Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Chronic Neurological Impairment In Patients With Thrombotic Thrombocytopenic Purpura: Findings In Quantitative Mri, Jeffrey Hamilton
Chronic Neurological Impairment In Patients With Thrombotic Thrombocytopenic Purpura: Findings In Quantitative Mri, Jeffrey Hamilton
Electronic Thesis and Dissertation Repository
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening, microvascular blood disorder that affects approximately 5 people per million per year. The disorder is characterized by insufficient activity in ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 repeats 13), which is an important enzyme in hemostasis because it prevents thrombosis. Along with blood clotting, other predominant symptoms are fever, anaemia, kidney failure, and neurological changes. Neurological changes may include confusion and decreased levels of consciousness, as well as depression and increased risk of seizures or stroke. However, little is known about the general pathology of these neurological changes and this forms …
Vascular Stiffening And The Brain: Direct Measures Of Cerebrovascular Stiffness In Aging And Vasodilation, Christopher S. Balestrini
Vascular Stiffening And The Brain: Direct Measures Of Cerebrovascular Stiffness In Aging And Vasodilation, Christopher S. Balestrini
Electronic Thesis and Dissertation Repository
Dampening of pulsatile pressure waves within blood vessels is an essential feature of the arterial system. Vascular stiffening increases the speed and the pulsatile energy of the pressure wave, leaving low resistance organs like the brain vulnerable to microvascular mechanical damage. Due to access limitations, the effect of cerebrovascular stiffening on brain structure and neurological outcomes remains unknown. The purpose of this thesis was to assess the influence of vascular stiffening in peripheral arteries on white matter integrity (WMLv) (Chapter 2), obtain direct measures of cerebrovascular stiffness via phase contrast magnetic resonance imaging (PCMRI) (Chapter 3), and examine the impact …