Medicine and Health Sciences Commons^™

Segmentation Of Pulmonary Nodules In Computed Tomography Using A Regression Neural Network Approach And Its Application To The Lung Image Database Consortium And Image Database Resource Initiative Dataset, Temesguen Messay, Russell C. Hardie, Timothy R. Tuinstra

Engineering and Computer Science Faculty Publications

We present new pulmonary nodule segmentation algorithms for computed tomography (CT). These include a fully-automated (FA) system, a semi-automated (SA) system, and a hybrid system. Like most traditional systems, the new FA system requires only a single user-supplied cue point. On the other hand, the SA system represents a new algorithm class requiring 8 user-supplied control points. This does increase the burden on the user, but we show that the resulting system is highly robust and can handle a variety of challenging cases. The proposed hybrid system starts with the FA system. If improved segmentation results are needed, the SA …

Finite Element Analysis (Fea) Of The Taper-Trunnion Interface In A Metal On Metal Hip Implant, Kyle M. Bradley, Timothy L. Norman, Thomas K. Fehring

The Research and Scholarship Symposium (2013-2019)

Metal on metal total hip replacements are a common procedure in which the hip joint is replaced with a metal stem, a metal femoral head and a metal socket, usually made of titanium or cobalt chromium. The stem has a tapered region (trunnion) where the femoral head is impacted onto. This creates what is known as the taper-trunnion interface within a hip implant. However, these hip implants seem to be very susceptible to fretting corrosion, where the corrosive fluid environment of the body accelerates the process of wear between two contact surfaces. Previous research has suggested that the design parameters …

Cilia Have A Significant Role In Regulating Cell Size In Response To Fluid Flow Induced Shear Stress In A Flow Chamber, Ryan M. Hecklinger, Schuyler E. Price, Matthew B. Welkie Jr., Timothy L. Norman, Elisha R. Injeti

The Research and Scholarship Symposium (2013-2019)

Cilia are hair-like protrusions on the apical surface of cells. Their function is to relay mechanical signals like shear stress from extracellular into intracellular environment and thereby maintain cellular homeostasis. Ciliary dysfunctions include polycystic kidney disease and new therapeutic interventions based on ciliary function are under investigation. The current study evaluates the use of a custom designed fluid flow chamber’s ability to study the role of cilia in regulating cell size in response to shear stress.

A fluid flow chamber that continually maintains laminar flow at different flow rates and temperature was designed. Endothelial wild type cells (ETWT) that have …

2015 Symposium Overview, Cedarville University

The Research and Scholarship Symposium (2013-2019)

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