Open Access. Powered by Scholars. Published by Universities.®
Pharmacology, Toxicology and Environmental Health Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Toxicology (511)
- Pharmacology (490)
- Medicine and Health Sciences (445)
- Environmental Health (363)
- Physical Sciences and Mathematics (261)
-
- Medicinal Chemistry and Pharmaceutics (216)
- Biochemistry, Biophysics, and Structural Biology (157)
- Environmental Sciences (154)
- Biology (136)
- Social and Behavioral Sciences (116)
- Public Health (109)
- Cell and Developmental Biology (106)
- Engineering (93)
- Biochemistry (89)
- Chemistry (87)
- Chemicals and Drugs (85)
- Neuroscience and Neurobiology (84)
- Physiology (82)
- Diseases (75)
- Medical Sciences (75)
- Molecular Biology (73)
- Pharmacy and Pharmaceutical Sciences (72)
- Medical Specialties (70)
- Other Pharmacology, Toxicology and Environmental Health (69)
- Animal Sciences (67)
- Microbiology (66)
- Ecology and Evolutionary Biology (64)
- Cell Biology (55)
- Institution
-
- Wright State University (97)
- Wayne State University (94)
- University of South Florida (74)
- University of Kentucky (66)
- Virginia Commonwealth University (65)
-
- Loyola University Chicago (59)
- Western University (56)
- University of Louisville (54)
- Utah State University (51)
- University of South Carolina (50)
- City University of New York (CUNY) (43)
- East Tennessee State University (43)
- University of Massachusetts Amherst (37)
- William & Mary (32)
- Air Force Institute of Technology (31)
- New Jersey Institute of Technology (31)
- University of Mississippi (31)
- Eastern Illinois University (28)
- University of Vermont (28)
- Loma Linda University (27)
- Old Dominion University (27)
- University of Nebraska Medical Center (27)
- University of Wisconsin Milwaukee (25)
- West Virginia University (25)
- Wilfrid Laurier University (23)
- The Texas Medical Center Library (21)
- University of Nevada, Las Vegas (20)
- Western Michigan University (20)
- Claremont Colleges (17)
- Marshall University (17)
- Keyword
-
- Department of Pharmacology and Toxicology (97)
- Pharmacology (66)
- Toxicology (49)
- Toxicity (31)
- Cancer (29)
-
- Health and environmental sciences (29)
- Oxidative stress (20)
- Zebrafish (20)
- Nanoparticles (19)
- Diabetes (17)
- Biological sciences (16)
- Arsenic (14)
- Dopamine (13)
- Pharmacokinetics (13)
- Pharmaceuticals (12)
- Cadmium (11)
- Nanomedicine (11)
- Nanotechnology (11)
- Obesity (11)
- Behavior (10)
- Cytotoxicity (10)
- Daphnia (10)
- Fish (10)
- Rat (10)
- Aging (9)
- Ecotoxicology (9)
- HIV (9)
- Inflammation (9)
- Macrophages (9)
- Mercury (9)
- Publication Year
- Publication
-
- Theses and Dissertations (189)
- Electronic Theses and Dissertations (131)
- Browse all Theses and Dissertations (97)
- USF Tampa Graduate Theses and Dissertations (74)
- Masters Theses (66)
-
- Wayne State University Dissertations (63)
- Electronic Thesis and Dissertation Repository (56)
- Dissertations (55)
- Honors Theses (55)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (48)
- Theses (44)
- Doctoral Dissertations (39)
- Dissertations, Theses, and Masters Projects (32)
- Wayne State University Theses (31)
- Graduate College Dissertations and Theses (28)
- Theses & Dissertations (28)
- Loma Linda University Electronic Theses, Dissertations & Projects (27)
- Master's Theses (27)
- Graduate Theses, Dissertations, and Problem Reports (25)
- Theses and Dissertations (Comprehensive) (23)
- Student Theses (22)
- Dissertations & Theses (Open Access) (21)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (20)
- Theses and Dissertations--Pharmacy (19)
- Dissertations and Theses (17)
- Theses, Dissertations and Capstones (17)
- Open Access Theses & Dissertations (16)
- Honors College Theses (13)
- Theses and Dissertations--Toxicology and Cancer Biology (12)
- Dissertations, Theses, and Capstone Projects (11)
- File Type
Articles 1 - 30 of 1689
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Analyzing Trends In Ground-Level Ozone, Keily Hart
Analyzing Trends In Ground-Level Ozone, Keily Hart
Honors Program Theses and Research Projects
In the last few decades, concerns regarding air pollution have led to many new laws and regulations being put into place to mitigate the e↵ects of pollution on the environment and humanity as a whole. This paper analyzes several decades’ worth of ground-level ozone readings in six of the largest metropolitan areas in Texas, using data from the United States Environmental Protection Agency (EPA). These regions include the Austin-Round Rock area, Corpus Christi, the Dallas-Fort Worth-Arlington area, El Paso, the Houston-The Woodlands-Sugar Land area, and the San Antonio-New Braunfels area. We identify trends in these readings using the Jonckheere-Terpstra test. …
Environmental Health Assessments For Foodborne Illness Outbreaks In The United States From 2017- 2019, Alyssa Shontel Woods
Environmental Health Assessments For Foodborne Illness Outbreaks In The United States From 2017- 2019, Alyssa Shontel Woods
Walden Dissertations and Doctoral Studies
Individual cases of foodborne illness can lead to outbreaks that result in severe morbidity and fatality. As the United States’ food scene continues to evolve and diversify, there is a need to consider cultural variations and how they may affect food safety practices. This quantitative study, based on the National Environmental Assessment Reporting System (NEARS) data, grounded in the socio-ecological model, examined the prevalence and factors associated with salmonella outbreaks in ethnic versus non-ethnic food service establishments (FSEs) in the U.S. from 2017 to 2019. The research questions involved understanding the relationship between the primary language spoken, food safety training, …
A Conservation Model: Costa Rican Conservation Strategies Effectively Preserve Their Threatened Primates, Ryan Belmont
A Conservation Model: Costa Rican Conservation Strategies Effectively Preserve Their Threatened Primates, Ryan Belmont
Regis University Student Publications (comprehensive collection)
The wildlife of Costa Rica has experienced various anthropogenic threats over the last century including climate change and agricultural expansion. The mantled howler monkey (Alloutta palliata), Central American spider monkey (Ateles geoffroyi), white-faced capuchin (Cebus imitator), and the Central American squirrel monkey (Saimiri oerstedii) are Costa Rica’s native primates that face several anthropogenic threats such as deforestation for agriculture and climate change. In response to increased threats to its four native species of non-human primates, Costa Rica has implemented effective governmental conservation tactics such as the Payments for Environmental Services program, ecotourism …
Characterization Of A Pathological Tau Point Mutation, E342v, Implicated In Frontotemporal Dementia, Liam Clancy
Characterization Of A Pathological Tau Point Mutation, E342v, Implicated In Frontotemporal Dementia, Liam Clancy
Graduate College Dissertations and Theses
Frontotemporal Dementia (FTD) is classified as a Tauopathy, a group of heterogenous neurodegenerative disorders characterized by the abnormal functioning of a microtubule associated protein (MAP), Tau. Microtubules, an integral cytoskeletal component in neurons, are thought to be stabilized by Tau. In disease states such as FTD, a reduction in binding affinity of Tau for the microtubule is believed to lead to intraneural Tau deposition and aggregation, which subsequently causes microtubule instability. Consequently, neuronal health is compromised and an array of brain functions decline creating the symptomology seen in FTD. However, it is now known that Tau has a myriad of …
Assessing Medication Compliance And The Usage Of Complementary Therapies Effecting Hba1c Among Patients With Type 2 Diabetes Mellitus In A Tertiary Care Hospital In Karachi, Pakistan, Neelam Nasruddin
Theses & Dissertations
Background: Diabetes Mellitus is a chronic illness. It remains to be a major public health matter and a financial burden on the medical system worldwide. This condition can be managed and better treatment strategies and compliance can reduce the risk of complications. In 2022, there will be around 33,000,000 new cases of diabetes worldwide, with 26.7% of the adults in Pakistan being affected, predicts the (International Diabetes Federation, 2022). However, it is observed that most individuals turn to complementary and alternative methods (CAM)/Traditional medicine because of the rising cost of therapy, adverse effects of anti-diabetic medications, and accessibility concerns.
Purpose: …
Impact Of Cadmium Stress On Soil Virus Reproduction And The Persistence Of Viruses Under Abiotic Conditions, Zhibo Cheng
Impact Of Cadmium Stress On Soil Virus Reproduction And The Persistence Of Viruses Under Abiotic Conditions, Zhibo Cheng
Doctoral Dissertations
Soil viruses are ubiquitous and greatly impact the structure and function of soil microbial communities, with their effects modulated by various environmental factors. This study investigates the inactivation of naturally occurring soil viruses in sterilized soil, as well as the effects of cadmium (Cd) exposure and carbon (C) and nitrogen (N) nutrient availability on the population dynamics of virus-host communities in agricultural soil.
Lab-scale slurry and unsaturated experiments were performed to examine virus inactivation in the absence of host bacteria in sterilized soil. In slurry experiments, virus abundance declined by over 90% after 10 days of incubation. The addition of …
Effects Of Short-Term Pesticides Exposure On Swimming Behavior, Tissue Morphology, Oxidative-Nitrative Stress, Antioxidant Expression, And Cellular Apoptosis In Kidneys Of Goldfish, Esmirna Cantú
Theses and Dissertations
The prevalence of pesticides in the aquatic environment continues to increase due to anthropogenic activities and poses a threat to aquatic organisms. The aim of this study was to determine the short-term exposure (one-week) of pesticide mixtures (metolachlor, linuron, isoproturon, tebucanazole, alconifen, atrazine, pendimethalin; azinphos-methyl) on swimming behaviors, kidney morphology, and expression of nitrotyrosine protein (NTP), dinitrophenyl protein (DNP), superoxide dismutase (SOD), catalase (CAT), renin, and cellular apoptosis in goldfish (Carassius auratus). Results indicated that both low- and high-dose pesticide mixtures decreased the distance swimming behavior. Histological analysis showed pesticide exposure alters kidney morphology. DNP, NTP, and renin expressions, and …
Study Of The Effects Of Chronic Cadmium Exposure On The Pathogenesis Of Pulmonary Arterial Hypertension., Dakotah Dominique Cathey
Study Of The Effects Of Chronic Cadmium Exposure On The Pathogenesis Of Pulmonary Arterial Hypertension., Dakotah Dominique Cathey
Electronic Theses and Dissertations
We reported pulmonary artery hypertension (PAH) patients had elevated levels of Cd in both blood and urine, therefore, this study tested whether Cd directly induces PAH or facilitates PAH pathogenesis in mouse models. C57/6J mice were initially exposed to drinking water with or without 5ppm Cd for 8 weeks. Then, half the mice in both control and Cd groups were given SU5416 and hypoxia (SuHx) for 4 weeks to induce PAH, resulting in 4 subgroups: Control, Cd, PAH, and Cd+PAH. Diastolic and systolic functions of the left and right ventricles (LV, RV) were examined with echocardiography before and after PAH. …
Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee
Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee
Electronic Theses and Dissertations
We are facing an aging crisis, with 20% of the U.S. population projected to be geriatric (65+) by 2030 and live another 40+ years. Age-related diseases accompany a growing geriatric population, emphasizing the need to understand their etiology. Environmental pollutants compound this crisis by: 1) geriatrics are more susceptible, exacerbating age-related diseases and comorbidities, and 2) they accelerate biological aging, inducing age-related diseases at younger ages. We address this crisis using a ‘toxic aging coin’ approach; heads examines how age impacts toxicity, tails examines how chemicals accelerate aging. This thesis applies the heads side for Cr(VI)-induced neurotoxicity across ages. We …
The Impact Of Environmental Pollutants On Alcohol-Associated Liver Disease Pathogenesis., Tyler Charles Gripshover
The Impact Of Environmental Pollutants On Alcohol-Associated Liver Disease Pathogenesis., Tyler Charles Gripshover
Electronic Theses and Dissertations
Steatotic liver disease is brought upon by differing etiologies and its global prevalence is expected to keep increasing over the next several decades. Particularly, alcohol-associated liver disease (ALD) manifests from excessive alcohol consumption where the liver retains lipids and progresses with metabolic dysfunction. Previous studies have demonstrated that environmental pollutants, polychlorinated biphenyls (PCBs) promote metabolic dysfunction associated steatotic liver disease (MASLD), in diet-induced obesity models. However, it is unknown if environmental pollutants may also promote ALD pathogenesis. Thus, this dissertation focuses on characterizing the effects of PCB126 in a rodent ALD model followed by multiple ‘Omics approaches to identify mechanisms …
The Method Development And Validation Of Designer Benzodiazepines In Oral Fluid Using Solid Phase Extraction And Lc-Ms/Ms, Jenna L. Monsell
The Method Development And Validation Of Designer Benzodiazepines In Oral Fluid Using Solid Phase Extraction And Lc-Ms/Ms, Jenna L. Monsell
Student Theses
Oral fluid is a useful biological matrix. Collection is non-invasive, quick, observable, and its correlation between oral fluid and blood drug concentration make oral fluid an important matrix to use as a roadside test. Designer benzodiazepines have become increasingly popular over the years, adversely affecting motor skills and leading to driving under the influence. Many previous studies have focused on the method development and validation of designer benzodiazepines in blood and hair but fail to validate a method to detect designer benzodiazepines in oral fluid. This study focuses on the method validation of 13 designer benzodiazepines in oral fluid using …
Microplastics In Local Communities’ Tap Water, Zachary T. Rattell
Microplastics In Local Communities’ Tap Water, Zachary T. Rattell
Masters Theses
Microplastics are an emerging environmental contaminant. One of the ways microplastics can get into the environment is by the breakdown of larger plastics. These plastics can come from industrial practices, discarded fabrics, agriculture, and general plastic waste. As these plastics are broken down microplastics leach into the environment. The widespread use of plastics has resulted in the spread of microplastic contaminants all over the world. Microplastics have been reported to be in drinking water, so this paper is looking at the presence of microplastics in local communities of different demographics and socioeconomic statuses. In other studies of different drinking water …
Identification Of Early Diagnostic And Predictive Biomarkers Of Cisplatin-Induced Acute Kidney Injury Using Metabolomics, Yong Jin Lim
Identification Of Early Diagnostic And Predictive Biomarkers Of Cisplatin-Induced Acute Kidney Injury Using Metabolomics, Yong Jin Lim
Electronic Thesis and Dissertation Repository
Cisplatin is an effective chemotherapeutic agent used for the treatment of a wide variety of solid tumors and hematologic cancers. Despite its effectiveness, cisplatin is associated with several toxic effects to non-cancerous tissues. Nephrotoxicity is the main dose-limiting toxicity in cisplatin therapy, manifesting as acute kidney injury (AKI) in approximately one-third of patients receiving cisplatin. AKI is defined as an abrupt decline in kidney function and is associated with several short- and long-term adverse outcomes, including chronic kidney disease, cardiovascular disease, and mortality. AKI is currently diagnosed by increased serum creatinine (SCr) concentrations. However, SCr is a marker of functional …
Developing A Point-Of-Care Detection Kit For Parkinson’S Disease Using Gold Nanoparticle-Based Lateral Flow Assay, Ali Aljassabi
Developing A Point-Of-Care Detection Kit For Parkinson’S Disease Using Gold Nanoparticle-Based Lateral Flow Assay, Ali Aljassabi
USF Tampa Graduate Theses and Dissertations
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease and the fastest-growing neurodegenerative disorder in the world. The major issue with PD is that it takes several years of biological changes until the patient starts to experience physiological symptoms that could affect their daily lives. The major hallmark of PD is the appearance of Lewy body inclusions in the neuron’s cytoplasm, which is rich in a protein called α-Synuclein (α-Syn). Several studies have shown that the levels of α-Syn in blood increase because the excess α-Syn is released from neurons into the bloodstream through extracellular vesicles. …
Monitoring The Leaching Of Bisphenol-A From Feminine Hygiene Products Using Fluorescence Spectroscopy, Madison Easley
Monitoring The Leaching Of Bisphenol-A From Feminine Hygiene Products Using Fluorescence Spectroscopy, Madison Easley
Honors Theses
Bisphenol-A (BPA) is a compound commonly used as a stabilizer in plastic products, including food storage containers and thermal paper receipts. Because BPA can bind to and activate estrogen receptors, it is linked to reduced fertility, altered development, and hormone-related cancers. A recent study at NYU Medical School confirmed the presence of BPA in pantyliners, pads, tampons, feminine washes and deodorants. This is concerning due to the high absorption capacity of the vulvar skin.
For the research performed in our lab this summer, the goal was to determine if fluorescence spectrophotometry could be used to determine the presence of BPA …
Roles Of Soil Pores In Determining Water Retention And Microbial Dynamics, Huihui Sun
Roles Of Soil Pores In Determining Water Retention And Microbial Dynamics, Huihui Sun
Doctoral Dissertations
Soil pore provides an essential habitat for microbial communities to participate in various biogeochemical processes. The complex pore spaces, which are defined by the arrangement of particles of varying sizes, govern the distribution of water for microbial dispersal and movement and microbial interaction with one another, such as bacterial cell-to-cell and bacterium-virus interactions. This research focused on exploring how soil pores influence soil water retention and bacterial interactions and quantify the spatial distribution of bacteria and viruses in fine-scale of soil pores. Using a mathematical model, this study simulated a soil water retention curve based on the relationship between soil …
Hair And Drugs: The Impact Of Dry Shampoo And Gel On Cocaine-Contaminated Hair, Marialejandra Faure Betancourt
Hair And Drugs: The Impact Of Dry Shampoo And Gel On Cocaine-Contaminated Hair, Marialejandra Faure Betancourt
Student Theses
Hair is a biological sample used in forensic toxicology to identify and quantify drug exposure. However, when interpreting analytical results, hair can be challenging due to the presence of external contamination. Previous studies have shown that cosmetic treatments remove drugs within the hair shaft decreasing their concentration. Nevertheless, not enough information is available to explain this phenomenon. This study focused to determine whether cosmetic products such as dry shampoo and gel influence the concentration of externally deposited cocaine (COC) and benzoylecgonine (BE) in different hair types/colors. Hair samples from fifteen COC-free volunteers of various hair colors/types were collected and divided …
Epitranscriptomic Regulation In Breast Cancer And Pcb-Induced Liver Disease., Belinda Petri
Epitranscriptomic Regulation In Breast Cancer And Pcb-Induced Liver Disease., Belinda Petri
Electronic Theses and Dissertations
Post-transcriptional RNA modifications including N6-methyladenosine (m6A) regulate mRNA stability, splicing, and translation. My research examined m6A in two disease models: breast cancer (BCa) and non-alcoholic fatty liver disease (NAFLD). Acquired resistance to endocrine therapies (ET) develops in approximately 20% of BCa patients with estrogen receptor α positive (ER+) tumors following treatment. The mechanisms by which tumor cells evade ET are not completely understood. Using a cell line model, we investigated the role of an m6A reader protein, HNRNPA2B1 (A2B1) that is upregulated in ET-resistant ER+ BCa cells. Stable overexpression of A2B1 in ET-sensitive MCF-7 cells (MCF-7-A2B1), results in ET resistance, …
Effect Of Authentic Kefir And Nigella Sativa On Broilers Challenged By Coccidia And Clostridium Perfringens, Julian E. Nixon
Effect Of Authentic Kefir And Nigella Sativa On Broilers Challenged By Coccidia And Clostridium Perfringens, Julian E. Nixon
All Dissertations
Black seed oil concentrations of 0%, 0.1%, 1% and 5% were added to milk inoculated with kefir grains and incubated at 25°C for 22 h. The pH and microbial count indicated 1% black seed oil caused low inhibition (P > 0.05) of fermentation, but 5% black seed oil caused significant inhibition of the kefir microorganisms (P < 0.05).
Cobb 500 male chicks (n = 256) were distributed in a randomized block design and received one of four treatments: CTRL1 (Non-medicated, no kefir, no Clostridium perfringens), CTRL2 (Non-medicated, no kefir, C. perfringens inoculated), CTRL3 (BMD medicated, no kefir, C. perfringens inoculated), KTRT (Non-medicated, …
The Role Of E-Liquid Constituents In E-Cigarette-Induced Cardiac Arrhythmia And Autonomic Imbalance., Cory Kucera
The Role Of E-Liquid Constituents In E-Cigarette-Induced Cardiac Arrhythmia And Autonomic Imbalance., Cory Kucera
Electronic Theses and Dissertations
Introduction. Accumulating evidence indicates that exposure to electronic cigarettes (e-cigs) promotes sympathetic dominance and electrophysiologic instability in the heart, potentially culminating in arrhythmogenesis. E-liquids contain various formulations of nicotine and flavorings, but the effects of specific e-liquid constituents and their concentrations on e-cig-induced autonomic imbalance and electrical dysfunction are unresolved. To that end, we tested the hypothesis that e-cigs modify cardiac autonomic balance and ventricular arrhythmogenesis in mice dependent on e-liquid constituent type and concentration. Methods. Using a crossover design and a serial exposure regimen, ECG-telemetered male C57BL/6J mice underwent whole-body exposure to e-cig aerosols generated from e-liquids containing different …
Toxicity Of Different Insecticides To Sitophilus Oryzae, Tribolium Castaeneum And Tribolium Confusum Infesting Corn, Amina Twaibu
Toxicity Of Different Insecticides To Sitophilus Oryzae, Tribolium Castaeneum And Tribolium Confusum Infesting Corn, Amina Twaibu
Graduate Theses and Dissertations
Corn is an important cereal crop cultivated across various countries, including the United States. Corn serves multiple purposes such as human and livestock food and raw material for industrial processes. Despite being an important crop, corn production faces challenges due to factors such as weather fluctuations and the presence of insect pests and diseases, both in the field and during storage. Among these challenges, insect infestation poses a major threat, as the insect damage not only reduces the quantity and quality of the grain but also renders it unfit for human and animal consumption, leading to a decrease in market …
Altering United States Drug Policy And Shifting The Focus Of Drug Use From Conviction Toward Drug Addiction Treatment, Natalie Marra
Altering United States Drug Policy And Shifting The Focus Of Drug Use From Conviction Toward Drug Addiction Treatment, Natalie Marra
Honors Projects
While these substances were not always controlled by law, drug use has been as issue throughout time going back thousands of years and continues to be a concern in the twenty-first century. Possession, distribution, and manufacturing of controlled substances outside of what is considered legal can lead to fines and or jail time and can also increases the severity of other crimes committed either due to or under the influence of drugs. As of Saturday June 10th, 2023, 44.5% of Federal inmates are incarcerated for drug offenses, including possession, distribution, and manufacturing1. Drug offenses make up the largest percentage of …
Antidepressants Versus Placebo For Generalized Anxiety Disorder: A Systematic Review And Meta-Analysis, Katarina Kopcalic
Antidepressants Versus Placebo For Generalized Anxiety Disorder: A Systematic Review And Meta-Analysis, Katarina Kopcalic
Electronic Thesis and Dissertation Repository
Objectives: To assess the efficacy and acceptability of antidepressants compared to placebo among adults with a primary diagnosis of generalized anxiety disorder (GAD). Methods: Five electronic databases and 2 trial registries were searched to identify studies for inclusion. The risk of bias version 1 tool was used to assess the risk of bias. A random-effects meta-analysis was conducted using RevMan web. Results were presented using forest plots. Results: 38 studies (12,570 participants) were included. Very low-quality evidence showed a benefit for antidepressants over placebo in the rate of treatment response (RR, 1.39: 95% CI: 1.27, 1.52) and no differences in …
Non-Renal Alterations Of Drug Disposition In Chronic Kidney Disease, Nicholas Tonial
Non-Renal Alterations Of Drug Disposition In Chronic Kidney Disease, Nicholas Tonial
Electronic Thesis and Dissertation Repository
Chronic kidney disease (CKD) results in profound changes to non-renal drug elimination pathways including hepatic drug metabolism and hepatic transport mediated excretion. This results in complex pharmacological changes to drug disposition in the setting of kidney dysfunction. Four million Canadians are affected by CKD and the average CKD patient takes 14 medications daily with up to 40% experiencing adverse drug reactions at some point in their disease progression. Better elucidation of these changes in the setting of CKD is required to properly dose medications to provide therapeutic benefits while minimizing toxicity. This thesis aimed to better understand the impact kidney …
Utilization Of Detonation Nanodiamonds: Nanocarrier For Gene Therapy In Non-Small Cell Lung Cancer, Allan E. Gutierrez
Utilization Of Detonation Nanodiamonds: Nanocarrier For Gene Therapy In Non-Small Cell Lung Cancer, Allan E. Gutierrez
USF Tampa Graduate Theses and Dissertations
Lung cancer is one of the most prevalent and high mortality cancers in the world. Two different categories of lung cancer are non-small cell lung cancer which makes up 85% of cases, and small cell lung cancer which makes up the remaining 15% of cases. A significant risk factor that can lead to lung cancer is cigarette smoking (CS) however non-smoking cases i.e., secondhand CS, exposure to certain toxins and family history are on the rise. Both the main types of lung cancer have different system of stages, different ranges of treatment, and consequently low survival rates. Unfortunately, detection and …
Reintroducing Hemp (Rongony) In The Material Palette Of Madagascar: A Study On The Potential Of Hemp Clay Components And Its Impact On Social And Ecological Communities., Henintsoa Thierry Andrianambinina
Reintroducing Hemp (Rongony) In The Material Palette Of Madagascar: A Study On The Potential Of Hemp Clay Components And Its Impact On Social And Ecological Communities., Henintsoa Thierry Andrianambinina
Masters Theses
When mentioning the word hemp, especially in the local language of Madagascar, the literal translation does not set it apart from marijuana, as they are both called “rongony” - creating the stigma around hemp as the negative stereotype of marijuana. However, the material has been used by the ancestors of Madagascar, as well as across cultures, in its fibrous form to produce fabrication like textile goods and packaging. During colonization, the prohibition of hemp intensified, and since then, any activity related to either of these plants is prohibited and will end in severe punitive measures. This thesis explores the strengths …
Migratory Material: Epigenetics & Weaving At The Us-Mexico Border, Valerie Navarrete
Migratory Material: Epigenetics & Weaving At The Us-Mexico Border, Valerie Navarrete
Masters Theses
Discourse often sutures the body shut, disallowing representations of identity to outgrow sociopolitical interests. This issue may originate from borders, but also from the unnamable pathology that generational colonial trauma transmits to the mind, body, and environment. Without a direct form of translatability, this thesis proposes a new materialism that deviates from any object-oriented ontology. Untethered and intra-active, epigenetics and weaving represent objects that transform typical ways of knowing and seeing. Their sensitivity to the environment, in addition to their mobility across generations of time, broaden the spatiotemporal loci of the body and its embodiment. Proposing new materials that expand …
Gpr75 Deficiency Attenuates High Fat Diet-Driven Obesity And Glucose Intolerance, Sakib Hossain
Gpr75 Deficiency Attenuates High Fat Diet-Driven Obesity And Glucose Intolerance, Sakib Hossain
NYMC Student Theses and Dissertations
Recently, a collaboration between Regeneron Pharmaceuticals and the Schwartzman-Garcia labs at New York Medical College published an exome sequencing study of individuals across the United Kingdom, United States, and Mexico which concluded that individuals possessing non-functioning, truncated mutations to the orphan g protein coupled receptor (GPCR), GPR75, had lower BMI and 54% reduced likelihood of obesity. The present study was undertaken to fully characterize the metabolic phenotype of Gpr75 deficient mice when fed a high fat diet (HFD) and explore potential mechanisms by which GPR75 activation links to increased adiposity and decreased glucose tolerance. After 14 weeks of HFD-feeding we …
Nursing Education In Complementary Alternative Modalities: A Case Study, Deborah Bird
Nursing Education In Complementary Alternative Modalities: A Case Study, Deborah Bird
Dissertations
Purpose: The purpose of this embedded case study was to describe the preparation for and utilization of complimentary alternative modality (CAM) interventions by an experienced Doctor of Nursing Practice (DNP) prepared nurse practitioner (NP) working in an outpatient setting.
Background: Given the widespread use of CAM by the American public and the potential complications involved in combining CAM and standard medical care, a lack of educational preparation in CAM interventions by NPs delivering primary care in outpatient health care settings represents both a potential risk and a missed opportunity to provide holistic patient care. Such a lack of knowledge also …
Neuroinflammatory And Metabolomic Temporal Dynamics From Inhaled Wildfire Smoke With Attenuation Via Pharmacological Intervention, David Scieszka, David Scieszka
Neuroinflammatory And Metabolomic Temporal Dynamics From Inhaled Wildfire Smoke With Attenuation Via Pharmacological Intervention, David Scieszka, David Scieszka
Biomedical Sciences ETDs
Wildfire smoke is a global issue affecting nearly all humans on the surface of this Earth. Smoke dispersion from wildfires can span continents and cross oceans with amazing ease. Furthermore, total acres of land burned per year in the United States has roughly doubled since 1980, meaning this issue will persist for an indeterminate amount of time. Exposure to wildfire smoke is hazardous and promotes aging-associated events in the cardiopulmonary systems. Yet long- and short-term effects on the brain remain relatively unknown. From these, it is critically important to understand the neurological impacts from wildfire smoke exposure; to compare these …