Medicine and Health Sciences Commons^™

I Hear You: The Everyday Struggle Living With Misophonia, Ashton Jones

Mahurin Honors College Capstone Experience/Thesis Projects

The term misophonia is derivated from the Greek words misos, (hate), and phónè, (voice); it translates as hatred of sound. It is the term used to describe people who are irregularly affected by everyday noises. The first scientific observations by Pawel J. Jastreboff regarding misophonia indicate “individuals with misophonia are sensitive to a specific set of trigger sounds, which are usually recognized since childhood.” These types of sounds tend to be trivial noises, such as chewing or crunching, sniffing, breathing, clicking, lip smacking, and tapping. The noises can trigger an onslaught of negative emotions and violent reactions.

This documentary film …

H-Discrete Fractional Model Of Tumor Growth And Anticancer Effects Of Mono And Combination Therapies, Kamala Dadashova

Masters Theses & Specialist Projects

In this thesis, we focus on h–discrete and h–discrete fractional representation of a pharmacokinetics-pharmacodynamics (PK-PD) model which describes tumor growth considering time on hNa, where h>0. First, we introduce some definitions, lemmas and theorems on both h–discrete and h–discrete fractional calculus in the preliminary section. In Chapter 3, we work on the PD model with delay by exam ining nabla h–discrete equations and nabla h–discrete fractional equations as well as variation of constants formulas, accordingly. We introduce our model and solve it using theorems we proved in the last section of the indicated chapter. When we do simulation for …

Impact Of Geographic Location And Social Determinants Of Health On Lung Cancer Incidence And Mortality Rates, Katherine Ashley

Mahurin Honors College Capstone Experience/Thesis Projects

This paper studies the effect of geographic location and socioeconomic status, specifically level of education and income, on rates of incidence and mortality of lung and bronchus cancer. While some prior studies have focused on socioeconomic status’ and global geographic location’s impact on these rates, few have focused on the impact in Appalachian Kentucky and non-Appalachian Kentucky. In this paper, level of education and income are controlled for using four variables: median household income, percentage of persons in poverty, percentage of high school graduates or higher who are at least 25, and percentage of persons with a bachelor’s degree or …

Parameter Estimation And Optimal Design Techniques To Analyze A Mathematical Model In Wound Healing, Nigar Karimli

Masters Theses & Specialist Projects

For this project, we use a modified version of a previously developed mathematical model, which describes the relationships among matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), and extracellular matrix (ECM). Our ultimate goal is to quantify and understand differences in parameter estimates between patients in order to predict future responses and individualize treatment for each patient. By analyzing parameter confidence intervals and confidence and prediction intervals for the state variables, we develop a parameter space reduction algorithm that results in better future response predictions for each individual patient. Moreover, use of another subset selection method, namely Structured Covariance Analysis, that …

Examining The Influence And Role Of Pharmacogenetics Among Children With Autism Spectrum Disorder, Nuha Shaker

Masters Theses & Specialist Projects

Pharmacogenetics is the study of genomic-guided individualized drug prescription that plays an important role in preventing the severe adverse effects of drugs, decreasing the time and cost of therapeutic choices, and directing healthcare professionals to choose medications that are effective and safe. It is noteworthy that this approach becomes highly beneficial in patients suffering from chronic diseases or disorders, since these conditions may require multiple and long term pharmacological therapies, as in children with autism spectrum disorder (ASD). However, public acceptance is a major challenge when implementation of pharmacogenetics merges into clinical practice. The purpose of this study is a) …

Numerically Solving A System Of Pdes Modeling Chronic Wounds Treated With Oxygen Therapy, Stefan Stryker

Mahurin Honors College Capstone Experience/Thesis Projects

Chronic wounds such as diabetic foot ulcers are the leading cause of non-traumatic amputations in developed countries. For researchers to better understand the physiology of these wounds, a mathematical model describing oxygen levels at the wound site can be used to help predict healing responses. The model utilizes equations that are modified from work by Guffey (2015) that consists of four variables – oxygen, bacteria, neutrophils, and chemoattractant within a system of partial differential equations. Our research focuses on numerically solving these partial differential equations using a finite volume approach. This numerical solver will be important for future research in …

Cytotoxicity Of Platinum Anticancer Drugs In Mammalian Cell Lines Of Metastatic Cancer, Hosannah Evie

Mahurin Honors College Capstone Experience/Thesis Projects

With the invention of advanced technology, focus has been put on understanding and looking for potential cures for many diseases, one of which is cancer. The difference in the leaving and non-leaving ligands of the FDA approved cancer drugs contributes to the differential cell specific cytotoxic effects. These drugs such as oxaliplatin approved for colorectal cancer, cisplatin approved for testicular cancer, and their analogs were used to treat different cancer cell lines in an MTT assay. This project aims to determine how changing the molecular shape of these compounds affects their uptake and toxicity into different cell lines. The assay …

Benefits Of A Flexitarian Diet: Educating College Students Of Lifestyle Approaches To Reduce The Risk Of Developing Breast And Prostate Cancer, Abbigail Pace

Mahurin Honors College Capstone Experience/Thesis Projects

Practicing the Flexitarian diet, a plant-based diet, in conjunction with physical activity can promote a lifestyle consistent with the American Cancer Society’s recommendations for reducing risks of breast and prostate cancer (American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention, 2015) College students were assessed on knowledge of the relationship between diet and cancer risk prior to and after accessing information on the American Institute of Cancer Research site or the WKU Flexitarian Pinterest Page. Participants were recruited from the National Panhellenic and Interfraternity Council memberships and the International students at Western Kentucky University. Participants completed a …

Endothelin-1 Promotes Bovine Corneal Endothelial Cell Proliferation Via A Mapk Pathway: Implications For Keratopathy And Deturgescence, Brandon C. Farmer

Mahurin Honors College Capstone Experience/Thesis Projects

The corneal endothelium is vital in maintaining the functions of the cornea, namely hydration, thickness, and transparency. Diseases that impair the corneal endothelium are currently remedied solely via surgery. These surgeries present obstacles to patients of underserved areas due to cost, ineffectiveness, and lack of access. Trachoma, an infection which can cause corneal opacities, is the leading cause of infectious blindness in the world. In order to eradicate trachoma, epidemiological data is needed. Three villages in Kasigau, Kenya were studied to quantify the occurrence of trachoma in the region. The three villages were found to have adequate access to antibiotics …

Genetic Genealogy: What Every Librarian Should Know, Katherine A. Pennavaria, Rosemary L. Meszaros

Rosemary L. Meszaros

The past few years television, podcasts, and blogs across the Internet promoted the role of DNA testing in genealogy. But what do you really get, and is it worth the price? We discuss the logistics of DNA testing as it relates to genealogy and take a hard look at the legal issues involved in genealogy’s hottest topic.

Molecular Level Interaction Of Human Fibroblast Growth Factor-1 (Hfgf-1) With Phloridzin, Rammohan Paripelly

Masters Theses & Specialist Projects

Fibroblast growth factors (FGFs) are a family of growth factors which includes twenty three proteins. FGFs work as modulators for various cellular activities like mitosis, differentiation and survival. Among the FGF family, human fibroblast growth factor-1 (hFGF-1), which is also known as acidic fibroblast growth factor, is a potent angiogenic agent, involved in the formation of new blood vessels in various tissues. hFGF-1 is regarded as a prototype of the FGF family. It serves as one of the potential targets in tumor inhibition and obesity due to its involvement in new blood vessel formation in cancerous regions and adipose tissues. …

Effect Of Coconut Oil On Ulcerative Colitis In The Mouse Model, Pranav Chandra Alok

Masters Theses & Specialist Projects

Ulcerative colitis (UC) is a chronic disease of the colon or large intestine that causes inflammation and ulceration of the inner lining of the colon and rectum. In patients with ulcerative colitis, the body’s immune system overreacts and the body mistakes food, bacteria or other internal materials in the colon for an invading substance. The immune system attacks the material, thus irritating the colon. Limited knowledge of inflammatory conditions coupled with a narrow range of therapeutic options necessitates investigating the role of natural products. This study describes the effect of natural coconut oil on chemically-induced acute and chronic disease in …

Chhs June 2012 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

The Prevalence Of Essential Hypertension In Kasigau, Kenya, Lindsay Williams

Mahurin Honors College Capstone Experience/Thesis Projects

Hypertension is the leading cause of cardiovascular disease worldwide. Cardiovascular disease (CVD) is a widespread chronic non-communicable disease (NCD) which is on the rise in developing countries. Evidence based on extensive research studies on risk factors for NCDs suggests that they could be easily significantly decreased by simply controlling their risk factors. Although high blood pressure has been recognized as a leading risk factor for CVD, little research has been done to document the prevalence and incidence of essential hypertension (EH) in lower socioeconomic developing countries. One such country is Kenya. It was found in our research study that Kasigau …

Biomass Assisted Synthesis Of Antibacterial Gold Nanoparticles And Commentary On Its Future Potential And Applications In Medicine, Chad Willis

Mahurin Honors College Capstone Experience/Thesis Projects

Xylose is a natural monosaccharide found in biomass such as straw, pecan shells, cottonseed hulls, and corncobs. Using this monosaccharide, we report the green synthesis and characterization of biocompatible, biodegradable xylose encapsulated gold nanoparticles (Xyl-GNPs) with potential antibacterial activity. GNPs were synthesized using the bioreduction property of xylose on the chloroaurate anions in an aqueous solution at room temperature and at atmospheric pressure. The characterization of synthesized GNPs was examined by UV-vis spectroscopy; transmission electron microscopy (TEM), energy-dispersive x-ray spectroscopy (EDS) and fourier transform infrared spectroscopy (FTIR). Results indicate that the particles were stable; near spherical in shape with an …

Racemization Of Amino Acids In Teeth For The Determination Of Age, Andrea Lee Toll

Masters Theses & Specialist Projects

Instrumental to forensic investigations is the ability to identify unknown human remains providing key evidence to criminal cases, resolution to missing persons, and assistance in mass or natural disasters. Identification of remains in an effort to determine age is an area of forensics that has received considerable attention. Traditional methods in age determination such as morphology are often biased, antiquated, and frequently result in a large margin of error. Conversely, the emergence of new forensic techniques provide promise to reduce the margin of error in determining age. One such technique has focused on relating the extent of amino acid racemization …

Environmental Friendly Synthesis, Characterization Of Surface Modifiable Starch Encapsulated Gold Nanoparticles With Bactericidal And Catalytic Activity, Dillon Pender

Mahurin Honors College Capstone Experience/Thesis Projects

In the present study, we report the green synthesis of gold nanoparticles (GNPs), using potato starch as a reducing as well as a stabilizing agent in an aqueous buffer medium. The resulting starch-GNPs (St-GNPs) were near spherical in shape with an average diameter of 15 ± 5 nm. In this approach, St-GNPs were characterized and investigated for their antibacterial properties against both gram negative (Escherichia coli) and gram positive (Staphylococcus epidermidis) bacteria. These St-GNPs were found to possess significant dose dependent antibacterial activity against bacteria. Also, St-GNPs showed a significant catalytic activity and can easily be …

Chhs January 2012 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, College Of Health And Human Services, Western Kentucky University

College of Health & Human Services Publications

No abstract provided.

Activity Of Analogs Of Anticancer Drugs On The Serine Protease Enzymes Subtilisin And Chymotrypsin, Dhatri Ravipati

Masters Theses & Specialist Projects

The anticancer activity of several platinum compounds is due to the formation of complexes with DNA. We hypothesize that the size and shape of the platinum compounds would impact interaction with proteins, and these interactions may be partly responsible for the anticancer activity. Chymotrypsin and subtilisin are serine proteases that have a histidine residue in the active site. We are investigating the inhibition of the digestive enzymes chymotrypsin and subtilisin by analogs of the anticancer drug cisplatin and trying to discern trends in the inhibition as the active site residues vary. In our research, we found that the enzyme subtilisin …

Measuring Accessibility To Primary Care Physicians In The Nashville Metropolitan Statistical Area, Sami M. Almudaris

Masters Theses & Specialist Projects

The growing concern for the shortage of primary care physicians (PCPs) prompted a government legislation to designate areas where shortage in the delivery of primary care services occurs. The implemented systems (e.g., HPSA, MUA, and MUP) analyze utilization of health services within confined administrative units and fail to account for spatial interactions that occur across administrative borders. This research examines the spatial accessibility to PCPs and the underlying demographic and socioeconomic settings. With the Nashville Metropolitan Statistical Area (MSA) as a study area, this study utilized data from the U.S. Census 2000 and 2010, as well as the known locations …

Ua1b1/2 L.Y. Lancaster Lecture Series, Wku Archives

WKU Archives Collection Inventories

Records regarding the L.Y. Lancaster Lecture Series.

Age, Reproduction, Growth, Condition And Diet Of The Introduced Yellow Bass, Morone Mississippiensis, In Barren River Lake, Kentucky, Peter Zervas

Masters Theses & Specialist Projects

Introduction of fish species to North American drainages has occurred for over 100 years. Introduced fish species have been documented to have adverse effects on both the environment and native species of the drainage into which they have been introduced. To better understand the effects that introduced species may have on a particular drainage, it is essential to understand aspects of the introduced species' life history. The objectives of the current study is to quantify the age, reproduction, growth, condition and diet of the yellow bass, Morone mississippiensis, in Barren River Lake, Kentucky. Monthly collections from three areas on Barren …

Role Of Cd4+Cd25+ Regulatory T Lymphocytes In Experimental Toxoplasmosis, Sanjay Varikuti

Masters Theses & Specialist Projects

Toxoplasmosis is an important cause of congenital disease, and it is one of the most common opportunistic infections in patients with acquired immunodeficiency syndrome. The need for a reliable experimental model of this infection is crucial not only for achieving a better understanding of the patho-physiology of the disease, but also for developing better methods for evaluating new therapeutic regimens. The purpose of the present study was to investigate the role of CD4+CD25+ T regulatory lymphocytes in mice infected with Toxoplasma gondii. T regulatory (Treg) cells have been shown to play an important role in our immune system in …

The Effect Of Endothelin-1 On The Expression Of Cdk Inhibitors P21 & P27 In Bovine Corneal Endothelial Cells, Lakshmi Reddy Bollu

Masters Theses & Specialist Projects

Mammalian corneal endothelial cells are considered to be non-proliferative due to the arrest of cells at the G1 phase of the cell cycle. The purpose of this study was to determine whether the down regulation of cyclin dependant kinase inhibitors (p21cip1 and p27kip1) levels by Endothelin-1 (ET-1), would overcome the G1 phase arrest and promote cell cycle progression and proliferation in cultured BCECs (Bovine corneal endothelial cells). BCECs were isolated from bovine corneas and cultured in DMEM supplemented with 10% serum. 5-Bromo 2-deoxy Uridine (BrdU) incorporation was determined in serum starved cultures in 24-well plates as a measure of cell …

Kelly, Rita Helen Roberts (Fa 353), Manuscripts & Folklife Archives

FA Finding Aids

Finding aid and full-text scan of paper (Click on “Additional Files” below) for Folklife Archives Project 353. Paper: "Good Mothering through Breast Feeding: Observations of a Meeting of the La Leche League" written by Rita H. Kelly for a Western Kentucky University folk studies class.

Population Structure Of Limenitis Butterflies In Hickman, Kentucky, Mollie Johnson

Masters Theses & Specialist Projects

Two species of Limenitis butterflies occur along the Mississippi River at Hickman, Kentucky: the viceroy, L. archippus, and the red-spotted purple, L. arthemis astyanax. Limenitis archippus occurs at a frequency that is 10-30 times more abundant than its congener, L. arthemis astyanax. Interspecific matings between L. archippus and L. arthemis astyanax are very rare in the wild and give rise to a hybrid form Limenitis archippus X L. arthemis astyanax form rubidus. Only 7 heterospecific pairings between the parental species and 72 "rubidus" individuals have been documented in the wild in all of North America. Of these documented cases, 2 …

Effects Of Barren Reservoir On Upstream Fish Assemblages Of Barren River Tributaries, Mario Sullivan

Masters Theses & Specialist Projects

The effects of dams have long been investigated by aquatic ecologists. However, most of the research has focused on the physio-chemical changes when a lotic system is turned into a lentic system, dams as barriers to migratory fishes, and the influence of introduced species often stocked into reservoirs. It has not been until relatively recently that the upstream effects have been studied. The central theme here is that while the dam proper creates a barrier it is possible that the resulting zone of standing water may also fragment streams from an otherwise connected river system. Stream adapted species that encounter …

Longitudinal Variation In Fish Community Along The Upper Green River Below The Green River Lake, Joshua Wilsey

Masters Theses & Specialist Projects

The impoundment of flowing waters can cause decreased variation in flow and temperature, reduce habitat availability, and decreased mean temperature below a reservoir. These types of alterations can influence fish communities. Twelve sites were sampled along the Upper Green river in order to address the potential influence of impoundment on fish communities below the Green River Lake. The habitat features: mean depth, flow, dominant substrate, embeddedness, percent riffle, run and pool were measured. Temperature probes were placed at each site in order to measure temperature over an extended period of time. Backpack electrofishing and seining was used to obtain fishes. …

Pcr-Ddge Comparison Of Fecal Bacteria From Captive And Wild Populations Of The Endangered San Esteban Island Chuckwalla (Sauromalus Varius), Tina Kelley

Masters Theses & Specialist Projects

Most modern reptiles are carnivorous or insectivorous, whereas less than 2% of the >7,800 currently recognized species are considered to be herbivorous. Of these, herbivory is confined entirely to lizards; less than 3% of known lizard species eat significant amounts of plants. Most, if not all, herbivorous animals utilize a population of symbiotic microorganisms which can break down plant structural polymers. This study analyzes the bacterial populations from fecal/uric acid deposits of wild and captive samples of the endangered, herbivorous San Esteban chuckwalla (Sauromalus varius: Iguanidae). Substrate and diet samples were also analyzed. Most studies of digestive symbionts use indirect …

Coregulation Of A Neighboring Est With Rhogap, Tia Hughes

Masters Theses & Specialist Projects

It has been reported that the crossveinless-c locus of Drosophila melanogaster corresponds the RhoGAP88C gene. This determination was based on three criteria: proximity in genetic map position, complementation tests, and similarity of phenotype between RhoGAP88C RNAi constructs and the phenotype of hypomorphic cv-c' mutant homozygotes, both of which eliminate posterior crossveins (Denholm et al. 2005). There are several genes that map to this region of chromosome 3, including both RhoGAP88C, and a poorly annotated PDZ-domain containing gene corresponding to Expressed Sequence Tag (EST) Clot 13975 (approximately 60 kb upstream from the RhoGAP88C transcriptional start). A P-element insertion P[PZ]l(3)06951 is located …