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Microcystic, Elongated, And Fragmented (Melf) Pattern Invasion In Ovarian Endometrioid Carcinoma: Immunohistochemical Profile And Prognostic Implications, Allison F. Goldberg, Md, Lauren Cooper, Md, D. De Cotiis, Norman G. Rosenblum, Md, Phd, Joanna Chan, Md
Microcystic, Elongated, And Fragmented (Melf) Pattern Invasion In Ovarian Endometrioid Carcinoma: Immunohistochemical Profile And Prognostic Implications, Allison F. Goldberg, Md, Lauren Cooper, Md, D. De Cotiis, Norman G. Rosenblum, Md, Phd, Joanna Chan, Md
Department of Pathology, Anatomy, and Cell Biology Resident's Posters
BACKGROUND
•Microcystic, Elongated and Fragmented (MELF) is a well-recognized pattern of uterine endometrioid carcinoma (UEC) associated with lymphovascular space invasion and occult lymph node metastasis
•MELF in UEC may be seen with Lynch Syndrome
•MELF in UEC is hypothesized to be histologic evidence of an epithelial mesenchymal transition
•MELF pattern invasion in ovarian endometrioid carcinoma (OEC) was first described at USCAP 2015 •
Current study evaluates MELF in OEC for
•Prognostic implications
•Immunohistochemical (IHC) profile related to
•Lynch Syndrome
•Epithelial mesenchymal transition
DESIGN
•42 consecutive cases of OEC without concurrent UEC (1996-2014) evaluated by 2 pathologists
•MELF defined as at …