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Full-Text Articles in Medicine and Health Sciences
Covid-19 Interactions With Angiotensin-Converting Enzyme 2 (Ace2) And The Kinin System; Looking At A Potential Treatment, Ramin Tolouian, Sepideh Zununi Vahed, Shahram Ghiyasvand, Audrey C. Tolouian, Mohammadreza Ardalan
Covid-19 Interactions With Angiotensin-Converting Enzyme 2 (Ace2) And The Kinin System; Looking At A Potential Treatment, Ramin Tolouian, Sepideh Zununi Vahed, Shahram Ghiyasvand, Audrey C. Tolouian, Mohammadreza Ardalan
Nursing Faculty Publications
The novel coronavirus disease 2019 (COVID-19) is a rapidly expanding infection around the world. The world Health Organization (WHO) in March 2020 announced the Coronavirus pandemic. This infection causes many deaths on daily basis. Therapeutic options are currently limited. It is revealed that COVID-19 binds to human angiotensin-converting enzyme 2 (ACE2) to enter the host cells. One of the activities of ACE2 is hydrolyzing the active bradykinin metabolite [des-Arg973] BK (DABK). A decreased activity or reducing expression of ACE2 by the virus impairs the inactivation of DABK. This enhances its signaling through the bradykinin B1 receptor (BKB1R) and could lead …