Open Access. Powered by Scholars. Published by Universities.®
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Diabetes -- Prevention | Blood sugar monitoring | Blood sugar -- Metabolism -- Regulations
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Evaluation Of The Role Of Fructosamine As An Indicator Of Diabetic Control, Katherine Hooley
Evaluation Of The Role Of Fructosamine As An Indicator Of Diabetic Control, Katherine Hooley
Theses
Diabetes mellitus, a common metabolic disease, is characterised by excess circulating glucose concentrations. Such a hyperglycaemic status provides the stimulus for irreversible glycation (non-enzymatically post-translational) of structural and functional proteins. Protein glycation, although a cause of complication (neuropathy, micro/macrovascular disease), provides a time-averaged index of diabetes status and control. In particular, glycated plasma proteins analysis, i.e., the fructosamine assay, has received favourable response due to its speed, simplicity, low cost, and ease of automation. However, lack of standardisation and a universally-accepted calibrant has limited technical and subsequent clinical confidence in fructosamine analysis. In response, a comprehensive technical evaluation (including novel …