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Articles 1 - 30 of 116
Full-Text Articles in Medicine and Health Sciences
Early Antipsychotic Treatment In Childhood/Adolescent Period Has Long-Term Effects On Depressive-Like, Anxiety-Like And Locomotor Behaviours In Adult Rats, Michael De Santis, Jiamei Lian, Xu-Feng Huang, Chao Deng
Early Antipsychotic Treatment In Childhood/Adolescent Period Has Long-Term Effects On Depressive-Like, Anxiety-Like And Locomotor Behaviours In Adult Rats, Michael De Santis, Jiamei Lian, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
Childhood/adolescent antipsychotic drug (APD) use is exponentially increasing worldwide, despite limited knowledge of the long-term effects of early APD treatment. Whilst investigations have found that early treatment has resulted in some alterations to dopamine and serotonin neurotransmission systems (essential to APD efficacy), there have only been limited studies into potential long-term behavioural changes. This study, using an animal model for childhood/adolescent APD treatment, investigated the long-term effects of aripiprazole, olanzapine and risperidone on adult behaviours of male and female rats. Open-field/holeboard, elevated plus maze (EPM), social interaction and forced swim (FS) tests were then conducted in adult rats. Our results …
Effects Of Pharmacological Blockade Of Lingo - 1 Signaling Pathways In A Phencyclidine Rat Model For Schizophrenia, Jessica L. Andrews, Ryan Sullivan, Kelly Newell, Xu-Feng Huang, Francesca Fernandez-Enright
Effects Of Pharmacological Blockade Of Lingo - 1 Signaling Pathways In A Phencyclidine Rat Model For Schizophrenia, Jessica L. Andrews, Ryan Sullivan, Kelly Newell, Xu-Feng Huang, Francesca Fernandez-Enright
Xu-Feng Huang
Abstract of a poster presentation at the 2014 Society for Neuroscience Meeting, Washington, DC, 15-19 November.
Central Administrations Of Palmitic Acid And Arachidonic Acid Decrease Central Leptin Sensitivity In Mice, L Cheng, Xu-Feng Huang, Y Yu
Central Administrations Of Palmitic Acid And Arachidonic Acid Decrease Central Leptin Sensitivity In Mice, L Cheng, Xu-Feng Huang, Y Yu
Xu-Feng Huang
Purpose: Leptin inhibits feeding and increases energy expenditure through the central nervous system. High-fat diet with saturated fatty acids (SFA) or n-6 polyunsaturated fatty acids (n-6 PUFA) has been reported to induce central leptin resistance and obesity. However, little is known if central administration of SFA or n-6 PUFA can reduce central leptin sensitivity. This study examined the central leptin sensitivity in response to intracerebroventricular (i.c.v.) injection of SFA, palmitic acid (PA) and n-6 PUFA, arachidonic acid (ARA) in mice. Methods: After overnight fasting, C57BL/6J male mice (n=24/group) were i.c.v. injected with either PA (50pmol/2ul), ARA (50pmol/2ul) or vehicle (saline, …
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Xu-Feng Huang
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) …
Alterations Of Mglur5 And Mglur5 Signaling Partners In Schizophrenia, Natalie Matosin, Martin Engel, Francesca Fernandez-Enright, Jeremy S. Lum, Jessica L. Andrews, Xu-Feng Huang, Kelly Newell
Alterations Of Mglur5 And Mglur5 Signaling Partners In Schizophrenia, Natalie Matosin, Martin Engel, Francesca Fernandez-Enright, Jeremy S. Lum, Jessica L. Andrews, Xu-Feng Huang, Kelly Newell
Xu-Feng Huang
No abstract provided.
A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang
A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang
Xu-Feng Huang
The neuregulin 1 gene has repeatedly been identified as a susceptibility gene for schizophrenia, thus mice with genetic mutations in this gene offer a valuable tool for studying the role of neuregulin 1 in schizophrenia-related neurotransmission. In this study, slide-based receptor autoradiography was used to quantify glutamatergic N-methyl-d-aspartate (NMDA), dopaminergic D2, cannabinoid CB1 and acetylcholine M1/4 receptor levels in the brains of male heterozygous transmembrane domain neuregulin 1 mutant (Nrg1+/−) mice at two ages. Mutant mice expressed small but significant increases in NMDA receptor levels in the cingulate cortex (7%, p = 0.044), sensory cortex (8%, p = 0.024), and …
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Arcuate Npy Controls Sympathetic Output And Bat Function Via A Relay Of Tyrosine Hydroxylase Neurons In The Pvn, Yan-Chuan Shi, Jackie Lau, Zhou Lin, Hui Zhang, Lei Zhai, Guenther Sperk, Regine Heilbronn, Mario Mietzsch, Stefan Weger, Xu-Feng Huang, Ronaldo F. Enriquez, Lesley Castillo, Paul A. Baldock, Lei Zhang, Amanda Sainsbury, Herbert Herzog, Shu Lin
Xu-Feng Huang
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) …
Alterations Of Mglur5 And Mglur5 Signaling Partners In Schizophrenia, Natalie Matosin, Martin Engel, Francesca Fernandez-Enright, Jeremy S. Lum, Jessica L. Andrews, Xu-Feng Huang, Kelly Newell
Alterations Of Mglur5 And Mglur5 Signaling Partners In Schizophrenia, Natalie Matosin, Martin Engel, Francesca Fernandez-Enright, Jeremy S. Lum, Jessica L. Andrews, Xu-Feng Huang, Kelly Newell
Xu-Feng Huang
No abstract provided.
An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell
An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell
Xu-Feng Huang
Purpose: Metabotropic glutamate receptors (mGluRs) are proposed novel therapeutic targets for a variety of brain disorders such as schizophrenia (SZ), bipolar disorder (BP) and major depression (MD). Despite their potential, the involvement of these receptors in these pathological processes is uncertain. This information is crucial to understand the efficiency of drugs that target these receptors. Methods: Using post-mortem human brains, mGluR2/3 and mGluR5 binding densities were measured in the anterior cingulate cortex of SZ, BP, MD and matched controls (CT) (n=15/group) by receptor autoradiography. Results: Whilst preliminary analyses indicated no diagnostic effect in mGluR2/3 or mGluR5 binding densities, mGluR2/3 binding …
A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang
A Neuregulin 1 Transmembrane Domain Mutation Causes Imbalanced Glutamatergic And Dopaminergic Receptor Expression In Mice, K A. Newell, T Karl, Xu-Feng Huang
Xu-Feng Huang
The neuregulin 1 gene has repeatedly been identified as a susceptibility gene for schizophrenia, thus mice with genetic mutations in this gene offer a valuable tool for studying the role of neuregulin 1 in schizophrenia-related neurotransmission. In this study, slide-based receptor autoradiography was used to quantify glutamatergic N-methyl-d-aspartate (NMDA), dopaminergic D2, cannabinoid CB1 and acetylcholine M1/4 receptor levels in the brains of male heterozygous transmembrane domain neuregulin 1 mutant (Nrg1+/−) mice at two ages. Mutant mice expressed small but significant increases in NMDA receptor levels in the cingulate cortex (7%, p = 0.044), sensory cortex (8%, p = 0.024), and …
Alterations Of Mglur5 And Mglur5 Signaling Partners In Schizophrenia, Natalie Matosin, Martin Engel, Francesca Fernandez-Enright, Jeremy S. Lum, Jessica L. Andrews, Xu-Feng Huang, Kelly Newell
Alterations Of Mglur5 And Mglur5 Signaling Partners In Schizophrenia, Natalie Matosin, Martin Engel, Francesca Fernandez-Enright, Jeremy S. Lum, Jessica L. Andrews, Xu-Feng Huang, Kelly Newell
Xu-Feng Huang
No abstract provided.
The Rhesus Monkey Brain : In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Michael Petrides, Arthur Toga
The Rhesus Monkey Brain : In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Michael Petrides, Arthur Toga
Xu-Feng Huang
Description The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain currently available. The second edition of this classic book is a complete revision, featuring many improvements and upgrades. Constructed by the established leaders in neuroanatomical atlas development, the new edition will again be the indispensable resource for all scientists working on the primate nervous system. Key Features * 151 coronal diagrams and 151 accompanying photographic plates spaced at 120 um intervals; diagrams completely revised * 60 photographic coronal plates of SMI immunoreactivity; delineations completely revised. New in this edition * DVD …
The Effects Of Phencyclidine Treatment On The Nmdar-Nrg1 Signalling Pathway In Rats, T Morosin, T Du Bois, K Newell, Xu-Feng Huang
The Effects Of Phencyclidine Treatment On The Nmdar-Nrg1 Signalling Pathway In Rats, T Morosin, T Du Bois, K Newell, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Diagnostic-Specific Reductions In Nmda And Mglu5 Glutamatergic Receptors In Schizophrenia, K Newell, N Jimenez, A Geddes, E Frank, T Du Bois, M Safadi, Xu-Feng Huang
Diagnostic-Specific Reductions In Nmda And Mglu5 Glutamatergic Receptors In Schizophrenia, K Newell, N Jimenez, A Geddes, E Frank, T Du Bois, M Safadi, Xu-Feng Huang
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
The Dopamine B-Hydroxylase 19 Bp Insertion/Deletion Polymorphism Was Associated With First-Episode But Not Medicated Chronic Schizophrenia, Li Hui, Xuan Zhang, Xu-Feng Huang, Mei Han, Francesca Fernandez, Yaqin Yu, Shilong Sun, Wenjun Li, Da Chen, Mei Xiu, Thomas Kosten, Xiang Zhang
Xu-Feng Huang
Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH50-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative …
Effects Of Dopamine D2 Receptor Partial Agonist Bifeprunox On Body Weight Gain, Food And Water Intake In Male Rats, M De Santis, Xu-Feng Huang, C Deng
Effects Of Dopamine D2 Receptor Partial Agonist Bifeprunox On Body Weight Gain, Food And Water Intake In Male Rats, M De Santis, Xu-Feng Huang, C Deng
Xu-Feng Huang
An abstract of a poster presentation that presented at Australian Neuroscience Society 32nd Annual meeting.
Metabotropic Glutamate Receptor Subtype 5 Is Reduced In Schizophrenia Subjects With Comorbid Major Depression And Unchanged Following Antipsychotic Drug Treatment, N Jimenez, Xu-Feng Huang, C Deng, K Newell
Metabotropic Glutamate Receptor Subtype 5 Is Reduced In Schizophrenia Subjects With Comorbid Major Depression And Unchanged Following Antipsychotic Drug Treatment, N Jimenez, Xu-Feng Huang, C Deng, K Newell
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting.
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Olanzapine Treatment And Time-Dependent Changes Of Hypothalamic Ampk-Acc-Cpt1 Signalling, Food Intake And Body Weight In Rats, Meng He, Q Zhang, H Wang, Jiamei Lian, C Deng, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Time-Dependant Alterations Of Hypothalamic Energy Regulatory Network By Olanzapine In Rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, Xu-Feng Huang
Time-Dependant Alterations Of Hypothalamic Energy Regulatory Network By Olanzapine In Rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, Xu-Feng Huang
Xu-Feng Huang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting.
The Rhesus Monkey Brain In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Arthur Toga
The Rhesus Monkey Brain In Stereotaxic Coordinates, George Paxinos, Xu-Feng Huang, Arthur Toga
Xu-Feng Huang
From the Back Cover The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive, detailed atlas of the monkey brain ever constructed. The first chapter, "Photographic and Diagrammatic Atlas of the Rhesus Monkey Brain," presents 151 plates illustrating the subcortex and parts of the cortex in high magnification, and 151 corresponding diagrams complementing each image. The second chapter, "Delineation of the Rhesus Monkey Cortex on the Basis of the Distribution of a Neurofilament Protein," consists of 64 fully labeled plates depicting an entire hemisphere. Jointly, the two chapters constitute the most serious morphological work ever undertaken on the monkey. …
Novel Olanzapine Analogues Presenting A Reduced H1 Receptor Affinity And Retained 5ht2a/D2 Binding Affinity Ratio, Somayeh Jafari, Marc E. Bouillon, Xu-Feng Huang, Stephen G. Pyne, Francesca Fernandez-Enright
Novel Olanzapine Analogues Presenting A Reduced H1 Receptor Affinity And Retained 5ht2a/D2 Binding Affinity Ratio, Somayeh Jafari, Marc E. Bouillon, Xu-Feng Huang, Stephen G. Pyne, Francesca Fernandez-Enright
Xu-Feng Huang
Background Olanzapine is an atypical antipsychotic drug with high clinical efficacy, but which can cause severe weight gain and metabolic disorders in treated patients. Blockade of the histamine 1 (H1) receptors is believed to play a crucial role in olanzapine induced weight gain, whereas the therapeutic effects of this drug are mainly attributed to its favourable serotoninergic 2A and dopamine 2 (5HT2A/D2) receptor binding affinity ratios. Results We have synthesized novel olanzapine analogues 8a and 8b together with the already known derivative 8c and we have examined their respective in vitro affinities for the 5HT2A, D2, and H1 receptors. Conclusions …
Neuregulin-1 Signalling And Antipsychotic Treatment: Potential Therapeutic Targets In A Schizophrenia Candidate Signalling Pathway, Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huang
Neuregulin-1 Signalling And Antipsychotic Treatment: Potential Therapeutic Targets In A Schizophrenia Candidate Signalling Pathway, Chao Deng, Bo Pan, Martin Engel, Xu-Feng Huang
Xu-Feng Huang
Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)-ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1-ErbB4 signalling plays crucial roles in regulating neurodevelopment and neurotransmission, with implications for the pathophysiology of schizophrenia. Post-mortem studies have demonstrated altered NRG1-ErbB4 signalling in the brain of schizophrenia patients. Antipsychotic drugs have different effects on NRG1-ErbB4 signalling depending on treatment duration. Abnormal behaviours relevant to certain features of schizophrenia are displayed in NRG1/ErbB4 knockout mice or …
Mglur5 And Nmda Receptor Density Are Reduced In The Dorsolateral Prefrontal Cortex Of Schizoaffective But Not Schizophrenia Patients, Kelly Newell, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang
Mglur5 And Nmda Receptor Density Are Reduced In The Dorsolateral Prefrontal Cortex Of Schizoaffective But Not Schizophrenia Patients, Kelly Newell, Natalie Matosin, Elisabeth Frank, Chao Deng, Xu-Feng Huang
Xu-Feng Huang
Abstract of a poster that presented at the Society of Biological Psychiatry 67th Annual Meeting.
Influence Of Dietary Fats On C-Fos-Like Immunoreactivity In Mouse Hypothalamus, Hong-Qin Wang, Leonard Storlien, Xu-Feng Huang
Influence Of Dietary Fats On C-Fos-Like Immunoreactivity In Mouse Hypothalamus, Hong-Qin Wang, Leonard Storlien, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang
Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang
Xu-Feng Huang
The serotonergic system has close interactions with the dopaminergic system and is strongly implicated in the pathophysiological mechanisms and therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate regional changes in 5-hydroxytryptamine (5-HT) 2A receptors in the rat brain 3 weeks after unilateral medial forebrain bundle lesion by 6-hydroxydopamine (6-OHDA). 5-HT 2A receptor distributions and alterations in the postmortem rat brain were detected by [3H]ketanserin-binding autoradiography. In the 6-OHDA-induced Parkinson’s rat model, nigrostriatal dopaminergic neuron loss significantly mediated the decreased [3H]ketanserin binding, predominantly in the agranular insular cortex (17.3%, P 5 0.03), cingulate cortex (18.2%, P < 0.001), prefrontal …
The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang
The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang
Xu-Feng Huang
Atypical antipsychotics such as olanzapine and clozapine are effective at treating the multiple domains of schizophrenia, with a lowrisk of extra-pyramidal side-effects. However amajor downfall to their use is metabolicside-effects particularly weight gain/obesity,which occurs by unknownmechanisms. The present paper explores the potential candidature of histaminergic neurotransmission in the mechanisms of atypical antipsychoticinduced weight gain, with a focus on the histaminergic H1 and H3 receptors. Olanzapine and clozapine have a high affinity for the H1 receptor, andmeta-analyses showa strong correlation between risk ofweight gain andH1 receptor affinity. In addition, olanzapine treatment decreases H1 receptor binding and mRNA expression in the rat …
Effects Of Simvastatin And 6-Hydroxydopamine On Histaminergic H1 Receptor Binding Density In Rat Brains, Chang-Hua Hu, Chao Deng, Nikolce Mackovski, Ling Long, Cansheng Zhu, Yu Yang, Yuge Wang, J-Z Chen, Xu-Feng Huang, Qing Wang
Effects Of Simvastatin And 6-Hydroxydopamine On Histaminergic H1 Receptor Binding Density In Rat Brains, Chang-Hua Hu, Chao Deng, Nikolce Mackovski, Ling Long, Cansheng Zhu, Yu Yang, Yuge Wang, J-Z Chen, Xu-Feng Huang, Qing Wang
Xu-Feng Huang
Statins have been widely used for the treatment of a variety of medical conditions including psychoneurological disorders beyond their original use in lowering cholesterol. Histamine receptors play an important role in the regulation of neural activity, however, it is unknown whether statins act on histamine receptors, particularly for their neural regulatory effects. This study examined the effects of simvastatin and 6-hydroxydopamine (6-OHDA) lesions on histamine H1 receptors using [3H] pyrilamine binding autoradiography. Compared to the saline group, simvastatin (1 mg/kg/day) significantly decreased H1 receptor bindings in the primary motor cortex (M1), ventromedial hypothalamic nucleus (VMH), caudate putamen (CPu), accumbens core …
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Xu-Feng Huang
Antipsychotic drugs have various neuropharmacological properties as a result of their structural diversity. Despite their therapeutic benefits, most of the prescribed atypical antipsychotics can induce severe side effects, including weight gain, type II diabetes mellitus, and cardiovascular diseases. Among the developed atypical antipsychotic agents, tetracyclic dibenzodiazepine and thienobenzodiazepine compounds, particularly clozapine and olanzapine, are associated with the greatest weight gain and metabolic disturbances. However, the unique chemical structure of these compounds causes the low risk of side effects reported for typical antipsychotics (e.g. extrapyramidal symptoms and tardive dyskinesia). This report reviews the recent discovery of the potential role of the …
Neurodevelopment, Neurotransmitter Imbalance And Cognitive Dysfunction In Schizophrenia, Teresa Du Bois, Xu-Feng Huang
Neurodevelopment, Neurotransmitter Imbalance And Cognitive Dysfunction In Schizophrenia, Teresa Du Bois, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Increases In Peptide Y-Y Levels Following Oat Β-Glucan Ingestion Are Dose-Dependent In Overweight Adults, Eleanor J. Beck, Linda C. Tapsell, Marijka J. Batterham, Susan M. Tosh, Xu-Feng Huang
Increases In Peptide Y-Y Levels Following Oat Β-Glucan Ingestion Are Dose-Dependent In Overweight Adults, Eleanor J. Beck, Linda C. Tapsell, Marijka J. Batterham, Susan M. Tosh, Xu-Feng Huang
Xu-Feng Huang
Peptide Y-Y (PYY) is an anorexigenic hormone implicated in appetite control, and β-glucan is a fiber known to affect appetite. We hypothesized that plasma PYY levels would increase in overweight human adults consuming increasing doses of β-glucan. The objective was to test whether the effect could be seen with β-glucan delivered through extruded cereals containing a high β-glucan oat bran with demonstrated high molecular weight and solubility. Fourteen subjects consumed a control meal and 3 cereals of varying β-glucan concentration (between 2.2 and 5.5 g), and blood samples were collected over 4 hours. Analysis of raw PYY data showed a …