Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Functional Comt Val158met Polymorphism, Risk Of Acute Coronary Events And Serum Homocysteine: The Kuopio Ischaemic Heart Disease Risk Factor Study, Sari Voutilainen, Tomi-Pekka Tuomainen, Maarit Korhonen, Jaakko Mursu, Jyrki K. Virtanen, Pertti Happonen, Georg Alfthan, Iris Erlund, Kari E. North, M.J. Mosher, Jussi Kauhanen, Jari Tiihonen, George A. Kaplan, Jukka T. Salonen
Functional Comt Val158met Polymorphism, Risk Of Acute Coronary Events And Serum Homocysteine: The Kuopio Ischaemic Heart Disease Risk Factor Study, Sari Voutilainen, Tomi-Pekka Tuomainen, Maarit Korhonen, Jaakko Mursu, Jyrki K. Virtanen, Pertti Happonen, Georg Alfthan, Iris Erlund, Kari E. North, M.J. Mosher, Jussi Kauhanen, Jari Tiihonen, George A. Kaplan, Jukka T. Salonen
Anthropology Faculty and Staff Publications
. The role of circulating levels of total homocysteine tHcy in the development of coronary heart disease (CHD) is still under debate. One reason for conflicting results between previous studies on homocysteine and heart diseases could be consequence of different interactions between homocysteine and genes in different study populations. Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met) in the Catechol-O-methyltransferase (COMT) gene. Methodology and Findings. Our aim was to examine the role of COMT Val158Met polymorphism and interaction of this polymorphism with serum tHcy and folate concentration on the risk of acute coronary and events …
Genotype-By-Sex Interaction In The Regulation Of High-Density Lipoprotein: Theframingham Heart Study, M.J. Mosher, L. J. Martin, L. A. Cupples, Q. Yang, T. D. Dyer, J. T. Williams, K. E. North
Genotype-By-Sex Interaction In The Regulation Of High-Density Lipoprotein: Theframingham Heart Study, M.J. Mosher, L. J. Martin, L. A. Cupples, Q. Yang, T. D. Dyer, J. T. Williams, K. E. North
Anthropology Faculty and Staff Publications
Low levels of high-density lipoprotein (HDL) are widely documented as a risk factor for cardiovascular disease (CVD). Furthermore, there is marked sexual dimorphism in both HDL levels and the prevalence of CVD. However, the extent to which genetic factors contribute to such dimorphism has been largely unexplored. We examined the evidence for genotypeby- sex effects on HDL in a longitudinal sample of 1,562 participants from 330 families in the Framingham Heart Study at three times points corresponding approximately to 1971-1974, 1980-1983, and 1988-1991. Using a variance component method, we conducted a genome scan of HDL at each time point in …