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Articles 1 - 30 of 36
Full-Text Articles in Medicine and Health Sciences
A Case Study Assessing The Integration Of Nuclear Safety And Security In Facilities Using A Monte Carlo Simulation Aided Analytical Hierarchy Process, Theodore A. Thomas, Shraddha Rane, Jason Timothy Harris
A Case Study Assessing The Integration Of Nuclear Safety And Security In Facilities Using A Monte Carlo Simulation Aided Analytical Hierarchy Process, Theodore A. Thomas, Shraddha Rane, Jason Timothy Harris
International Journal of Nuclear Security
Nuclear safety and security are essential in all operations using nuclear and radioactive materials. Even though both elements are important, the evolution of these programs has not developed at the same rate. As such, their integration has been met with challenges. This study analyzed the potential for synergy across different criteria and settings when integrating nuclear safety and security. The criteria included eight points where overlap could be identified between nuclear safety and security. Three work settings—industrial, medical, and research—were evaluated. Responses were collected from nine individuals who worked with nuclear materials in various capacities and different nuclear work settings. …
Advanced Air Quality Management With Machine Learning, Cheng-Pin Kuo
Advanced Air Quality Management With Machine Learning, Cheng-Pin Kuo
Doctoral Dissertations
Air pollution has been a significant health risk factor at a regional and global scale. Although the present method can provide assessment indices like exposure risks or air pollutant concentrations for air quality management, the modeling estimations still remain non-negligible bias which could deviate from reality and limit the effectiveness of emission control strategies to reduce air pollution and derive health benefits. The current development in air quality management is still impeded by two major obstacles: (1) biased air quality concentrations from air quality models and (2) inaccurate exposure risk estimations
Inspired by more available and overwhelming data, machine learning …
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
Masters Theses
One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …
Effect Of Amputation On Muscle Structure Properties In A Rabbit Model, Roy Caleb Stubbs
Effect Of Amputation On Muscle Structure Properties In A Rabbit Model, Roy Caleb Stubbs
Masters Theses
After amputation, muscles in the residual limb are detached from their insertion points and no longer span the missing joints. Our objective was to quantify the effect of amputation-induced disuse on residual muscle structure, an indirect indicator of muscle force-generating capacity. One hind paw was surgically removed at the ankle joint of ten rabbits. At two weeks (n=5) and 4 weeks (n=5) post-amputation and for select muscles (gastrocnemius, soleus, tibialis cranialis, extensor digitorum, and flexor digitorum superficialis), we measured and computed several muscle structure properties. Additionally, we qualitatively assessed the muscle fiber appearance of histological samples at each timepoint. At …
Development Of A Low-Dose Radiation Therapy Device For Acute Respritory Distress Syndrome, Thomas Heath Davis
Development Of A Low-Dose Radiation Therapy Device For Acute Respritory Distress Syndrome, Thomas Heath Davis
Masters Theses
This research focuses on the development of a low dose radiotherapy (LD-RT) device for treatment of acute respiratory distress syndrome (ARDS), a respiratory illness that affects millions of people a year. The use of orthovoltage (200 – 500 keV) X-ray energy provides many advantages over traditional radiotherapy delivery with linear accelerators, such as low cost and greater accessibility. In addition, X-ray tubes have been shown throughout history to provide good treatment outcomes for pneumonia, and research has shown LD-RT to be just as effective with ARDS. This proposal summarizes my efforts in determining the dosimetric properties of a LD-RT system …
Design And Development Of The Urban Population Health Observatory To Improve Disease Surveillance And Response, Whitney Brakefield
Design And Development Of The Urban Population Health Observatory To Improve Disease Surveillance And Response, Whitney Brakefield
Doctoral Dissertations
Chronic and infectious diseases have a profound impact on the quality and length of life of populations that suffer from these conditions. Scientists, physicians, and health officials are seeking innovative approaches to decrease the morbidity and mortality of deadly diseases. Incorporating artificial intelligence and data science techniques across the health science domain could improve disease surveillance, intervention planning, and policymaking. In this dissertation, we describe the design and development of the Urban Population Health Observatory (UPHO), an explainable knowledge-based multimodal big data analytics platform. A common challenge for conducting multimodal big data analytics is integrating multidimensional heterogeneous data sources, which …
Medical Sound Simuvest, Jordan Grant
Medical Sound Simuvest, Jordan Grant
Chancellor’s Honors Program Projects
No abstract provided.
Nuclear Security Awareness Survey At A University, Marcia P. Robinson, Naomi German, Destiny B. White, Shraddha V. Rane, Jason Timothy Harris
Nuclear Security Awareness Survey At A University, Marcia P. Robinson, Naomi German, Destiny B. White, Shraddha V. Rane, Jason Timothy Harris
International Journal of Nuclear Security
The concept of assessing safety culture in an organization emerged with its application at the nuclear power industry and has expanded since then. An assessment of nuclear security, on the contrary, is still under-developed, especially at non-nuclear facilities, such as academic institutions and medical facilities. To identify the level of the awareness and understanding of credible nuclear and radiological threats, response preparedness, security culture, and the integrity of nuclear security systems among non-radioactive material users at a university setting; a campus-wide survey was deployed. A total of 3,336 non-radioactive material users, including students, faculty, and staff participated in the survey. …
Qualitative And Quantitative Improvements For Positron Emission Tomography Using Different Motion Correction Methodologies, Tasmia Rahman Tumpa
Qualitative And Quantitative Improvements For Positron Emission Tomography Using Different Motion Correction Methodologies, Tasmia Rahman Tumpa
Doctoral Dissertations
Positron Emission Tomography (PET) data suffers from low image quality and quantitative accuracy due to different kinds of motion of patients during imaging. Hardware-based motion correction is currently the standard; however, is limited by several constraints, the most important of which is retroactive data correction. Data-driven techniques to perform motion correction in this regard are active areas of research. The motivation behind this work lies in developing a complete data-driven approach to address both motion detection and correction. The work first presents an algorithm based on the positron emission particle tracking (PEPT) technique and makes use of time-of-flight (TOF) information …
Assessment Of The Use Of Low Molecular Weight Diblock Copolymers For The Formation Of Stable, Tunable Droplet Interface Bilayers, Joseph Tawfik
Assessment Of The Use Of Low Molecular Weight Diblock Copolymers For The Formation Of Stable, Tunable Droplet Interface Bilayers, Joseph Tawfik
Masters Theses
This thesis presents the use of diblock copolymers, poly(butadiene)-b-poly(ethylene oxide) (PBm PEOn) and poly(isoprene)-b-poly(ethylene oxide) (PImPEOn), as amphiphilic molecular building blocks for the formation of synthetic polymer bilayer membranes using the droplet interface bilayer (DIB) technique. The DIB technique makes use of the self-assembly of amphiphilic macromolecules along oil-water droplet interfaces that can then be physically connected for the construction of liquid supported macromolecular bilayers at the droplet interface. These bilayer membranes are capable of hosting both naturally occurring and synthetic protein channels. This technique has been used to form synthetic bilayer membranes …
Emergency Eye Simulation Model, Gavin L. Warrington, Christopher Forsyth, Lexus Morris, Natalie Ledezma
Emergency Eye Simulation Model, Gavin L. Warrington, Christopher Forsyth, Lexus Morris, Natalie Ledezma
Chancellor’s Honors Program Projects
No abstract provided.
Combating Intersection-Related Imposter Phenomenon In The Workplace Through Career Readiness, Simone Stewart
Combating Intersection-Related Imposter Phenomenon In The Workplace Through Career Readiness, Simone Stewart
Black Issues Conference
Research has determined that Impostor Phenomenon (IP) most likely occurs in members of minority groups, students, first generation professionals and persons for whom success came quickly. Other studies have shown that many professional women are One of the ways to combat IP is through the development of competencies needed in your career. Attend this workshop to learn how to develop strategies to approach career competency while on campus and throughout your career to keep you on top of your game!
Final Design Report For The Bioburden Pre-Cleaning Device And Dr. Mark Rasnake At The University Of Tennessee Medical Center, Katherine Elizabeth Stiles, Megan Pitz, Kayla Franklin, Simran Dayal, Austin Bullock
Final Design Report For The Bioburden Pre-Cleaning Device And Dr. Mark Rasnake At The University Of Tennessee Medical Center, Katherine Elizabeth Stiles, Megan Pitz, Kayla Franklin, Simran Dayal, Austin Bullock
Chancellor’s Honors Program Projects
No abstract provided.
The Comparison Of Verbalized Feedback In Human To Computer Interfacing Versus Human To Human Interaction, Kea Francis
The Comparison Of Verbalized Feedback In Human To Computer Interfacing Versus Human To Human Interaction, Kea Francis
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
The project evaluates response to social robots for purposeful tasks. The study uses a social robot, Rapiro, along with a smartphone that serves as a visual interface for the robot system. My role was to design a program on a Raspberry Pi that allows simultaneous control of Rapiro’s actions and a response from a phone application. The phone app is downloaded to an Android phone and designed using MIT App Inventor software. This allows pre-programmed and real-time control of the robot. The user inputs what they want the robot to say through the terminal of the Raspberry Pi. Through serial …
The Future Of Nuclear Security: A Medical Physicist’S Perspective, Katharine E. Thomson
The Future Of Nuclear Security: A Medical Physicist’S Perspective, Katharine E. Thomson
International Journal of Nuclear Security
Planning for the future of nuclear security is a vital and complex task, requiring cooperation and contribution from many disciplines and industries. This diversity of expertise should include the medical sector, which faces many of the same challenges as the nuclear industry: controlling access to dangerous material, creating a strong security culture, cooperating with the wider world and engaging the public.
Medical physicists, of which the author is one, oversee all aspects of small-scale radiation use. This paper discusses three key areas increasingly important to both medical and nuclear uses of radioactive materials: public engagement, prevention of nuclear and radiological …
Evaluation Of Increased Targeted Enforcement And Community-Based Outreach And Education Programs To Increase Nighttime Seatbelt Use In East Tennessee, Kwaku Frimpong Boakye
Evaluation Of Increased Targeted Enforcement And Community-Based Outreach And Education Programs To Increase Nighttime Seatbelt Use In East Tennessee, Kwaku Frimpong Boakye
Doctoral Dissertations
According to the National Highway Traffic Safety Administration (NHTSA), motor vehicle crashes are the leading cause of death among people aged 1-54 in the United Sates. In 2015, the number of motor-vehicle deaths on U.S. roadways totaled 35,092, a 7% increase from 2014 (32,744). Though lower gas prices and increased vehicle mileage combined with risky driving behaviors (e.g. speeding, driving while texting) account for the increased fatality rate, seatbelt non-use has been a significant contributory factor. It is estimated that nearly half (48%) of passenger vehicle occupants involved in fatal crashes each year are unrestrained.
In a recent 2014 report …
Elucidating The Effects Of Metabolic State On Nanoparticle Distribution In Mice And In Vitro Uptake, Kevin James Quigley
Elucidating The Effects Of Metabolic State On Nanoparticle Distribution In Mice And In Vitro Uptake, Kevin James Quigley
Doctoral Dissertations
Since almost 70% of the U.S. population over 20 years old is overweight and 30% is obese, with much of the western world following suit, many patients that will potentially be administered circulating nanoparticles designed to localize to tumors and avoid non-target areas will have significant amounts of white adipose tissue (WAT), enlarged livers, and additional metabolic complications such as type 2 diabetes. However, studies on nanoparticle biodistribution and efficacy take place almost without exception in lean rodents with healthy metabolic states. In this work, I determined the biodistribution of model nanoparticles – neutral filomicelles and polystyrene spheres both carrying …
A Feasibility Study Of Just-In-Time Asthma Self-Management Intervention, Phillip Charles Scruggs
A Feasibility Study Of Just-In-Time Asthma Self-Management Intervention, Phillip Charles Scruggs
Masters Theses
Quality asthma care requires not only an initial diagnosis, but long term follow up care and education on long term control. Preventable symptoms continue to reduce the quality of life for chronic asthma sufferers and place an unnecessary burden on emergency services and the health care system at large. A mobile health (mHealth) solution is proposed to effectively improve outcomes for patients while ultimately reducing the overall burden of mismanagement on the healthcare system as a whole. The Just-in-Time Asthma Self- Management and Intervention (JASMIN) system provides a way for a patient or user to track, self-manage, and interact with …
High Reliability Organizational Suggestions To Reduce The Risk Of Hospital-Associated Infections, Sandra Catrice Affare
High Reliability Organizational Suggestions To Reduce The Risk Of Hospital-Associated Infections, Sandra Catrice Affare
Doctoral Dissertations
Over 1.7 million hospital-associated infections (HAIs), resulting in 99,000 deaths, occur each year in the United States. HAIs are defined as infections that occur within 48 hours of hospital admission without evidence of the infection being present or incubating at the time of admission. HAIs are a major concern to the medical community due to the potential loss of life and high costs. Healthcare providers should be accountable for reducing the rates of HAIs and society needs to hold them accountable for the safe implementation and outcomes of the services they provide.
A high-reliability organization (HRO) is commonly described as …
Improving Ventricular Catheter Design Through Computational Fluid Dynamics, Sofy Hefets Weisenberg
Improving Ventricular Catheter Design Through Computational Fluid Dynamics, Sofy Hefets Weisenberg
Masters Theses
Cerebrospinal fluid (CSF) shunts are fully implantable medical devices that are used to treat patients suffering from conditions characterized by elevated intracranial pressure, such as hydrocephalus. In cases of shunt failure or malfunction, patients are often required to endure one or more revision surgeries to replace all or part of the shunt. One of the primary causes of CSF shunt failure is obstruction of the ventricular catheter, a component of the shunt system implanted directly into the brain's ventricular system. This work aims to improve the design of ventricular catheters in order to reduce the incidence of catheter obstruction and …
Lost And Found: Use Of Gps Technology To Improve Storage Of Patient Belongings In Hospital Setting, Shelby A. Sievers, Griffin M. Heise, Min G. Kang, Michael Totty
Lost And Found: Use Of Gps Technology To Improve Storage Of Patient Belongings In Hospital Setting, Shelby A. Sievers, Griffin M. Heise, Min G. Kang, Michael Totty
Chancellor’s Honors Program Projects
No abstract provided.
Interactive Debriefing Application (Ida), Quentin Eastridge, Erik Vass
Interactive Debriefing Application (Ida), Quentin Eastridge, Erik Vass
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Health Information Technology & Simulation Lab (HITS Lab) is an interprofessional effort aimed at enhancing consumer and professional health education through the advancement of health information technology. The HITS Lab brings together expertise from multiple disciplines to promote active simulated learning and the development and testing of new health technology. The lab’s latest development is the Interactive Debriefing Application (IDA). This tablet application will engage students as they observe medical simulations. The IDA will transform students from passive to active observers as they engage with what they are seeing in the simulation. The application will also enhance the face-to-face debriefing …
Icloudecg: A Mobile Cardiac Telemedicine System, David S. Clifford
Icloudecg: A Mobile Cardiac Telemedicine System, David S. Clifford
Masters Theses
With rising healthcare costs and a substantially growing number of patients 65 or over, the benefits of telemedicine and patient self-monitoring systems are becoming increasingly evident. Patients, physicians, hospitals, and even insurance providers benefit from vigilant, cost-effective patient monitoring systems. This thesis describes the development of a portable, smart-phone connected system for continuous cardiac monitoring. The system is capable of continuously monitoring the conditions of the heart, automated detection of cardiac arrhythmias, and real-time notifying patients and physicians of the detected abnormalities. The system consists of four main subsystems: 1) a Bluetooth capable chest-strap ECG, 2) an Android-enabled mobile device, …
Effects Of Varus Knee Alignment And Using Toe-Cages On Frontal Plane Knee Biomechanics In Stationary Cycling, Guangping Shen
Effects Of Varus Knee Alignment And Using Toe-Cages On Frontal Plane Knee Biomechanics In Stationary Cycling, Guangping Shen
Masters Theses
Effects of varus knee alignment on the internal knee abduction moment (KAM) in walking has been widely studied. KAM has been shown to be closely associated with the development of medial knee osteoarthritis (OA). Despite the importance of the knee alignment, no studies have explored its effects on knee frontal plane biomechanics during stationary cycling. The purpose of this study was to examine the effects of varus knee alignment and using a toe-cage on the knee frontal plane biomechanics during stationary cycling. Eleven participants in each of the varus and neutral groups participated in the study. The participants performed in …
Developing An Optimal Model For Infant Home Visitation, Isaac Atuahene
Developing An Optimal Model For Infant Home Visitation, Isaac Atuahene
Doctoral Dissertations
The United States, Great Britain, Denmark, Canada and many other countries have accepted home visitation (HV) as a promising strategy for interventions for infants after births and for their mothers. Prior HV studies have focused on theoretical foundations, evaluations of programs, cost/benefit analysis and cost estimation by using hospital/payer/insurance data to prove its effectiveness and high cost. As governments and private organizations continue to fund HVs, it is an opportune time to develop and formulate operations research (OR) models of HV coverage, quality and cost so they might be used in program implementation as done for adult home healthcare (HHC) …
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague
Masters Theses
Photo-crosslinkable polymeric biomaterials have emerged in the field of biomedical research to promote tissue regeneration. For example, scaffolds that can be crosslinked and hardened in situ have been known to make suitable implant alternatives. Since injectable and photo-crosslinkable biomaterials offer the advantage of being minimally invasive, they have emerged to compete with autografts, a current highly invasive method to repair diseased tissue. A series of novel photo-crosslinkable, injectable, and biodegradable nano-hybrid polymers consisting of poly(ε-caprolactone fumarate) (PCLF) and polyhedral oligomeric silsesquioxane (POSS) has been synthesized in our laboratory via polycondensation. To engineer the material properties of the nano-hybrid networks, varied …
Fiber Optic Bandage, Logan Mcneil, Cameron Pilkey, Brittani Erwin, Adam Wojnar
Fiber Optic Bandage, Logan Mcneil, Cameron Pilkey, Brittani Erwin, Adam Wojnar
Faculty Publications and Other Works -- Biomedical and Diagnostic Sciences
The purpose of this document is to show the report for the Fiber optic device formulated through the biomedical engineering department with a senior design group. A growing issue in medical technology is open wound care. Particularly prevalent in diabetics, open wound care is expensive and time consuming. Certain wavelengths of light have not only shown to have germicidal properties, but also allow cell growth and regeneration. The following design was founded around these ideas, and an initial design was developed. The design centered around using fiber optics as a means of replacing a wet bandage in a normal wound …
Fiber Optic Bandage, Logan Mcneil
Fiber Optic Bandage, Logan Mcneil
Chancellor’s Honors Program Projects
No abstract provided.
Dynamic Simulation And Neuromuscular Control Of Movement: Applications For Predictive Simulations Of Balance Recovery, Misagh Mansouri Boroujeni
Dynamic Simulation And Neuromuscular Control Of Movement: Applications For Predictive Simulations Of Balance Recovery, Misagh Mansouri Boroujeni
Doctoral Dissertations
Balance is among the most challenging tasks for patients with movement disorders. Study and treatment of these disorders could greatly benefit from combined software tools that offer better insights into neuromuscular biomechanics, and predictive capabilities for optimal surgical and rehabilitation treatment planning. A platform was created to combine musculoskeletal modeling, closed-loop forward dynamic simulation, optimization techniques, and neuromuscular control system design. Spinal (stretch-reflex) and supraspinal (operational space task-based) controllers were developed to test simulation-based hypotheses related to balance recovery and movement control. A corrective procedure (rectus femoris transfer surgery) was targeted for children experiencing stiff-knee gait and how this procedure …
Red Bird Water Kiosk Pavilion _ Clean Water Clean Life, Garrett Keyes Nelli
Red Bird Water Kiosk Pavilion _ Clean Water Clean Life, Garrett Keyes Nelli
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Architecture has the power to strengthen community bonds, support a healthy life style and enrich individual lives. The Red Bird Water Kiosk seeks to achieve all three of these on the site of the Red Bird Mission campus, located deep in the Appalachian Mountains of Clay County, Kentucky. This is an area where most live below the poverty line, and about 64 percent of water sources are contaminated. As a result, lack of clean water has forced many locals to turn to unhealthy living standards. Because of these conditions, the county ranks as one of the poorest in the nation, …