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Caveolin-1, Tgf-Β Receptor Internalization, And The Pathogenesis Of Systemic Sclerosis, Francesco Del Galdo, Michael P. Lisanti, Sergio A. Jimenez
Caveolin-1, Tgf-Β Receptor Internalization, And The Pathogenesis Of Systemic Sclerosis, Francesco Del Galdo, Michael P. Lisanti, Sergio A. Jimenez
Jefferson Institute of Molecular Medicine Papers and Presentations
PURPOSE OF REVIEW: To review the scientific literature supporting the participation of caveolin-1 in the pathogenesis of tissue fibrosis and the notion that modulation of the caveolin-1 pathway may represent a novel treatment for systemic sclerosis and other fibrotic diseases.
RECENT FINDINGS: Caveolin-1 plays an important role in the regulation of transforming growth factor-beta (TGF-beta) signaling owing to its participation in TGF-beta receptor internalization. TGF-beta receptor internalized through caveolin-1 lipid rafts undergoes rapid degradation, effectively decreasing TGF-beta signaling. Studies have shown that caveolin-1 knockdown in vitro markedly increased collagen gene expression in normal human lung fibroblasts. Caveolin-1 was reduced in …