Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Janus Kinase 1 Is Required For Transcriptional Reprograming Of Murine Astrocytes In Response To Endoplasmic Reticulum Stress, Savannah G. Sims, Gordon P. Meares
Janus Kinase 1 Is Required For Transcriptional Reprograming Of Murine Astrocytes In Response To Endoplasmic Reticulum Stress, Savannah G. Sims, Gordon P. Meares
Faculty & Staff Scholarship
Neurodegenerative diseases are associated with the accumulation of misfolded proteins in the endoplasmic reticulum (ER), leading to ER stress. To adapt, cells initiate the unfolded protein response (UPR). However, severe or unresolved UPR activation leads to cell death and inflammation. The UPR is initiated, in part, by the transER membrane kinase PKR-like ER kinase (PERK). Recent evidence indicates ER stress and inflammation are linked, and we have shown that this involves PERKdependent signaling via Janus Kinase (JAK) 1. This signaling provokes the production of soluble inflammatory mediators such as interleukin-6 (IL-6) and chemokine C-C motif ligand 2 (CCL2). We, therefore, …