax attacks on the United States during World War I, the tuberculin war of 1931, Japanese biological warfare in the 1940s, and today’s bioterror dangers.

Veterinary science in the rural Midwest arose from agriculture, …


Cats And Conservationists: The Debate Over Who Owns The Outdoors, Dara M. Wald, Anna L. Peterson Mar 2020

Cats And Conservationists: The Debate Over Who Owns The Outdoors, Dara M. Wald, Anna L. Peterson

New Directions in the Human-Animal Bond

Cats and Conservationists is the first multidisciplinary analysis of the heated debate about free-roaming cats. The debate pits conservationists against cat lovers, who disagree both on the ecological damage caused by the cats and the best way to manage them. An impassioned and spirited conflict, it also sheds light on larger questions about how we interpret science, incorporate diverse perspectives, and balance competing values in order to encourage constructive dialogue on contentious social and environmental issues.

On one side of the cat debate stand many environmentalists, especially birders and conservation organizations, who believe that outdoor cats seriously threaten native wildlife. …


Glioma Mimics: Magnetic Resonance Imaging Characteristics Of Granulomas In Dogs, Lauren Diangelo, Aaron A. Cohen-Gadol, Hock Gan Heng, Margaret A. Miller, Devon W. Hague, John H. Rossmeisl, Robin T. Bentley Aug 2019

Glioma Mimics: Magnetic Resonance Imaging Characteristics Of Granulomas In Dogs, Lauren Diangelo, Aaron A. Cohen-Gadol, Hock Gan Heng, Margaret A. Miller, Devon W. Hague, John H. Rossmeisl, Robin T. Bentley

Purdue University Libraries Open Access Publishing Fund

Granulomas can “mimic” gliomas on magnetic resonance imaging (MRI) in human patients. The goal of this retrospective study was to report canine brain granulomas that were consistent with glioma based upon MRI, report their histologic diagnosis, and identify MRI criteria that might be useful to distinguish granuloma from glioma. Ten granulomas, initially suspected to be glioma based on MRI, were ultimately diagnosed as granulomatous meningoencephalomyelitis (n = 5), infectious granulomas (n = 3) or other meningoencephalitis (n = 2). Age was 1.6–15.0 years and two dogs were brachycephalic breeds. MRI characteristics overlapping with glioma included intra-axial, heterogeneous, …


Transforming Trauma: Resilience And Healing Through Our Connections With Animals, Philip Tedeschi, Molly Anne Jenkins Jul 2019

Transforming Trauma: Resilience And Healing Through Our Connections With Animals, Philip Tedeschi, Molly Anne Jenkins

Purdue University Press Books

Have you ever looked deep into the eyes of an animal and felt entirely known? Often, the connections we share with non-human animals represent our safest and most reliable relationships, offering unique and profound opportunities for healing in periods of hardship. This book focuses on research developments, models, and practical applications of human-animal connection and animal-assisted intervention for diverse populations who have experienced trauma. Physiological and psychological trauma are explored across three broad and interconnected domains: 1) child maltreatment and family violence; 2) acute and post-traumatic stress, including military service, war, and developmental trauma; and 3) times of crisis, such …


That Sheep May Safely Graze: Rebuilding Animal Health Care In War-Torn Afghanistan, David M. Sherman Mar 2019

That Sheep May Safely Graze: Rebuilding Animal Health Care In War-Torn Afghanistan, David M. Sherman

Purdue University Press Book Previews

The very mention of Afghanistan conjures images of war, international power politics, the opium trade, and widespread corruption. Yet the untold story of Afghanistan’s seemingly endless misfortune is the disruptive impact that prolonged conflict has had on ordinary rural Afghans, their culture, and the timeless relationship they share with their land and animals. In rural Afghanistan, when animals die, livelihoods are lost, families and communities suffer, and people may perish. That Sheep May Safely Graze details a determined effort, in the midst of war, to bring essential veterinary services to an agrarian society that depends day in and day out …


Animal-Assisted Interventions In Health Care Settings: A Best Practices Manual For Establishing New Programs: Volunteer Manual Template, Sandra B. Barker, Rebecca A. Vokes, Randolph T. Barker Jan 2019

Animal-Assisted Interventions In Health Care Settings: A Best Practices Manual For Establishing New Programs: Volunteer Manual Template, Sandra B. Barker, Rebecca A. Vokes, Randolph T. Barker

AAI

This document accompanies Animal-Assisted Interventions in Health Care Settings: A Best Practices Manual for Establishing New Programs (Purdue Press, 2019) and serves as a template for readers to personalize for their facility. The generic terms “ABC Health Care Facility” and “AAI Program” are intended to be replaced by the names of the reader's facility and AAI program.

The book can be purchased from Purdue University Press.


Animal-Assisted Interventions In Health Care Settings: A Best Practices Manual For Establishing New Programs, Sandra B. Barker, Rebecca A. Vokes, Randolph T. Barker Jan 2019

Animal-Assisted Interventions In Health Care Settings: A Best Practices Manual For Establishing New Programs, Sandra B. Barker, Rebecca A. Vokes, Randolph T. Barker

Purdue University Press Book Previews

Growing literature around the benefits of animal-assisted intervention (AAI) spurs health care professionals and administrators to start new programs. Yet the trend also raises questions of how best to begin and run successful AAI programs—under what circumstances, with what staff, and within what guidelines.

Animal-Assisted Interventions in Health Care Settings: A Best Practices Manual for Establishing New Programs succinctly outlines how best to develop, implement, run, and evaluate AAI programs. Drawing on extensive professional experiences and research from more than fifteen years leading the Center for Human-Animal Interaction in the Virginia Commonwealth University School of Medicine, the authors discuss both …


Assessment Of Recent Cases Of Animal Hoarding In Germany: The Challenge For Animal Shelters And Public Authorities, Sophie Arnold, Henriette Mackensen, Evelyn Ofensberger, Brigitte Rusche Nov 2018

Assessment Of Recent Cases Of Animal Hoarding In Germany: The Challenge For Animal Shelters And Public Authorities, Sophie Arnold, Henriette Mackensen, Evelyn Ofensberger, Brigitte Rusche

People and Animals: The International Journal of Research and Practice

Animal hoarding is a severe problem in the field of human-animal interaction. The goal of this study was to assess the current situation of animal hoarding in Germany. Reports of animal hoarding cases were collected from animal shelters and public media between January 2012 and December 2015; 120 cases were analyzed. A total of 9,174 animals were hoarded during the investigated time period. The results showed that cases involving cats were most common, followed by cases involving dogs and small mammals. The average number (x¯) of animals hoarded per case was 76 (x˜ = 43). Small mammals were hoarded in …


Leaders Of The Pack: Women And The Future Of Veterinary Medicine, Julie Kumble, Donald Smith Mar 2017

Leaders Of The Pack: Women And The Future Of Veterinary Medicine, Julie Kumble, Donald Smith

New Directions in the Human-Animal Bond

Veterinary medicine has undergone sweeping changes in the last few decades. Women now account for 55 percent of the active veterinarians in the field, and nearly 80 percent of veterinary students are women. However, average salaries have dropped as this shift has occurred, and even with women in the vast majority, only 25 percent of leadership roles are held by women. These trends point to gender-based inequality that veterinary medicine, a profession that tilts so heavily toward women, is struggling to address. How will the profession respond? What will this mean for our students and schools? What will it mean …


Leaders Of The Pack: Women And The Future Of Veterinary Medicine, Julie Kumble, Donald F. Smith Mar 2017

Leaders Of The Pack: Women And The Future Of Veterinary Medicine, Julie Kumble, Donald F. Smith

Purdue University Press Book Previews

Veterinary medicine has undergone sweeping changes in the last few decades. Women now account for 55 percent of the active veterinarians in the field, and nearly 80 percent of veterinary students are women. However, average salaries have dropped as this shift has occurred, and even with women in the vast majority, only 25 percent of leadership roles are held by women.

These trends point to gender-based inequality that veterinary medicine, a profession that tilts so heavily toward women, is struggling to address. How will the profession respond? What will this mean for our students and schools? What will it mean …


Evaluation Of Several Pre-Clinical Tools For Identifying Characteristics Associated With Limb Bone Fracture In Thoroughbred Racehorses, Anthony Nicholas Corsten Dec 2016

Evaluation Of Several Pre-Clinical Tools For Identifying Characteristics Associated With Limb Bone Fracture In Thoroughbred Racehorses, Anthony Nicholas Corsten

Open Access Theses

Catastrophic skeletal fractures in racehorses are devastating not only to the animals, owners and trainers, but also to the perception of the sport in the public eye. The majority of these fatal accidents are unlikely to be due to chance, but are rather an end result failure from stress fractures. Stress fractures are overuse injuries resulting from an accumulation of bone tissue damage over time. Because stress fractures are pathological, it is possible that overt fractures can be predicted and prevented. In this study, third metacarpals (MC3) from 33 thoroughbred racehorse comprised of 8 non-fractured controls and 25 horses that …


The Impact Of Tickling Rats On Human-Animal Interactions And Rat Welfare, Megan Renee Lafollette Dec 2016

The Impact Of Tickling Rats On Human-Animal Interactions And Rat Welfare, Megan Renee Lafollette

Open Access Theses

Rats initially fear humans which can lead to negative affect, poor welfare, and difficult handling. Also, modeling and measuring positive affect states in rats can pose an additional challenge. Heterospecific play, or “tickling,” is a handling habituation technique that mimics rat rough-and-tumble play that is being used to study positive affect. It can also be used to reduce fear of human, improve welfare, and elicit a positive affect state. However, current studies implementing the technique in laboratory rats use a wide variety of protocols to achieve differential results. Unlike in laboratory environment, pet store rats experience high levels of novelty …


Evaluating The Physical Welfare Of Dogs In Commercial Breeding Facilities In The United States, Moriah J. Hurt Aug 2016

Evaluating The Physical Welfare Of Dogs In Commercial Breeding Facilities In The United States, Moriah J. Hurt

Open Access Theses

Despite high levels of public concern, the state of commercial breeding (CB) dog welfare is largely unknown. Therefore, this study aimed to characterize the physical welfare of dogs in CB facilities and their environment in Indiana. This study specifically aimed 1) to characterize dog foot health in CB facilities as a function of the length of time dogs were housed on a given flooring substrate, 2) to characterize visual dog body cleanliness and visual kennel cleanliness as a function of the flooring substrate, 3) to determine the efficacy of kennel cleaning procedures and 4) to characterize the dog dental and …


Influence Of Dietary Component Manipulation And Feed Management Strategies On Growth And Rumen Development Of Weaned Dairy Heifers, Tana Shea Dennis Aug 2016

Influence Of Dietary Component Manipulation And Feed Management Strategies On Growth And Rumen Development Of Weaned Dairy Heifers, Tana Shea Dennis

Open Access Dissertations

Well-developed replacement heifers provide a central foundation for the continued success of the dairy industry. Emphasis on improving pre-weaned calf nutrition has predominated in the industry, but opportunities exist to improve post-weaning heifer nutrition and management. We aimed to evaluate common feed management strategies seen in the industry and their effects on growth, feed efficiency (G:F), and rumen development of calves from birth to 8 mo of age using pen- and individually-fed animal trials. Little information exists regarding post-weaning performance and rumen development of calves fed conventional or high planes of nutrition pre-weaning; therefore, we evaluated two milk replacer feeding …


Evaluating The Prevalence And Effectiveness Of Breed-Specific Legislation, Felicia E. Trembath Aug 2016

Evaluating The Prevalence And Effectiveness Of Breed-Specific Legislation, Felicia E. Trembath

Open Access Dissertations

Dog bites pose a persistent public health problem, which some jurisdictions pass breed-specific legislation (BSL) to address. However, very little non-anecdotal evidence regarding the efficacy of BSL has been presented. Currently, BSL research is hampered by the absence of standard terminology, an established prevalence, or a scientific consensus on its effectiveness. The purpose of this study is to propose standardized terminology for BSL, establish the prevalence of each type of BSL in the USA, and conduct a systematic review of the effectiveness of BSL.

After review of terminology currently in use, as well as review of the regulatory actions of …


Evaluation Of Negative Energy And Mineral Balance In Periparturient Holstein-Friesian Cattle, Ameer Ahmed Abdelhameed Apr 2016

Evaluation Of Negative Energy And Mineral Balance In Periparturient Holstein-Friesian Cattle, Ameer Ahmed Abdelhameed

Open Access Dissertations

Most cows experience a state of negative energy and mineral balance during the periparturient period. This imbalance is a major problem in the dairy industry and it is more frequently seen in multiparous cattle due to their high milk production. A large amount of fat and protein is mobilized in order to address the energy deficit during the periparturient period. The ability to accurately monitor energetics and electrolytes status using accurate, rapid, and low cost point-of-care instruments will assist in optimizing animal health and productivity.

This dissertation contains three studies that evaluated point-of-care instruments for measuring blood and plasma glucose, …


The Effects Of Acidified Pepsin On Porcine Vocal Fold Tissue: Developing A Porcine Model Of Laryngopharyngeal Reflux Disease, Abigail Cox Durkes Feb 2016

The Effects Of Acidified Pepsin On Porcine Vocal Fold Tissue: Developing A Porcine Model Of Laryngopharyngeal Reflux Disease, Abigail Cox Durkes

Open Access Dissertations

Approximately 7.5 million Americans are affected by a voice disorder. In the last year, 7.2% of people missed one or more days of work due to a voice problem. For professional voice users, such as teachers, the rate increases to 20% and an annual cost of $2.5 billion. Voice disorders are complex and multi-faceted, as well as difficult to diagnose and treat. Prospective animal studies are necessary to study the pathophysiology of voice disorders, optimize our understanding of laryngeal pathology, and improve treatment outcomes. The pig provides a unique opportunity to test hypotheses relating to laryngeal disease because porcine vocal …


Repurposing Celecoxib As A Topical Antimicrobial Agent, Shankar Thangamani, Waleed Younis, Mohamed N. Seleem Jul 2015

Repurposing Celecoxib As A Topical Antimicrobial Agent, Shankar Thangamani, Waleed Younis, Mohamed N. Seleem

Department of Comparative Pathobiology Faculty Publications

There is an urgent need for new antibiotics and alternative strategies to combat multidrug-resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing approved drugs with known pharmacology and toxicology is an alternative strategy to accelerate antimicrobial research and development. In this study, we show that celecoxib, a marketed inhibitor of cyclooxygenase-2, exhibits broad-spectrum antimicrobial activity against Gram-positive pathogens from a variety of genera, including Staphylococcus, Streptococcus, Listeria, Bacillus, and Mycobacterium, but not against Gram-negative pathogens. However, celecoxib is active against all of the Gram-negative bacteria tested, including strains of, Acinetobacter, and Pseudomonas, when …


Baylisascaris Spp. In Non-Raccoon Procyonid Hosts And Assessment Of Potential Risk Of Human Exposure, Max Carlin Parkanzky Apr 2015

Baylisascaris Spp. In Non-Raccoon Procyonid Hosts And Assessment Of Potential Risk Of Human Exposure, Max Carlin Parkanzky

Open Access Theses

Baylisascaris procyonis (Bp) is a large roundworm of the common raccoon (Procyon lotor) which serves as the definitive host. Bp is an important cause of clinical larva migrans, including severe neurological disease, across numerous taxa including humans. Other procyonids, as well as occasionally dogs, can act as definitive hosts for this or other Baylisascaris spp. Many of these animals are becoming more common as household pets, posing a risk to people who come in contact with these animals. We have investigated whether patent Baylisascaris spp. infection exists in captive non-raccoon procyonids and if humans who contact these animals …


Show Horse Welfare, Melissa A. Voigt Jan 2015

Show Horse Welfare, Melissa A. Voigt

Open Access Dissertations

In recent years there has been an increase in the public's attention to situations where trainers, owners, and handlers have compromised the well-being of show horses for the sake of winning. These situations may be due to training negligence or naivety of individuals working with the horse. Either way, due to these incidents, increasing pressure has been placed on the horse industry to address show horse welfare. The purpose of this research was to expound on the welfare of stock-type show horses through the perspective of those directly involved; considering the understanding of welfare, the value placed on welfare, and …


Antibacterial Activity Of Novel Cationic Peptides Against Clinical Isolates Of Multi-Drug Resistant Staphylococcus Pseudintermedius From Infected Dogs, Mohamed F. Mohamed, G. Kenitra Hammac, Lynn F. Guptil, Mohamed N. Seleem Dec 2014

Antibacterial Activity Of Novel Cationic Peptides Against Clinical Isolates Of Multi-Drug Resistant Staphylococcus Pseudintermedius From Infected Dogs, Mohamed F. Mohamed, G. Kenitra Hammac, Lynn F. Guptil, Mohamed N. Seleem

Department of Comparative Pathobiology Faculty Publications

Staphylococcus pseudintermedius is a major cause of skin and soft tissue infections in companion animals and has zoonotic potential. Additionally, methicillin-resistant S. pseudintermedius (MRSP) has emerged with resistance to virtually all classes of antimicrobials. Thus, novel treatment options with new modes of action are required. Here, we investigated the antimicrobial activity of six synthetic short peptides against clinical isolates of methicillin-susceptible and MRSP isolated from infected dogs. All six peptides demonstrated potent antistaphylococcal activity regardless of existing resistance phenotype. The most effective peptides were RRIKA (with modified C terminus to increase amphipathicity and hydrophobicity) and WR-12 (α-helical peptide consisting exclusively …


Ontogenetic Scaling Patterns And Functional Anatomy Of The Pelvic Limb Musculature In Emus (Dromaius Novaehollandiae), Luis P. Lamas, Russell P. Main, John R. Hutchinson Dec 2014

Ontogenetic Scaling Patterns And Functional Anatomy Of The Pelvic Limb Musculature In Emus (Dromaius Novaehollandiae), Luis P. Lamas, Russell P. Main, John R. Hutchinson

Department of Basic Medical Sciences Faculty Publications

Emus (Dromaius novaehollandiae) are exclusively terrestrial, bipedal and cursorial ratites with some similar biomechanical characteristics to humans. Their growth rates are impressive, as their body mass increases eighty-fold from hatching to adulthood whilst maintaining the same mode of locomotion throughout life. These ontogenetic characteristics stimulate biomechanical questions about the strategies that allow emus to cope with their rapid growth and locomotion, which can be partly addressed via scaling (allometric) analysis of morphology. In this study we have collected pelvic limb anatomical data (muscle architecture, tendon length, tendon mass and bone lengths) and calculated muscle physiological cross sectional area …


Review Of The Pathogenesis And Treatment Of Acute Spinal Cord Injury And Investigation Into The Use Of Urine 3-Hpma As A Novel Biomarker Of Secondary Injury After Acute Spinal Cord Injury In The Dog, Andrea Sangster Oct 2014

Review Of The Pathogenesis And Treatment Of Acute Spinal Cord Injury And Investigation Into The Use Of Urine 3-Hpma As A Novel Biomarker Of Secondary Injury After Acute Spinal Cord Injury In The Dog, Andrea Sangster

Open Access Theses

Acute spinal cord injury (ASCI) has two pathophysiological stages of injury: the primary injury and the secondary injury cascade. Primary injury includes the initial or mechanical insult to the spinal cord. Secondary injury is a cascade of biochemical events that propagates damage of adjacent, healthy tissue increasing the overall volume of spinal cord tissue that is affected. Acrolein is a toxic byproduct of lipid peroxidation produced during secondary injury. A metabolite of acrolein-glutathione adduct found in urine, 3-HPMA, has recently been shown to increase after spinal cord injury in a rat model. The aim of our study was to apply …


The Effects Of Heat Stress On Immunity In Laying Hens And Dairy Cattle, Rebecca Ann Strong Oct 2014

The Effects Of Heat Stress On Immunity In Laying Hens And Dairy Cattle, Rebecca Ann Strong

Open Access Theses

With the increase in global climate change and the population growth driving the high demand for additional food production, heat stress (HS) is a major concern in the livestock industry across all species. Animals experience HS when exposed to high environmental temperatures outside their thermal neutral zone. The level of the effects can vary due to the length and intensity of HS to which the animal is exposed to. In experiment one, laying hens with access to cooled perches during HS had a lower heterophil to lymphocyte ratio compared to the control hens after 4 h of acute heat stress, …


Efficacy Of Short Novel Antimicrobial And Anti-Inflammatory Peptides In A Mouse Model Of Methicillin-Resistant Staphylococcus Aureus (Mrsa) Skin Infection, Mohamed F. Mohamed, Mohamed N. Seleem Oct 2014

Efficacy Of Short Novel Antimicrobial And Anti-Inflammatory Peptides In A Mouse Model Of Methicillin-Resistant Staphylococcus Aureus (Mrsa) Skin Infection, Mohamed F. Mohamed, Mohamed N. Seleem

Department of Comparative Pathobiology Faculty Publications

The therapeutic efficacy of two novel short antimicrobial and anti-inflammatory peptides (RR and RRIKA) was evaluated in a mouse model of staphylococcal skin infection. RR (2%) and RRIKA (2%) significantly reduced the bacterial counts and the levels of proinflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, in methicillin-resistant Staphylococcus aureusUSA 300-0114 skin lesions. Furthermore, the combined therapy of RRIKA (1%) and lysostaphin (0.5%) had significantly higher antistaphylococcal and anti-inflammatory activity compared to monotherapy. This study supports the potential use of these peptides for topical treatment of methicillin-resistant Staphylococcus aureus skin infections.