Medicine and Health Sciences Commons^™

The Case For Shifting Clinical Dentistry Toward Regenerative Biological Treatment Using Stem Cells: A Life-Changing Impact On The Profession’S Future, Merna Gress

International Programs

The conventional current procedures targeting the periodontal treatment for the diseased teeth and gums are based on arresting the destruction of these supporting structures and limiting the number of bacteria present. However, an ideal treatment would be regenerative in nature and should be accompanied with the reconstruction of these periodontal tissues back to normal. The application of Regenerative Dentistry is achieved through using the concept of cell and molecular biology to empower dental treatments that target a repair process for oral tissues instead of utilizing synthetic materials. One of the main applications of this concept is adult tissue-derived Mesenchymal Stem …

Clinical, Radiographic, And Histomorphometric Outcomes Following Ridge Preservation Using Leukocyte- And Platelet-Rich Fibrin (L-Prf) And Freeze-Dried Bone Allograft (Fdba) Layered Technique: A Prospective, Randomized Clinical Trial, Geisy Galviz

All ETDs from UAB

Objective: The present randomized controlled clinical trial aims to evaluate clinically, radiographic, and histologically the efficacy of L-PRF in combination with FDBA either in a homogeneous mixture or using a layered technique in improving quantity and quality of new vital bone formation and alveolar ridge dimensional stability in comparison to LPRF alone for ridge preservation after tooth extraction. Materials and Methods: Twentythree patients successfully completed the study. They were randomized to receive either L-PRF/FDBA layered technique (LAY), L-PRF/FDBA homogeneous mixture (MIX), or L-PRF alone. After minimally traumatic tooth extraction, direct clinical assessment and a Cone-Beam Computed Tomography (CBCT) scan were …

Biomaterials In Valvular Heart Diseases, Bita Taghizadeh, Laleh Ghavami, Hossein Derakhshankhah, Ehsan Zangene, Mahdieh Razmi, Mehdi Jaymand, Payam Zarrintaj, Nosratollah Zarghami, Mahmoud Reza Jaafari, Matin Moallem Shahri, Adrineh Moghaddasian, Lobat Tayebi, Zhila Izadi

School of Dentistry Faculty Research and Publications

Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient's quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach …

Efficacy Of The Biomaterials 3 Wt%-Nanostrontium-Hydroxyapatite-Enhanced Calcium Phosphate Cement (Nanosr-Cpc) And Nanosr-Cpc-Incorporated Simvastatin-Loaded Poly(Lactic-Co-Glycolic-Acid) Microspheres In Osteogenesis Improvement, Reza Masaeli, Tahereh S. Jafarzadeh Kashi, Rassoul Dinarvand, Vahid Rakhshan, Hossein Shahoon, Behzad Hooshmand, Fatemeh Mashhadi Abbas, Majid Raz, Alireza Rajabnejad, Hossein Eslami, Kimia Khoshroo, Mohammadreza Tahriri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Aims

The purpose of this multi-phase explorative in vivo animal/surgical and in vitro multi-test experimental study was to (1) create a 3 wt%-nanostrontium hydroxyapatite-enhanced calcium phosphate cement (Sr-HA/CPC) for increasing bone formation and (2) creating a simvastatin-loaded poly(lactic-co-glycolic acid) (SIM-loaded PLGA) microspheres plus CPC composite (SIM-loaded PLGA + nanostrontium-CPC). The third goal was the extensive assessment of multiple in vitro and in vivo characteristics of the above experimental explorative products in vitro and in vivo (animal and surgical studies).

Methods and results pertaining to Sr-HA/CPC

Physical and chemical properties of the prepared Sr-HA/CPC were evaluated. MTT assay and …

Three-Dimensional Bioprinting Materials With Potential Application In Preprosthetic Surgery, Mina D. Fahmy, Hossein E. Jazayeri, Mehdi Razavi, Radi Masri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon’s skills and the inherent potential in the patients’ bodies for regenerating lost tissues. Employing custom-designed 3D printed scaffolds that securely and effectively reconstruct the defects by using tissue engineering and regenerative medicine techniques can revolutionize preprosthetic surgeries. Various polymers, ceramics, natural and synthetic bioplastics, proteins, biomolecules, living cells, and growth factors as well as their hybrid structures can be used in 3D printing of scaffolds, which are still under development by scientists. These scaffolds not only are beneficial due to their patient-specific design, but …

Retention Of Cad/Cam Crowns Luted With A Novel Biomimetic Cement, Nan Xiang

All ETDs from UAB

Objectives: To measure the tensile strength of e.max copings cemented with resin, calcium silicate and calcium phosphate cements following thermocycling. Methods: 40 extracted non-carious mandibular premolar teeth were examined and selected using Keyence microscope for no carious cracks etc.were mounted in acrylic. The teeth were placed in a lathe and prepared to uniform dimensions (22° total taper) using a flat-end tapered diamond bur (846.11.025HP, Brasseler) and a 3mm preparation height. The surface area of the prepared surface was calculated with digital microscopy. The teeth were scanned with a Cerec 3 (Sirona) digital scanner. E.max crowns were milled using Cerec 3 …

Transdermal Delivery Of Functional Collagen Via Polyvinylpyrrolidone Microneedles, Wenchao Sun, Mohammed Inayathullah, Martin A. C. Manoukian, Andrey V. Malkovskiy, Sathish Manickam, M. Peter Marinkovich, Alfred T. Lane, Lobat Tayebi, Alexander M. Seifalian, Jayakumar Rajadas

School of Dentistry Faculty Research and Publications

Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities. This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system. The microneedle patches were made with concentrations of 1, 2, 4, and 8% type I collagen (w/w). Microneedle structures and the distribution of collagen were characterized using scanning electron microscopy and confocal microscopy. Patches were then applied on the porcine and human skin, and their effectiveness was examined using fluorescence …

Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague

Masters Theses

Photo-crosslinkable polymeric biomaterials have emerged in the field of biomedical research to promote tissue regeneration. For example, scaffolds that can be crosslinked and hardened in situ have been known to make suitable implant alternatives. Since injectable and photo-crosslinkable biomaterials offer the advantage of being minimally invasive, they have emerged to compete with autografts, a current highly invasive method to repair diseased tissue. A series of novel photo-crosslinkable, injectable, and biodegradable nano-hybrid polymers consisting of poly(ε-caprolactone fumarate) (PCLF) and polyhedral oligomeric silsesquioxane (POSS) has been synthesized in our laboratory via polycondensation. To engineer the material properties of the nano-hybrid networks, varied …

Influence Of Fluoride And Stress On The Mechanical Properties Of Nickel-Titanium Coils, Jennifer Ann Fehrman Roloff

Master's Theses (2009 -)

Objective: The objective of this study was to determine the influence of fluoride and stress on the mechanical properties of nickel-titanium open coil springs. Materials and Methods: Sentalloy nickel-titanium open coil springs (15 mm length) were divided into five groups. A control group was tested mechanically in as-received condition. The other four experimental groups were exposed to artificial saliva (Fusayama-Meyer solution) at 37oC for 12 weeks in a 2x2 factorial design with fluoride exposure and stress (compression) as the two factors. Those springs which were under compression were held at 5 mm in length for the entirety of the testing …

Influence Of Fluoride And Stress On The Electrochemical Properties Of Nickel-Titanium Coils, Ashley Barnes

Master's Theses (2009 -)

The aim of this study was to examine the effects of fluoride and stress on the electrochemical properties of nickel-titanium coils. Forty Dentsply GAC NiTi coils were divided into four groups of ten and individually tested. Twenty coils were placed in a solution of artificial saliva, where ten of the twenty were compressed and the other ten were not stressed. The other twenty coils were placed in a 1500 ppm NaF solution, where ten were compressed and ten were not. The coils were connected to a computer driven potentiostat and three tests were conducted: open circuit potential monitoring for 2 …

Histological And Immunohistochemical Evaluation Of Biphasic Calcium Phosphate And A Mineral Trioxide Aggregate For Bone Healing In Rat Calvaria, Luis Gustavo Régio De Carvalho Silva, Sung Hyun Kim, Sônia Mara Luczyszyn, Allan Giovanini, Luis Eduardo Almeida, Vinícius Augusto Tramontina

School of Dentistry Faculty Research and Publications

This work focused on the process of bone repair of defects in standardized calvaria of Wistar rats treated with biphasic calcium phosphate (BCP), mineral trioxide aggregate (MTA), or a combination of the two. Eighty Wistar rats were divided into four treatment groups and were examined at 2 and 8 weeks. A surgical defect was created in the calvaria using a 6-mm diameter trephine drill. The cavity was treated with BCP, MTA, or BCP + MTA; untreated rats with clot formation served as controls. Samples were evaluated histologically and by immunohistochemical staining for areas of new osteoid tissue and new bone …

Surface Modification Of Biodegradable Porous Mg Bone Scaffold Using Polycaprolactone/Bioactive Glass Composite, Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dip-coating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable …

Retention Of Cad/Cam Crowns Luted With Resin Cements And Rmgi, Shruti Sushilkumar Sonavane

All ETDs from UAB

Objectives: To measure retention of lithium disilicate (IPS e.max CAD, Ivoclar Viva-dent) and zirconia reinforced lithium disilicate (CELTRATM DUO, Dentsply) copings luted using resin cements and resin-modified glass ionomer cement. Methods: 110 Extracted human, non-carious mandibular 2nd premolars (n=10) were embedded in PVC cylinders with acrylic resin and placed into a lathe to produce a uni-form crown preparation (22°-convergence & 3mm-height). Following the orientation groove placement (69L bur), preparations were scanned and milled using a CEREC 3D/Sirona machine to produce e.max and CELTRATM DUO crowns. Preparations were imaged with a digital microscope (Keyence/VHX-600-20X) and the surface area of each crown …

Microstructure And Mechanical Properties Of Nickel-Free And Nickel-Containing Stainless Steel Orthodontic Wires, Amanda Olejniczak

Master's Theses (2009 -)

Introduction: In orthodontics, contact dermatitis caused by nickel allergy should be of concern with the number of nickel-containing appliances and wires used. Stainless steel archwires are commonly used throughout orthodontic treatment. With the release of nickel from these wires, some manufacturers have turned to nickel-free stainless steel alternatives. The goal of this research was to compare nickel-free stainless steel with traditional stainless steel archwires with regard to mechanical properties and microstructure. Materials and Methods: Nickel-free stainless steel and regular stainless steel archwires from four companies were included. Five random samples of each wire, vertically mounted in fast-set acrylic, were indented …

Alumina Ceramic For Dental Applications: A Review Article., Ahmed A. Madfa

Ahmed A. Madfa

Alumina has received considerable attention and has been historically wellaccepted as biomaterials for dental and medical applications. This article reviews the applications of this material in dentistry. It presents a brief history, dental applications and methods for improving the mechanical properties of aluminabased materials. It also offers perspectives on recent research aimed at the further development of alumina for clinical uses, at their evaluation and selection, and very importantly, their clinical performance. This article also stated about the Functionally Graded Materials (FGMs) which has been conceived as a new material design approach to improve performance compared to traditional homogeneous and …

Management Of Crown-Related Fractures In Children: An Update Review, H. Cem Güngör

School of Dentistry Faculty Research and Publications

Traumatic dental injuries (TDIs) are a serious public health problem. Epidemiology of dental trauma indicates that these injuries are more prevalent in child population of the world. Children are the sufferers in two-thirds of all TDIs observed. Although being a major fraction, crown-related fractures are a less severe form of TDIs with respect to their complications and sequelae. However, as with other types of traumatic injuries, the delay in seeking for immediate care following a traumatic injury and the lack of appropriate treatment may compromise long-term outcomes. This article reviews the occurrence, management, and prognosis of crown-related fractures in primary …

Application Of Calcium Phosphate Materials In Dentistry, Ahmed A. Madfa

Ahmed A. Madfa

Calcium phosphate materials are similar to bone in composition and in having bioactive and osteoconductive properties. Calcium phosphate materials in different forms, as cements, composites, and coatings, are used in many medical and dental applications. This paper reviews the applications of these materials in dentistry. It presents a brief history, dental applications, and methods for improving their mechanical properties. Notable research is highlighted regarding (1) application of calcium phosphate into various fields in dentistry; (2) improving mechanical properties of calcium phosphate; (3) biomimetic process and functionally graded materials. This paper deals with most common types of the calcium phosphate materials …

A New Multilayer Composite With Functionally Graded Design For Endodontic Application., Ahmed A. Madfa

Ahmed A. Madfa

Multilayer composite with FG structure were fabricated using zirconia (ZrO), alumina (AI2O3), Hydroxyapatite (HA) and titanium (Ti) micropowders. Powder selection and their combination in each layer were according to the results of finite element analysis.

Microstructural Characteristics Of Functionally Graded Materials Designed As Dental Post, Ahmed A. Madfa

Ahmed A. Madfa

To study the interfaces and microstructure of multilayered materials fabricated based on functionally graded concept for use as dental posts.

New Generation Of The Dental Posts For Endodontic Application., Ahmed A. Madfa

Ahmed A. Madfa

Fabricated multilayer dental post with the functionally graded design is a novel product that exhibits graded properties varied from coronal to apical parts of the tooth. The new dental post definitely performs better than posts available in the market and improves the quality of human life