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Articles 1 - 9 of 9
Full-Text Articles in Toxicology
Immunomodulatory Effects Of Diesel Exhaust Particles, Ashley Kay Masterson
Immunomodulatory Effects Of Diesel Exhaust Particles, Ashley Kay Masterson
Boise State University Theses and Dissertations
Diesel exhaust particles (DEP) represent a key component of particulate matter pollution and a serious cardiopulmonary health risk, as these particles have been associated with increased morbidity and mortality following exposure. In this study, we investigated the immunomodulatory properties of DEP on helper T cells by measuring changes in activation, cytokine production, and viability. The expression of CD40L, a key regulatory protein, was increased by DEP in the absence of physiologic stimuli without parallel increases in the expression of CD25 and CD69 activation markers. Additional studies utilizing a variety of T cell stimuli, including T cell receptor signaling and CD28 …
Interaction Of Fish Aryl Hydrocarbon Receptor Paralogs (Ahr1 And Ahr2) With The Retinoblastoma Protein, Rebeka R. Merson, Sibel I. Karchner, Mark E. Hahn
Interaction Of Fish Aryl Hydrocarbon Receptor Paralogs (Ahr1 And Ahr2) With The Retinoblastoma Protein, Rebeka R. Merson, Sibel I. Karchner, Mark E. Hahn
Faculty Publications
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) and related compounds. In some mammalian cell lines, TCDD induces G1 cell cycle arrest, which depends on an interaction between the AHR and the retinoblastoma tumor suppressor (RB). Mammals possess one AHR, whereas fishes possess two or more AHR paralogs that differ in the domains important for AHR-RB interactions in mammals. To test the hypothesis that fish AHR paralogs differ in their ability to interact with RB, we cloned RB cDNA from Atlantic killifish, Fundulus heteroclitus, and studied the interactions of killifish RB protein with killifish AHR1 and …
Effects Of The Polycyclic Musk Hhcb On Individual- And Population-Level Endpoints In Potamopyrgus Antipodarum, Signe Pedersen, Henriette Selck, Daniel Salvito, Valery E. Forbes
Effects Of The Polycyclic Musk Hhcb On Individual- And Population-Level Endpoints In Potamopyrgus Antipodarum, Signe Pedersen, Henriette Selck, Daniel Salvito, Valery E. Forbes
Valery Forbes Publications
Although the polycyclic musk 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran (HHCB) is frequently detected in aquatic sediments, very little is known about its effects on sediment-feeding organisms. Effects of sediment-associated HHCB on growth, feeding rate, survival and reproduction in the gastropod Potamopyrgus antipodarum were measured in the laboratory. Snails were exposed to six nominal HHCB concentrations: 0, 0.1, 1, 10, 30 and 100 μg g−1 dry weight (dw) sediment. Adult survival and growth were not affected by HHCB. However, juvenile growth and survival, reproduction, time to first reproduction and adult feeding rate were more sensitive endpoints and declined with increasing HHCB concentration. Individual-level endpoints for …
In Vitro Toxicity Of Silver Nanoparticles In Human Lung Epithelial Cells, Christina R. Kearns
In Vitro Toxicity Of Silver Nanoparticles In Human Lung Epithelial Cells, Christina R. Kearns
Theses and Dissertations
Nanotechnology is quickly becoming incorporated into everyday products and uses. Silver nanoparticles, specifically, are being used in commercial products, to include aerosols. The purpose of this research was to determine whether silver nanoparticles are toxic to human lung epithelial cells. Different types (coated vs. uncoated), concentrations (10, 50, 100, and 200 µg/mL) and sizes (coated 5 and 80nm, uncoated 10 and 80nm) of silver nanoparticles were used during this study. Toxicity measurements were completed through in vitro techniques. Another study was also completed on toxicity mechanisms by measuring the reactive oxygen species (ROS) generated. Results showed that silver nanoparticles induce …
The Amphipod Orchomenella Pinguis — A Potential Bioindicator For Contamination In The Arctic, Lis Bach, Valery E. Forbes, Ingela Dahllöf
The Amphipod Orchomenella Pinguis — A Potential Bioindicator For Contamination In The Arctic, Lis Bach, Valery E. Forbes, Ingela Dahllöf
Valery Forbes Publications
Indigenous organisms can be used as bioindicators for effects of contaminants, but no such bioindicator has been established for Arctic areas. Orchomenella pinguis is a benthic amphipod, ubiquitous in the Arctic and can be found in high numbers. We collected O. pinguis at sites with different contamination levels. Population characteristics (body length distribution, average dry weight and amphipod organic content) were related to sediment contaminant concentrations, in order to identify suitable endpoints for using this species as a bioindicator. We show that O. pinguis was prevalent in both clean and contaminated areas, easy to sample and that its population characteristics …
Application Of Multiple Mass Spectrometric Techniques In The Isolation, Determination And Characterisation Of The Marine Toxins; Azaspiracid, Keith O'Callaghan
Application Of Multiple Mass Spectrometric Techniques In The Isolation, Determination And Characterisation Of The Marine Toxins; Azaspiracid, Keith O'Callaghan
Theses
The Azaspiracids are a class of polyether marine biotoxins that present a significant health risk to consumers of shellfish. Since their discovery in the late 1990s several human intoxications have been reported, and traced to Irish shellfish farms resulting in closures or harvest rejections. As such incidents involving azaspiracid shellfish poisoning have a major socio-economic impact on communities that rely on shellfish farming revenues.
Recent evidence suggests that azaspiracid poisoning events may become more commonplace. With this increased risk the understanding of azaspiracids mode of action and biological targets becomes crucial. To support these endeavours effective analytical methods need to …
Evaluating Acute Toxicity Of Cadmium To Chironomid Using Hemoglobin As A Molecular Biomarker, Jun Taek Oh
Evaluating Acute Toxicity Of Cadmium To Chironomid Using Hemoglobin As A Molecular Biomarker, Jun Taek Oh
Seton Hall University Dissertations and Theses (ETDs)
Effects of cadmium (Cd), a heavy metal contaminant, on hemoglobin were investigated in aquatic midge fly larvae of the Family, Chironomidae. In this study, chironomid populations from one polluted site, Kearny Marsh, New Jersey, two reference sites, North East Creek, and Bass Harbor, ME, and a laboratory population were taxonomically identified and tested for their sensitivity to Cd. Heavy metals in tissue, water and sediment were analyzed using Atomic Absorption Spectroscopy. Water quality at each site was assessed by measuring pH, dissolved oxygen (DO), oxidation-reduction potential ( eH), salinity and temperature. Hemoglobin proteins in individual larvae were easily detected using …
The Effects Of Adolescent Nicotine Exposure On Adult Learning, Andrea Marie Spaeth
The Effects Of Adolescent Nicotine Exposure On Adult Learning, Andrea Marie Spaeth
Dissertations, Theses, and Masters Projects
No abstract provided.
Toxicology Of Decabromodiphenyl Ether In Avian Embryos: Disposition Of The Flame Retardant Bde-209 In Yolk-Injected Chicken Embryos (Gallus Gallus), Samantha D. Sifleet
Toxicology Of Decabromodiphenyl Ether In Avian Embryos: Disposition Of The Flame Retardant Bde-209 In Yolk-Injected Chicken Embryos (Gallus Gallus), Samantha D. Sifleet
Dissertations, Theses, and Masters Projects
Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals of toxicological concern present in humans, wildlife, and the environment. Deca-BDE is the highest production product due to historical use patterns and recent regulatory limitations on the other two commercial formulations (Penta-BDE and Octa-BDE) in the U.S and Europe. The EU banned Deca-BDE starting July 1, 2008. However, it remains in usage in North America and elsewhere in the world. BDE-209 is the dominant congener in all Deca- BDE commercial products. BDE-209 has been reported to under go metabolic debromination to lesser brominated and more toxic and bioaccumulative congeners. However, insufficient data …