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Articles 1 - 10 of 10
Full-Text Articles in Animal Experimentation and Research
Arkansas Animal Science Department Report 2000, Zelpha B. Johnson, D. Wayne Kellogg
Arkansas Animal Science Department Report 2000, Zelpha B. Johnson, D. Wayne Kellogg
Arkansas Agricultural Experiment Station Research Series
Animal Science is very much devoted to youth education and development. During the past year, over 20,000 youth were involved in 4-H livestock projects. Two very successful activities that took place last year were the Mid-American Grassland Evaluation Contest and Livestock Judging Camps. The Grassland Contest is designed to teach students about grassland resource management for livestock and wildlife uses. The contest was held in Cape Girardeau, Missouri. Firstplace honors in the 4-H division went to White County, and second place honors went to Van Buren County. Two Livestock Judging Camps (Fayetteville and Hope) were conducted this past year. A …
Chronic Hypoxia, Exercise Training, And Skeletal Muscle Capillarity: Angiogenic Regulation And Morphological Consequences, Ivan Mark Olfert
Chronic Hypoxia, Exercise Training, And Skeletal Muscle Capillarity: Angiogenic Regulation And Morphological Consequences, Ivan Mark Olfert
Loma Linda University Electronic Theses, Dissertations & Projects
Angiogenesis is important in health and disease. In particular, exercise training is known to increase skeletal muscle capillarity, providing there is sufficient training intensity. The stimulus for this may be intracellular hypoxia activating angiogenic growth factor gene expression. Acute hypoxia alone has been shown to increase the gene expression of several key angiogenic regulators, e.g. vascular endothelial growth factor (VEGF) and to a lesser degree transforming growth factor-β1 (TGF-β1), basic fibroblast growth factor (bFGF), and thrombospondin-1 (TSP-1), an endogenous negative angiogenic regulator. Paradoxically, however, chronic hypoxia is generally not found to increase mammalian skeletal muscle capillarity. Accordingly, we hypothesized that …
Primate Numerical Competence: Contributions Toward Understanding Nonhuman Cognition, Sarah T. Boysen, Karen I. Hallberg
Primate Numerical Competence: Contributions Toward Understanding Nonhuman Cognition, Sarah T. Boysen, Karen I. Hallberg
Sentience Collection
Nonhuman primates represent the most significant extant species for comparative studies of cognition, including such complex phenomena as numerical competence, among others. Studies of numerical skills in monkeys and apes have a long, though somewhat sparse history, although questions for current empirical studies remain of great interest to several fields, including comparative, developmental, and cognitive psychology; anthropology; ethology; and philosophy, to name a few. In addition to demonstrated similarities in complex information processing, empirical studies of a variety of potential cognitive limitations or constraints have provided insights into similarities and differences across the primate order, and continue to offer theoretical …
Taking Animal Welfare Seriously: Minimizing Pain And Distress In Research Animals, The Humane Society Of The United States
Taking Animal Welfare Seriously: Minimizing Pain And Distress In Research Animals, The Humane Society Of The United States
ANIMAL RESEARCH
Pain and distress caused by specific research models and techniques raise serious concerns for those in the animal welfare community as well as in the scientific community. Yet good estimates of how much animal pain and/or animal distress is caused by particular techniques or methods are not yet available. The HSUS has compiled a preliminary list of research models and techniques that cause pain and distress. Analyses by the USDA and HSUS indicate that the majority of the animals reported in Column E are used in various testing procedures, with vaccine testing prominent among them. More data are needed to …
Periradicular Response Of Immunodeficient Rats To Mechanical Pulpal Exposure, James E. Stich
Periradicular Response Of Immunodeficient Rats To Mechanical Pulpal Exposure, James E. Stich
Loma Linda University Electronic Theses, Dissertations & Projects
Periradicular lesions develop as a result of the interaction between root canal irritants and the immune system. The purpose of this study was to investigate the periradicular response of immunodeficient rats to their oral flora. Twenty Sprague-Dawley rats received a total body irradiation dose of 750 cGy one week prior to the investigation. The pulps of the mandibular first molars of these animals and six nonirradiated rats were exposed mechanically with a ½ round bur and left open to the oral cavity. Additional irradiation (350 cGy) was administered bi-weekly to maintain immunosuppression. Periradicular specimens were obtained after two and four …
The Use Of Animals In Higher Education: Problems, Alternatives, & Recommendations, Jonathan Balcombe
The Use Of Animals In Higher Education: Problems, Alternatives, & Recommendations, Jonathan Balcombe
eBooks
Despite recent advances in technology and increasing societal concern for animals, animals continue to be exploited and killed in large numbers so that students can learn about their structure and function. Dissection may not be without its merits from an educational standpoint, if well implemented, but it appears from student surveys that it usually is not. When one considers the associated costs—animal suffering and death in the supply trade, disruption of wild animal populations, messages that tend to undermine rather than reinforce respect for life and concern for others, rising costs of animal carcasses (as compared with alternatives with longer …
Arkansas Animal Science Department Report 1999, Zelpha B. Johnson, D. Wayne Kellogg
Arkansas Animal Science Department Report 1999, Zelpha B. Johnson, D. Wayne Kellogg
Arkansas Agricultural Experiment Station Research Series
No abstract provided.
Role Of KAtp Channels In Reduced Antinociceptive Effect Of Morphine In Streptozotocin-Induced Diabetic Mice, Vivek Sood, Ajay Sharma, Manjeet Singh
Role Of KAtp Channels In Reduced Antinociceptive Effect Of Morphine In Streptozotocin-Induced Diabetic Mice, Vivek Sood, Ajay Sharma, Manjeet Singh
Pharmacy Faculty Articles and Research
The nociceptive effect was measured using withdrawal latency in tail flick test in mice rendered diabetic by administering streptozotocin (200 mg/kg, i.p.). The antinociceptive effect of morphine (4 and 8 mg/kg, s.c.) and cromakalim, a KATP channel opener, (0.3, 1 and 2 micrograms, i.c.v.) was significantly reduced in diabetic mice. Moreover, co-administration of cromakalim(0.3 microgram) did not alter the reduced antinociceptive effect of morphine(4 mg/kg) in diabetic mice. Spleenectomy in diabetic mice restored the decrease in antinociceptive effect of morphine and cromakalim. Multiple dose treatment with insulin to maintain euglycaemia for 3 days in diabetic mice prevented the decrease in …
Effect Of Actinomycin D And Cycloheximide On Ischemic Preconditioning-Induced Delayed Cardioprotective Effect In Rats, Devinder Singh, Ajay Sharma, Manjeet Singh
Effect Of Actinomycin D And Cycloheximide On Ischemic Preconditioning-Induced Delayed Cardioprotective Effect In Rats, Devinder Singh, Ajay Sharma, Manjeet Singh
Pharmacy Faculty Articles and Research
The present study was designed to investigate the effect of actinomycin D, a transcription inhibitor, and cycloheximide, a translation inhibitor, on the delayed cardioprotective effect of ischemic preconditioning. Left thoracotomy was performed in anaesthetized rats at 4th/5th intercostal space and polypropylene suture (5-0) was employed to occlude left common coronary artery. Ischemic preconditioning was produced by four episodes of 5 min of coronary artery occlusion followed by 5 min of reperfusion and thoracic cavity was sutured. Left thoracotomy was performed again after 24 hr of ischemic preconditioning and left coronary artery was occluded for 30 min followed by reperfusion for …
Evaluation Of Animal Model Research, Kenneth J. Shapiro
Evaluation Of Animal Model Research, Kenneth J. Shapiro
Experimentation Collection
It is argued that a concept of evaluation of animal models that is broader and more useful than validation is available. Productive generativity refers to the degree to which a model furthers understanding and leads to more-effective treatment interventions. Results of the application of this novel evaluative frame to several animal models of eating disorders show that this animal-based research has not been productive. The question of the relation between clinic and animal laboratory is discussed.