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Full-Text Articles in Medicine and Health Sciences
Kinetics And Mechanisms Of Crystal Growth Inhibition Of Indomethacin By Model Precipitation Inhibitors, Dhaval D. Patel
Kinetics And Mechanisms Of Crystal Growth Inhibition Of Indomethacin By Model Precipitation Inhibitors, Dhaval D. Patel
Theses and Dissertations--Pharmacy
Supersaturating Drug Delivery Systems (SDDS) could enhance oral bioavailability of poorly water soluble drugs (PWSD). Precipitation inhibitors (PIs) in SDDS could maintain supersaturation by inhibiting nucleation, crystal growth, or both. The mechanisms by which these effects are realized are generally unknown. The goal of this dissertation was to explore the mechanisms underpinning the effects of model PIs including hydroxypropyl β-cyclodextrins (HP-β-CD), hydroxypropyl methylcellulose (HPMC), and polyvinylpyrrolidone (PVP) on the crystal growth of indomethacin, a model PWSD. At high degrees of supersaturation (S), the crystal growth kinetics of indomethacin was bulk diffusion-controlled, which was attributed to a high energy form deposited …
Chemical And Biochemical Modification Of Surfaces For Control Of Wettability, Adsorption, And Drug Delivery, Susan C. D'Andrea
Chemical And Biochemical Modification Of Surfaces For Control Of Wettability, Adsorption, And Drug Delivery, Susan C. D'Andrea
Seton Hall University Dissertations and Theses (ETDs)
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